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21. 发明授权

US06200988B1 Heterocyclic derivatives and pharmaceutical use thereof 失效
标题翻译：杂环衍生物及其药物用途
公开(公告)号：US06200988B1
公开(公告)日：2001-03-13
申请号：US09506839
申请日：2000-02-18
申请人： Shoji Kamiya , Hiroaki Shirahase , Hiroshi Matsui , Shohei Nakamura , Katsuo Wada
发明人： Shoji Kamiya , Hiroaki Shirahase , Hiroshi Matsui , Shohei Nakamura , Katsuo Wada
IPC分类号： C07D21540
CPC分类号： C07D209/08
摘要： A heterocyclic derivative of the formula (I) wherein each symbol is as defined in the specification, and pharmaceutically acceptable salts thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof exhibit superior ACAT inhibitory activity and lipoperoxidation inhibitory activity in mammals, and are useful as ACAT inhibitors and lipoperoxidation inhibitors. Specifically, they are useful for the prophylaxis and treatment of arteriosclerosis, hyperlipemia, arteriosclerosis in diabetes, and cerebrovascular and cardiovascular ischemic diseases.
摘要翻译：式（I）的杂环衍生物，其中每个符号如说明书中所定义，及其药学上可接受的盐。本发明的化合物（I）及其药学上可接受的盐在哺乳动物中表现出优异的ACAT抑制活性和脂过氧化抑制活性，可用作ACAT抑制剂和脂质过氧化抑制剂。具体地说，它们可用于预防和治疗动脉硬化，高脂血症，糖尿病中的动脉硬化，以及脑血管和心血管缺血性疾病。

22. 发明授权

US06194673B1 Rotary encoder 失效
标题翻译：旋转编码器
公开(公告)号：US06194673B1
公开(公告)日：2001-02-27
申请号：US09467813
申请日：1999-12-20
申请人： Jun Sato , Hiroshi Matsui
发明人： Jun Sato , Hiroshi Matsui
IPC分类号： H01H900
CPC分类号： H01H19/005 , H01H25/008 , H01H2019/006 , H01H2019/146
摘要： A rotary encoder used mainly in a peripheral apparatus for computers, a portable telephone, an on-board electronic device for automobiles, and the like, in which an encoder unit and a linearly-driven type component are operable by a rotating manipulation and a tilting manipulation of an operating axle. The rotary encoder provides accuracy and is capable of producing a large number of output signals without requiring an increase in external dimensions. The rotary encoder is so constructed that flexible contacts and make resilient contact with movable contacts on a peripheral surface of a cylindrical rotor in a main unit of the encoder. The operating axle is pivotally supported by fitting it in an axle-supporting portion of the rotor in a manner that the operating axle is rotatable together with the rotor and is also tiltable. A cylindrical operating knob is attached to the operating axle that protrudes sideways from the rotor, and a push switch is disposed in a position to be in contact with a distal end of the same operating axle, and thereby making the main unit of the encoder operable by rotating manipulation and the push switch by tilting manipulation of the operating axle.
摘要翻译：主要用于计算机的周边设备，便携式电话机，车载电子设备等的旋转编码器，其中编码器单元和线性驱动型部件通过旋转操作和倾斜操作操纵轴的操作。旋转编码器提供精度并且能够产生大量的输出信号，而不需要增加外部尺寸。旋转编码器被构造成使得柔性接触件与编码器主单元中的圆柱形转子的外周表面上的活动触头弹性接触。操作轴通过将其安装在转子的轴支撑部分中以使得操作轴与转子一起旋转并且也可倾斜的方式枢转地支撑。一个圆柱形操作旋钮连接到从转子侧向突出的操作轴上，并且按钮开关设置在与相同操作轴的远端接触的位置，从而使编码器的主单元可操作通过使操作轴的操纵倾斜来旋转操作和按压开关。

