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1. 发明申请

WO2006107312A1 NANOSENSORS 审中-公开
公开(公告)号：WO2006107312A1
公开(公告)日：2006-10-12
申请号：PCT/US2005/020974
申请日：2005-06-15
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , WANG, Wayne , CHEN, Chuo , LIN, Keng-hui , FANG, Ying , LIEBER, Charles, M.
发明人： WANG, Wayne , CHEN, Chuo , LIN, Keng-hui , FANG, Ying , LIEBER, Charles, M.
IPC分类号： G01N27/414 , G01N33/543
CPC分类号： B82Y15/00 , G01N27/4146 , G01N33/54373
摘要： The present invention generally relates to nanoscale wires for use in determining analytes suspected to be present in a sample, especially in connection with determining information about a sample containing, or suspected of containing, two or more analytes. For example, the invention can involve a competitive, uncompetitive, or non-competitive binding assay including a nanoscale wire to a sample containing a species able to interact with the retain entity to produce a product, where the sample also contains or is suspected of containing a second species able to interact with the reaction entity to prevent production of the product resulting from interaction of the first species and the reaction entity. Based upon determination of production of the product, determination of the second species in the sample can be made. In one set of embodiments, nanoscale wires can be used that have been functionalized at their surface, and/or in close proximity to their surface, for example, by immobilizing a protein or an enzyme relative to the nanoscale wire. Functionalization may permit interaction of the nanoscale wire with various analytes, and such interaction may induce a determinable change in a property of the nanoscale wire. Determination of two or more analytes, o one analyte and the suspected presence of another analyte can involve, for example, binding species to a protein or an enzyme immobilized relative to the nanoscale wire. Other aspects of the invention include assays, sensors, detectors, and/or other devices that include functionalized nanoscale wires, methods of making and/or using functionalized nanoscale wires (for example, in drug screening or high throughput screening) and the like.
摘要翻译：本发明一般涉及用于确定疑似存在于样品中的分析物的纳米尺度丝，特别是关于确定含有或怀疑含有两种或多种分析物的样品的信息。例如，本发明可涉及竞争性的，无竞争性的或非竞争性的结合测定，其包括纳米尺度的丝线，其含有能够与保留实体相互作用以产生产品的样品，其中样品还含有或被怀疑含有能够与反应实体相互作用以防止由第一种和反应实体的相互作用产生的产物的第二种。基于产品生产的确定，可以确定样品中的第二种。在一组实施方案中，可以使用在其表面和/或其表面附近功能化的纳米线，例如通过相对于纳米线固定蛋白质或酶。功能化可以允许纳米尺度线与各种分析物的相互作用，并且这种相互作用可以诱导纳米尺度线的性质的可确定的变化。测定两种或更多种分析物，一种分析物和怀疑存在另一种分析物可涉及例如将物质结合到相对于纳米尺度线固定的蛋白质或酶。本发明的其它方面包括测定，传感器，检测器和/或包括功能化的纳米线的其它器件，制造和/或使用官能化的纳米线（例如在药物筛选或高通量筛选）等的方法。

2. 发明申请

WO2008051316A3 NANOSENSORS AND RELATED TECHNOLOGIES 审中-公开
公开(公告)号：WO2008051316A3
公开(公告)日：2008-05-02
申请号：PCT/US2007/013700
申请日：2007-06-11
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , LIEBER, Charles, M. , FANG, Ying , PATOLSKY, Fernando
发明人： LIEBER, Charles, M. , FANG, Ying , PATOLSKY, Fernando
IPC分类号： C12Q1/68 , H01L29/06
摘要： The present invention generally relates to nanotechnology and sub-microelectronic circuitry, as well as associated methods and devices, for example, nanoscale wire devices and methods for use in determining nucleic acids or other analytes suspected to be present in a sample (for example, their presence and/or dynamical information), e.g., at the single molecule level. For example, a nanoscale wire device can be used in some cases to detect single base mismatches within a nucleic acid (e.g., by determining association and/or dissociation rates). In one aspect, dynamical information such as a binding constant, an association rate, and/or a dissociation rate, can be determined between a nucleic acid or other analyte, and a binding partner immobilized relative to a nanoscale wire. In some cases, the nanoscale wire includes a first portion comprising a metal-semiconductor compound, and a second portion that does not include a metal-semiconductor compound. The binding partner, in some embodiments, is immobilized relative to at least the second portion of the nanoscale wire, and the size of the second portion of the nanoscale wire may be minimized and/or controlled in some instances. Articles and devices of size greater than the nanoscale are also included in certain embodiments. Still other aspects of the invention include assays, sensors, kits, and/or other devices that include such nanoscale wires, methods of making and/or using such nanoscale wires, or the like.

