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1. 发明授权

US08162841B2 Standalone systemic arterial blood pressure monitoring device 有权
标题翻译：独立的全身动脉血压监测装置
公开(公告)号：US08162841B2
公开(公告)日：2012-04-24
申请号：US12474276
申请日：2009-05-29
申请人： Allen J. Keel , Brian Jeffrey Wenzel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi , Timothy A. Fayram , Eric S. Fain , Paul A. Levine
发明人： Allen J. Keel , Brian Jeffrey Wenzel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi , Timothy A. Fayram , Eric S. Fain , Paul A. Levine
IPC分类号： A61B5/02
CPC分类号： A61B5/02158 , A61B5/02125 , A61B5/0295 , A61B5/0452 , A61B5/1459 , A61B2562/0219 , A61N1/36557 , A61N1/36564 , A61N1/36585 , G06F19/00
摘要： Certain embodiments of the present invention are related to an implantable monitoring device to monitor a patient's arterial blood pressure, where the device is configured to be implanted subcutaneously. The device includes subcutaneous (SubQ) electrodes and a plethysmography sensor. Additionally, the device includes an arterial blood pressure monitor configured to determine at least one value indicative of the patient's arterial blood pressure based on at least one detected predetermined feature of a SubQ ECG and at least one detected predetermined feature of a plethysmography signal. Alternative embodiments of the present invention are directed to a non-implantable monitoring device to monitor a patient's arterial blood pressure based on features of a surface ECG and a plethysmography signal obtained from a non-implanted sensor.
摘要翻译：本发明的某些实施例涉及一种用于监测患者的动脉血压的可植入监测装置，其中该装置被配置为被皮下植入。该装置包括皮下（SubQ）电极和体积描记传感器。另外，该装置包括动脉血压监测器，其被配置为基于至少一个检测到的SubQ ECG的预定特征和至少一个检测到的体积描记信号的预定特征来确定指示患者的动脉血压的至少一个值。本发明的替代实施例涉及一种非植入式监测装置，用于基于从非植入传感器获得的表面ECG和体积描记信号的特征来监测患者的动脉血压。

2. 发明申请

US20090281399A1 STANDALONE SYSTEMIC ARTERIAL BLOOD PRESSURE MONITORING DEVICE 有权
标题翻译： STANDALONE系统动态血压监测装置
公开(公告)号：US20090281399A1
公开(公告)日：2009-11-12
申请号：US12474276
申请日：2009-05-29
申请人： Allen J. Keel , Brian Jeffrey Wenzel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi , Timothy A. Fayram , Eric S. Fain , Paul A. Levine
发明人： Allen J. Keel , Brian Jeffrey Wenzel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi , Timothy A. Fayram , Eric S. Fain , Paul A. Levine
IPC分类号： A61B5/00 , A61B5/02 , A61B5/0402
CPC分类号： A61B5/02158 , A61B5/02125 , A61B5/0295 , A61B5/0452 , A61B5/1459 , A61B2562/0219 , A61N1/36557 , A61N1/36564 , A61N1/36585 , G06F19/00
摘要： Certain embodiments of the present invention are related to an implantable monitoring device to monitor a patient's arterial blood pressure, where the device is configured to be implanted subcutaneously. The device includes subcutaneous (SubQ) electrodes and a plethysmography sensor. Additionally, the device includes an arterial blood pressure monitor configured to determine at least one value indicative of the patient's arterial blood pressure based on at least one detected predetermined feature of a SubQ ECG and at least one detected predetermined feature of a plethysmography signal. Alternative embodiments of the present invention are directed to a non-implantable monitoring device to monitor a patient's arterial blood pressure based on features of a surface ECG and a plethysmography signal obtained from a non-implanted sensor.
摘要翻译：本发明的某些实施例涉及一种用于监测患者的动脉血压的可植入监测装置，其中该装置被配置为被皮下植入。该装置包括皮下（SubQ）电极和体积描记传感器。另外，该装置包括动脉血压监测器，其被配置为基于至少一个检测到的SubQ ECG的预定特征和至少一个检测到的体积描记信号的预定特征来确定指示患者的动脉血压的至少一个值。本发明的替代实施例涉及一种非植入式监测装置，用于基于从非植入传感器获得的表面ECG和体积描记信号的特征来监测患者的动脉血压。

