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1. 发明授权

EP3053604B1 COMPOSITIONS AND METHODS FOR TREATING JOINTS 有权
公开(公告)号：EP3053604B1
公开(公告)日：2018-10-17
申请号：EP16151940.0
申请日：2016-01-19
申请人： DePuy Synthes Products, Inc.
发明人： STORY, Brooks J. , WADSWORTH, Scott A. , PARRISH, William R. , HERZBERG, Uri , TORRES, Donna , BYERS, Benjamin A. , HWANG, Julia , SU, Dongling
IPC分类号： A61L27/20 , A61L27/50
CPC分类号： A61K31/737 , A61K9/0019 , A61K31/7016 , A61K31/726 , A61K31/728 , A61K47/36 , A61L27/20 , A61L27/50 , A61L2300/236 , A61L2400/06 , A61L2430/24 , A61M5/31596 , C08B37/0069 , C08B37/0072
摘要： Compositions and methods are disclosed for the treatment of osteoarthritis. The compositions comprising combinations of hyaluronic acid, glucosamine, and chondroitin sulfate, can be useful for any synovial joint, including the knee, shoulder, hip, ankle, hands, spinal facet, or temporomandibular joint, both for the relief of pain and for slowing disease progression.

2. 发明授权

EP2700421B1 Immobilized biologically active entities having a high degree of biological activity 有权转让
公开(公告)号：EP2700421B1
公开(公告)日：2018-07-18
申请号：EP13189447.9
申请日：2008-11-06
申请人： W. L. Gore & Associates, Inc.
发明人： Cleek, Robert , Daly, Michael, D. , Pietrzak, Krzysztof, R.
IPC分类号： A61L33/00 , A61L33/08 , A61L33/06 , A61L2/00 , A61L31/10 , A61L31/12 , A61K31/727 , A61L27/34 , A61L27/54 , A61L27/20 , A61K38/17
CPC分类号： A61L31/16 , A61K31/727 , A61K38/1709 , A61L27/20 , A61L27/34 , A61L27/54 , A61L31/042 , A61L33/0011 , A61L33/0029 , A61L2300/222 , A61L2300/236 , A61L2300/416 , A61L2300/42 , A61L2300/45 , C08L5/02 , C08L5/10
摘要： The present invention relates to immobilized biologically active entities having heparin cofactor II binding activity.

3. 发明公开

EP3328453A1 METHOD OF PREPARING AN OSTEOGENIC BONE GRAFT 有权
公开(公告)号：EP3328453A1
公开(公告)日：2018-06-06
申请号：EP16753497.3
申请日：2016-07-20
申请人： DePuy Synthes Products, Inc. , ThermoGenesis Corp.
发明人： LEHMICKE, Michael , COELHO, Philip H.
IPC分类号： A61L27/38 , A61L27/54
CPC分类号： A61L27/3804 , A61L27/54 , A61L2300/236 , A61L2300/412 , A61L2300/42 , A61L2430/02
摘要： The present disclosure is directed to a method of preparing an osteogenic bone graft. The method includes introducing an anticoagulant compound into a volume of cellular material including a mononuclear cell population from the intramedullary canal of a long bone; collecting an effluent including the volume of cellular material containing the anticoagulant compound at a collection point; separating a concentrated cell fraction from the effluent, the concentrated cell fraction including the mononuclear cell population and the anticoagulant compound; and preparing an osteogenic bone graft from the concentrated cell fraction.

4. 发明公开

EP3319652A1 VERFAHREN ZUR HERSTELLUNG EINES BIOARTIFIZIELLEN, PRIMÄR AZELLULÄREN KONSTRUKTS AUF FIBRINBASIS UND DIESES KONSTRUKT SELBST 有权
标题翻译：在纤维蛋白碱基上制备生物分解性一次性蜂窝状构建体的方法及其构建体本身
公开(公告)号：EP3319652A1
公开(公告)日：2018-05-16
申请号：EP16736169.0
申请日：2016-07-07
申请人： Medizinische Hochschule Hannover
发明人： APER, Thomas , WILHELMI, Mathias , HAVERICH, Axel
IPC分类号： A61L27/22 , A61L31/04
CPC分类号： A61L27/26 , A61L27/225 , A61L27/507 , A61L27/54 , A61L31/046 , A61L33/0011 , A61L33/08 , A61L2300/236 , A61L2300/252 , A61L2300/254 , A61L2300/418 , A61L2300/42 , A61L2420/02 , A61L2430/06 , A61L2430/20
摘要： The invention relates to a method for producing a bioartificial and primarily acellular fibrin-based construct, wherein a mixture of cell-free compositions containing fibrinogen and thrombin is applied to a surface and subsequently pressurised. An additional aspect of the invention is directed to such fibrin-based bioartificial acellular constructs obtained according to the invention, with improved biomechanical properties, as well as to the use of same in the field of implantology, cartilage replacement or tissue replacement.

