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1. 发明公开

EP3229855A4 NOVEL WOUND-HEALING-ENHANCING DEVICES 有权转让
公开(公告)号：EP3229855A4
公开(公告)日：2018-05-30
申请号：EP15867142
申请日：2015-12-09
申请人： UNIV CALIFORNIA
发明人： SOO B CHIA , TING KANG , ZHENG ZHONG , WU BENJAMIN , ZHANG YULONG
IPC分类号： A61L31/08 , A61K38/17 , A61L27/54 , A61L31/16
CPC分类号： A61L27/54 , A61K38/1709 , A61L2300/252 , A61L2300/62 , A61L2300/622 , A61L2300/624
摘要： Provided herein is a wound-healing-enhancing device that comprises a body structure and a wound-healing-enhancing agent in a wound-healing-enhancing effective amount. Methods of fabricating and using the device are also provided.

2. 发明公开

EP3319654A1 DRUG-COATED MEDICAL DEVICES 有权转让
标题翻译：药物涂层的医疗设备
公开(公告)号：EP3319654A1
公开(公告)日：2018-05-16
申请号：EP16821752.9
申请日：2016-07-08
申请人： Vascuros Medical (Shanghai) Co., Ltd. , Vascuros Medical Pte Ltd.
发明人： LUO, Jingnan , LEE, Qian Yi, Michele , WANG, Honglei
IPC分类号： A61L29/08 , A61M25/10 , A61L33/00 , A61K31/00 , A61K47/30
CPC分类号： A61L29/16 , A61K31/337 , A61K31/436 , A61L29/085 , A61L2300/416 , A61L2300/62 , A61L2300/622 , A61L2300/624 , A61L2420/02 , A61M25/1029 , A61M2025/1004 , A61M2025/1031 , A61M2025/105 , A61M2025/1075
摘要： Disclosed herein is a drug-coated medical device in the form of a balloon having an inner surface and an outer hydrophobic surface, an adhesion balance layer directly on the outer hydrophobic surface of the balloon, comprising a hydrophilic polymer and/or a hydrophilic compound where the hydrophilic compound has a molecular weight of less than 1,000 Daltons, and a therapeutic layer directly on the adhesion balance layer comprising a therapeutic agent and a pharmaceutically acceptable carrier, wherein the therapeutic agent is a hydrophobic therapeutic agent with one or more hydrogen-bonding groups and is provided as discrete drug particles in the therapeutic layer, the drug particles have at least one dimension that is less than 25 μηι and are uniformly distributed on the surface of the balloon, and the pharmaceutically acceptable carrier is hydrophilic and has a molecular weight of less than 1,000 Daltons. A process to make the drug-coated medical device and uses thereof are also disclosed.

3. 发明公开

EP3269400A1 AMOPRHOUS HYALURONIC ACID-MAGNESIUM/CALCIUM POLYPHOSPHATE MICROPARTICLES FOR CARTILAGE REGENERATION AND REPAIR 审中-公开
标题翻译： AMOPRHOUS HYALURONIC ACID-MAGNESIUM /钙多磷酸盐微粒用于软骨再生和修复
公开(公告)号：EP3269400A1
公开(公告)日：2018-01-17
申请号：EP17181497.3
申请日：2017-07-14
申请人： NanotecMARIN GmbH
发明人： MÜLLER, Werner E.G.
IPC分类号： A61L27/12 , A61L27/46
CPC分类号： A61L27/54 , A61K9/0019 , A61K9/06 , A61K9/14 , A61K31/728 , A61K33/42 , A61L27/20 , A61L27/46 , A61L27/56 , A61L2300/112 , A61L2300/236 , A61L2300/412 , A61L2300/622 , A61L2400/06 , A61L2430/06 , C08L5/08
摘要： This invention concerns a biomimetic material based on energy-rich amorphous magnesium polyphosphate (Mg-polyP) microparticles that enhance cartilage synthesis and regeneration. One preferred formulation of the inventive material is a hyaluronic acid-Mg/Ca-polyP paste that can be produced from a water-soluble salt of polyP and water-soluble hyaluronic acid in the presence of water-insoluble/nearly insoluble calcium carbonate. Surprisingly, the inventor found that this cartilage-like material comprising amorphous Mg/Ca-polyP microparticles promotes the adhesion of chondrocytes and strongly upregulates the expression of the chondrocyte marker genes encoding alkaline phosphatase, collagen type 3A1, aggrecan and Sox9. The material through scavenging calcium ions (Mg 2+ /Ca 2+ exchange) and binding of the calcium-polyP to hyaluronic acid shows biomechanical properties, comparable to cartilage and thus can be used for prevention of calcium crystal formation in the synovial fluid and treatment of joint dysfunctions caused by osteoarthritis.
摘要翻译：本发明涉及基于高能量无定形聚磷酸镁（Mg-polyP）微粒的仿生材料，其增强软骨合成和再生。本发明材料的一种优选制剂是透明质酸-Mg / Ca-polyP糊剂，其可以在水不溶性/几乎不溶的碳酸钙存在下由聚P和水溶性透明质酸的水溶性盐制备。令人惊讶的是，发明人发现这种包含无定形Mg / Ca-polyP微粒的软骨样物质促进软骨细胞的粘附，并强烈地上调编码碱性磷酸酶，3A1型胶原蛋白，聚集蛋白聚糖和Sox9的软骨细胞标记基因的表达。通过清除钙离子（Mg2 + / Ca2 +交换）以及钙-PolyP与透明质酸的结合，材料显示出与软骨相当的生物力学特性，因此可用于预防滑液中的钙晶体形成和治疗引起的关节功能障碍通过骨关节炎。

