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61. 发明公开

EP0832655A2 Drug release stent coating and process 无效
标题翻译：药物释放支架涂层和工艺
公开(公告)号：EP0832655A2
公开(公告)日：1998-04-01
申请号：EP97109380.2
申请日：1997-06-10
申请人： SCHNEIDER (USA) INC.
发明人： Ding, Ni , Helmus, Michael N.
IPC分类号： A61L33/00 , A61F2/06
CPC分类号： A61L33/0011 , A61F2210/0014 , A61F2250/0067 , A61L27/227 , A61L31/08 , A61L31/10 , A61L31/16 , A61L2300/236 , A61L2300/42 , A61L2300/602 , A61L2300/606 , A61L2300/622 , C08L5/00 , C08L71/02 , C08L83/08 , C08L83/00 , C08L83/04
摘要： A coating and method for implantable open lattice metallic stent prostheses are disclosed. The coating includes a relatively thin layer of biostable elastomeric material containing an amount of biologically active material particularly heparin, dispersed in the coating in combination with a non-thrombogenic surface. In one embodiment, the surface is provided with sites of high electronegativity species by coating with fluorosilicone which aid in controlling elution, particularly the initial release rate, and reduced thrombogenic activity. Other non-thrombogenic outer layers for heparin such as covalently bound polyethylene glycol (PEG) are also disclosed.
摘要翻译：公开了用于植入式开放式金属支架假体的涂层和方法。该涂层包括含有一定量的生物活性物质，特别是肝素的相对薄的生物稳定弹性体材料，其与非血栓形成表面结合分散在涂层中。在一个实施方案中，通过用有助于控制洗脱，特别是初始释放速率和降低的血栓形成活性的氟硅氧烷涂布，为表面提供高电负性物种的位置。还公开了用于肝素的其他非血栓形成外层，如共价结合的聚乙二醇（PEG）。

62. 发明公开

EP0708671A4 DRUG DELIVERY 失效
标题翻译： MEDIZINABGABE
公开(公告)号：EP0708671A4
公开(公告)日：1997-01-29
申请号：EP94922724
申请日：1994-07-25
申请人： BOSTON SCIENT CORP
发明人： SAHATJIAN RONALD A , BARRY JAMES J
IPC分类号： A61M25/00 , A61B17/03 , A61F2/00 , A61F2/90 , A61K9/00 , A61K38/49 , A61K48/00 , A61L29/08 , A61L29/14 , A61L29/16 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/00 , A61M16/04 , A61M29/02 , A61M31/00
CPC分类号： A61M25/104 , A61F2/90 , A61F2230/0013 , A61F2250/0067 , A61K9/0024 , A61K38/49 , A61K48/00 , A61L29/085 , A61L29/145 , A61L29/16 , A61L31/10 , A61L31/145 , A61L31/16 , A61L33/0023 , A61L33/0029 , A61L2300/256 , A61L2300/258 , A61L2300/416 , A61L2300/42 , A61L2300/45 , A61L2300/602 , A61L2300/606 , A61L2300/622 , A61M16/0481 , A61M25/0045 , A61M2025/0046 , A61M2025/0057 , A61M2025/09183 , A61M2025/105 , A61M2025/1086 , A61M2205/0266 , C08L33/02 , C08L35/00
摘要： The invention features a catheter (1) for delivering drugs to tissue at a desired location of the wall of a body lumen (2). The catheter (1) has a catheter shaft (3) and an expandable portion (4) mounted on the catheter shaft (3). The expandable portion (4) is expandable to a controlled pressure to fill the cross section of the body lumen (2) and press against the wall of the body lumen (2). At least a portion of the exterior surface of the expandable portion (4) is defined by a coating (6) of a tenaciously adhered swellable hydrogel polymer. Incorporated in the hydrogel polymer is an aqueous solution (8) of a preselected drug to be delivered to the tissue or plaque. The hydrogel polymer (6) and drug (8) are selected to allow rapid release of a desired dosage of the drug from the hydrogel polymer coating (6) during compression of the hydrogel polymer coating (6) against the wall of the lumen (2) when the expandable portion (4) is expanded.
摘要翻译：本发明的特征在于用于将药物输送到体腔（2）的壁的期望位置处的组织的导管（1）。导管（1）具有导管轴（3）和安装在导管轴（3）上的可扩张部分（4）。可膨胀部分（4）可膨胀至受控压力以填充体腔（2）的横截面并压靠体腔（2）的壁。可膨胀部分（4）的外表面的至少一部分由顽固粘附的可膨胀水凝胶聚合物的涂层（6）限定。结合在水凝胶聚合物中的是预先选择的待输送到组织或斑块的药物的水溶液（8）。选择水凝胶聚合物（6）和药物（8）以允许在将水凝胶聚合物涂层（6）压缩在内腔壁（2）上期间从水凝胶聚合物涂层（6）快速释放期望剂量的药物）当可扩张部分（4）扩张时。

