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1. 发明授权

US08630692B2 Method and implantable system for blood-glucose concentration monitoring using parallel methodologies 有权
标题翻译：使用并行方法进行血糖浓度监测的方法和植入式系统
公开(公告)号：US08630692B2
公开(公告)日：2014-01-14
申请号：US12433414
申请日：2009-04-30
申请人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi , Euljoon Park , Eric Falkenberg , Michael E. Benser
发明人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi , Euljoon Park , Eric Falkenberg , Michael E. Benser
IPC分类号： A61B5/0205 , A61B5/0402 , A61B5/042 , A61B5/0452 , A61B5/145
CPC分类号： A61B5/0006 , A61B5/0205 , A61B5/04012 , A61B5/0428 , A61B5/0452 , A61B5/14532 , A61B5/14542 , A61B5/14551 , A61B5/1459 , A61B5/4836 , A61B5/4866 , A61B5/6846 , A61B5/686 , A61B5/7285 , A61B5/746
摘要： In an implantable medical device for monitoring glucose concentration in the blood, a blood-glucose concentration analysis is performed using correlations of blood-glucose concentration with measures of metabolic oxygen consumption including oxymetric, and/or temperature. Analysis of electrocardiographic data is used in a parallel method to detect and/or confirm the onset and/or existence and/or extent of hypoglycemia and/or hyperglycemia. Blood-glucose concentration calculation is enhanced by using the combination of the oxygen metabolism analysis and electrocardiographic analysis.
摘要翻译：在用于监测血液中葡萄糖浓度的可植入医疗装置中，使用血糖浓度与包括氧测量和/或温度在内的代谢氧消耗量的相关性进行血糖浓度分析。使用并行方法来分析心电图数据以检测和/或确认低血糖和/或高血糖症的发作和/或存在和/或程度。通过使用氧代谢分析和心电图分析的组合，提高血糖浓度计算。

2. 发明申请

US20100280348A1 METHOD AND IMPLANTABLE SYSTEM FOR BLOOD-GLUCOSE CONCENTRATION MONITORING USING PARALLEL METHODOLOGIES 有权
标题翻译：使用并行方法对血液葡萄糖浓度监测的方法和可植入系统
公开(公告)号：US20100280348A1
公开(公告)日：2010-11-04
申请号：US12433414
申请日：2009-04-30
申请人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi , Euljoon Park , Eric Falkenberg , Michael E. Benser
发明人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi , Euljoon Park , Eric Falkenberg , Michael E. Benser
IPC分类号： A61B5/145
CPC分类号： A61B5/0006 , A61B5/0205 , A61B5/04012 , A61B5/0428 , A61B5/0452 , A61B5/14532 , A61B5/14542 , A61B5/14551 , A61B5/1459 , A61B5/4836 , A61B5/4866 , A61B5/6846 , A61B5/686 , A61B5/7285 , A61B5/746
摘要： In an implantable medical device for monitoring glucose concentration in the blood, a blood-glucose concentration analysis is performed using correlations of blood-glucose concentration with measures of metabolic oxygen consumption including oxymetric, and/or temperature. Analysis of electrocardiographic data is used in a parallel method to detect and/or confirm the onset and/or existence and/or extent of hypoglycemia and/or hyperglycemia. Blood-glucose concentration calculation is enhanced by using the combination of the oxygen metabolism analysis and electrocardiographic analysis.
摘要翻译：在用于监测血液中葡萄糖浓度的可植入医疗装置中，使用血糖浓度与包括氧测量和/或温度在内的代谢氧消耗量的相关性进行血糖浓度分析。使用并行方法来分析心电图数据以检测和/或确认低血糖和/或高血糖症的发作和/或存在和/或程度。通过使用氧代谢分析和心电图分析的组合，提高血糖浓度计算。

