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1. 发明申请

US20100057158A1 Neurostimulation Based On Glycemic Condition 审中-公开
标题翻译：基于血糖条件的神经刺激
公开(公告)号：US20100057158A1
公开(公告)日：2010-03-04
申请号：US12198791
申请日：2008-08-26
申请人： Rodolfo Rodriguez , Brian Jeffrey Wenzel , Fujian Qu , Rupinder Bharmi , Karin Jarverud , Taraneh Ghaffari Farazi
发明人： Rodolfo Rodriguez , Brian Jeffrey Wenzel , Fujian Qu , Rupinder Bharmi , Karin Jarverud , Taraneh Ghaffari Farazi
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/36114 , A61N1/365
摘要： A glycemic condition is indicated based on variance of a feature derived from cardiac electrogram data. Neurostimulation is then used to counteract a cardiac-related autonomic response to the glycemic condition. For example, stimulation of parasympathetic innervation may be used to counteract an autonomic sympathetic response that is associated with hypoglycemia or hyperglycemia. In addition, stimulation of sympathetic innervation may be used to counteract an autonomic parasympathetic response that is associated with hypoglycemia or hyperglycemia.
摘要翻译：根据心脏电图数据得出的特征的方差来指示血糖状况。然后使用神经刺激来抵消对血糖状况的心脏相关的自主反应。例如，可以使用副交感神经支配的刺激来抵消与低血糖或高血糖相关的自主交感神经反应。此外，交感神经支配的刺激可用于抵消与低血糖或高血糖相关的自主神经副交感神经反应。

2. 发明授权

US07909764B1 Methods and systems to monitor venous blood oxygen saturation 有权
标题翻译：监测静脉血氧饱和度的方法和系统
公开(公告)号：US07909764B1
公开(公告)日：2011-03-22
申请号：US11948381
申请日：2007-11-30
申请人： Brian Jeffrey Wenzel , Fujian Qu , Taraneh Ghaffari Farazi
发明人： Brian Jeffrey Wenzel , Fujian Qu , Taraneh Ghaffari Farazi
IPC分类号： A61B5/00 , A61B5/04
CPC分类号： A61B5/14542 , A61B5/0452 , A61N1/36557
摘要： Methods and system are provided for monitoring a patients venous blood oxygen saturation (SvO2). At least one signal indicative of electrical activity of a patient's heart is obtained. Such a signal can be, e.g., an IEGM or ECG signal. In specific embodiments, such a signal(s) can be obtained from implanted electrodes, and thus, embodiments of the present invention can be implemented by an implantable system. Additionally, there are measurements of at least one metric of cardiac cycles represented in the at least one signal indicative of electrical activity of the patient's heart, where the metric changes with changes in SvO2. Examples of such metric include T-wave metrics and PR intervals. SvO2, and changes therein, are monitored based on the measured metric(s).
摘要翻译：方法和系统用于监测患者静脉血氧饱和度（SvO2）。获得指示患者心脏的电活动的至少一个信号。这样的信号可以是例如IEGM或ECG信号。在具体实施例中，可以从植入的电极获得这样的信号，因此本发明的实施例可以由可植入系统实现。此外，在指示患者心脏的电活动的至少一个信号中表示的心脏周期的至少一个度量的度量，其中度量随SvO2的变化而变化。这种度量的示例包括T波度量和PR间隔。 SvO2及其中的变化基于测量的度量来监测。

3. 发明授权

US08326429B2 Acquiring nerve activity from carotid body and/or sinus 有权
公开(公告)号：US08326429B2
公开(公告)日：2012-12-04
申请号：US13088223
申请日：2011-04-15
申请人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi
发明人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi
IPC分类号： A61N1/08
CPC分类号： A61B5/04001 , A61B5/4047 , A61B5/4818 , A61B5/4866 , A61B5/7264 , A61N1/36117 , A61N1/365 , A61N1/3702
摘要： An exemplary includes acquiring an electroneurogram of the right carotid sinus nerve or the left carotid sinus nerve, analyzing the electroneurogram for at least one of chemosensory information and barosensory information and calling for one or more therapeutic actions based at least in part on the analyzing. Therapeutic actions may aim to treat conditions such as sleep apnea, an increase in metabolic demand, hypoglycemia, hypertension, renal failure, and congestive heart failure. Other exemplary methods, devices, systems, etc., are also disclosed.