63. 发明公开

EP0734721A3 Method of incorporating drugs into a polymer component of stents 失效
标题翻译：在支架的聚合物成分掺入药物的方法
公开(公告)号：EP0734721A3
公开(公告)日：1997-01-15
申请号：EP96301909.6
申请日：1996-03-20
申请人： ADVANCED CARDIOVASCULAR SYSTEMS, INC.
发明人： Eury, Robert P. , Garguilo, Darlene , Villareal, Plaridel
IPC分类号： A61K9/22 , A61K9/70 , A61M29/00
CPC分类号： A61L31/16 , A61L31/10 , A61L31/146 , A61L2300/602 , A61L2300/606 , A61L2300/622 , A61M2025/0057 , C08L83/04 , C08L67/04 , C08L31/04
摘要： The drug-loaded polymeric material containing a therapeutic drug can be applied to a structure of an intravascular stent. A therapeutically effective amount of a therapeutic drug is incorporated into such a layer of polymeric material, without significantly increasing the thickness of the stent, to avoid interfering with the function of the stent. The drug-loaded polymer coating of the stent can formed to include pores, can be multi-layered to permit the combination of a plurality of different drug containing materials in a single stent, and can include a rate controlling membrane to allow for controlled retention and delivery of selected drugs within the affected blood vessel upon implantation. The layer of polymeric material is manufactured by combining the selected polymeric material with a relatively high loading of the therapeutic drug in a thermal process, such as coextrusion of the therapeutic drug with the polymeric material. The therapeutic drug is dispersed and incorporated into the polymer as small particles, preferably having a maximum cross-sectional dimension of 10 microns.

64. 发明公开

EP0739219A1 CATHETER HAVING A LONG-LASTING ANTIMICROBIAL SURFACE TREATMENT 失效
标题翻译：长效抗菌表面处理导管
公开(公告)号：EP0739219A1
公开(公告)日：1996-10-30
申请号：EP95903502.0
申请日：1994-09-22
申请人： SPIRE CORPORATION
发明人： BRICAULT, Raymond, J., Jr. , BARRY, John, E. , SIOSHANSI, Piran
IPC分类号： A61L29 , A61F2 , A61L27 , A61L31 , A61M25 , C23C14 , A61B17
CPC分类号： A61L29/16 , A61B17/60 , A61B17/72 , A61F2/20 , A61F2/30767 , A61F2/3094 , A61F2/82 , A61F2002/30677 , A61L27/54 , A61L29/10 , A61L31/082 , A61L31/16 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/606 , A61L2300/622 , A61L2400/18 , A61M25/0017 , A61M2025/0056 , C23C14/20 , C23C14/505 , C23C14/566
摘要： Catheters including at least one component having a tissue interfacing surface characterized by a substantially nonleaching surface treatment of antimicrobial metal. The component can be a subcutaneous cuff, and the antimicrobial metal can be silver. The process for implanting the silver atoms can include dry coating the tissue interfacing surface of the catheter by way of ion beam assisted deposition. Alternatively, the silver can be introduced into the tissue interfacing surface by ion implantation.

