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1. 发明申请

US20120184867A1 SYSTEMS AND METHODS FOR INCREASED SPECIFICITY IN DIAGNOSTICS 有权
标题翻译：诊断中提高特异性的系统和方法
公开(公告)号：US20120184867A1
公开(公告)日：2012-07-19
申请号：US13432923
申请日：2012-03-28
申请人： Taraneh Ghaffari Farazi , Rupinder Bharmi , Brian Jeffrey Wenzel
发明人： Taraneh Ghaffari Farazi , Rupinder Bharmi , Brian Jeffrey Wenzel
IPC分类号： A61B5/0452 , A61B5/0432
CPC分类号： A61B5/0452 , A61B5/4842 , A61B5/686 , A61N1/365
摘要： Specific embodiments provided herein relate to diagnosing, with improved specificity, occurrences of episodes relating to disorders that are known to affect T-wave morphology. One or more propensity metric is obtained, each of which is indicative of a patient's propensity for a specific disorder that is known to affect T-wave morphology. T-wave variability is monitored. Additionally, there is monitoring for a specific change in T-wave morphology that is known to be indicative of episodes relating to a disorder. When the specific change in T-wave morphology is detected, a diagnosis is determined for detecting the specific change in T-wave morphology, taking into account the propensity metric(s) and the T-wave variability.
摘要翻译：本文提供的具体实施方案涉及具有改善的特异性诊断与已知影响T波形态的病症相关的发作的发生。获得一个或多个倾向度量，每个倾向度量指示患者对已知影响T波形态的特定病症的倾向。监测T波变化。另外，监测T波形态的具体变化已知是指示与病症相关的发作。当检测到T波形态的具体变化时，考虑到倾向度量和T波变异性，确定检测T波形态的具体变化的诊断。

2. 发明申请

US20100057158A1 Neurostimulation Based On Glycemic Condition 审中-公开
标题翻译：基于血糖条件的神经刺激
公开(公告)号：US20100057158A1
公开(公告)日：2010-03-04
申请号：US12198791
申请日：2008-08-26
申请人： Rodolfo Rodriguez , Brian Jeffrey Wenzel , Fujian Qu , Rupinder Bharmi , Karin Jarverud , Taraneh Ghaffari Farazi
发明人： Rodolfo Rodriguez , Brian Jeffrey Wenzel , Fujian Qu , Rupinder Bharmi , Karin Jarverud , Taraneh Ghaffari Farazi
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/36114 , A61N1/365
摘要： A glycemic condition is indicated based on variance of a feature derived from cardiac electrogram data. Neurostimulation is then used to counteract a cardiac-related autonomic response to the glycemic condition. For example, stimulation of parasympathetic innervation may be used to counteract an autonomic sympathetic response that is associated with hypoglycemia or hyperglycemia. In addition, stimulation of sympathetic innervation may be used to counteract an autonomic parasympathetic response that is associated with hypoglycemia or hyperglycemia.
摘要翻译：根据心脏电图数据得出的特征的方差来指示血糖状况。然后使用神经刺激来抵消对血糖状况的心脏相关的自主反应。例如，可以使用副交感神经支配的刺激来抵消与低血糖或高血糖相关的自主交感神经反应。此外，交感神经支配的刺激可用于抵消与低血糖或高血糖相关的自主神经副交感神经反应。