3. 发明授权

US07856266B1 Implantable cardiac stimulation device providing reduced defibrillation thresholds and method 有权
标题翻译：植入式心脏刺激装置提供降低的除颤阈值和方法
公开(公告)号：US07856266B1
公开(公告)日：2010-12-21
申请号：US11756283
申请日：2007-05-31
申请人： Gene A. Bornzin , Michael E. Benser , Euljoon Park , Taraneh Ghaffari Farazi
发明人： Gene A. Bornzin , Michael E. Benser , Euljoon Park , Taraneh Ghaffari Farazi
IPC分类号： A61N1/39
CPC分类号： A61N1/3962 , A61N1/3622 , A61N1/36521 , A61N1/3943
摘要： An implantable cardiac defibrillation device provides pre-shock stimuli to reduce the defibrillation threshold (DFT). The device includes an arrhythmia detector that detects fibrillation of a fibrillating chamber of a heart and a pulse generator that provides a fibrillation therapy output responsive to the arrhythmia detector detecting fibrillation of the fibrillating chamber of the heart. The therapy output includes a defibrillating shock having an output magnitude exceeding a temporary defibrillation threshold of the fibrillating chamber and at least one pre-defibrillating shock output pulse that reduces an initial defibrillation threshold of the fibrillating chamber to the temporary defibrillation threshold. An electrode system having at least two defibrillation electrodes delivers both the at least one pre-defibrillating shock output pulse to the heart and the defibrillating shock to the fibrillating chamber of the heart.
摘要翻译：植入式心脏除颤装置提供预冲击刺激以减少除颤阈值（DFT）。该装置包括心律失常检测器，其检测心脏的原纤化室的原纤维和脉冲发生器，其提供响应于心律失常检测器检测心脏原纤化室的纤颤的原纤维化治疗输出。治疗输出包括具有超过原纤化室的暂时除颤阈值的输出量值的至少一个除纤颤前冲击输出脉冲，其将原纤化室的初始除颤阈值降低到临时除颤阈值。具有至少两个除颤电极的电极系统将至少一个除颤前的冲击输出脉冲和心脏的去纤维化颤动传递给心脏的原纤维室。

4. 发明授权

US09162067B1 Methods and devices for monitoring myocardial electro-mechanical stability 有权
标题翻译：监测心肌机电稳定性的方法和装置
公开(公告)号：US09162067B1
公开(公告)日：2015-10-20
申请号：US11925273
申请日：2007-10-26
申请人： Taraneh Ghaffari Farazi , Eric Falkenberg , Euljoon Park
发明人： Taraneh Ghaffari Farazi , Eric Falkenberg , Euljoon Park
IPC分类号： A61N1/365 , A61N1/37 , A61B5/0452 , A61N1/362
CPC分类号： A61N1/3702 , A61B5/02028 , A61B5/0452 , A61B5/4836 , A61B5/686 , A61N1/3627 , A61N1/36514
摘要： Embodiments of the present invention relate to implantable systems, and methods for use therewith, for monitoring myocardial electro-mechanical stability, and responding to the same. One or more signal indicative of electrical functioning of a patient's heart is obtained, as is one or more signal indicative of mechanical functioning of the patient's heart. The patient's myocardial electrical stability is monitored based on the one or more signal indicative of electrical functioning of the patient's heart, and the patient's myocardial mechanical stability is monitored based on the one or more signal indicative of mechanical functioning of the patient's heart. Based on both the myocardial electrical stability and myocardial mechanical stability, the patient's risk of an adverse cardiac event is monitored. Further, when the patient is at risk of an adverse cardiac event, a response is triggered that is specific to both the myocardial electrical stability and the myocardial mechanical stability. This abstract is not intended to be a complete description of, or limit the scope of, the invention.
摘要翻译：本发明的实施例涉及可植入系统及其使用的方法，用于监测心肌电 - 机械稳定性并对其进行响应。获得指示患者心脏的电功能的一个或多个信号，以及指示患者心脏的机械功能的一个或多个信号。基于指示患者心脏的电功能的一个或多个信号来监测患者的心肌电稳定性，并且基于指示患者心脏的机械功能的一个或多个信号监测患者的心肌机械稳定性。基于心肌电稳定性和心肌机械稳定性，监测患者心脏不良事件的风险。此外，当患者处于不良心脏事件的风险时，触发与心肌电稳定性和心肌机械稳定性特异性的反应。本摘要不是对本发明的完整描述或限制本发明的范围。