5. 发明公开

EP3310402A1 HIGHLY EFFICACIOUS HEMOSTATIC ADHESIVE POLYMER SCAFFOLD 有权
标题翻译：高效静脉用粘合剂聚合物支架
公开(公告)号：EP3310402A1
公开(公告)日：2018-04-25
申请号：EP15896492.4
申请日：2015-06-22
申请人： Cresilon, Inc.
发明人： LANDOLINA, Joseph, A. , AHMAD, Omar, M.
IPC分类号： A61L15/22
CPC分类号： A61L26/0052 , A61L15/225 , A61L15/42 , A61L15/58 , A61L24/001 , A61L24/043 , A61L26/0066 , A61L26/008 , A61L2300/232 , A61L2300/236 , A61L2300/418 , C08J3/075 , C08J2305/04 , C08J2305/08 , C08L5/04 , C08L5/08
摘要： The invention relates to biocompatible polymer gel compositions useful in facilitating and maintaining hemostasis. The biocompatible polymeric gel composition is comprised of (a) one or more than one polyanionic polymer, (b) one or more than one polycationic polymer, and (c) a solvent. A preferred composition includes sodium alginate, chitosan, and water to produce an adhesive hemostatic device that is useful in facilitating and maintaining rapid hemostasis.

6. 发明公开

EP3297751A1 FUNCTIONALIZED MEMBRANES FOR BIOARTIFICIAL ORGANS 审中-实审转让
标题翻译：用于生物器官的功能化膜
公开(公告)号：EP3297751A1
公开(公告)日：2018-03-28
申请号：EP16725071.1
申请日：2016-05-17
申请人： Defymed
发明人： BOU AOUN, Richard , BURCEZ, Charles-Thibault , MAGISSON, Jordan , SIGRIST, Séverine
IPC分类号： B01D69/10 , A61L33/00 , A61F2/02 , A61M1/34
CPC分类号： B01D67/0088 , A61L27/26 , A61L27/34 , A61L27/54 , A61L27/56 , A61L33/0011 , A61L33/08 , A61L2300/236 , A61L2300/42 , A61L2400/18 , B01D69/02 , B01D69/105 , B01D69/12 , B01D71/08 , B01D2323/36 , B01D2325/04
摘要： The invention relates to a heparin-functionalized semi-permeable membrane comprising at least one layer of porous biocompatible polymer, and one layer of non-woven biocompatible polymer wherein said heparin is covalently bound to a layer on the surface of said porous biocompatible polymer.

7. 发明授权

EP2477668B1 NOVEL HEPARIN ENTITIES AND METHODS OF USE 有权转让
标题翻译：新的肝素实体和使用方法
公开(公告)号：EP2477668B1
公开(公告)日：2018-02-07
申请号：EP10755304.2
申请日：2010-09-16
申请人： W. L. Gore & Associates, Inc.
发明人： BIRAN, Roy , CLAUDE, Charles, D. , CLEEK, Robert, L. , DRUMHELLER, Paul, D. , LI, Mei , MARDIROSIAN, Nora
IPC分类号： A61L33/00 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/16
CPC分类号： A61L33/0011 , A61L27/54 , A61L29/16 , A61L31/022 , A61L31/048 , A61L31/10 , A61L31/16 , A61L33/08 , A61L33/128 , A61L2300/236 , A61L2300/42 , C08L27/12
摘要： The present invention relates to immobilized biologically active entities that retain a significant biological activity following manipulation. The invention also comprises a medical substrate comprising a heparin entity bound onto a substrate via at least one heparin molecule, wherein said bound heparin entity is heparinase-1 sensitive.