4. 发明公开

EP3231454A1 BONE CEMENT COMPRISING MICROENCAPSULATED ANTIMICROBIAL 有权
标题翻译：骨水泥包含微囊化抗菌剂
公开(公告)号：EP3231454A1
公开(公告)日：2017-10-18
申请号：EP16382170.5
申请日：2016-04-14
申请人： UNIVERSIDAD PONTIFICIA COMILLAS , Inescop Instituto Tecnologico de calzado y conexas , Carbo Laso, Esther , Sanz Ruiz, Pablo , Vaquero Martin, Javier
发明人： CARBO LASO, Esther , SANZ RUIZ, Pablo , VAQUERO MARTÍN, Javier , DEL REAL ROMERO, Juan Carlos , BALLESTEROS IGLESIAS, María Yolanda , PAZ JIMÉNEZ, Eva , ARÁN AIS, Francisca , PÉREZ LIMIÑANA, María Ángeles , SÁNCHEZ NAVARRO, María Magdalena
IPC分类号： A61L27/16 , A61L27/54 , A61L24/00 , A61L24/06
CPC分类号： A61L24/06 , A61L24/0015 , A61L27/16 , A61L27/54 , A61L2300/406 , A61L2300/622 , A61L2430/02 , C08L33/12
摘要： The present invention relates to bone cement comprising microcapsules containing an antimicrobial selected from rifampicin, rifabutin, rifapentine, rifalazil, amphotericin B, imidazole antifungicides, triazole fungicides, carbapenem antibiotics, vancomycin and any combination thereof.
摘要翻译：本发明涉及包含含有选自利福平，利福布汀，利福喷丁，利福拉齐，两性霉素B，咪唑杀真菌剂，三唑类杀真菌剂，碳青霉烯类抗生素，万古霉素及其任何组合的抗微生物剂的微胶囊的骨水泥。

5. 发明公开

EP3086748A4 ODOR CONTROL IN PERSONAL CARE PRODUCTS 审中-公开
标题翻译： GERUCHSREGULIERUNG INKÖRPERPFLEGEPRODUKTEN
公开(公告)号：EP3086748A4
公开(公告)日：2017-08-16
申请号：EP14875205
申请日：2014-12-26
申请人： KIMBERLY CLARK CO
发明人： QUINCY ROGER BRADSHAW , MACDONALD JOHN GAVIN , SPENCER ANTHONY STEPHEN
IPC分类号： A61F13/49 , A61F13/534 , A61F13/84 , A61L9/014 , A61L15/18 , A61L15/46
CPC分类号： A61F13/8405 , A61F13/472 , A61F13/49009 , A61F13/496 , A61F13/534 , A61F2013/5349 , A61F2013/8408 , A61F2013/8414 , A61F2013/842 , A61L9/014 , A61L15/18 , A61L15/46 , A61L2300/104 , A61L2300/404 , A61L2300/622 , A61L2300/624 , A61L2400/12
摘要： A urine odor control system for personal care products includes a substrate with a formulation of activated carbon and an absorbent core with a formulation of silver. The personal care product includes diapers, training pants, absorbent underpants, adult incontinence products, or feminine hygiene products. The personal care product can include a liquid-permeable bodyside liner, liquid-impermeable outer cover affixed to the bodyside liner, wherein the absorbent core and substrate are disposed between the bodyside liner and the outer cover.
摘要翻译：用于个人护理产品的尿液气味控制系统包括具有活性炭配方的基材和具有银配方的吸收芯。个人护理产品包括尿布，训练裤，吸收性内裤，成人失禁产品或女性卫生产品。个人护理产品可以包括液体可渗透的体侧衬里，固定到体侧衬里的液体不可渗透的外覆层，其中吸收芯和衬底设置在体侧衬里和外覆层之间。