3. 发明授权

US08798724B2 Systems and methods for increased specificity in diagnostics 有权
标题翻译：在诊断中提高特异性的系统和方法
公开(公告)号：US08798724B2
公开(公告)日：2014-08-05
申请号：US13432923
申请日：2012-03-28
申请人： Taraneh Ghaffari Farazi , Rupinder Bharmi , Brian Jeffrey Wenzel
发明人： Taraneh Ghaffari Farazi , Rupinder Bharmi , Brian Jeffrey Wenzel
IPC分类号： A61B5/0402 , A61B5/0452 , A61B5/00 , A61N1/365
CPC分类号： A61B5/0452 , A61B5/4842 , A61B5/686 , A61N1/365
摘要： Methods and apparatuses for monitoring, with improved specificity, occurrences of episodes relating to disorders that are known to affect T-wave morphology. T-wave variability is monitored. When T-wave variability, or a change therein, exceeds a corresponding threshold for a specific period of time, monitoring for a specific change in T-wave morphology that is known to be indicative of episodes relating to a disorder may be triggered.
摘要翻译：具有改善的特异性的用于监测与已知影响T波形态的病症相关的发作的方法和装置。监测T波变化。当T波变化或其中的变化在特定时间段内超过相应的阈值时，可以触发已知指示与病症相关的发作的T波形态的特定变化的监测。

4. 发明授权

US08165664B1 Systems and methods for increased specificity in diagnostics 有权
标题翻译：在诊断中提高特异性的系统和方法
公开(公告)号：US08165664B1
公开(公告)日：2012-04-24
申请号：US11928233
申请日：2007-10-30
申请人： Taraneh Ghaffari Farazi , Rupinder Bharmi , Brian Jeffrey Wenzel
发明人： Taraneh Ghaffari Farazi , Rupinder Bharmi , Brian Jeffrey Wenzel
IPC分类号： A61B5/0402
CPC分类号： A61B5/0452 , A61B5/4842 , A61B5/686 , A61N1/365
摘要： Specific embodiments provided herein relate to diagnosing, with improved specificity, occurrences of episodes relating to disorders that are known to affect T-wave morphology. One or more propensity metric is obtained, each of which is indicative of a patient's propensity for a specific disorder that is known to affect T-wave morphology. T-wave variability is monitored. Additionally, there is monitoring for a specific change in T-wave morphology that is known to be indicative of episodes relating to a disorder. When the specific change in T-wave morphology is detected, a diagnosis is determined for detecting the specific change in T-wave morphology, taking into account the propensity metric(s) and the T-wave variability.
摘要翻译：本文提供的具体实施方案涉及具有改善的特异性诊断与已知影响T波形态的病症相关的发作的发生。获得一个或多个倾向度量，每个倾向度量指示患者对已知影响T波形态的特定病症的倾向。监测T波变化。另外，监测T波形态的具体变化已知是指示与病症相关的发作。当检测到T波形态的具体变化时，考虑到倾向度量和T波变异性，确定检测T波形态的具体变化的诊断。

5. 发明授权

US08326429B2 Acquiring nerve activity from carotid body and/or sinus 有权
公开(公告)号：US08326429B2
公开(公告)日：2012-12-04
申请号：US13088223
申请日：2011-04-15
申请人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi
发明人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi
IPC分类号： A61N1/08
CPC分类号： A61B5/04001 , A61B5/4047 , A61B5/4818 , A61B5/4866 , A61B5/7264 , A61N1/36117 , A61N1/365 , A61N1/3702
摘要： An exemplary includes acquiring an electroneurogram of the right carotid sinus nerve or the left carotid sinus nerve, analyzing the electroneurogram for at least one of chemosensory information and barosensory information and calling for one or more therapeutic actions based at least in part on the analyzing. Therapeutic actions may aim to treat conditions such as sleep apnea, an increase in metabolic demand, hypoglycemia, hypertension, renal failure, and congestive heart failure. Other exemplary methods, devices, systems, etc., are also disclosed.

