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1. 发明公开

EP3357532A1 MEDICAL ELONGATE MEMBER 有权
公开(公告)号：EP3357532A1
公开(公告)日：2018-08-08
申请号：EP16851560.9
申请日：2016-09-27
申请人： Terumo Kabushiki Kaisha
发明人： OKAMURA, Ryo , OMATA, Kazuya
IPC分类号： A61M25/00 , A61M25/06
CPC分类号： A61M25/0045 , A61L29/10 , A61M25/00 , A61M25/06 , A61M25/0662 , A61M2025/0046 , A61M2025/0675 , B05D5/08 , C08L27/06 , C08L35/08 , C08L75/04
摘要： [Task] Provided is a medical elongated body which can be smoothly put in and taken out with respect to a living body in a low-invasive manner and which can prevent an imprudent movement from occurring while being in use.
[Solution] A hydrophilic lubricating coating layer 160 which exhibits lubricating characteristics when wet, and a temperature responsive lubricating coating layer 170 which exhibits hydrophilic characteristics and lubricating characteristics at a temperature lower than a critical temperature when wet and exhibits hydrophobic characteristics and non-lubricating characteristics at a temperature equal to or higher than the critical temperature when wet are formed on an outer surface of a sheath tube 110. The temperature responsive lubricating coating layer is disposed on a proximal side of the hydrophilic lubricating coating layer and is formed on a proximal side of the sheath tube.

2. 发明授权

EP1979016B1 METHODS OF APPLYING A HYDROPHILIC COATING TO A SUBSTRATE, AND SUBSTRATES HAVING A HYDROPHILIC COATING 有权
标题翻译：安装的亲水性涂层的对基材和衬底，亲水涂层方法
公开(公告)号：EP1979016B1
公开(公告)日：2015-07-01
申请号：EP07762800.6
申请日：2007-01-30
申请人： HOLLISTER INCORPORATED
发明人： GILMAN, Thomas, H.
IPC分类号： A61L29/08 , A61L29/14
CPC分类号： A61L31/10 , A61L27/34 , A61L27/50 , A61L29/041 , A61L29/06 , A61L29/085 , A61L29/10 , A61L29/14 , A61L2400/10 , A61L2420/02 , B05D1/18 , B05D3/067 , B05D5/00 , B05D5/08 , C10M157/00 , C10M157/04 , C10M173/00 , C10M2207/08 , C10M2207/12 , C10M2209/04 , C10M2209/084 , C10M2209/102 , C10M2215/086 , C10M2215/22 , C10M2217/024 , C10M2217/028 , C10M2217/045 , C10N2250/121 , Y10T428/31 , Y10T428/31504 , Y10T428/31536 , Y10T428/31551 , Y10T428/31576 , Y10T428/31725 , Y10T428/31736 , Y10T428/31935

3. 发明授权

EP2537879B1 ROOM TEMPERATURE-CURABLE POLYMERS 有权
标题翻译：在室温下固化聚合物
公开(公告)号：EP2537879B1
公开(公告)日：2015-01-21
申请号：EP12180872.9
申请日：2006-12-14
申请人： Abbott Laboratories
发明人： Hauenstein, Dale
IPC分类号： C08G77/442 , A61F2/02 , A61L33/00 , C08L53/00 , C08L83/10 , C09D183/10 , A61L29/08
CPC分类号： C08G77/442 , A61L29/10 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/606 , C08G77/045 , C08G77/06 , C08G77/16 , C08G77/18 , C08G77/42 , C08L83/04 , C08L83/10 , C09D183/10
摘要： Methods of making room temperature-curable polymers. Reactants include siloxane-terminated polymers and silanols. The reactants are mixed, and the polymerization allowed to proceed in air at room temperature. The polymers are exceptionally useful because they allow for the incorporation into the polymers themselves of one or more therapeutic compounds. Thus, medical devices from which controlled drug release is desirable (for either local or systemic delivery) can be coated with therapeutic compound-containing polymers of the invention. In a preferred embodiment, a polymer of poly(MPC w :LAM x :HPMA y :TSMA z ) where w, x, y, and z represent the molar ratios of monomers used in the feed for preparing the polymer; MPC represents the unit 2-methacryoyloxyethylphosphorylcholine, LMA represents the unit lauryl methacrylate, HPMA represents the unit 2-hydroxypropyl methacrylate, and TSMA represents the unit 3-trimethoxysilylpropyl methacrylate is reacted with polydimethylsiloxane. In another preferred embodiment, a therapeutic compound is incorporated into the polymer, such as dexamethasone.