5. 发明申请

US20100042173A1 SYSTEM AND METHOD FOR EVALUATING AND OPTIMIZING THE CONTRIBUTION OF PARTICULAR HEART CHAMBERS TO THE OVERALL EFFICACY OF CARDIAC PACING THERAPY 审中-公开
标题翻译：用于评估和优化特定心脏瓣膜对心脏瓣膜治疗的总体效果的系统和方法
公开(公告)号：US20100042173A1
公开(公告)日：2010-02-18
申请号：US12603829
申请日：2009-10-22
申请人： Taraneh Ghaffari Farazi , Euljoon Park
发明人： Taraneh Ghaffari Farazi , Euljoon Park
IPC分类号： A61N1/368 , A61N1/08 , A61N1/365
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/3684 , A61N1/3688
摘要： Techniques are provided for evaluating and optimizing the contribution of particular heart chambers to pacing efficacy. Briefly, a pacemaker temporarily alters the mode with which pacing therapy is delivered so as to selectively alter the heart chambers that are paced. The pacemaker detects any transient changes in pacing efficacy following the alteration in pacing mode. The pacemaker then assesses the contribution of particular heart chambers to pacing efficacy based on the alteration in the pacing mode and on any transient changes in the pacing efficacy. Additionally, techniques are provided herein for automatically adjusting pacing parameters to optimize the contribution of particular chambers to pacing efficacy.
摘要翻译：提供技术来评估和优化特定心室对起搏功效的贡献。简而言之，起搏器暂时改变了起搏治疗的方式，以便选择性地改变起搏的心室。心脏起搏器检测起搏模式改变后起搏功效的任何瞬时变化。起搏器然后根据起搏模式的改变以及起搏功效的任何短暂变化来评估特定心室对起搏功效的贡献。此外，本文提供了用于自动调整起搏参数以优化特定腔室对起搏功效的贡献的技术。

6. 发明授权

US07620448B1 Methods and devices for monitoring myocardial mechanical stability 有权
标题翻译：监测心肌机械稳定性的方法和装置
公开(公告)号：US07620448B1
公开(公告)日：2009-11-17
申请号：US11421915
申请日：2006-06-02
申请人： Taraneh Ghaffari Farazi , Euljoon Park
发明人： Taraneh Ghaffari Farazi , Euljoon Park
IPC分类号： A61B5/04
CPC分类号： A61B5/0452 , A61B5/0031 , A61B5/0215 , A61B5/029 , A61B5/0295 , A61B5/0422 , A61B5/0535 , A61B5/1107 , A61B5/1459 , A61B5/6852 , A61B5/7264 , A61B7/023 , A61B2562/0219 , A61N1/3622 , A61N1/36521 , A61N1/37258 , A61N1/3962
摘要： Embodiments of the present invention relate to implantable systems, and methods for use therewith, for monitoring myocardial mechanical stability based on a signal that is indicative of mechanical functioning of a patient's heart for a plurality of consecutive beats. Certain embodiments use time domain techniques, while other embodiments use frequency domain techniques, to monitor myocardial mechanical stability. In certain embodiments the patient's heart is paced using a patterned pacing sequence that repeats every N beats. In other embodiments, the patient's heart need not be paced. This abstract is not intended to be a complete description of, or limit the scope of, the invention.
摘要翻译：本发明的实施例涉及可植入系统及其使用的方法，用于基于指示患者心脏对于多个连续节拍的机械功能的信号来监测心肌机械稳定性。某些实施例使用时域技术，而其他实施例使用频域技术来监测心肌机械稳定性。在某些实施例中，使用重复每N次跳动的图案化起搏序列来对患者的心脏进行起搏。在其他实施例中，患者的心脏不需要起搏。本摘要不是对本发明的完整描述或限制本发明的范围。

7. 发明授权

US08934971B1 Implantable cardiac stimulation device and method that stabilizes ventricular rate during episodes of atrial fibrillation 有权
标题翻译：可植入式心脏刺激装置及其在房颤发作期间稳定心室率的方法
公开(公告)号：US08934971B1
公开(公告)日：2015-01-13
申请号：US11940174
申请日：2007-11-14
申请人： Euljoon Park , You-Ho Kim , Taraneh Ghaffari Farazi
发明人： Euljoon Park , You-Ho Kim , Taraneh Ghaffari Farazi
IPC分类号： A61N1/00
CPC分类号： A61N1/3624 , A61N1/3605 , A61N1/36053 , A61N1/365 , A61N1/368 , A61N1/395
摘要： An implantable cardiac stimulation device and method provide electrical stimulation therapy to stabilize the ventricular rate of a heart during episodes of atrial fibrillation. The stimulation therapy may be a plurality of stimulation pulses delivered to the AV node during the AV node refractory period following the sensing of an atrial event. Alternatively, the stimulation therapy may be a plurality of sub-threshold stimulation pulses delivered to capture AV node vagal innervations following the detection of atrial fibrillation.
摘要翻译：可植入心脏刺激装置和方法提供电刺激治疗以在房颤发作期间稳定心脏心室率。刺激治疗可以是在感觉心房事件之后的AV结节不应期期间传送到AV节点的多个刺激脉冲。或者，刺激治疗可以是递送的多个次阈值刺激脉冲，以在检测心房颤动之后捕获AV节点迷走神经支配。