3. 发明授权

US08147416B2 Implantable systemic blood pressure measurement systems and methods 有权
标题翻译：植入式全身血压测量系统和方法
公开(公告)号：US08147416B2
公开(公告)日：2012-04-03
申请号：US11848586
申请日：2007-08-31
申请人： Timothy A. Fayram , Eric S. Fain , Paul A. Levine , Anders Björling
发明人： Timothy A. Fayram , Eric S. Fain , Paul A. Levine , Anders Björling
IPC分类号： A61B5/02 , A61B5/021
CPC分类号： A61B5/0215 , A61B5/02108 , A61B5/02116 , A61B5/02125 , A61B5/0285 , A61B5/0295 , A61B5/0452 , A61B5/6846 , A61B2562/0219 , A61N1/36564 , A61N1/36578 , A61N1/36585
摘要： Implantable systems, and methods for use therewith, for monitoring arterial blood pressure on a chronic basis are provided herein. A first signal indicative of electrical activity of a patient's heart, and a second signal indicative of mechanical activity of the patient's heart, are obtained using implanted electrodes and an implanted sensor. By measuring the times between various features of the first signal relative to features of the second signal, values indicative of systolic pressure and diastolic pressure can be determined. In specific embodiments, such features are used to determine a peak pulse arrival time (PPAT), which is used to determine the value indicative of systolic pressure. Additionally, a peak-to-peak amplitude at the maximum peak of the second signal, and the value indicative of systolic pressure, can be used to determine the value indicative of diastolic pressure.
摘要翻译：本文提供了可植入系统及其使用方法，用于长期监测动脉血压。使用植入电极和植入的传感器获得指示患者心脏的电活动的第一信号和指示患者心脏的机械活动的第二信号。通过测量第一信号的各个特征相对于第二信号的特征之间的时间，可以确定指示收缩压和舒张压的值。在具体实施例中，这些特征用于确定峰值脉冲到达时间（PPAT），其用于确定指示收缩压的值。此外，可以使用在第二信号的最大峰值处的峰 - 峰幅度和指示收缩压的值来确定指示舒张压的值。

4. 发明申请

US20120108987A1 IMPLANTABLE SYSTEMIC BLOOD PRESSURE MEASUREMENT SYSTEMS AND METHODS 审中-公开
标题翻译：可植入系统血压测量系统和方法
公开(公告)号：US20120108987A1
公开(公告)日：2012-05-03
申请号：US13342864
申请日：2012-01-03
申请人： Timothy A. Fayram , Eric S. Fain , Paul A. Levine , Anders Björling
发明人： Timothy A. Fayram , Eric S. Fain , Paul A. Levine , Anders Björling
IPC分类号： A61B5/0215
CPC分类号： A61B5/0215 , A61B5/02108 , A61B5/02116 , A61B5/02125 , A61B5/0285 , A61B5/0295 , A61B5/0452 , A61B5/6846 , A61B2562/0219 , A61N1/36564 , A61N1/36578 , A61N1/36585
摘要： Implantable systems, and methods for use therewith, for monitoring arterial blood pressure on a chronic basis are provided herein. A first signal indicative of electrical activity of a patient's heart, and a second signal indicative of mechanical activity of the patient's heart, are obtained using implanted electrodes and an implanted sensor. By measuring the times between various features of the first signal relative to features of the second signal, values indicative of systolic pressure and diastolic pressure can be determined. In specific embodiments, such features are used to determine a peak pulse arrival time (PPAT), which is used to determine the value indicative of systolic pressure. Additionally, a peak-to-peak amplitude at the maximum peak of the second signal, and the value indicative of systolic pressure, can be used to determine the value indicative of diastolic pressure.
摘要翻译：本文提供了可植入系统及其使用方法，用于长期监测动脉血压。使用植入电极和植入的传感器获得指示患者心脏的电活动的第一信号和指示患者心脏的机械活动的第二信号。通过测量第一信号的各个特征相对于第二信号的特征之间的时间，可以确定指示收缩压和舒张压的值。在具体实施例中，这些特征用于确定峰值脉冲到达时间（PPAT），其用于确定指示收缩压的值。此外，可以使用在第二信号的最大峰值处的峰 - 峰幅度和指示收缩压的值来确定指示舒张压的值。