4. 发明公开

EP2769742A1 MRI visible medical device. 审中-公开
标题翻译：在Magnetresonanzbildgebung sichtbare medizinische Vorrichtung
公开(公告)号：EP2769742A1
公开(公告)日：2014-08-27
申请号：EP13156291.0
申请日：2013-02-22
申请人： Cardiatis S.A.
发明人： Frid, Haroun
IPC分类号： A61L27/30 , A61L29/10 , A61L31/08 , A61L31/14
CPC分类号： A61F2/82 , A61F2/01 , A61F2/2418 , A61F2210/009 , A61F2250/0096 , A61L27/045 , A61L27/30 , A61L27/50 , A61L29/02 , A61L29/10 , A61L29/14 , A61L31/022 , A61L31/082 , A61L31/088 , A61L31/14 , A61L2420/02 , C23C14/221 , C23C14/34
摘要： Cobalt in oxidized state for use as anti-artifact layer (4) covering a metallic substrate (1) of a medical device for reducing the production of artifacts in MRI caused by the magnetic property of the metallic substrate (1), wherein the anti-artifact layer (4) is present at outermost surface of the metallic substrate (1) and has at least 30% of cobalt ratio (at% Co) to the total amount of transition metallic atoms present therein, and at least 90% of cobalt atoms present within the anti-artifact layer (4) are converted into at least one of Co(II) oxidized state and Co(III) oxidized state.
摘要翻译：处于氧化状态的钴用作抗伪影层（4），其覆盖医疗装置的金属基底（1），用于减少由金属基底（1）的磁性引起的MRI中伪像的产生，其中，人造物层（4）存在于金属基材（1）的最外表面，并且具有至少30％的钴比（％Co）与其中存在的过渡金属原子的总量，并且至少90％的钴原子存在于抗伪影层（4）中的至少一种被转化为Co（II）氧化态和Co（III）氧化态中的至少一种。

