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1. 发明授权

US09687656B2 Arterial blood pressure monitoring devices, systems and methods for use while pacing 有权
公开(公告)号：US09687656B2
公开(公告)日：2017-06-27
申请号：US12637574
申请日：2009-12-14
申请人： Brian Jeffrey Wenzel , Timothy A. Fayram , Allen J. Keel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi
发明人： Brian Jeffrey Wenzel , Timothy A. Fayram , Allen J. Keel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi
IPC分类号： A61B5/02 , A61N1/365 , A61B5/0215 , A61B5/0295 , A61B5/1459 , A61N1/08 , G03F7/00 , B82Y10/00 , B82Y40/00 , A61B5/021 , A61B5/053 , A61B5/00
CPC分类号： A61N1/36585 , A61B5/02125 , A61B5/0215 , A61B5/0295 , A61B5/0535 , A61B5/1459 , A61B5/7239 , A61N1/08 , B82Y10/00 , B82Y40/00 , G03F7/0002
摘要： Provided herein are implantable systems, and methods for use therewith, for monitoring a patient's arterial blood pressure while a patient's heart is being paced. A signal (e.g., PPG or IPG signal) indicative of changes in arterial blood volume remote from the patient's heart is obtained using a sensor or electrodes that are implanted remote from the patient's heart. One or more metrics indicative of pulse arrival time (PAT) are determined, where each metric can be determined by determining a time from a paced cardiac event to one or more predetermined features of the signal indicative of changes in arterial blood volume. Based on at the metric(s) indicative of PAT, arterial blood pressure is estimated, which can include determining values indicative of systolic blood pressure, diastolic blood pressure, pulse pressure and/or mean arterial blood pressure, and/or changes in such values.

2. 发明授权

US08934971B1 Implantable cardiac stimulation device and method that stabilizes ventricular rate during episodes of atrial fibrillation 有权
标题翻译：可植入式心脏刺激装置及其在房颤发作期间稳定心室率的方法
公开(公告)号：US08934971B1
公开(公告)日：2015-01-13
申请号：US11940174
申请日：2007-11-14
申请人： Euljoon Park , You-Ho Kim , Taraneh Ghaffari Farazi
发明人： Euljoon Park , You-Ho Kim , Taraneh Ghaffari Farazi
IPC分类号： A61N1/00
CPC分类号： A61N1/3624 , A61N1/3605 , A61N1/36053 , A61N1/365 , A61N1/368 , A61N1/395
摘要： An implantable cardiac stimulation device and method provide electrical stimulation therapy to stabilize the ventricular rate of a heart during episodes of atrial fibrillation. The stimulation therapy may be a plurality of stimulation pulses delivered to the AV node during the AV node refractory period following the sensing of an atrial event. Alternatively, the stimulation therapy may be a plurality of sub-threshold stimulation pulses delivered to capture AV node vagal innervations following the detection of atrial fibrillation.
摘要翻译：可植入心脏刺激装置和方法提供电刺激治疗以在房颤发作期间稳定心脏心室率。刺激治疗可以是在感觉心房事件之后的AV结节不应期期间传送到AV节点的多个刺激脉冲。或者，刺激治疗可以是递送的多个次阈值刺激脉冲，以在检测心房颤动之后捕获AV节点迷走神经支配。

3. 发明授权

US08706239B2 Systems and methods for controlling neurostimulation based on regional cardiac performance for use by implantable medical devices 有权
标题翻译：基于区域心脏性能的控制神经刺激的系统和方法，用于可植入医疗器械
公开(公告)号：US08706239B2
公开(公告)日：2014-04-22
申请号：US13485404
申请日：2012-05-31
申请人： Rupinder Bharmi , Taraneh Ghaffari Farazi , Ryan Rooke , Stuart Rosenberg , Kritika Gupta , Riddhi Shah , Gene A. Bornzin , Wenbo Hou , Laurence S. Sloman
发明人： Rupinder Bharmi , Taraneh Ghaffari Farazi , Ryan Rooke , Stuart Rosenberg , Kritika Gupta , Riddhi Shah , Gene A. Bornzin , Wenbo Hou , Laurence S. Sloman
IPC分类号： A61N1/00
CPC分类号： A61N1/36071 , A61B5/029 , A61B5/042 , A61B5/0538 , A61B5/1116 , A61B5/4836 , A61B5/686 , A61B5/7239 , A61N1/36139 , A61N1/36146 , A61N1/36185
摘要： Techniques are provided for controlling neurostimulation such as spinal cord stimulation (SCS) using a cardiac rhythm management device (CRMD). In various examples described herein, neurostimulation is delivered to a patient while regional cardiac performance of the heart of the patient is assessed by the CRMD. The delivery of further neurostimulation is adjusted or controlled based, at least in part, on the regional cardiac performance, preferably to enhance positive effects on the heart due to the neurostimulation or to mitigate any negative effects. Regional cardiac performance is assessed based on parameters derived from cardiogenic impedance signals detected along various vectors through the heart.
摘要翻译：提供了使用心律管理装置（CRMD）来控制神经刺激如脊髓刺激（SCS）的技术。在本文描述的各种示例中，神经刺激被递送给患者，同时通过CRMD来评估患者心脏的区域心脏性能。至少部分地基于区域心脏性能来调整或控制进一步神经刺激的递送，优选地由于神经刺激而增强对心脏的积极作用或减轻任何负面影响。基于通过心脏沿着各种载体检测到的心源性阻抗信号的参数来评估区域心脏性能。