6. 发明公开

EP2956185A4 A POLYMERIC SYSTEM FOR RELEASE OF AN ACTIVE AGENT 有权
标题翻译：聚合物体系用于释放活性物质
公开(公告)号：EP2956185A4
公开(公告)日：2016-08-17
申请号：EP14751487
申请日：2014-02-13
申请人： AGENCY SCIENCE TECH & RES
发明人： KURISAWA MOTOICHI , BAE KI HYUN , LEE FAN
IPC分类号： A61L27/44 , A61K47/30 , A61K47/48 , A61L27/50
CPC分类号： A61K47/4823 , A61K9/0019 , A61K9/0024 , A61K38/21 , A61K38/212 , A61K38/28 , A61K38/385 , A61K47/10 , A61K47/36 , A61K47/60 , A61K47/61 , A61K47/6903 , A61L15/44 , A61L15/60 , A61L27/20 , A61L27/22 , A61L27/48 , A61L27/52 , A61L27/54 , A61L31/042 , A61L31/043 , A61L31/129 , A61L31/145 , A61L31/16 , A61L2300/622 , A61L2400/06 , C08B37/0021 , C08L5/02 , C08L89/00 , C08L5/00 , C08L71/02
摘要： The present disclosure relates to a polymeric system for release of an active agent, comprising a first polymeric phase containing the active agent, the first polymeric phase forming discrete regions of a set size range and being dispersed within a second polymeric phase comprising a cross-linked polymer-phenol conjugate for release of the active agent therein. The present disclosure further provides an injectable hydrogel comprising the disclosed polymeric system, a carrier for delivering a biologically active substance or a drug comprising the injectable hydrogel, and a method for producing the disclosed polymeric system.

7. 发明公开

EP3032949A1 MITTEL ENTHALTEND MIKROPARTIKEL ZUR REINIGUNG UND ZUM SCHUTZ VON TECHNISCHEN OBERFLÄCHEN 有权
标题翻译： AGENT包含清洁技术表面处理保护微粒
公开(公告)号：EP3032949A1
公开(公告)日：2016-06-22
申请号：EP14755619.5
申请日：2014-08-13
申请人： Aimecs GmbH
发明人： WENDEL, Hans-Peter , WEINDL, Juergen
IPC分类号： A01N25/28 , A01N31/08 , A61L27/54 , A61L31/16
CPC分类号： A01N31/08 , A61L27/54 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/404 , A61L2300/606 , A61L2300/622 , A01N25/10 , A01N25/28
摘要： A means for cleaning, disinfecting and/or protecting technical surfaces contains microparticles charged with an antibacterial ingredient. The ingredient can be totarol. Microparticles charged with totarol can also be used for coating medical implants.
摘要翻译：一种用于清洁，消毒，保护性处理，或它们的技术表面的组合的组合物含有抗菌有效成分装载有微粒。该抗菌有效成分可能是桃拓酚。装载有桃拓酚的微粒可用于医疗植入物的涂层。覆有用于清洁，消毒，保护性处理或提供它们的组合的组合物的医用植入物。

8. 发明公开

EP2898902A4 ADVANCED HEART FAILURE TREATMENT MATERIAL AS MYOCARDIAL/CARDIOVASCULAR REGENERATION DEVICE 审中-公开
标题翻译：晚期心力衰竭处理材料心脏/心血管再生设备
公开(公告)号：EP2898902A4
公开(公告)日：2016-04-06
申请号：EP13838722
申请日：2013-09-13
申请人： UNIV OSAKA , NIPRO CORP , ONO PHARMACEUTICAL CO
发明人： SAWA YOSHIKI , MIYAGAWA SHIGERU , FUKUSHIMA SATSUKI , SAITO ATSUHIRO , SAKAI YOSHIKI , MATSUDA KAZUHISA , MARUYAMA TAKAYUKI
IPC分类号： A61L15/00 , A61K9/00 , A61K9/70 , A61K31/4406 , A61K47/34 , A61K47/36 , A61K47/42 , A61L17/00 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P9/12 , A61P21/00 , A61P29/00 , A61P37/06 , A61P43/00
CPC分类号： A61L31/16 , A61F2/2481 , A61K9/0024 , A61K9/16 , A61K9/1647 , A61K31/343 , A61K31/4406 , A61K47/42 , A61L17/005 , A61L17/12 , A61L17/145 , A61L31/06 , A61L31/10 , A61L31/146 , A61L31/148 , A61L2300/412 , A61L2300/622 , A61L2430/20 , C08L89/00 , C08L89/06 , C08L67/04
摘要： Provided is an advanced heart failure treatment material, as a myocardial/cardiovascular regeneration device, that self-assembles, which can improve the universality and be used in an emergency by commercialization with no need of cell-culturing (cell-free) by controlling stem cells, and has a high therapeutic effect on the fundamental treatment of intractable cardiovascular diseases, in particular, advanced heart failure, in which not only the saving of lives but also improving the patient's quality of life (QOL) are urgent issues. The advanced heart failure treatment material of the present invention includes a pharmaceutical agent, an agent holding for the pharmaceutical agent, and a myocardial support device.