6. 发明公开

EP2537879A1 Room temperature-curable polymers 有权
标题翻译： BEI RAUMTEMPERATURHÄRTBAREPOLYMERE
公开(公告)号：EP2537879A1
公开(公告)日：2012-12-26
申请号：EP12180872.9
申请日：2006-12-14
申请人： ABBOTT LABORATORIES
发明人： Hauenstein, Dale
IPC分类号： C08G77/442 , A61F2/02 , A61L33/00 , C08L53/00 , C08L83/10 , C09D183/10 , A61L29/08
CPC分类号： C08G77/442 , A61L29/10 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/606 , C08G77/045 , C08G77/06 , C08G77/16 , C08G77/18 , C08G77/42 , C08L83/04 , C08L83/10 , C09D183/10
摘要： Methods of making room temperature-curable polymers. Reactants include siloxane-terminated polymers and silanols. The reactants are mixed, and the polymerization allowed to proceed in air at room temperature. The polymers are exceptionally useful because they allow for the incorporation into the polymers themselves of one or more therapeutic compounds. Thus, medical devices from which controlled drug release is desirable (for either local or systemic delivery) can be coated with therapeutic compound-containing polymers of the invention. In a preferred embodiment, a polymer of poly(MPC w :LAM x :HPMA y :TSMA z ) where w, x, y, and z represent the molar ratios of monomers used in the feed for preparing the polymer; MPC represents the unit 2-methacryoyloxyethylphosphorylcholine, LMA represents the unit lauryl methacrylate, HPMA represents the unit 2-hydroxypropyl methacrylate, and TSMA represents the unit 3-trimethoxysilylpropyl methacrylate is reacted with polydimethylsiloxane. In another preferred embodiment, a therapeutic compound is incorporated into the polymer, such as dexamethasone.
摘要翻译：室温固化聚合物的制备方法。反应物包括硅氧烷封端的聚合物和硅烷醇。将反应物混合，并使聚合在室温下在空气中进行。聚合物是特别有用的，因为它们允许将一种或多种治疗化合物本身掺入聚合物本身。因此，可以用本发明的含治疗化合物的聚合物涂覆受控药物释放的医疗装置（用于局部或全身输送）。在优选的实施方案中，聚（MPC w：LAM x：HPMA y：TSMA z）的聚合物其中w，x，y和z表示用于制备聚合物的进料中使用的单体的摩尔比; MPC代表2-甲基丙烯酰氧基乙基磷酰胆碱单元，LMA代表甲基丙烯酸月桂酯单元，HPMA代表甲基丙烯酸2-羟丙酯单元，TSMA代表甲基丙烯酸3-三甲氧基甲硅烷基丙酯与聚二甲基硅氧烷反应。在另一个优选的实施方案中，将治疗化合物掺入聚合物中，例如地塞米松。

7. 发明公开

EP2281589A3 An article to be inserted in a body cavity having electrically connected electrode materials 审中-公开
标题翻译：可部署到体腔中与第二条电连接电极材料
公开(公告)号：EP2281589A3
公开(公告)日：2011-08-31
申请号：EP10179973.2
申请日：2006-03-17
申请人： Impactcare ApS
发明人： Rasmussen, Anette, Alsted , Moller, Per
IPC分类号： A61L29/14
CPC分类号： A61L29/10 , A61L29/14
摘要： An article to be inserted in a human or animal body cavity, use of the article and preparation thereof. The article has a biologically inhibiting arrangement of electrically connected electrode materials in direct contact with each other on one or more surfaces of the article The arrangement includes as electrode materials a metallic anode material and a cathode material, where the potential of the cathode material is higher than the potential of the anode material, The cathode material is an electrically conductive material selected among certain non-metallic materials. The arrangement provided on the article releases biological inhibiting ions of the metallic anode material or complexes of such ions when the biologically inhibiting arrangement is contacted with a body fluid. The article can be designed with a controlled release rate suitable for the purpose in question for example an initial high rate of ion release after insertion of a catheter to combat bacteria introduced during the insertion followed by a prolonged release at a lower rate to maintain a low level of bacteria.

8. 发明公开

EP2337584A2 LOCAL DELIVERY OF WATER-SOLUBLE OR WATER-INSOLUBLE THERAPEUTIC AGENTS TO THE SURFACE OF BODY LUMENS 有权转让
标题翻译： LOKALE FREISETZUNGWASSERLÖSLICHERODERWASSERUNLÖSLICHERTHERAPEUTIKA AUF DEROBERFLÄCHEVONKÖRPERLUMEN
公开(公告)号：EP2337584A2
公开(公告)日：2011-06-29
申请号：EP09792515.0
申请日：2009-09-14
申请人： CV Ingenuity
发明人： MICHAL, Eugene, T. , LERNER, Daniel, J. , POLLMAN, Matthew, J.
IPC分类号： A61K47/02 , A61K31/337 , A61K31/4353 , A61K31/436 , A61L31/08 , A61L31/16
CPC分类号： A61L29/106 , A61K47/02 , A61L29/10 , A61L29/16 , A61L2300/114 , A61L2300/216 , A61L2300/41 , A61L2300/416
摘要： A method and device for local delivery of water-soluble or water-insoluble therapeutic agents to the surface of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with an amphiphilic polymer coating comprising a therapeutic agent and an amphiphilic polymer or co-polymer. The medical disposable device is inserted into a body lumen, and expanded to contact the amphiphilic polymer coating against the body lumen. The total solubility of the polymer or co-polymer in vivo prevents any embolic hazard associated with the amphiphilic polymer coating.
摘要翻译：公开了一种用于将水溶性或水不溶性治疗剂局部递送到正常或患病体腔表面的方法和装置。医疗一次性装置的可膨胀结构，例如球囊导管的球囊，涂覆有包含治疗剂和两亲性聚合物或共聚物的两亲性聚合物涂层。将医疗一次性装置插入体腔中，并且膨胀以使两亲性聚合物涂层抵靠体腔接触。聚合物或共聚物在体内的总溶解度可防止与两亲性聚合物涂层相关的任何栓塞危险。