4. 发明申请

US20120184867A1 SYSTEMS AND METHODS FOR INCREASED SPECIFICITY IN DIAGNOSTICS 有权
标题翻译：诊断中提高特异性的系统和方法
公开(公告)号：US20120184867A1
公开(公告)日：2012-07-19
申请号：US13432923
申请日：2012-03-28
申请人： Taraneh Ghaffari Farazi , Rupinder Bharmi , Brian Jeffrey Wenzel
发明人： Taraneh Ghaffari Farazi , Rupinder Bharmi , Brian Jeffrey Wenzel
IPC分类号： A61B5/0452 , A61B5/0432
CPC分类号： A61B5/0452 , A61B5/4842 , A61B5/686 , A61N1/365
摘要： Specific embodiments provided herein relate to diagnosing, with improved specificity, occurrences of episodes relating to disorders that are known to affect T-wave morphology. One or more propensity metric is obtained, each of which is indicative of a patient's propensity for a specific disorder that is known to affect T-wave morphology. T-wave variability is monitored. Additionally, there is monitoring for a specific change in T-wave morphology that is known to be indicative of episodes relating to a disorder. When the specific change in T-wave morphology is detected, a diagnosis is determined for detecting the specific change in T-wave morphology, taking into account the propensity metric(s) and the T-wave variability.
摘要翻译：本文提供的具体实施方案涉及具有改善的特异性诊断与已知影响T波形态的病症相关的发作的发生。获得一个或多个倾向度量，每个倾向度量指示患者对已知影响T波形态的特定病症的倾向。监测T波变化。另外，监测T波形态的具体变化已知是指示与病症相关的发作。当检测到T波形态的具体变化时，考虑到倾向度量和T波变异性，确定检测T波形态的具体变化的诊断。

5. 发明授权

US07949399B2 Acquiring nerve activity from carotid body and/or sinus 有权
公开(公告)号：US07949399B2
公开(公告)日：2011-05-24
申请号：US12915991
申请日：2010-10-29
申请人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi
发明人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi
IPC分类号： A61N1/08
CPC分类号： A61N1/36114 , A61B5/04001 , A61B5/4047 , A61B5/7264 , A61N1/36117 , A61N1/36514 , A61N1/36557 , A61N1/36564
摘要： An exemplary includes acquiring an electroneurogram of the right carotid sinus nerve or the left carotid sinus nerve, analyzing the electroneurogram for at least one of chemosensory information and barosensory information and calling for one or more therapeutic actions based at least in part on the analyzing. Therapeutic actions may aim to treat conditions such as sleep apnea, an increase in metabolic demand, hypoglycemia, hypertension, renal failure, and congestive heart failure. Other exemplary methods, devices, systems, etc., are also disclosed.

6. 发明申请

US20100274219A1 ACQUIRING NERVE ACTIVITY FROM CAROTID BODY AND/OR SINUS 有权
标题翻译：从CAROTID身体和/或SINUS获得神经活动
公开(公告)号：US20100274219A1
公开(公告)日：2010-10-28
申请号：US12833170
申请日：2010-07-09
申请人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi
发明人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi
IPC分类号： A61N1/365 , A61M37/00
CPC分类号： A61N1/36114 , A61B5/04001 , A61B5/4047 , A61B5/7264 , A61N1/36117 , A61N1/36514 , A61N1/36557 , A61N1/36564
摘要： An exemplary includes acquiring an electroneurogram of the right carotid sinus nerve or the left carotid sinus nerve, analyzing the electroneurogram for at least one of chemosensory information and barosensory information and calling for one or more therapeutic actions based at least in part on the analyzing. Therapeutic actions may aim to treat conditions such as sleep apnea, an increase in metabolic demand, hypoglycemia, hypertension, renal failure, and corgestive heart failure. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性的包括获取右颈动脉窦神经或左颈动脉窦神经的电子图，分析至少一个化学感觉信息和感知信息的电子图，并至少部分地基于分析来呼叫一个或多个治疗动作。治疗作用可能旨在治疗诸如睡眠呼吸暂停，代谢需求增加，低血糖症，高血压，肾衰竭和充血性心力衰竭等病症。还公开了其它示例性方法，装置，系统等。