65. 发明公开

EP0734721A2 Method of incorporating drugs into a polymer component of stents 失效
标题翻译： Zugabe von Arzneistoffen in eine polymere Komponente von Stents
公开(公告)号：EP0734721A2
公开(公告)日：1996-10-02
申请号：EP96301909.6
申请日：1996-03-20
申请人： ADVANCED CARDIOVASCULAR SYSTEMS, INC.
发明人： Eury, Robert P. , Garguilo, Darlene , Villareal, Plaridel
IPC分类号： A61K9/22 , A61K9/70 , A61M29/00
CPC分类号： A61L31/16 , A61L31/10 , A61L31/146 , A61L2300/602 , A61L2300/606 , A61L2300/622 , A61M2025/0057 , C08L83/04 , C08L67/04 , C08L31/04
摘要： The drug-loaded polymeric material containing a therapeutic drug can be applied to a structure of an intravascular stent. A therapeutically effective amount of a therapeutic drug is incorporated into such a layer of polymeric material, without significantly increasing the thickness of the stent, to avoid interfering with the function of the stent. The drug-loaded polymer coating of the stent can formed to include pores, can be multi-layered to permit the combination of a plurality of different drug containing materials in a single stent, and can include a rate controlling membrane to allow for controlled retention and delivery of selected drugs within the affected blood vessel upon implantation. The layer of polymeric material is manufactured by combining the selected polymeric material with a relatively high loading of the therapeutic drug in a thermal process, such as coextrusion of the therapeutic drug with the polymeric material. The therapeutic drug is dispersed and incorporated into the polymer as small particles, preferably having a maximum cross-sectional dimension of 10 microns.
摘要翻译：含有治疗药物的载药聚合材料可以应用于血管内支架的结构。将治疗有效量的治疗药物并入到这种聚合物材料层中，而不显着增加支架的厚度，以避免干扰支架的功能。支架的载药聚合物涂层可以形成为包括孔，可以是多层的，以允许在单个支架中组合多种不同的药物包含材料，并且可以包括速率控制膜以允许受控保留和在植入后在受影响的血管内递送选定的药物。聚合物材料层通过在热处理中将所选择的聚合物材料与治疗药物的相对高负荷组合而制备，例如治疗性药物与聚合物材料的共挤出。将治疗药物分散并作为小颗粒并入聚合物中，优选具有10微米的最大横截面尺寸。

66. 发明公开

EP0691856A1 ARTICLES CONTAINING SMALL PARTICLE SIZE CYCLODEXTRIN FOR ODOR CONTROL 失效
标题翻译：关于小CYCLODEXTRINTEILCHENGRÖSSE物体控制气味
公开(公告)号：EP0691856A1
公开(公告)日：1996-01-17
申请号：EP94910957.0
申请日：1994-03-17
申请人： THE PROCTER & GAMBLE COMPANY
发明人： TRINH, Toan (NMN) , PHAN, Dean, Van
IPC分类号： A61F13 , A61K8 , A61L9 , A61L15 , A61Q13 , A61Q15 , C08B37 , C08L5 , C11D3
CPC分类号： C08L5/16 , A61K8/0208 , A61K8/19 , A61K8/25 , A61K8/26 , A61K8/738 , A61K2800/56 , A61L15/20 , A61L15/46 , A61L2300/404 , A61L2300/622 , A61L2300/802 , A61Q13/00 , A61Q15/00
摘要： The present invention relates to compositions and articles such as catamenials, diapers, pantiliners, paper towels, tissues, underarm shields, etc., which minimize odor caused from body fluids through the incorporation of an effective amount of cyclodextrin, having a particle size of less than 12 microns. Combinations of small particle size cyclodextrins with other odor-controlling materials are also disclosed.

67. 发明公开

EP0581387A1 Bone cement composition and method of manufacture 失效
标题翻译： Knochenzement和Verfahren zu seiner Herstellung。
公开(公告)号：EP0581387A1
公开(公告)日：1994-02-02
申请号：EP93202227.0
申请日：1993-07-28
申请人： Bristol-Myers Squibb Company
发明人： Lin, Steve T.
IPC分类号： A61L25/00 , C08K9/10
CPC分类号： C08K9/10 , A61L24/001 , A61L24/0015 , A61L24/0089 , A61L2300/406 , A61L2300/414 , A61L2300/44 , A61L2300/622 , A61L2430/02
摘要： A bone cement composition has adjustable rheological properties, high strength, and produces a uniform radiological image. The cement comprises beads containing a polymerization initiator in controllable concentrations from 0% to 5% or more by weight. These same beads or others may also contain an opacifier. The polymerization initiator and the opacifier may be selectively distributed throughout the beads or at specific radial locations in the beads or within the beads in specific strata. They may also be selectively placed in beads of a particular advantageous size range. Furthermore, in other embodiments of the invention, other advantageous additives can be incorporated in the beads such as dyes, antibiotics, bone growth factors, and other pharmacological or therapeutic agents.
摘要翻译：骨水泥组合物具有可调节的流变性能，高强度，并产生均匀的放射图像。该水泥包含含有可控浓度为0％至5％或更高重量的聚合引发剂的珠粒。这些相同的珠子或其他珠子还可以含有遮光剂。聚合引发剂和遮光剂可以选择性地分布在整个珠粒或珠粒中的特定径向位置或特定层的珠粒内。它们也可以选择性地放置在特定有利尺寸范围的珠子中。此外，在本发明的其它实施方案中，其它有利的添加剂可以掺入珠粒中，例如染料，抗生素，骨生长因子和其他药理学或治疗剂。