9. 发明公开

EP1903982A4 MEDICAL DEVICES COATED WITH A FAST DISSOLVING BIOCOMPATIBLE COATING 审中-公开
标题翻译：凭借快速的水溶性生物相容涂层涂覆的医疗器具
公开(公告)号：EP1903982A4
公开(公告)日：2011-03-16
申请号：EP06787346
申请日：2006-07-14
申请人： FMC BIOPOLYMER AS
发明人： DORNISH MICHAEL , LARSEN CHRISTIAN KLEIN , ANDERSEN THERESE
IPC分类号： A61L27/20 , A61L27/34 , A61L27/50 , A61L27/58 , A61L29/04 , A61L29/12 , A61L31/00 , A61L31/08
CPC分类号： A61L31/10 , A61L27/34 , A61L29/10 , A61L29/14 , A61L31/14 , C08L5/00 , C08L5/04 , C08L5/08
摘要： The present invention relates to a medical device comprising a biocompatible medical coating adhered thereto, wherein the coating comprises at least one of a non-crosslinked, water soluble salt of: (i) alginic acid, (ii) hyaluronic acid or (iii) chitosan, wherein the coating is readily dissolvable in at least one mammalian body fluid.

10. 发明公开

EP2059272A1 COATING FORMULATION FOR MEDICAL COATING 有权
标题翻译： BESCHICHTUNGSFORMULIERUNGFÜREINEN MEDIZINISCHENÜBERZUG
公开(公告)号：EP2059272A1
公开(公告)日：2009-05-20
申请号：EP07818144.3
申请日：2007-09-13
申请人： DSM IP Assets B.V.
发明人： DIAS, Aylvin, Jorge Angelo Athanasius , VAN DEN BOSCH, Edith Elisabeth M. , BRUIN, Peter , ROOIJMANS, Marnix , VAN BENTHEM, Rudolfus Antonius Theodorus Maria
IPC分类号： A61L27/34 , C09D151/08 , C08F290/06
CPC分类号： A61L31/10 , A61L29/085 , A61L29/10 , A61L29/14 , A61L31/14 , A61L2420/02 , A61L2420/06 , C08G65/3322 , C08G65/33324 , C08G2650/50 , C08L33/26 , C09D4/06 , C09D5/00 , C09D135/00 , C09D135/02 , C23C14/06 , C23C14/22 , Y10T428/1393 , Y10T428/24975 , Y10T428/31504 , Y10T428/31562 , Y10T428/31725 , Y10T428/31935
摘要： The invention relates to an article comprising a coating, which coating comprises at least two layers, of which the inner layer is a primer layer, comprising a supporting network comprising a supporting polymer, and the outer layer is a functional layer comprising a multifunctional polymerizable compound.
摘要翻译：本发明涉及一种包括涂层的制品，该涂层包括至少两层，其中内层是底层，其包括支撑网络，其包括支撑聚合物，外层是包含多官能可聚合化合物的功能层。

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