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1. 发明公开

EP0734721A3 Method of incorporating drugs into a polymer component of stents 失效
标题翻译：在支架的聚合物成分掺入药物的方法
公开(公告)号：EP0734721A3
公开(公告)日：1997-01-15
申请号：EP96301909.6
申请日：1996-03-20
申请人： ADVANCED CARDIOVASCULAR SYSTEMS, INC.
发明人： Eury, Robert P. , Garguilo, Darlene , Villareal, Plaridel
IPC分类号： A61K9/22 , A61K9/70 , A61M29/00
CPC分类号： A61L31/16 , A61L31/10 , A61L31/146 , A61L2300/602 , A61L2300/606 , A61L2300/622 , A61M2025/0057 , C08L83/04 , C08L67/04 , C08L31/04
摘要： The drug-loaded polymeric material containing a therapeutic drug can be applied to a structure of an intravascular stent. A therapeutically effective amount of a therapeutic drug is incorporated into such a layer of polymeric material, without significantly increasing the thickness of the stent, to avoid interfering with the function of the stent. The drug-loaded polymer coating of the stent can formed to include pores, can be multi-layered to permit the combination of a plurality of different drug containing materials in a single stent, and can include a rate controlling membrane to allow for controlled retention and delivery of selected drugs within the affected blood vessel upon implantation. The layer of polymeric material is manufactured by combining the selected polymeric material with a relatively high loading of the therapeutic drug in a thermal process, such as coextrusion of the therapeutic drug with the polymeric material. The therapeutic drug is dispersed and incorporated into the polymer as small particles, preferably having a maximum cross-sectional dimension of 10 microns.

2. 发明公开

EP0734721A2 Method of incorporating drugs into a polymer component of stents 失效
标题翻译： Zugabe von Arzneistoffen in eine polymere Komponente von Stents
公开(公告)号：EP0734721A2
公开(公告)日：1996-10-02
申请号：EP96301909.6
申请日：1996-03-20
申请人： ADVANCED CARDIOVASCULAR SYSTEMS, INC.
发明人： Eury, Robert P. , Garguilo, Darlene , Villareal, Plaridel
IPC分类号： A61K9/22 , A61K9/70 , A61M29/00
CPC分类号： A61L31/16 , A61L31/10 , A61L31/146 , A61L2300/602 , A61L2300/606 , A61L2300/622 , A61M2025/0057 , C08L83/04 , C08L67/04 , C08L31/04
摘要： The drug-loaded polymeric material containing a therapeutic drug can be applied to a structure of an intravascular stent. A therapeutically effective amount of a therapeutic drug is incorporated into such a layer of polymeric material, without significantly increasing the thickness of the stent, to avoid interfering with the function of the stent. The drug-loaded polymer coating of the stent can formed to include pores, can be multi-layered to permit the combination of a plurality of different drug containing materials in a single stent, and can include a rate controlling membrane to allow for controlled retention and delivery of selected drugs within the affected blood vessel upon implantation. The layer of polymeric material is manufactured by combining the selected polymeric material with a relatively high loading of the therapeutic drug in a thermal process, such as coextrusion of the therapeutic drug with the polymeric material. The therapeutic drug is dispersed and incorporated into the polymer as small particles, preferably having a maximum cross-sectional dimension of 10 microns.
摘要翻译：含有治疗药物的载药聚合材料可以应用于血管内支架的结构。将治疗有效量的治疗药物并入到这种聚合物材料层中，而不显着增加支架的厚度，以避免干扰支架的功能。支架的载药聚合物涂层可以形成为包括孔，可以是多层的，以允许在单个支架中组合多种不同的药物包含材料，并且可以包括速率控制膜以允许受控保留和在植入后在受影响的血管内递送选定的药物。聚合物材料层通过在热处理中将所选择的聚合物材料与治疗药物的相对高负荷组合而制备，例如治疗性药物与聚合物材料的共挤出。将治疗药物分散并作为小颗粒并入聚合物中，优选具有10微米的最大横截面尺寸。

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