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1. 发明申请

US20100057158A1 Neurostimulation Based On Glycemic Condition 审中-公开
标题翻译：基于血糖条件的神经刺激
公开(公告)号：US20100057158A1
公开(公告)日：2010-03-04
申请号：US12198791
申请日：2008-08-26
申请人： Rodolfo Rodriguez , Brian Jeffrey Wenzel , Fujian Qu , Rupinder Bharmi , Karin Jarverud , Taraneh Ghaffari Farazi
发明人： Rodolfo Rodriguez , Brian Jeffrey Wenzel , Fujian Qu , Rupinder Bharmi , Karin Jarverud , Taraneh Ghaffari Farazi
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/36114 , A61N1/365
摘要： A glycemic condition is indicated based on variance of a feature derived from cardiac electrogram data. Neurostimulation is then used to counteract a cardiac-related autonomic response to the glycemic condition. For example, stimulation of parasympathetic innervation may be used to counteract an autonomic sympathetic response that is associated with hypoglycemia or hyperglycemia. In addition, stimulation of sympathetic innervation may be used to counteract an autonomic parasympathetic response that is associated with hypoglycemia or hyperglycemia.
摘要翻译：根据心脏电图数据得出的特征的方差来指示血糖状况。然后使用神经刺激来抵消对血糖状况的心脏相关的自主反应。例如，可以使用副交感神经支配的刺激来抵消与低血糖或高血糖相关的自主交感神经反应。此外，交感神经支配的刺激可用于抵消与低血糖或高血糖相关的自主神经副交感神经反应。

2. 发明授权

US07909764B1 Methods and systems to monitor venous blood oxygen saturation 有权
标题翻译：监测静脉血氧饱和度的方法和系统
公开(公告)号：US07909764B1
公开(公告)日：2011-03-22
申请号：US11948381
申请日：2007-11-30
申请人： Brian Jeffrey Wenzel , Fujian Qu , Taraneh Ghaffari Farazi
发明人： Brian Jeffrey Wenzel , Fujian Qu , Taraneh Ghaffari Farazi
IPC分类号： A61B5/00 , A61B5/04
CPC分类号： A61B5/14542 , A61B5/0452 , A61N1/36557
摘要： Methods and system are provided for monitoring a patients venous blood oxygen saturation (SvO2). At least one signal indicative of electrical activity of a patient's heart is obtained. Such a signal can be, e.g., an IEGM or ECG signal. In specific embodiments, such a signal(s) can be obtained from implanted electrodes, and thus, embodiments of the present invention can be implemented by an implantable system. Additionally, there are measurements of at least one metric of cardiac cycles represented in the at least one signal indicative of electrical activity of the patient's heart, where the metric changes with changes in SvO2. Examples of such metric include T-wave metrics and PR intervals. SvO2, and changes therein, are monitored based on the measured metric(s).
摘要翻译：方法和系统用于监测患者静脉血氧饱和度（SvO2）。获得指示患者心脏的电活动的至少一个信号。这样的信号可以是例如IEGM或ECG信号。在具体实施例中，可以从植入的电极获得这样的信号，因此本发明的实施例可以由可植入系统实现。此外，在指示患者心脏的电活动的至少一个信号中表示的心脏周期的至少一个度量的度量，其中度量随SvO2的变化而变化。这种度量的示例包括T波度量和PR间隔。 SvO2及其中的变化基于测量的度量来监测。

3. 发明授权

US08401627B1 Methods and systems for monitoring heart instabilities 有权
标题翻译：监测心脏不稳定的方法和系统
公开(公告)号：US08401627B1
公开(公告)日：2013-03-19
申请号：US11848631
申请日：2007-08-31
申请人： Taraneh Ghaffari Farazi , Fujian Qu
发明人： Taraneh Ghaffari Farazi , Fujian Qu
IPC分类号： A61N1/362
CPC分类号： A61N1/3702 , A61N1/36592
摘要： Systems and method for assessing a patient's myocardial electrical stability by pacing a patient's heart using a pacing sequence that includes at least two different types of pacing pulses. The pacing rate used is preferably only slightly above the patient's intrinsic heart rate. A degree of alternans, in a signal (e.g., IEGM or ECG) that is indicative of cardiac activity in response to the pacing sequence, is determined. The degree of alternans can be determined by comparing portions of the signal that are indicative of cardiac activity in response to the first type of pacing pulses to portions of the signal that are indicative of cardiac activity in response to the second type of pacing pulses. The patient's myocardial electrical stability is assessed based on the determined degree of alternans.
摘要翻译：通过使用包括至少两种不同类型的起搏脉冲的起搏序列来对患者的心脏进行起搏来评估患者的心肌电稳定性的系统和方法。起搏率优选仅略高于患者的内在心率。确定在响应于起搏序列指示心脏活动的信号（例如，IEGM或ECG）中的交替量的程度。可以通过将响应于第一类型的起搏脉冲的指示心脏活动的部分的信号的部分与响应于第二类型的起搏脉冲的指示心脏活动的信号的部分进行比较来确定交替的程度。基于确定的交替量程度评估患者的心肌电稳定性。