3. 发明申请

WO2012170630A3 NANOSCALE WIRES, NANOSCALE WIRE FET DEVICES, AND NANOTUBE-ELECTRONIC HYBRID DEVICES FOR SENSING AND OTHER APPLICATIONS 审中-公开
公开(公告)号：WO2012170630A3
公开(公告)日：2012-12-13
申请号：PCT/US2012/041253
申请日：2012-06-07
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , LIEBER, Charles, M. , DUAN, Xiaojie , GAO, Ruixuan , XIE, Ping , JIANG, Xiaocheng
发明人： LIEBER, Charles, M. , DUAN, Xiaojie , GAO, Ruixuan , XIE, Ping , JIANG, Xiaocheng
IPC分类号： H01L29/78 , H01L21/336
摘要： The present invention generally relates to nanotechnology, including field effect transistors and other devices used as sensors (for example, for electrophysiological studies), nanotube structures, and applications. Certain aspects of the present invention are generally directed to transistors such as field effect transistors, and other similar devices. In one set of embodiments, a field effect transistor is used where a nanoscale wire, for example, a silicon nanowire, acts as a transistor channel connecting a source electrode to a drain electrode. In some cases, a portion of the transistor channel is exposed to an environment that is to be determined, for example, the interior or cytosol of a cell. A nanotube or other suitable fluidic channel may be extended from the transistor channel into a suitable environment, such as a contained environment within a cell, so that the environment is in electrical communication with the transistor channel via the fluidic channel. In some embodiments, the rest of the transistor channel may be coated, e.g., so that the electrical properties of the transistor channel reflect the electrical behavior of the environment that the fluidic channel is in communication with. Other aspects of the invention are generally directed to methods of making such sensors, methods of using such sensors, kits involving such sensors, or the like.

4. 发明申请

WO2011038228A1 BENT NANOWIRES AND RELATED PROBING OF SPECIES 审中-公开
标题翻译： BENT NANOWIRES和相关物种的探索
公开(公告)号：WO2011038228A1
公开(公告)日：2011-03-31
申请号：PCT/US2010/050199
申请日：2010-09-24
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , TIAN, Bozhi , XIE, Ping , KEMPA, Thomas, J. , LIEBER, Charles, M. , COHEN-KARNI, Tzahi , QING, Quan , DUAN, Xiaojie
发明人： TIAN, Bozhi , XIE, Ping , KEMPA, Thomas, J. , LIEBER, Charles, M. , COHEN-KARNI, Tzahi , QING, Quan , DUAN, Xiaojie
IPC分类号： G01N33/487 , H01L29/06
CPC分类号： G01N27/4146 , B82Y10/00 , B82Y15/00 , G01N33/48728 , H01L21/02603 , H01L29/045 , H01L29/0665 , H01L29/0669 , H01L51/0048
摘要： Kinked nanowires are used for measuring electrical potentials inside simple cells. An improved intracellular entrance is achieved by modifying the kinked nanowires with phospholipids.
摘要翻译：扭曲的纳米线用于测量简单电池内的电位。改进的细胞内入口通过用磷脂修饰扭结的纳米线来实现。