5. 发明申请

US20090062667A1 Implantable Systemic Blood Pressure Measurement Systems and Methods 有权
标题翻译：植入式系统血压测量系统和方法
公开(公告)号：US20090062667A1
公开(公告)日：2009-03-05
申请号：US11848586
申请日：2007-08-31
申请人： Timothy A. Fayram , Eric S. Fain , Paul A. Levine
发明人： Timothy A. Fayram , Eric S. Fain , Paul A. Levine
IPC分类号： A61B5/0215
CPC分类号： A61B5/0215 , A61B5/02108 , A61B5/02116 , A61B5/02125 , A61B5/0285 , A61B5/0295 , A61B5/0452 , A61B5/6846 , A61B2562/0219 , A61N1/36564 , A61N1/36578 , A61N1/36585
摘要： Implantable systems, and methods for use therewith, for monitoring arterial blood pressure on a chronic basis are provided herein. A first signal indicative of electrical activity of a patient's heart, and a second signal indicative of mechanical activity of the patient's heart, are obtained using implanted electrodes and an implanted sensor. By measuring the times between various features of the first signal relative to features of the second signal, values indicative of systolic pressure and diastolic pressure can be determined. In specific embodiments, such features are used to determine a peak pulse arrival time (PPAT), which is used to determine the value indicative of systolic pressure. Additionally, a peak-to-peak amplitude at the maximum peak of the second signal, and the value indicative of systolic pressure, can be used to determine the value indicative of diastolic pressure.
摘要翻译：本文提供了可植入系统及其使用方法，用于长期监测动脉血压。使用植入电极和植入的传感器获得指示患者心脏的电活动的第一信号和指示患者心脏的机械活动的第二信号。通过测量第一信号的各个特征相对于第二信号的特征之间的时间，可以确定指示收缩压和舒张压的值。在具体实施例中，这些特征用于确定峰值脉冲到达时间（PPAT），其用于确定指示收缩压的值。此外，可以使用在第二信号的最大峰值处的峰 - 峰幅度和指示收缩压的值来确定指示舒张压的值。

6. 发明授权

US5679026A Header adapter for an implantable cardiac stimulation device 失效
标题翻译：用于植入式心脏刺激装置的头适配器
公开(公告)号：US5679026A
公开(公告)日：1997-10-21
申请号：US577593
申请日：1995-12-21
申请人： Eric S. Fain , Timothy A. Fayram
发明人： Eric S. Fain , Timothy A. Fayram
IPC分类号： A61N1/375 , H01R27/00 , H01R25/00
CPC分类号： A61N1/3752 , H01R27/00 , H01R2201/12 , Y10S439/909
摘要： A header adapter which is a separately molded part and which is designed to be secured to receiving portions of the header and pulse generator case of an implantable cardiac stimulation device, such as a pacemaker or implantable cardioverter-defibrillator, in order to provide a different lead connector port configuration than that provided by the header of the device. The header adapter has a plurality of adapter lead connector ports and a plurality of lead connectors affixed to a rear portion (mounting side) thereof. The lead connectors extend outwardly from the rear portion of the header adapter, and are insertable into corresponding lead connector ports of the header of the implantable cardiac stimulation device to which the header adapter is to be secured. At least one of the plurality of adapter lead connector ports is of a different size than any of the header lead connector ports of the device to which the header adapter is to be secured, and/or the number of adapter lead connector ports is different (greater or less than) the number of header lead connector ports of the device to which the header adapter is to be secured. Two or more leads inserted into the header adapter lead connector ports can be electrically connected to the same lead connector and/or one or more of the leads inserted into a header adapter lead connector port(s) can each be electrically connected to two or more of the lead connectors. Further, one or more of the lead connectors can be an electrically inactive "dummy" lead connector. The header adapter is preferably made of a transparent or translucent polymeric or other electrically insulative, biocompatible material, such as an epoxy resin or a thermoplastic elastomer. The invention also relates to an implantable cardiac stimulation device to which the header adapter is secured.
摘要翻译：头部适配器，其是单独模制的部件，并且被设计成固定到可植入心脏刺激装置（例如起搏器或可植入式心律转复除颤器）的头部和脉冲发生器壳体的接收部分，以便提供不同的引线连接器端口配置比设备头部提供的配置。插头适配器具有多个适配器引线连接器端口和固定到其后部（安装侧）上的多个引线连接器。引线连接器从插头适配器的后部向外延伸，并且可插入可插入心脏刺激装置的头部的相应引线连接器端口中，头部适配器将被固定到该引导连接器端口。多个适配器引线连接器端口中的至少一个具有与要固定插头适配器的设备的头部引线连接器端口的尺寸不同的尺寸，和/或适配器引线连接器端口的数量不同（大于或小于）头部适配器要固定到的设备的插头引线连接器端口的数量。插入插头适配器引线连接器端口中的两个或更多个引线可以电连接到同一导线连接器和/或插入插头适配器引线连接器端口中的一个或多个引线可以各自电连接到两个或更多个的引线连接器。此外，一个或多个引线连接器可以是电不活动的“虚拟”引线连接器。插头适配器优选由透明或半透明的聚合物或其它电绝缘的生物相容性材料制成，例如环氧树脂或热塑性弹性体。本发明还涉及一种植入式心脏刺激装置，头部适配器固定到该心脏刺激装置。