7. 发明申请

US20100228136A1 SYSTEMS AND METHODS FOR MONITORING DP, IVRT, DiFT, DIASTOLIC FUNCTION AND/OR HF 有权
标题翻译：用于监测DP，IVRT，DiFT，DIASTOLIC功能和/或HF的系统和方法
公开(公告)号：US20100228136A1
公开(公告)日：2010-09-09
申请号：US12474275
申请日：2009-05-29
申请人： Allen J. Keel , Brian Jeffrey Wenzel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi
发明人： Allen J. Keel , Brian Jeffrey Wenzel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi
IPC分类号： A61B5/02 , A61B5/0402
CPC分类号： A61B5/0402 , A61B5/02416 , A61B5/6846
摘要： Implantable systems, and methods for use therewith, are provided for monitoring a patient's diastolic function and/or heart failure (HF) condition. A signal indicative of changes in arterial blood volume and a signal indicative of electrical activity of the patient's heart are obtained. Beginnings of diastolic periods can be detected based on a feature of the signal indicative of changes in arterial blood volume. Ends of the diastolic periods can be detected based on a feature of the signal indicative of electrical activity of the patient's heart, or on the signal indicative of changes in arterial blood volume. Diastolic periods (DPs), isovolumic relaxation times (IVRTs) and/or diastolic filling times (DiFTs) can be estimated based on the detected beginnings of the diastolic periods and detected ends of the diastolic periods. The patient's diastolic function and/or HF condition (and/or changes therein) can be monitored based on the estimates of DP, IVRT and/or DiFT.
摘要翻译：提供了可植入系统及其使用方法，用于监测患者的舒张功能和/或心力衰竭（HF）状况。获得指示动脉血容量变化的信号和表示患者心脏的电活动的信号。可以基于指示动脉血容量变化的信号的特征来检测舒张期的开始。可以基于指示患者心脏的电活动的信号的特征或指示动脉血容量变化的信号来检测舒张期的结束。舒张期（DPs），等容舒张时间（IVRT）和/或舒张期充盈时间（DiFT）可以基于检测到的舒张期的开始和舒张期的检测结束来估计。可以基于DP，IVRT和/或DiFT的估计来监测患者的舒张功能和/或HF状态（和/或其中的变化）。

8. 发明授权

US09687656B2 Arterial blood pressure monitoring devices, systems and methods for use while pacing 有权
公开(公告)号：US09687656B2
公开(公告)日：2017-06-27
申请号：US12637574
申请日：2009-12-14
申请人： Brian Jeffrey Wenzel , Timothy A. Fayram , Allen J. Keel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi
发明人： Brian Jeffrey Wenzel , Timothy A. Fayram , Allen J. Keel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi
IPC分类号： A61B5/02 , A61N1/365 , A61B5/0215 , A61B5/0295 , A61B5/1459 , A61N1/08 , G03F7/00 , B82Y10/00 , B82Y40/00 , A61B5/021 , A61B5/053 , A61B5/00
CPC分类号： A61N1/36585 , A61B5/02125 , A61B5/0215 , A61B5/0295 , A61B5/0535 , A61B5/1459 , A61B5/7239 , A61N1/08 , B82Y10/00 , B82Y40/00 , G03F7/0002
摘要： Provided herein are implantable systems, and methods for use therewith, for monitoring a patient's arterial blood pressure while a patient's heart is being paced. A signal (e.g., PPG or IPG signal) indicative of changes in arterial blood volume remote from the patient's heart is obtained using a sensor or electrodes that are implanted remote from the patient's heart. One or more metrics indicative of pulse arrival time (PAT) are determined, where each metric can be determined by determining a time from a paced cardiac event to one or more predetermined features of the signal indicative of changes in arterial blood volume. Based on at the metric(s) indicative of PAT, arterial blood pressure is estimated, which can include determining values indicative of systolic blood pressure, diastolic blood pressure, pulse pressure and/or mean arterial blood pressure, and/or changes in such values.