6. 发明授权

US07949399B2 Acquiring nerve activity from carotid body and/or sinus 有权
公开(公告)号：US07949399B2
公开(公告)日：2011-05-24
申请号：US12915991
申请日：2010-10-29
申请人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi
发明人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi
IPC分类号： A61N1/08
CPC分类号： A61N1/36114 , A61B5/04001 , A61B5/4047 , A61B5/7264 , A61N1/36117 , A61N1/36514 , A61N1/36557 , A61N1/36564
摘要： An exemplary includes acquiring an electroneurogram of the right carotid sinus nerve or the left carotid sinus nerve, analyzing the electroneurogram for at least one of chemosensory information and barosensory information and calling for one or more therapeutic actions based at least in part on the analyzing. Therapeutic actions may aim to treat conditions such as sleep apnea, an increase in metabolic demand, hypoglycemia, hypertension, renal failure, and congestive heart failure. Other exemplary methods, devices, systems, etc., are also disclosed.

7. 发明申请

US20100274219A1 ACQUIRING NERVE ACTIVITY FROM CAROTID BODY AND/OR SINUS 有权
标题翻译：从CAROTID身体和/或SINUS获得神经活动
公开(公告)号：US20100274219A1
公开(公告)日：2010-10-28
申请号：US12833170
申请日：2010-07-09
申请人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi
发明人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi
IPC分类号： A61N1/365 , A61M37/00
CPC分类号： A61N1/36114 , A61B5/04001 , A61B5/4047 , A61B5/7264 , A61N1/36117 , A61N1/36514 , A61N1/36557 , A61N1/36564
摘要： An exemplary includes acquiring an electroneurogram of the right carotid sinus nerve or the left carotid sinus nerve, analyzing the electroneurogram for at least one of chemosensory information and barosensory information and calling for one or more therapeutic actions based at least in part on the analyzing. Therapeutic actions may aim to treat conditions such as sleep apnea, an increase in metabolic demand, hypoglycemia, hypertension, renal failure, and corgestive heart failure. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性的包括获取右颈动脉窦神经或左颈动脉窦神经的电子图，分析至少一个化学感觉信息和感知信息的电子图，并至少部分地基于分析来呼叫一个或多个治疗动作。治疗作用可能旨在治疗诸如睡眠呼吸暂停，代谢需求增加，低血糖症，高血压，肾衰竭和充血性心力衰竭等病症。还公开了其它示例性方法，装置，系统等。

8. 发明申请

US20100228136A1 SYSTEMS AND METHODS FOR MONITORING DP, IVRT, DiFT, DIASTOLIC FUNCTION AND/OR HF 有权
标题翻译：用于监测DP，IVRT，DiFT，DIASTOLIC功能和/或HF的系统和方法
公开(公告)号：US20100228136A1
公开(公告)日：2010-09-09
申请号：US12474275
申请日：2009-05-29
申请人： Allen J. Keel , Brian Jeffrey Wenzel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi
发明人： Allen J. Keel , Brian Jeffrey Wenzel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi
IPC分类号： A61B5/02 , A61B5/0402
CPC分类号： A61B5/0402 , A61B5/02416 , A61B5/6846
摘要： Implantable systems, and methods for use therewith, are provided for monitoring a patient's diastolic function and/or heart failure (HF) condition. A signal indicative of changes in arterial blood volume and a signal indicative of electrical activity of the patient's heart are obtained. Beginnings of diastolic periods can be detected based on a feature of the signal indicative of changes in arterial blood volume. Ends of the diastolic periods can be detected based on a feature of the signal indicative of electrical activity of the patient's heart, or on the signal indicative of changes in arterial blood volume. Diastolic periods (DPs), isovolumic relaxation times (IVRTs) and/or diastolic filling times (DiFTs) can be estimated based on the detected beginnings of the diastolic periods and detected ends of the diastolic periods. The patient's diastolic function and/or HF condition (and/or changes therein) can be monitored based on the estimates of DP, IVRT and/or DiFT.
摘要翻译：提供了可植入系统及其使用方法，用于监测患者的舒张功能和/或心力衰竭（HF）状况。获得指示动脉血容量变化的信号和表示患者心脏的电活动的信号。可以基于指示动脉血容量变化的信号的特征来检测舒张期的开始。可以基于指示患者心脏的电活动的信号的特征或指示动脉血容量变化的信号来检测舒张期的结束。舒张期（DPs），等容舒张时间（IVRT）和/或舒张期充盈时间（DiFT）可以基于检测到的舒张期的开始和舒张期的检测结束来估计。可以基于DP，IVRT和/或DiFT的估计来监测患者的舒张功能和/或HF状态（和/或其中的变化）。