4. 发明申请

US20140039238A1 SYSTEMS AND METHODS FOR CONTROLLING NEUROSTIMULATION OF ACUPUNCTURE SITES USING AN IMPLANTABLE CARDIAC RHYTHM MANAGEMENT DEVICE 有权
标题翻译：使用可植入式心脏管理装置控制针刺部位神经细胞的系统和方法
公开(公告)号：US20140039238A1
公开(公告)日：2014-02-06
申请号：US13563417
申请日：2012-07-31
申请人： Xiaoyi Min , Stuart Rosenberg , Taraneh Ghaffari Farazi , Timothy A. Fayram
发明人： Xiaoyi Min , Stuart Rosenberg , Taraneh Ghaffari Farazi , Timothy A. Fayram
IPC分类号： A61N1/365 , A61N2/00 , A61F7/00 , A61N1/39
CPC分类号： A61N1/36139 , A61B5/0215 , A61B5/042 , A61B5/0538 , A61B5/14532 , A61B5/4818 , A61B5/4836 , A61F7/00 , A61H39/002 , A61H39/06 , A61H2201/5002 , A61H2230/045 , A61H2230/305 , A61N1/3606 , A61N1/36114 , A61N1/36117 , A61N1/3621 , A61N1/3627 , A61N1/3962 , A61N2/02
摘要： Techniques are provided for use with an implantable cardiac rhythm management (CRMD) system equipped to deliver neurostimulation to acupuncture sites within anterior regions of the neck, thorax or abdomen of the patient. Parameters associated with the health of the patient are detected, such as parameters indicative of arrhythmia, heart failure and hypertension.
摘要翻译：技术提供用于与植入式心律管理（CRMD）系统一起使用，该系统被配备用于向患者的颈部，胸部或腹部前区域内的针灸位置递送神经刺激。检测与患者健康有关的参数，例如指示心律失常，心力衰竭和高血压的参数。

5. 发明授权

US08630692B2 Method and implantable system for blood-glucose concentration monitoring using parallel methodologies 有权
标题翻译：使用并行方法进行血糖浓度监测的方法和植入式系统
公开(公告)号：US08630692B2
公开(公告)日：2014-01-14
申请号：US12433414
申请日：2009-04-30
申请人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi , Euljoon Park , Eric Falkenberg , Michael E. Benser
发明人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi , Euljoon Park , Eric Falkenberg , Michael E. Benser
IPC分类号： A61B5/0205 , A61B5/0402 , A61B5/042 , A61B5/0452 , A61B5/145
CPC分类号： A61B5/0006 , A61B5/0205 , A61B5/04012 , A61B5/0428 , A61B5/0452 , A61B5/14532 , A61B5/14542 , A61B5/14551 , A61B5/1459 , A61B5/4836 , A61B5/4866 , A61B5/6846 , A61B5/686 , A61B5/7285 , A61B5/746
摘要： In an implantable medical device for monitoring glucose concentration in the blood, a blood-glucose concentration analysis is performed using correlations of blood-glucose concentration with measures of metabolic oxygen consumption including oxymetric, and/or temperature. Analysis of electrocardiographic data is used in a parallel method to detect and/or confirm the onset and/or existence and/or extent of hypoglycemia and/or hyperglycemia. Blood-glucose concentration calculation is enhanced by using the combination of the oxygen metabolism analysis and electrocardiographic analysis.
摘要翻译：在用于监测血液中葡萄糖浓度的可植入医疗装置中，使用血糖浓度与包括氧测量和/或温度在内的代谢氧消耗量的相关性进行血糖浓度分析。使用并行方法来分析心电图数据以检测和/或确认低血糖和/或高血糖症的发作和/或存在和/或程度。通过使用氧代谢分析和心电图分析的组合，提高血糖浓度计算。