7. 发明授权

US5658321A Conductive housing for implantable cardiac device 失效
标题翻译：用于植入式心脏装置的导电外壳
公开(公告)号：US5658321A
公开(公告)日：1997-08-19
申请号：US489096
申请日：1995-06-09
申请人： Timothy A. Fayram , Eric S. Fain
发明人： Timothy A. Fayram , Eric S. Fain
IPC分类号： A61N1/375 , A61N1/39
CPC分类号： A61N1/375
摘要： An implantable cardiac stimulator having a housing defining an interior cavity and having an exterior surface, and a defibrillation pulse generator circuit contained within the cavity. The housing exterior surface has a number of ridges, and each ridge includes at least two surfaces that are angularly offset from each other at an edge. The ridges may be formed by creating grooves in the housing in a closely spaced arrangement.
摘要翻译：一种植入式心脏刺激器，其具有限定内腔并具有外表面的壳体，以及包含在腔内的除颤脉冲发生器电路。壳体外表面具有多个脊，并且每个脊包括在边缘处彼此成角度地偏移的至少两个表面。脊可以通过以紧密间隔的布置在壳体中产生凹槽来形成。

8. 发明授权

US08798762B2 Communication device, communication system and communication implantable medical device 有权
标题翻译：通信设备，通信系统和通信植入式医疗设备
公开(公告)号：US08798762B2
公开(公告)日：2014-08-05
申请号：US13149608
申请日：2011-05-31
申请人： Eric S. Fain , Ronald R. Rios
发明人： Eric S. Fain , Ronald R. Rios
IPC分类号： A61N1/00 , A61N1/372
CPC分类号： A61B5/0015 , A61N1/37211
摘要： A communication device for an implantable medical device may include: an input/output interface configured to communicate with a wireless communication device; a communication interface configured to communicate with a remote system; and a processor configured to perform an analysis of data received from the wireless communication device via the input/output interface and associated with the implantable medical device. The communication device may include a user interface configured to receive data input by a user. A communication system may include a wireless communication device and the aforementioned communication device. A communication method for an implantable medical device may include: providing a communication device that is configured to communicate with a wireless communication device, to communicate with a remote system and to perform an analysis of data; communicating data associated with an implantable medical device from a wireless device to the communication device; and analyzing the received data at the communication device.
摘要翻译：用于可植入医疗设备的通信设备可以包括：被配置为与无线通信设备进行通信的输入/输出接口; 通信接口，被配置为与远程系统通信; 以及处理器，被配置为经由所述输入/输出接口执行从所述无线通信设备接收的数据的分析并与所述可植入医疗设备相关联。通信设备可以包括被配置为接收用户输入的数据的用户界面。通信系统可以包括无线通信设备和上述通信设备。用于可植入医疗设备的通信方法可以包括：提供被配置为与无线通信设备进行通信以与远程系统通信并且执行数据分析的通信设备; 将与可植入医疗设备相关联的数据从无线设备传送到通信设备; 以及在通信设备处分析接收到的数据。

