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1. 发明申请

WO2012170630A3 NANOSCALE WIRES, NANOSCALE WIRE FET DEVICES, AND NANOTUBE-ELECTRONIC HYBRID DEVICES FOR SENSING AND OTHER APPLICATIONS 审中-公开
公开(公告)号：WO2012170630A3
公开(公告)日：2012-12-13
申请号：PCT/US2012/041253
申请日：2012-06-07
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , LIEBER, Charles, M. , DUAN, Xiaojie , GAO, Ruixuan , XIE, Ping , JIANG, Xiaocheng
发明人： LIEBER, Charles, M. , DUAN, Xiaojie , GAO, Ruixuan , XIE, Ping , JIANG, Xiaocheng
IPC分类号： H01L29/78 , H01L21/336
摘要： The present invention generally relates to nanotechnology, including field effect transistors and other devices used as sensors (for example, for electrophysiological studies), nanotube structures, and applications. Certain aspects of the present invention are generally directed to transistors such as field effect transistors, and other similar devices. In one set of embodiments, a field effect transistor is used where a nanoscale wire, for example, a silicon nanowire, acts as a transistor channel connecting a source electrode to a drain electrode. In some cases, a portion of the transistor channel is exposed to an environment that is to be determined, for example, the interior or cytosol of a cell. A nanotube or other suitable fluidic channel may be extended from the transistor channel into a suitable environment, such as a contained environment within a cell, so that the environment is in electrical communication with the transistor channel via the fluidic channel. In some embodiments, the rest of the transistor channel may be coated, e.g., so that the electrical properties of the transistor channel reflect the electrical behavior of the environment that the fluidic channel is in communication with. Other aspects of the invention are generally directed to methods of making such sensors, methods of using such sensors, kits involving such sensors, or the like.

2. 发明申请

WO2011038228A1 BENT NANOWIRES AND RELATED PROBING OF SPECIES 审中-公开
标题翻译： BENT NANOWIRES和相关物种的探索
公开(公告)号：WO2011038228A1
公开(公告)日：2011-03-31
申请号：PCT/US2010/050199
申请日：2010-09-24
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , TIAN, Bozhi , XIE, Ping , KEMPA, Thomas, J. , LIEBER, Charles, M. , COHEN-KARNI, Tzahi , QING, Quan , DUAN, Xiaojie
发明人： TIAN, Bozhi , XIE, Ping , KEMPA, Thomas, J. , LIEBER, Charles, M. , COHEN-KARNI, Tzahi , QING, Quan , DUAN, Xiaojie
IPC分类号： G01N33/487 , H01L29/06
CPC分类号： G01N27/4146 , B82Y10/00 , B82Y15/00 , G01N33/48728 , H01L21/02603 , H01L29/045 , H01L29/0665 , H01L29/0669 , H01L51/0048
摘要： Kinked nanowires are used for measuring electrical potentials inside simple cells. An improved intracellular entrance is achieved by modifying the kinked nanowires with phospholipids.
摘要翻译：扭曲的纳米线用于测量简单电池内的电位。改进的细胞内入口通过用磷脂修饰扭结的纳米线来实现。

3. 发明申请

WO2013166259A1 NANOSCALE SENSORS FOR INTRACELLULAR AND OTHER APPLICATIONS 审中-公开
标题翻译：纳米级传感器用于细胞和其他应用
公开(公告)号：WO2013166259A1
公开(公告)日：2013-11-07
申请号：PCT/US2013/039228
申请日：2013-05-02
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： LIEBER, Charles, M. , GAO, Ruixuan , STREHLE, Steffen , DUAN, Xiaojie , TIAN, Bozhi , COHEN-KARNI, Itzhaq , XIE, Ping , QING, Quan
IPC分类号： G01N27/414 , G01N33/487
CPC分类号： G01R1/30 , B82Y40/00 , B82Y99/00 , G01N27/4146 , G01N33/48728 , G01R1/06705 , G01R1/06755 , G01R3/00 , H01L21/283 , H01L29/413 , H01L29/42316 , H01L29/772
摘要： The present invention generally relates to nanoscale wires for use in sensors and other applications. In various embodiments, a probe (10) comprising a nanotube (or other nanoscale wire) (20) is provided that can be directly inserted into a cell (50) to determine a property of the cell, e.g., an electrical property. In some cases, only the tip of the nanoscale wire is inserted into the cell; this tip may be very small relative to the cell, allowing for very precise study. In some aspects, the tip of the probe is held by a holding member (30) positioned on a substrate (40), e.g., at an angle, which makes it easier for the probe to be inserted into the cell. The nanoscale wire may also be connected to electrodes (31, 32) and/or form part of a transistor, such that a property of the nanoscale wire, and thus of the cell, may be determined. Such probes may also be useful for studying other samples besides cells. Other aspects of the invention are generally directed to methods of making or using such probes, kits involving such probes, devices involving such probes, or the like.
摘要翻译：本发明一般涉及用于传感器和其它应用的纳米尺度线。在各种实施例中，提供了包括纳米管（或其他纳米级线）（20）的探针（10），其可以直接插入到电池（50）中以确定电池的性质，例如电性质。在某些情况下，只有纳米线的尖端插入电池中; 该尖端可能相对于细胞非常小，允许非常精确的研究。在一些方面，探针的尖端由例如以一定角度定位在基底（40）上的保持构件（30）保持，这使得探针更容易插入细胞中。纳米尺寸的导线也可以连接到电极（31,32）和/或形成晶体管的一部分，使得可以确定纳米尺寸导线（因此，电池的属性）。这样的探针也可用于研究细胞外的其他样品。本发明的其他方面通常涉及制造或使用这种探针，涉及这种探针的试剂盒，涉及这种探针的装置等的方法。

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