9. 发明授权

EP2379045B1 COMPOSITE MATERIAL WITH PROPERTIES OF SELF-HEALING AND RELEASE OF ACTIVE INGREDIENTS, FOR BIOMEDICAL APPLICATIONS 有权转让
标题翻译：具有自愈性能，及生物医学应用活性成分的释放复合材料
公开(公告)号：EP2379045B1
公开(公告)日：2016-02-24
申请号：EP09778905.1
申请日：2009-12-14
申请人： Vittoria, Vittoria , Peluso, Gianfranco , Minale, Mario
发明人： VITTORIA, Vittoria , PELUSO, Gianfranco , TAMMARO, Loredana , GUADAGNO, Liberata , RAIMONDO, Marialuigia , PETILLO, Orsolina , MARGARUCCI, Sabrina , CALARCO, Anna
IPC分类号： A61K6/08 , A61L27/48 , A61L27/54
CPC分类号： A61K6/08 , A61L27/48 , A61L27/54 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/622 , A61L2300/624

10. 发明公开

EP2983682A1 THERAPEUTIC VIRAL MICROPARTICLES FOR PROMOTING STENT BIOFUNCTIONALITY AND WOUND HEALING IN VERTEBRATE INDIVIDUALS 无效
标题翻译：治疗性病毒性微粒促进和涡STENTBIOFUNKTIONALITÄT动物中个体伤口愈合
公开(公告)号：EP2983682A1
公开(公告)日：2016-02-17
申请号：EP14783183.8
申请日：2014-04-11
申请人： MANGOGEN PHARMA INC.
发明人： PRAKASH, Satya , PAUL, Arghya , SHUM-TIM, Dominique
IPC分类号： A61K35/76 , A61K31/7088 , A61K38/18 , A61K47/34 , A61K9/14 , A61L31/08 , A61L31/14 , A61P17/02 , C12N11/08 , C12N15/866 , C12N7/01
CPC分类号： A61K35/76 , A61K9/5031 , A61K9/5089 , A61K38/19 , A61K38/36 , A61K38/363 , A61K48/00 , A61L31/10 , A61L31/125 , A61L31/148 , A61L31/16 , A61L2300/414 , A61L2300/418 , A61L2300/622 , A61L2430/34 , C12N7/00 , C12N2710/14032 , C12N2710/14043 , C12N2710/14143
摘要： The present disclosure provides viral microparticles comprising genetically-engineered baculoviruses (at least partially) embedded in a polymeric matrix for the local delivery of therapeutic nucleic acid molecules to the cells of a vertebrate individual (optionally in combination with a medical implant such as vascular stent platform). The viral microparticles are especially useful for promoting the healing of a wound as well as the repair of a blood vessel and prevent pathological scarring. Also provided herein are processes for making the viral microparticles, pharmaceutical compositions comprising viral microparticles as well as supports comprising the viral microparticles for the locating the viral microparticles in a wound or in the vicinity of a wound.
摘要翻译：本发明提供的病毒微粒，包括基因工程改造的杆状病毒（至少部分地）嵌入在用于局部递送治疗性核酸分子的脊椎动物个体的细胞中的聚合物基体（任选与医疗植入物的组合：如血管支架平台）。病毒微粒的爱宣传片婷伤口愈合以及血管的修复是特别有用的，防止病理性疤痕。所以提供了可用于制备病毒微粒过程中，药物组合物包含病毒微粒以及支撑件，其包括用于在伤口或在伤口附近的定位病毒微粒的病毒微粒。

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