5. 发明申请

WO2007044034A2 NANOSCALE WIRE-BASED DATA STORAGE 审中-公开
标题翻译：纳米线基数据存储
公开(公告)号：WO2007044034A2
公开(公告)日：2007-04-19
申请号：PCT/US2005/044212
申请日：2005-12-06
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , LIEBER, Charles, M. , WU, Yue , YAN, Hao
发明人： LIEBER, Charles, M. , WU, Yue , YAN, Hao
IPC分类号： H01R24/00
CPC分类号： H01L29/0665 , B82Y10/00 , B82Y30/00 , G11C11/22 , G11C11/223 , G11C11/54 , G11C11/56 , G11C11/5657 , G11C13/003 , G11C13/025 , G11C2213/16 , G11C2213/17 , G11C2213/18 , G11C2213/75 , G11C2213/77 , H01L29/0673 , H01L29/068 , H01L29/78391
摘要： The present invention generally relates to nanotechnology and submicroelectronic devices that can be used in circuitry and, in some cases, to nanoscale wires and other nanostructures able to encode data. One aspect of the invention provides a nanoscale wire or other nanostructure having a region that is electrically-polarizable, for example, a nanoscale wire may comprise a core and an electrically-polarizable shell. In some cases, the electrically-polarizable region is able to retain its polarization state in the absence of an external electric field. All, or only a portion, of the electricallypolarizable region may be polarized, for example, to encode one or more bits of data. In one set of embodiments, the electrically-polarizable region comprises a functional oxide or a ferroelectric oxide material, for example, BaTiO 3 , lead zirconium titanate, or the like. In some embodiments, the nanoscale wire (or other nanostructure) may further comprise other materials, for example, a separation region separating the electricallypolarizable region from other regions of the nanoscale wire. For example, in a nanoscale wire, one or more intermediate shells may separate the core from the electricallypolarizable shell.
摘要翻译：本发明一般涉及可用于电路中并且在某些情况下可用于纳米级线和其他能够编码数据的纳米结构的纳米技术和次级微电子器件。本发明的一个方面提供了具有可电极化的区域的纳米线或其他纳米结构，例如纳米线可以包括核和电极化壳。在一些情况下，电极化区域能够在没有外部电场的情况下保持其极化状态。例如，所有或只有一部分电极和可怕极化区域可以被极化，以编码一个或多个数据位。在一组实施例中，可电极化区域包括功能氧化物或铁电氧化物材料，例如BaTiO 3，钛酸铅锆等。在一些实施例中，纳米线（或其他纳米结构）可以进一步包括其他材料，例如将纳米级线的其他区域与电和可;的可极化区域分开的分离区域。例如，在纳米线中，一个或多个中间壳可以将芯与电极和可怕的极化壳分开。

6. 发明申请

WO2003063208A2 ARRAY-BASED ARCHITECTURE FOR MOLECULAR ELECTRONICS 审中-公开
标题翻译：分子电子学基于阵列的架构
公开(公告)号：WO2003063208A2
公开(公告)日：2003-07-31
申请号：PCT/US2003/001555
申请日：2003-01-17
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE , DEHON, Andre , LIEBER, Charles, M.
发明人： DEHON, Andre , LIEBER, Charles, M.
IPC分类号： H01L21/00
CPC分类号： G11C13/025 , B82Y10/00 , G11C8/10 , G11C13/0023 , G11C13/003 , G11C2213/75 , G11C2213/77 , G11C2213/81 , H01L27/28 , H01L27/285 , H01L51/0508 , H01L51/0595
摘要： An architecture for nanoscale electronics is disclosed. The architecture comprises arrays of crossed nanoscale wires having selectively programmable crosspoints. Nanoscale wires of one array are shared by other arrays, thus providing signal propagation between the arrays. Nanoscale signal restoration elements are also provided, allowing an output of a first array to be used as an input to a second array. Signal restoration occurs without routing of the signal to non-nanoscalewires.
摘要翻译：公开了一种用于纳米尺度电子学的架构。该架构包括具有选择性可编程交叉点的交叉纳米线的阵列。一个阵列的纳米线由其他阵列共享，从而在阵列之间提供信号传播。还提供了纳米尺度信号恢复元件，允许将第一阵列的输出用作第二阵列的输入。信号恢复发生，而不会将信号路由到非纳米级别。

7. 发明申请

WO2005093831A1 NANOSTRUCTURES CONTAINING METAL-SEMICONDUCTOR COMPOUNDS 审中-公开
标题翻译：包含金属半导体化合物的纳米结构
公开(公告)号：WO2005093831A1
公开(公告)日：2005-10-06
申请号：PCT/US2005/004459
申请日：2005-02-14
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , LIEBER, Charles, M. , WU, Yue , XIANG, Jie , YANG, Chen , LU, Wei
发明人： LIEBER, Charles, M. , WU, Yue , XIANG, Jie , YANG, Chen , LU, Wei
IPC分类号： H01L23/49
CPC分类号： B82Y30/00 , B82Y10/00 , H01L29/0673 , H01L29/068 , H01L2924/0002 , H01L2924/00
摘要： The present invention generally relates to devices and components for use in nanotechnology and sub-microelectronic circuitry that include metal-semiconductor compounds such as metal silicides. The present invention also, in some embodiments, provides methods of forming such devices and components by allowing a first material to diffuse into a second material, optionally creating a new compound. Thus, as an example, metal atoms are allowed to diffuse into a semiconductor to create the metal-semiconductor compound. In some cases, the device may include a component that is a single crystal. Certain metal-semiconductor compounds of the invention have novel physical/electrical properties, for example, low resistivities, high conductivities, high current density capacities, and the like. In some embodiments, a component of the invention may have two or more regions that differ in composition, where one or both of the regions can include a metal-semiconductor compound. In some cases, the regions may be created by using a mask or a nanoscale wire to define the two or more regions.
摘要翻译：本发明一般涉及用于纳米技术的器件和组件，以及包括诸如金属硅化物的金属 - 半导体化合物的亚微电子电路。在一些实施方案中，本发明还提供了通过允许第一材料扩散到第二材料中，任选地产生新化合物来形成这种装置和组分的方法。因此，作为示例，允许金属原子扩散到半导体中以形成金属 - 半导体化合物。在一些情况下，该装置可以包括作为单晶的部件。本发明的某些金属 - 半导体化合物具有新的物理/电学性质，例如低电阻率，高电导率，高电流密度容量等。在一些实施方案中，本发明的组分可以具有两个或更多个组成不同的区域，其中一个或两个区域可以包括金属 - 半导体化合物。在一些情况下，可以通过使用掩模或纳米级线来形成区域来限定两个或更多个区域。