8. 发明公开

EP3263146A1 METHOD FOR MANUFACTURING MEDICAL MATERIAL, MEDICAL MATERIAL, AND ANTI-ADHESION MATERIAL 审中-公开
标题翻译：制造医用材料，医用材料和抗粘材料的方法
公开(公告)号：EP3263146A1
公开(公告)日：2018-01-03
申请号：EP16755629.9
申请日：2016-02-25
申请人： Dainichiseika Color & Chemicals Mfg. Co., Ltd.
发明人： ISONO, Yasuyuki , NOISHIKI, Yasuharu
IPC分类号： A61L31/00
CPC分类号： A61L31/042 , A61L31/00 , A61L31/16 , A61L2300/236 , A61L2300/424 , C08J5/18 , C08J2305/08
摘要： There is provided a process for producing a medical material that retains the properties which are inherent in a polyanionic polysaccharide being a raw material, that has a high level of safety because there is no need to use a chemical crosslinking agent, and that has moderate strength and flexibility. The present invention is a process for producing a medical material, the process including a step of dispersing a powder or a granular product of a first polyanionic polysaccharide, the first polyanionic polysaccharide water-insolubilized with a treatment liquid containing a first acid anhydride, in an aqueous solution of a water-soluble salt of a second polyanionic polysaccharide, thereby obtaining a dispersion liquid, a step of drying the dispersion liquid obtained, thereby obtaining a dried film, and a step of water-insolubilizing the dried film obtained with a treatment liquid containing a second acid anhydride, thereby obtaining the medical material.
摘要翻译：本发明提供一种医疗用材料的制造方法，该医疗用材料保持作为原料的聚阴离子性多糖类固有的特性，因为不需要使用化学交联剂，所以安全性高，具有适度的强度和灵活性。本发明是一种医疗用材料的制造方法，其特征在于，包括：将第一聚阴离子性多糖类的粉末或粒状生成物与含有第一酸酐的处理液不溶于水的第一聚阴离子类多糖分散于由此得到分散液的工序;将得到的分散液干燥而得到干燥膜的工序;以及将用处理液得到的干燥膜进行水不溶化的工序含有第二酸酐，由此获得医用材料。

9. 发明授权

EP2205294B1 IMMOBILIZED BIOLOGICALLY ACTIVE ENTITIES HAVING A HIGH DEGREE OF BIOLOGICAL ACTIVITY 有权转让
标题翻译：具有高度生物活性的固定的生物活性实体
公开(公告)号：EP2205294B1
公开(公告)日：2017-09-13
申请号：EP08850202.6
申请日：2008-11-06
申请人： W. L. Gore & Associates, Inc.
发明人： CLEEK, Robert, L. , DALY, Michael, D. , PIETRZAK, Krzysztof, R.
IPC分类号： A61L33/00 , A61L33/08 , A61L33/06 , A61L2/00 , A61L31/10 , A61L31/12
CPC分类号： A61L31/16 , A61K31/727 , A61K38/1709 , A61L27/20 , A61L27/34 , A61L27/54 , A61L31/042 , A61L33/0011 , A61L33/0029 , A61L2300/222 , A61L2300/236 , A61L2300/416 , A61L2300/42 , A61L2300/45 , C08L5/02 , C08L5/10

10. 发明授权

EP2023967B1 IMMOBILIZED BIOLOGICALLY ACTIVE ENTITIES HAVING A HIGH DEGREE OF BIOLOGICAL ACTIVITY FOLLOWING MECANICAL MANIPULATION OR STERILIZATION 有权转让
标题翻译：具有生物活性程度高，固定化生物活性的微量元素的机械操纵或消毒
公开(公告)号：EP2023967B1
公开(公告)日：2017-03-22
申请号：EP07777001.4
申请日：2007-05-11
申请人： W. L. Gore & Associates, Inc.
发明人： CLEEK, Robert, L. , DALY, Michael, D. , PIETRZAK, Krzysztof, R.
IPC分类号： A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/00
CPC分类号： A61L27/54 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L33/0029 , A61L33/0088 , A61L2300/222 , A61L2300/236 , A61L2300/252 , A61L2300/406 , A61L2300/416 , A61L2300/42 , Y10T428/31544 , C08L79/02

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