4. 发明申请

US20100057155A1 IMPLANTABLE SYSTEMS AND METHOD FOR USE THEREWITH FOR TRACKING CHANGES IN HEMODYNAMICS AND CARDIAC DISEASE 有权
标题翻译：用于跟踪血液动力学和心脏病疾病变化的可植入系统及其使用方法
公开(公告)号：US20100057155A1
公开(公告)日：2010-03-04
申请号：US12204683
申请日：2008-09-04
申请人： Taraneh Ghaffari Farazi , Fujian Qu
发明人： Taraneh Ghaffari Farazi , Fujian Qu
IPC分类号： A61N1/00 , A61B19/00
CPC分类号： A61N1/371 , A61B5/02028 , A61B5/0422 , A61N1/3627 , A61N1/3956
摘要： Embodiments of the present invention relate to monitoring a patient's atrial stretch, heart failure (HF) condition, and/or risk of atrial fibrillation (AF), as well as methods for estimating a change in at least one of a patient's left atrial pressure (LAP), pulmonary capillary wedge pressure (PCWP), and right pulmonary artery pressure (RPAP). Embodiments of the present invention also relate to selecting a pacing energy level. Such embodiments involve determining atrial evoked response metrics when a patient's atrium is paced, and monitoring changes in such metrics.
摘要翻译：本发明的实施例涉及监测患者的心房伸展，心力衰竭（HF）状况和/或心房颤动（AF）的风险）以及用于估计患者左心房压力（至少一个）的变化的方法 LAP），肺毛细血管楔压（PCWP）和右肺动脉压（RPAP）。本发明的实施例还涉及选择起搏能量水平。这样的实施例涉及当患者的心房起搏时确定心房诱发响应度量，以及监视这些度量的变化。

5. 发明授权

US09205274B2 Devices, systems, and methods for characterizing a tachycardia and/or selecting treatment for a tachycardia using results of a dominant frequency analysis 有权
标题翻译：使用主频率分析结果表征心动过速和/或选择治疗心动过速的装置，系统和方法
公开(公告)号：US09205274B2
公开(公告)日：2015-12-08
申请号：US13090059
申请日：2011-04-19
申请人： Fujian Qu , Timothy A. Fayram , Michael E. Benser , Taraneh Ghaffari Farazi , Mark Carlson
发明人： Fujian Qu , Timothy A. Fayram , Michael E. Benser , Taraneh Ghaffari Farazi , Mark Carlson
IPC分类号： A61B5/0402 , A61N1/39 , A61B5/04 , A61N1/362 , A61B5/0464 , A61B5/00
CPC分类号： A61N1/3962 , A61B5/04014 , A61B5/0464 , A61B5/7257 , A61N1/3622
摘要： Provided herein are implantable systems, and methods for use therewith, for characterizing a tachycardia and/or selecting treatment for a tachycardia using results of a dominant frequency analysis. One or more electrogram (EGM) signal(s) indicative of cardiac electrical activity are obtained. For at least one of the EGM signal(s) a dominant frequency (DF) analysis is performed, and the results of the DF analysis are used to characterize a tachycardia and/or to select treatment for a tachycardia.
摘要翻译：本文提供的可植入系统及其使用的方法用于表征心动过速和/或使用主频率分析的结果来选择治疗心动过速。获得指示心脏电活动的一个或多个电描记图（EGM）信号。对于至少一个EGM信号进行主频（DF）分析，并且DF分析的结果用于表征心动过速和/或选择心动过速的治疗。