6. 发明授权

US08606352B2 Methods and devices for monitoring myocardial mechanical stability 有权
公开(公告)号：US08606352B2
公开(公告)日：2013-12-10
申请号：US12576488
申请日：2009-10-09
申请人： Taraneh Ghaffari Farazi , Euljoon Park
发明人： Taraneh Ghaffari Farazi , Euljoon Park
IPC分类号： A61B5/04
CPC分类号： A61B5/0452 , A61B5/0031 , A61B5/0215 , A61B5/029 , A61B5/0295 , A61B5/0422 , A61B5/0535 , A61B5/1107 , A61B5/1459 , A61B5/6852 , A61B5/7264 , A61B7/023 , A61B2562/0219 , A61N1/3622 , A61N1/36521 , A61N1/37258 , A61N1/3962
摘要： Embodiments of the present invention relate to implantable systems, and methods for use therewith, for monitoring myocardial mechanical stability based on a signal that is indicative of mechanical functioning of a patient's heart for a plurality of consecutive beats. Certain embodiments use time domain techniques, while other embodiments use frequency domain techniques, to monitor myocardial mechanical stability. In certain embodiments the patient's heart is paced using a patterned pacing sequence that repeats every N beats. In other embodiments, the patient's heart need not be paced. This abstract is not intended to be a complete description of, or limit the scope of, the invention.

7. 发明授权

US08280523B2 System and method for monitoring diastolic function using an implantable medical device 有权
标题翻译：使用可植入医疗装置监测舒张功能的系统和方法
公开(公告)号：US08280523B2
公开(公告)日：2012-10-02
申请号：US12341355
申请日：2008-12-22
申请人： Allen Keel , Steve Koh , Taraneh Ghaffari Farazi
发明人： Allen Keel , Steve Koh , Taraneh Ghaffari Farazi
IPC分类号： A61N1/36 , A61N1/378
CPC分类号： A61N1/3702 , A61N1/3627 , A61N1/36507 , A61N1/368 , A61N1/3712
摘要： Diastolic function is monitored within a patient using a pacemaker or other implantable medical device. In one example, the implantable device uses morphological parameters derived from the T-wave evoked response waveform as proxies for ventricular relaxation rate and ventricular compliance. In particular, the magnitude of the peak of the T-wave evoked response is employed as a proxy for ventricular compliance. The maximum slew rate of the T-wave evoked response following its peak is employed as a proxy for ventricular relaxation. A metric is derived from these proxy values to represent diastolic function. The metric is tracked over time to evaluate changes in diastolic function. In other examples, specific values for ventricular compliance and ventricular relaxation are derived for the patient based on the T-wave evoked response parameters.
摘要翻译：使用起搏器或其他可植入医疗器械在患者体内监测舒张功能。在一个示例中，可植入装置使用从T波诱发反应波形导出的形态参数作为心室松弛率和心室顺应性的代理。特别地，T波诱发反应的峰值的大小被用作心室顺应性的代表。其峰值后的T波诱发反应的最大压摆率被用作心室松弛的代用品。来自这些代理值的度量来表示舒张功能。随着时间的推移跟踪度量以评估舒张功能的变化。在其他实例中，基于T波诱发反应参数为患者导出心室顺应性和心室松弛的具体值。

8. 发明授权

US08209010B2 Systems and methods for optimizing multi-site cardiac pacing and sensing configurations for use with an implantable medical device 有权
标题翻译：用于优化与可植入医疗装置一起使用的多部位心脏起搏和感测配置的系统和方法
公开(公告)号：US08209010B2
公开(公告)日：2012-06-26
申请号：US12703069
申请日：2010-02-09
申请人： Kyungmoo Ryu , Stuart Rosenberg , Allen Keel , Taraneh Ghaffari Farazi , Xiaoyi Min
发明人： Kyungmoo Ryu , Stuart Rosenberg , Allen Keel , Taraneh Ghaffari Farazi , Xiaoyi Min
IPC分类号： A61N1/00
CPC分类号： A61N1/36514 , A61N1/3627 , A61N1/368 , A61N1/3708
摘要： Techniques are provided for use with an implantable cardiac stimulation device equipped for multi-site left ventricular (MSLV) pacing using a multi-pole LV lead. In one example, referred to herein as QuickStim, cardiac pacing configurations are optimized based on an assessment of hemodynamic benefit and device longevity. In another example, referred to herein as QuickSense, cardiac sensing configurations are optimized based on sensing profiles input by a clinician. Various virtual sensing channels are also described that provide for the multiplexing or gating of sensed signals. Anisotropic oversampling is also described.
摘要翻译：提供技术用于使用多极LV引线配备用于多位点左心室（MSLV）起搏的可植入心脏刺激装置。在一个例子中，本文称为QuickStim，基于对血液动力学益处和器械寿命的评估来优化心脏起搏配置。在另一个例子中，本文称为QuickSense，基于由临床医生输入的感测曲线来优化心脏感测配置。还描述了各种虚拟感测通道，其提供感测信号的复用或门控。还描述了各向异性过采样。