9. 发明申请

US20110230734A1 COMMUNICATION DEVICE, COMMUNICATION SYSTEM AND COMMUNICATION METHOD FOR AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：通信设备，通信系统和用于可植入医疗设备的通信方法
公开(公告)号：US20110230734A1
公开(公告)日：2011-09-22
申请号：US13149608
申请日：2011-05-31
申请人： Eric S. Fain , Ronald R. Rios
发明人： Eric S. Fain , Ronald R. Rios
IPC分类号： A61B5/07
CPC分类号： A61B5/0015 , A61N1/37211
摘要： A communication device for an implantable medical device may include: an input/output interface configured to communicate with a wireless communication device; a communication interface configured to communicate with a remote system; and a processor configured to perform an analysis of data received from the wireless communication device via the input/output interface and associated with the implantable medical device. The communication device may include a user interface configured to receive data input by a user. A communication system may include a wireless communication device and the aforementioned communication device. A communication method for an implantable medical device may include: providing a communication device that is configured to communicate with a wireless communication device, to communicate with a remote system and to perform an analysis of data; communicating data associated with an implantable medical device from a wireless device to the communication device; and analyzing the received data at the communication device.
摘要翻译：用于可植入医疗设备的通信设备可以包括：被配置为与无线通信设备进行通信的输入/输出接口; 通信接口，被配置为与远程系统通信; 以及处理器，被配置为经由所述输入/输出接口执行从所述无线通信设备接收的数据的分析并与所述可植入医疗设备相关联。通信设备可以包括被配置为接收用户输入的数据的用户界面。通信系统可以包括无线通信设备和上述通信设备。用于可植入医疗设备的通信方法可以包括：提供被配置为与无线通信设备进行通信以与远程系统通信并且执行数据分析的通信设备; 将与可植入医疗设备相关联的数据从无线设备传送到通信设备; 以及在通信设备处分析接收到的数据。

10. 发明授权

US07565195B1 Failsafe satellite pacemaker system 有权
标题翻译：失速安全卫星起搏器系统
公开(公告)号：US07565195B1
公开(公告)日：2009-07-21
申请号：US11104383
申请日：2005-04-11
申请人： Mark W. Kroll , Eric S. Fain , Eric Falkenberg
发明人： Mark W. Kroll , Eric S. Fain , Eric Falkenberg
IPC分类号： A61N1/00
CPC分类号： A61N1/37288 , A61N1/3756
摘要： In one implementation, a failsafe method for implantable satellite pacemaker pacing is provided, which includes pacing with a satellite pacemaker and monitoring for a local pacing pulse with an other satellite pacemaker. This implementation further includes, pacing with a surrogate satellite pacemaker if the local pacing pulse is not detected by the other satellite pacemaker. Certain implementations may include transmitting a wireless signal from the other satellite pacemaker to a master pacemaker if the local pacing pulse is not detected by the other satellite pacemaker and using the master pacemaker to select the surrogate satellite pacemaker. Certain implementations may include monitoring for the local pacing pulse with a plurality of satellite and causing the plurality of satellite pacemakers to select the surrogate satellite pacemaker.
摘要翻译：在一个实施方案中，提供了一种用于植入式卫星起搏器起搏器的故障安全方法，其包括使用卫星起搏器起搏并且与另一个卫星起搏器监测局部起搏脉冲。该实施还包括如果另一个卫星起搏器没有检测到本地起搏脉冲，则可以用替代卫星起搏器进行起搏。如果局部起搏脉冲没有被另一个卫星起搏器检测到并且使用主起搏器来选择替代卫星起搏器，某些实现可以包括将无线信号从另一个卫星起搏器传输到主起搏器。某些实施方案可以包括用多个卫星监测局部起搏脉冲，并且使多个卫星起搏器选择替代卫星起搏器。

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