8. 发明申请

WO2012138357A1 NANOPORE SENSING BY LOCAL ELECTRICAL POTENTIAL MEASUREMENT 审中-公开
标题翻译：通过本地电位测量进行纳米感测
公开(公告)号：WO2012138357A1
公开(公告)日：2012-10-11
申请号：PCT/US2011/034426
申请日：2011-04-29
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , LIEBER, Charles, M. , XIE, Ping
发明人： LIEBER, Charles, M. , XIE, Ping
IPC分类号： C12Q1/68 , G01N33/487 , B82Y15/00
CPC分类号： G01N27/447 , B82Y15/00 , B82Y30/00 , C12Q1/6869 , G01N33/48721 , C12Q2565/631
摘要： There is provided a nanopore disposed in a support structure, with a fluidic connection between a first fluidic reservoir and an inlet to the nanopore and a second fluidic connection between a second fluidic reservoir and an outlet from the nanopore. A first ionic solution of a first buffer concentration is disposed in the first reservoir and a second ionic solution of a second buffer concentration, different than the first concentration, is disposed in the second reservoir, with the nanopore providing the sole path of fluidic communication between the first and second reservoirs. An electrical connection is disposed at a location in the nanopore sensor that develops an electrical signal indicative of electrical potential local to at least one site in the nanopore sensor as an object translocates through the nanopore between the two reservoirs.
摘要翻译：提供了一种设置在支撑结构中的纳米孔，在第一流体储存器和纳米孔的入口之间具有流体连接，以及在第二流体储存器和来自纳米孔的出口之间的第二流体连接。将第一缓冲液浓度的第一离子溶液设置在第一储存器中，并且将第二缓冲液浓度与第一浓度不同的第二离子溶液设置在第二储存器中，其中纳米孔提供在第二储存器之间的流体连通的唯一路径第一和第二水库。电连接被设置在纳米孔传感器中的位置处，当物体通过两个储存器之间的纳米孔移位时，该电信号产生指示纳米孔传感器中至少一个位点局部电势的电信号。