9. 发明授权

US08170664B1 Monitoring heart disease using implantable sensors and slopes determined therefrom 有权
标题翻译：使用由其确定的可植入传感器和斜坡来监测心脏病
公开(公告)号：US08170664B1
公开(公告)日：2012-05-01
申请号：US11931165
申请日：2007-10-31
申请人： Yelena Nabutovsky , Kyungmoo Ryu , Taraneh Ghaffari Farazi , Gene A. Bornzin
发明人： Yelena Nabutovsky , Kyungmoo Ryu , Taraneh Ghaffari Farazi , Gene A. Bornzin
IPC分类号： A61N1/37 , A61N1/08
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/36557 , A61N1/36564 , A61N1/36578 , A61N1/3702
摘要： Specific embodiments of the present invention use an implanted sensor, during a period of time, to measure a physiologic property when the patient's heart is not stressed, and when the patient's heart is stressed. A slope is determined, where the slope is indicative of a change in the physiologic property during the period of time. Heart disease is monitored based on a magnitude of the slope. In further embodiments of the present invention, a slope indicative of a change in a physiologic property during a period of time is determined, for each of a plurality of periods of time. Changes in the patient's heart disease are monitored based on changes in the slope.
摘要翻译：本发明的具体实施例在一段时间内使用植入式传感器来测量当患者的心脏没有受到压力时以及当患者的心脏被压力时的生理特性。确定斜率，其中斜率表示在一段时间内生理特性的变化。基于斜率的大小来监测心脏病。在本发明的另外的实施例中，对于多个时间段中的每一个确定指示在一段时间内的生理特性变化的斜率。根据斜率的变化监测患者心脏病变化。

10. 发明授权

US08162841B2 Standalone systemic arterial blood pressure monitoring device 有权
标题翻译：独立的全身动脉血压监测装置
公开(公告)号：US08162841B2
公开(公告)日：2012-04-24
申请号：US12474276
申请日：2009-05-29
申请人： Allen J. Keel , Brian Jeffrey Wenzel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi , Timothy A. Fayram , Eric S. Fain , Paul A. Levine
发明人： Allen J. Keel , Brian Jeffrey Wenzel , Edward Karst , Wenbo Hou , Taraneh Ghaffari Farazi , Timothy A. Fayram , Eric S. Fain , Paul A. Levine
IPC分类号： A61B5/02
CPC分类号： A61B5/02158 , A61B5/02125 , A61B5/0295 , A61B5/0452 , A61B5/1459 , A61B2562/0219 , A61N1/36557 , A61N1/36564 , A61N1/36585 , G06F19/00
摘要： Certain embodiments of the present invention are related to an implantable monitoring device to monitor a patient's arterial blood pressure, where the device is configured to be implanted subcutaneously. The device includes subcutaneous (SubQ) electrodes and a plethysmography sensor. Additionally, the device includes an arterial blood pressure monitor configured to determine at least one value indicative of the patient's arterial blood pressure based on at least one detected predetermined feature of a SubQ ECG and at least one detected predetermined feature of a plethysmography signal. Alternative embodiments of the present invention are directed to a non-implantable monitoring device to monitor a patient's arterial blood pressure based on features of a surface ECG and a plethysmography signal obtained from a non-implanted sensor.
摘要翻译：本发明的某些实施例涉及一种用于监测患者的动脉血压的可植入监测装置，其中该装置被配置为被皮下植入。该装置包括皮下（SubQ）电极和体积描记传感器。另外，该装置包括动脉血压监测器，其被配置为基于至少一个检测到的SubQ ECG的预定特征和至少一个检测到的体积描记信号的预定特征来确定指示患者的动脉血压的至少一个值。本发明的替代实施例涉及一种非植入式监测装置，用于基于从非植入传感器获得的表面ECG和体积描记信号的特征来监测患者的动脉血压。

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