8. 发明授权

US08606352B2 Methods and devices for monitoring myocardial mechanical stability 有权
公开(公告)号：US08606352B2
公开(公告)日：2013-12-10
申请号：US12576488
申请日：2009-10-09
申请人： Taraneh Ghaffari Farazi , Euljoon Park
发明人： Taraneh Ghaffari Farazi , Euljoon Park
IPC分类号： A61B5/04
CPC分类号： A61B5/0452 , A61B5/0031 , A61B5/0215 , A61B5/029 , A61B5/0295 , A61B5/0422 , A61B5/0535 , A61B5/1107 , A61B5/1459 , A61B5/6852 , A61B5/7264 , A61B7/023 , A61B2562/0219 , A61N1/3622 , A61N1/36521 , A61N1/37258 , A61N1/3962
摘要： Embodiments of the present invention relate to implantable systems, and methods for use therewith, for monitoring myocardial mechanical stability based on a signal that is indicative of mechanical functioning of a patient's heart for a plurality of consecutive beats. Certain embodiments use time domain techniques, while other embodiments use frequency domain techniques, to monitor myocardial mechanical stability. In certain embodiments the patient's heart is paced using a patterned pacing sequence that repeats every N beats. In other embodiments, the patient's heart need not be paced. This abstract is not intended to be a complete description of, or limit the scope of, the invention.

9. 发明授权

US07702391B1 Monitoring short term fluctuations in PR intervals following premature ventricular contractions 有权
标题翻译：监测心室早期收缩后PR间期的短期波动
公开(公告)号：US07702391B1
公开(公告)日：2010-04-20
申请号：US11265704
申请日：2005-11-01
申请人： Taraneh Ghaffari Farazi , Euljoon Park
发明人： Taraneh Ghaffari Farazi , Euljoon Park
IPC分类号： A61N1/362 , A61B5/0452
CPC分类号： A61B5/0452 , A61B5/7275 , A61N1/36114 , A61N1/362 , G06F19/00
摘要： Implantable systems, and methods for use therein, perform at least one of a cardiac assessment and an autonomic assessment. Short-term fluctuations in PR intervals, that follow the premature contractions in the ventricles, are monitored. At least one of a cardiac assessment and an autonomic assessment is performed based on the monitored fluctuations in PR intervals that follow the premature contractions in the ventricles. This can include assessing a patient's risk of sudden cardiac death (SCD), assessing a patient's autonomic tone and/or detecting myocardial ischemic events based on the monitored fluctuations in PR intervals that follow the premature contractions in the ventricles.
摘要翻译：可植入系统及其中使用的方法执行心脏评估和自主评估中的至少一个。监测在心室过早收缩的PR间期短期波动。基于监测的脑室过早收缩后PR间期的波动，进行心脏评估和自主评估中的至少一个。这可以包括评估患者心源性猝死（SCD）的风险，评估患者的自主神经紧张度和/或根据心室过早收缩的PR间期监测的波动来检测心肌缺血事件。

10. 发明授权

US07627374B1 System and method for evaluating and optimizing the contribution of particular heart chambers to the overall efficacy of cardiac pacing therapy 有权
标题翻译：用于评估和优化特定心室对心脏起搏治疗总体疗效的贡献的系统和方法
公开(公告)号：US07627374B1
公开(公告)日：2009-12-01
申请号：US11421936
申请日：2006-06-02
申请人： Taraneh Ghaffari Farazi , Euljoon Park
发明人： Taraneh Ghaffari Farazi , Euljoon Park
IPC分类号： A61N1/362
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3688
摘要： Techniques are provided for evaluating and optimizing the contribution of particular heart chambers to pacing efficacy. Briefly, a pacemaker temporarily alters the mode with which pacing therapy is delivered so as to selectively alter the heart chambers that are paced. The pacemaker detects any transient changes in pacing efficacy following the alteration in pacing mode. The pacemaker then assesses the contribution of particular heart chambers to pacing efficacy based on the alteration in the pacing mode and on any transient changes in the pacing efficacy. Additionally, techniques are provided herein for automatically adjusting pacing parameters to optimize the contribution of particular chambers to pacing efficacy.
摘要翻译：提供技术来评估和优化特定心室对起搏功效的贡献。简而言之，起搏器暂时改变了起搏治疗的方式，以便选择性地改变起搏的心室。心脏起搏器检测起搏模式改变后起搏功效的任何瞬时变化。起搏器然后根据起搏模式的改变以及起搏功效的任何暂时变化来评估特定心室对起搏功效的贡献。此外，本文提供了用于自动调整起搏参数以优化特定腔室对起搏功效的贡献的技术。

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