9. 发明授权

US08630692B2 Method and implantable system for blood-glucose concentration monitoring using parallel methodologies 有权
标题翻译：使用并行方法进行血糖浓度监测的方法和植入式系统
公开(公告)号：US08630692B2
公开(公告)日：2014-01-14
申请号：US12433414
申请日：2009-04-30
申请人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi , Euljoon Park , Eric Falkenberg , Michael E. Benser
发明人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi , Euljoon Park , Eric Falkenberg , Michael E. Benser
IPC分类号： A61B5/0205 , A61B5/0402 , A61B5/042 , A61B5/0452 , A61B5/145
CPC分类号： A61B5/0006 , A61B5/0205 , A61B5/04012 , A61B5/0428 , A61B5/0452 , A61B5/14532 , A61B5/14542 , A61B5/14551 , A61B5/1459 , A61B5/4836 , A61B5/4866 , A61B5/6846 , A61B5/686 , A61B5/7285 , A61B5/746
摘要： In an implantable medical device for monitoring glucose concentration in the blood, a blood-glucose concentration analysis is performed using correlations of blood-glucose concentration with measures of metabolic oxygen consumption including oxymetric, and/or temperature. Analysis of electrocardiographic data is used in a parallel method to detect and/or confirm the onset and/or existence and/or extent of hypoglycemia and/or hyperglycemia. Blood-glucose concentration calculation is enhanced by using the combination of the oxygen metabolism analysis and electrocardiographic analysis.
摘要翻译：在用于监测血液中葡萄糖浓度的可植入医疗装置中，使用血糖浓度与包括氧测量和/或温度在内的代谢氧消耗量的相关性进行血糖浓度分析。使用并行方法来分析心电图数据以检测和/或确认低血糖和/或高血糖症的发作和/或存在和/或程度。通过使用氧代谢分析和心电图分析的组合，提高血糖浓度计算。

10. 发明授权

US08162841B2 Standalone systemic arterial blood pressure monitoring device 有权
标题翻译：独立的全身动脉血压监测装置
公开(公告)号：US08162841B2
公开(公告)日：2012-04-24
申请号：US12474276
申请日：2009-05-29
申请人： Allen J. Keel , Brian Jeffrey Wenzel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi , Timothy A. Fayram , Eric S. Fain , Paul A. Levine
发明人： Allen J. Keel , Brian Jeffrey Wenzel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi , Timothy A. Fayram , Eric S. Fain , Paul A. Levine
IPC分类号： A61B5/02
CPC分类号： A61B5/02158 , A61B5/02125 , A61B5/0295 , A61B5/0452 , A61B5/1459 , A61B2562/0219 , A61N1/36557 , A61N1/36564 , A61N1/36585 , G06F19/00
摘要： Certain embodiments of the present invention are related to an implantable monitoring device to monitor a patient's arterial blood pressure, where the device is configured to be implanted subcutaneously. The device includes subcutaneous (SubQ) electrodes and a plethysmography sensor. Additionally, the device includes an arterial blood pressure monitor configured to determine at least one value indicative of the patient's arterial blood pressure based on at least one detected predetermined feature of a SubQ ECG and at least one detected predetermined feature of a plethysmography signal. Alternative embodiments of the present invention are directed to a non-implantable monitoring device to monitor a patient's arterial blood pressure based on features of a surface ECG and a plethysmography signal obtained from a non-implanted sensor.
摘要翻译：本发明的某些实施例涉及一种用于监测患者的动脉血压的可植入监测装置，其中该装置被配置为被皮下植入。该装置包括皮下（SubQ）电极和体积描记传感器。另外，该装置包括动脉血压监测器，其被配置为基于至少一个检测到的SubQ ECG的预定特征和至少一个检测到的体积描记信号的预定特征来确定指示患者的动脉血压的至少一个值。本发明的替代实施例涉及一种非植入式监测装置，用于基于从非植入传感器获得的表面ECG和体积描记信号的特征来监测患者的动脉血压。

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