9. 发明申请

WO2012033869A1 CONTROLLED SYNTHESIS OF MONOLITHICALLY-INTEGRATED GRAPHENE STRUCTURES 审中-公开
标题翻译：单一组合的石墨结构的控制合成
公开(公告)号：WO2012033869A1
公开(公告)日：2012-03-15
申请号：PCT/US2011/050752
申请日：2011-09-08
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , PARK, Jang-Ung , NAM, SungWoo , LIEBER, Charles, M.
发明人： PARK, Jang-Ung , NAM, SungWoo , LIEBER, Charles, M.
IPC分类号： C01B31/04 , H01L21/336 , H01L29/786 , H01L29/16
CPC分类号： H01L21/02527 , B82Y30/00 , B82Y40/00 , C01B32/186 , H01L21/02381 , H01L21/02488 , H01L21/02491 , H01L21/02494 , H01L21/02502 , H01L21/0262 , H01L21/02645 , H01L21/02664 , H01L23/53276 , H01L29/1606 , H01L29/66477 , H01L29/66742 , H01L29/7781 , H01L29/78618 , H01L29/78684 , H01L2924/0002 , Y10S977/734 , Y10S977/936 , Y10S977/938 , H01L2924/00
摘要： In a method for fabricating a graphene structure, there is formed on a fabrication substrate a pattern of a plurality of distinct graphene catalyst materials. In one graphene synthesis step, different numbers of graphene layers are formed on the catalyst materials in the formed pattern. In a method for fabricating a graphene transistor, on a fabrication substrate at least one graphene catalyst material is provided at a substrate region specified for synthesizing a graphene transistor channel and at least one graphene catalyst material is provided at a substrate region specified for synthesizing a graphene transistor source, and at a substrate region specified for synthesizing a graphene transistor drain. Then in one graphene synthesis step, at least one layer of graphene is formed at the substrate region for the graphene transistor channel, and at the regions for the transistor source and drain there are formed a plurality of layers of graphene.
摘要翻译：在制造石墨烯结构的方法中，在制造衬底上形成多个不同的石墨烯催化剂材料的图案。在一个石墨烯合成步骤中，在所形成的图案中的催化剂材料上形成不同数量的石墨烯层。在制造石墨烯晶体管的方法中，在制造衬底上，在用于合成石墨烯晶体管沟道的衬底区域处提供至少一个石墨烯催化剂材料，并且至少一个石墨烯催化剂材料设置在用于合成石墨烯的基板区域晶体管源，以及在合成石墨烯晶体管漏极所规定的衬底区域。然后在一个石墨烯合成步骤中，在用于石墨烯晶体管沟道的衬底区域上形成至少一层石墨烯，在晶体管源极和漏极的区域形成多层石墨烯。

10. 发明申请

WO2009134291A2 NANOSCALE WIRE-BASED MEMORY DEVICES 审中-公开
标题翻译：基于纳米电路的存储器件
公开(公告)号：WO2009134291A2
公开(公告)日：2009-11-05
申请号：PCT/US2009/000337
申请日：2009-01-21
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , LIEBER, Charles, M. , DONG, Yajie , LU, Wei , YU, Guihua , MCALPINE, Michael
发明人： LIEBER, Charles, M. , DONG, Yajie , LU, Wei , YU, Guihua , MCALPINE, Michael
IPC分类号： H01L27/10 , H01L29/06
CPC分类号： H01L29/0665 , B82Y10/00 , G11C13/0002 , G11C13/0069 , G11C2213/77 , G11C2213/81 , H01L27/10 , H01L27/101 , H01L29/0673 , H01L29/16 , H01L29/1602 , H01L29/1604 , H01L2924/0002 , H01L2924/00
摘要： The present invention generally relates to nanotechnology and sub- microelectronic devices that can be used in circuitry and, in particular, to nanoscale wires and other nanostructures able to encode data. One aspect of the present invention is directed to a device comprising an electrical crossbar array comprising at least two crossed wires at a cross point. In some cases, at least one of the crossed wires is a nanoscale wire, and in certain instances, at least one of the crossed wires is a nanoscale wire comprising a core and at least one shell surrounding the core. For instance, the core may comprise a crystal (e.g., crystalline silicon) and the shell may be at least partially amorphous (e.g., amorphous silicon). In certain embodiments, the cross point may exhibit intrinsic current rectification, or other electrical behaviors, and the cross point can be used as a memory device. For example, in one embodiment, the cross point may exhibit a first conductance at a positive voltage, and the cross point may exhibit a second conductance at a negative voltage. Accordingly, by applying suitable voltages to the cross point, data may be stored at the cross point. Other aspects of the present invention are directed to systems and methods for making or using such devices, kits involving such devices, or the like.
摘要翻译：本发明一般涉及可用于电路中的纳米技术和亚微电子器件，特别涉及能够对数据进行编码的纳米线和其他纳米结构。本发明的一个方面涉及一种装置，其包括在交叉点处包括至少两根交叉线的电横排阵列。在一些情况下，交叉导线中的至少一个是纳米线，并且在某些情况下，交叉导线中的至少一个是纳米线，其包括芯和围绕芯的至少一个壳。例如，芯可以包括晶体（例如，晶体硅），并且壳可以是至少部分无定形的（例如非晶硅）。在某些实施例中，交叉点可以表现出固有的电流整流或其他电气行为，并且交叉点可以用作存储器件。例如，在一个实施例中，交叉点可以在正电压下呈现第一电导，并且交叉点可以在负电压下显示第二电导。因此，通过向交叉点施加合适的电压，可以在交叉点存储数据。本发明的其他方面涉及用于制造或使用这种装置的系统和方法，涉及这种装置的套件等。

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