6. 发明申请

US20130041274A1 SYSTEMS AND METHODS FOR USE BY IMPLANTABLE MEDICAL DEVICES FOR DETECTING AND DISCRIMINATING STROKE AND CARDIAC ISCHEMIA USING ELECTROCARDIAC SIGNALS 有权
标题翻译：用于通过电刺激信号检测和鉴别卒中和心脏病的植入式医疗设备使用的系统和方法
公开(公告)号：US20130041274A1
公开(公告)日：2013-02-14
申请号：US13207307
申请日：2011-08-10
申请人： Jong Gill , Rupinder Bharmi , Edward Karst , Ryan Rooke , Riddhi Shah , Fujian Qu , Gene A. Bornzin , Taraneh Ghaffari Farazi , Euljoon Park
发明人： Jong Gill , Rupinder Bharmi , Edward Karst , Ryan Rooke , Riddhi Shah , Fujian Qu , Gene A. Bornzin , Taraneh Ghaffari Farazi , Euljoon Park
IPC分类号： A61B5/0468
CPC分类号： A61B5/0468 , A61B5/0031 , A61B5/0205 , A61B5/02158 , A61B5/02405 , A61B5/0295 , A61B5/0422 , A61B5/4839 , A61N1/3702
摘要： Techniques are provided for detecting and distinguishing stroke and cardiac ischemia based on electrocardiac signals. In one example, the device senses atrial and ventricular signals within the patient along a set of unipolar sensing vectors and identifies certain morphological features within the signals such as PR intervals, ST intervals, QT intervals, T-waves, etc. The device detects changes, if any, within the morphological features such as significant shifts in ST interval elevation or an inversion in T-wave shape, which are indicative of stroke or cardiac ischemia. By selectively comparing changes detected along different unipolar sensing vectors, the device distinguishes or discriminates stroke from cardiac ischemia within the patient. The discrimination may be corroborated using various physiological and hemodynamic parameters. In some examples, the device further identifies the location of the ischemia within the heart. In still other examples, the device detects cardiac ischemia occurring during stroke.
摘要翻译：提供了用于基于心电信号检测和区分中风和心脏缺血的技术。在一个示例中，该装置沿着一组单极感测向量感测患者内的心房和心室信号，并且识别信号内的某些形态特征，例如PR间隔，ST间隔，QT间隔，T波等。该装置检测变化（如果有的话）在形态学特征之中，例如ST间期升高的显着变化或T波形的反转，其指示中风或心脏缺血。通过选择性地比较沿着不同的单极性感测向量检测的变化，该装置区分或区分患者体内的心脏缺血的中风。可以使用各种生理和血液动力学参数来确认辨别。在一些实例中，该装置还识别心脏内局部缺血的位置。在另外的例子中，该装置检测在中风期间发生的心脏缺血。

7. 发明授权

US08032213B1 Ventricular defibrillation threshold estimation 有权
标题翻译：心室除颤阈值估计
公开(公告)号：US08032213B1
公开(公告)日：2011-10-04
申请号：US11753890
申请日：2007-05-25
申请人： Fujian Qu , Taraneh Ghaffari Farazi
发明人： Fujian Qu , Taraneh Ghaffari Farazi
IPC分类号： A61N1/08
CPC分类号： A61N1/3943 , A61N1/3962
摘要： Systems and methods are provided for estimating a patient's ventricular defibrillation threshold (VDFT). Stimulation pulses, which are of at least three different energy levels up to 2 Joules, are delivered to the patient's right ventricle during a window defined between an R-wave and a vulnerable period that follows the R-wave. Voltage potentials, induced in response to the delivered RV stimulation pulses, are measured at a location of the patient's left ventricle (LV) where it is predicted that potential gradients induced in response to RV stimulation pulses will be lowest. Potential gradients are computed using the measured voltage potentials. The patient's VDFT can then be estimated by estimating, based on the computed potential gradients, the RV stimulation energy level that would be required to achieve a minimum acceptable potential gradient at the location of the patient's LV where it is predicted that potential gradients induced in response to RV stimulation pulses will be lowest.
摘要翻译：提供了用于估计患者的心室除颤阈值（VDFT）的系统和方法。具有至少三个不同能量级别至多2个焦耳的刺激脉冲在R波和R波之后的易受伤害的时期内界定的窗口内传送到患者的右心室。在患者的左心室（LV）的位置处测量响应于递送的RV刺激脉冲诱导的电压电位，其中预测响应RV刺激脉冲诱导的电位梯度将最低。使用测量的电压电位计算电位梯度。然后可以通过基于计算的潜在梯度估计在患者LV的位置处达到最小可接受电位梯度所需的RV刺激能量水平来估计患者的VDFT，其中预测响应中诱发的潜在梯度 RV刺激脉冲最低。