68. 发明公开

EP0575516A1 BINDER COATED DISCONTINUOUS FIBERS WITH ADHERED PARTICULATE MATERIALS 失效
标题翻译：涂有粘合剂，并用spezialen附着物短纤维。
公开(公告)号：EP0575516A1
公开(公告)日：1993-12-29
申请号：EP92908654.0
申请日：1992-03-20
申请人： WEYERHAEUSER COMPANY
发明人： YOUNG, Richard, H., Sr. , NEOGI, Amar, N. , HANSEN, Michael, R. , HODGSON, Kevin, T. , HALABISKY, Donald, D. , MARSH, David, G. , BRUNNENKANT, Christel , PARK, David, W. , GADDIS, Paul, G. , JOHNSTON, William, C., Jr.
IPC分类号： A61F13 , A61L15 , D04H1 , D06M11 , D06M13 , D06M15 , D21H17 , D06M101
CPC分类号： A61F13/15658 , A61F13/511 , A61F13/531 , A61F13/539 , A61F13/8405 , A61F2013/15967 , A61F2013/530007 , A61F2013/530131 , A61F2013/530343 , A61F2013/530496 , A61F2013/530569 , A61F2013/530583 , A61F2013/5395 , A61F2013/8414 , A61F2013/842 , A61F2013/8423 , A61L15/46 , A61L2300/102 , A61L2300/402 , A61L2300/404 , A61L2300/418 , A61L2300/42 , A61L2300/622 , D04H1/407 , D04H1/413 , D04H1/425 , D04H1/4382 , D04H1/54 , D06M11/46 , D06M11/74 , D21H17/48 , Y10T428/29 , Y10T428/2907 , Y10T428/2927 , Y10T428/2929 , Y10T428/2933 , Y10T428/2938 , Y10T428/2965
摘要： Des fibres discontinues sont enrobées d'un liant et des matières particulaires solides sont collées aux fibres par ledit liant. Les fibres sont typiquement enrobées de liant en continu. La matière liante peut être liée à chaud et les fibres traitées peuvent être mélangées à d'autres fibres destinées à être utilisées dans la production d'une large variété de structures et de produits.

69. 发明授权

EP0306389B1 Application de microcapsules à la fabrication d'un dispositif prophylactique en matériau élastomère, comme un préservatif ou analogue et son procédé de fabrication 失效
标题翻译：在制造弹性预制装置中的微生物的使用，如等级或其制造方法及其制造方法
公开(公告)号：EP0306389B1
公开(公告)日：1992-07-08
申请号：EP88402116.3
申请日：1988-08-17
申请人： HUTCHINSON
发明人： Busnel, René Guy , Argy, Gilles
IPC分类号： A61F6/04 , A61B19/04 , B29C41/22 , B32B25/02 , A61L31/00
CPC分类号： B32B25/02 , A61B42/00 , A61B42/10 , A61F6/04 , A61L31/16 , A61L2300/404 , A61L2300/622 , B29C41/10 , B29C41/14 , B29C41/22 , B29K2021/00 , B29K2105/0005 , B29K2105/0076 , B32B25/042 , B32B25/12 , Y10S2/901

70. 发明公开

EP3265139A1 MICROPARTICLES 有权转让
标题翻译：微粒
公开(公告)号：EP3265139A1
公开(公告)日：2018-01-10
申请号：EP16707800.5
申请日：2016-03-03
申请人： Spheritech Ltd
发明人： WELLINGS, Donald A
IPC分类号： A61L15/32 , A61L26/00 , C08J3/24 , C08G69/48 , C12N11/02 , C12N11/08
CPC分类号： B01J13/185 , A01N25/08 , A61K9/1617 , A61L15/425 , A61L15/44 , A61L15/46 , A61L26/0019 , A61L26/0066 , A61L26/0085 , A61L2300/404 , A61L2300/622 , A61L2430/02 , C08G69/10 , C08G69/48 , C12N5/0075 , C12N5/0654 , C12N2513/00 , C12N2533/20 , C12N2537/10
摘要： The invention provides a self-assembled microparticle having an acid having two or more acid groups and an organic base in a solvent. The microparticles may form into a macrostructure and provide a scaffold for cell culture. The particle is of micron scale. The microparticle may be obtained by contacting a bis-acid and organic base in a hydrophilic solvent, wherein the acid is insoluble or sparingly soluble in the hydrophilic solvent and the organic base is soluble in a hydrophilic solvent. The microparticles have antimicrobial activity and may be used in a wide range of consumer product applications, cell culture and medical products, such as wound dressings.

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