9. 发明授权

US09687656B2 Arterial blood pressure monitoring devices, systems and methods for use while pacing 有权
公开(公告)号：US09687656B2
公开(公告)日：2017-06-27
申请号：US12637574
申请日：2009-12-14
申请人： Brian Jeffrey Wenzel , Timothy A. Fayram , Allen J. Keel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi
发明人： Brian Jeffrey Wenzel , Timothy A. Fayram , Allen J. Keel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi
IPC分类号： A61B5/02 , A61N1/365 , A61B5/0215 , A61B5/0295 , A61B5/1459 , A61N1/08 , G03F7/00 , B82Y10/00 , B82Y40/00 , A61B5/021 , A61B5/053 , A61B5/00
CPC分类号： A61N1/36585 , A61B5/02125 , A61B5/0215 , A61B5/0295 , A61B5/0535 , A61B5/1459 , A61B5/7239 , A61N1/08 , B82Y10/00 , B82Y40/00 , G03F7/0002
摘要： Provided herein are implantable systems, and methods for use therewith, for monitoring a patient's arterial blood pressure while a patient's heart is being paced. A signal (e.g., PPG or IPG signal) indicative of changes in arterial blood volume remote from the patient's heart is obtained using a sensor or electrodes that are implanted remote from the patient's heart. One or more metrics indicative of pulse arrival time (PAT) are determined, where each metric can be determined by determining a time from a paced cardiac event to one or more predetermined features of the signal indicative of changes in arterial blood volume. Based on at the metric(s) indicative of PAT, arterial blood pressure is estimated, which can include determining values indicative of systolic blood pressure, diastolic blood pressure, pulse pressure and/or mean arterial blood pressure, and/or changes in such values.

10. 发明授权

US08630692B2 Method and implantable system for blood-glucose concentration monitoring using parallel methodologies 有权
标题翻译：使用并行方法进行血糖浓度监测的方法和植入式系统
公开(公告)号：US08630692B2
公开(公告)日：2014-01-14
申请号：US12433414
申请日：2009-04-30
申请人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi , Euljoon Park , Eric Falkenberg , Michael E. Benser
发明人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi , Euljoon Park , Eric Falkenberg , Michael E. Benser
IPC分类号： A61B5/0205 , A61B5/0402 , A61B5/042 , A61B5/0452 , A61B5/145
CPC分类号： A61B5/0006 , A61B5/0205 , A61B5/04012 , A61B5/0428 , A61B5/0452 , A61B5/14532 , A61B5/14542 , A61B5/14551 , A61B5/1459 , A61B5/4836 , A61B5/4866 , A61B5/6846 , A61B5/686 , A61B5/7285 , A61B5/746
摘要： In an implantable medical device for monitoring glucose concentration in the blood, a blood-glucose concentration analysis is performed using correlations of blood-glucose concentration with measures of metabolic oxygen consumption including oxymetric, and/or temperature. Analysis of electrocardiographic data is used in a parallel method to detect and/or confirm the onset and/or existence and/or extent of hypoglycemia and/or hyperglycemia. Blood-glucose concentration calculation is enhanced by using the combination of the oxygen metabolism analysis and electrocardiographic analysis.
摘要翻译：在用于监测血液中葡萄糖浓度的可植入医疗装置中，使用血糖浓度与包括氧测量和/或温度在内的代谢氧消耗量的相关性进行血糖浓度分析。使用并行方法来分析心电图数据以检测和/或确认低血糖和/或高血糖症的发作和/或存在和/或程度。通过使用氧代谢分析和心电图分析的组合，提高血糖浓度计算。

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