8. 发明授权

US08548587B2 Devices, systems and methods for characterizing a tachycardia and/or selecting treatment for a tachycardia using results of a fractionation analysis 有权
$Devices, systems and methods for characterizing a tachycardia and/or selecting treatment for a tachycardia using results of a fractionation analysis$
标题翻译：用于表征心动过速和/或使用分级分析结果选择治疗心动过速的装置，系统和方法
公开(公告)号：US08548587B2
公开(公告)日：2013-10-01
申请号：US13090079
申请日：2011-04-19
申请人： Fujian Qu , Timothy A. Fayram , Michael E. Benser , Taraneh Ghaffari Farazi , Mark Carlson
发明人： Fujian Qu , Timothy A. Fayram , Michael E. Benser , Taraneh Ghaffari Farazi , Mark Carlson
IPC分类号： A61N1/365
CPC分类号： A61N1/3962 , A61N1/3622 , A61N1/3702
摘要： Provided herein are implantable systems, and methods for use therewith, for characterizing a tachycardia and/or selecting treatment for a tachycardia using results of a fractionation analysis. One or more electrogram (EGM) signal(s) indicative of cardiac electrical activity are obtained. At least one of the EGM signal(s) is analyzed to determine whether the EGM signal is fractionated, and the results of the analyzing are used to characterize a tachycardia and/or to select treatment for a tachycardia.
摘要翻译：本文提供了可植入系统及其使用的方法，用于表征心动过速和/或使用分级分析结果选择治疗心动过速。获得指示心脏电活动的一个或多个电描记图（EGM）信号。分析至少一个EGM信号以确定EGM信号是否被分级，并且分析结果用于表征心动过速和/或选择心动过速的治疗。

9. 发明授权

US08521277B2 Implantable systems and method for use therewith for tracking changes in hemodynamics and cardiac disease 有权
标题翻译：可植入系统及其用于跟踪血液动力学和心脏病变化的方法
公开(公告)号：US08521277B2
公开(公告)日：2013-08-27
申请号：US12204683
申请日：2008-09-04
申请人： Taraneh Ghaffari Farazi , Fujian Qu
发明人： Taraneh Ghaffari Farazi , Fujian Qu
IPC分类号： A61N1/362
CPC分类号： A61N1/371 , A61B5/02028 , A61B5/0422 , A61N1/3627 , A61N1/3956
摘要： Embodiments of the present invention relate to monitoring a patient's atrial stretch, heart failure (HF) condition, and/or risk of atrial fibrillation (AF), as well as methods for estimating a change in at least one of a patient's left atrial pressure (LAP), pulmonary capillary wedge pressure (PCWP), and right pulmonary artery pressure (RPAP). Embodiments of the present invention also relate to selecting a pacing energy level. Such embodiments involve determining atrial evoked response metrics when a patient's atrium is paced, and monitoring changes in such metrics.
摘要翻译：本发明的实施例涉及监测患者的心房伸展，心力衰竭（HF）状况和/或心房颤动（AF）的风险）以及用于估计患者左心房压力（至少一个）的变化的方法 LAP），肺毛细血管楔压（PCWP）和右肺动脉压（RPAP）。本发明的实施例还涉及选择起搏能量水平。这样的实施例涉及当患者的心房起搏时确定心房诱发响应度量，以及监视这些度量的变化。

10. 发明申请

US20120271368A1 DEVICES, SYSTEMS AND METHODS FOR CHARACTERIZING A TACHYCARDIA AND/OR SELECTING TREATMENT FOR A TACHYCARDIA USING RESULTS OF A FRACTIONATION ANALYSIS 有权
标题翻译：使用分析分析结果表征TACHYCARDIA和/或选择TACHYCARDIA处理的装置，系统和方法
公开(公告)号：US20120271368A1
公开(公告)日：2012-10-25
申请号：US13090079
申请日：2011-04-19
申请人： Fujian Qu , Timothy A. Fayram , Michael E. Benser , Taraneh Ghaffari Farazi , Mark Carlson
发明人： Fujian Qu , Timothy A. Fayram , Michael E. Benser , Taraneh Ghaffari Farazi , Mark Carlson
IPC分类号： A61N1/365
CPC分类号： A61N1/3962 , A61N1/3622 , A61N1/3702
摘要： Provided herein are implantable systems, and methods for use therewith, for characterizing a tachycardia and/or selecting treatment for a tachycardia using results of a fractionation analysis. One or more electrogram (EGM) signal(s) indicative of cardiac electrical activity are obtained. At least one of the EGM signal(s) is analyzed to determine whether the EGM signal is fractionated, and the results of the analyzing are used to characterize a tachycardia and/or to select treatment for a tachycardia.
摘要翻译：本文提供了可植入系统及其使用的方法，用于表征心动过速和/或使用分级分析结果选择治疗心动过速。获得指示心脏电活动的一个或多个电描记图（EGM）信号。分析至少一个EGM信号以确定EGM信号是否被分级，并且分析结果用于表征心动过速和/或选择心动过速的治疗。

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