23. 发明授权

US6063806A Indolyl or indolinyl derivatives and medicinal use thereof as ACAT or lipid peroxidation inhibitors 失效
标题翻译：吲哚基或二氢吲哚衍生物及其作为ACAT或脂质过氧化抑制剂的药用
公开(公告)号：US6063806A
公开(公告)日：2000-05-16
申请号：US51202
申请日：1998-04-03
申请人： Shoji Kamiya , Hiroaki Shirahase , Hiroshi Matsui , Shohei Nakamura , Katsuo Wada
发明人： Shoji Kamiya , Hiroaki Shirahase , Hiroshi Matsui , Shohei Nakamura , Katsuo Wada
IPC分类号： C07D209/08 , A61K31/40 , C07D209/12 , C07D209/14 , C07D209/18
CPC分类号： C07D209/08
摘要： A heterocyclic derivative of the formula (I) ##STR1## wherein each symbol is as defined in the specification, and pharmaceutically acceptable salts thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof exhibit superior ACAT inhibitory activity and lipoperoxidation inhibitory activity in mammals, and are useful as ACAT inhibitors and lipoperoxidation inhibitors. Specifically, they are useful for the prophylaxis and treatment of arteriosclerosis, hyperlipemia, arteriosclerosis in diabetes, and cerebrovascular and cardiovascular ischemic diseases.
摘要翻译： PCT No.PCT / JP96 / 02852 Sec。 371日期：1998年4月3日 102（e）1998年4月3日PCT PCT 1996年9月30日PCT公布。公开号WO97 / 12860 PCT 日期1997年4月10日一种式（I）的杂环衍生物，其中每个符号如说明书中所定义，及其药学上可接受的盐。本发明的化合物（I）及其药学上可接受的盐在哺乳动物中表现出优异的ACAT抑制活性和脂过氧化抑制活性，可用作ACAT抑制剂和脂质过氧化抑制剂。具体地说，它们可用于预防和治疗动脉硬化，高脂血症，糖尿病中的动脉硬化，以及脑血管和心血管缺血性疾病。

24. 发明授权

US5990150A Heterocyclic derivatives, method of production thereof and pharmaceutical use thereof 失效
标题翻译：杂环衍生物，其制备方法和药物用途
公开(公告)号：US5990150A
公开(公告)日：1999-11-23
申请号：US809242
申请日：1997-03-19
申请人： Hiroshi Matsui , Shoji Kamiya , Hiroaki Shirahase , Shohei Nakamura , Katsuo Wada
发明人： Hiroshi Matsui , Shoji Kamiya , Hiroaki Shirahase , Shohei Nakamura , Katsuo Wada
IPC分类号： C07D215/40 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/415 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/445 , A61K31/4523 , A61K31/47 , A61K31/495 , A61P3/06 , A61P3/08 , A61P3/10 , A61P9/00 , A61P9/10 , A61P43/00 , C07D209/08 , C07D215/06 , C07D215/26 , C07D401/12 , C07D403/12 , C07D521/00
CPC分类号： C07D231/12 , A61K31/404 , A61K31/47 , C07D209/08 , C07D215/06 , C07D215/26 , C07D233/56 , C07D249/08 , C07D401/12 , Y10S514/824 , Y10S514/866
摘要： Heterocyclic derivatives of the formula (I) ##STR1## wherein each symbol is as defined in the specification, pharmaceutically acceptable salts thereof and method of producing them. Pharmaceutical compositions containing the heterocyclic derivative or a pharmaceutically acceptable salt thereof, particularly, ACAT inhibitors and lipoperoxidation inhibitors. The heterocyclic derivatives and pharmaceutically acceptable salts thereof of the present invention show superior ACAT inhibitory activity and lipoperoxidation inhibitory activity, and are useful as ACAT inhibitors and hyperlipemia inhibitors. To be specific, they are useful for the prevention and treatment of arteriosclerotic lesions of arteriosclerosis, hyperlipemia and diabetes, as well as ischemic diseases of brain, heart and the like.
摘要翻译： PCT No.PCT / JP95 / 01873 Sec。 371日期1997年3月19日 102（e）1997年3月19日PCT PCT 1995年9月20日PCT公布。公开号WO96 / 09287 日期：1996年3月28日式（I）的杂环衍生物，其中每个符号如说明书中所定义，其药学上可接受的盐及其制备方法。含有杂环衍生物或其药学上可接受的盐，特别是ACAT抑制剂和脂质过氧化抑制剂的药物组合物。本发明的杂环衍生物及其药学上可接受的盐显示出优异的ACAT抑制活性和脂质过氧化抑制活性，并且可用作ACAT抑制剂和高脂血症抑制剂。具体而言，它们可用于预防和治疗动脉硬化，高脂血症和糖尿病的动脉硬化病变，以及脑，心脏等的缺血性疾病。

25. 发明授权

US5826431A Gas turbine multi-hole film cooled combustor liner and method of manufacture 失效
标题翻译：燃气轮机多孔薄膜冷却燃烧器衬管及其制造方法
公开(公告)号：US5826431A
公开(公告)日：1998-10-27
申请号：US596827
申请日：1996-02-05
申请人： Yoshinobu Makino , Kiyoshi Yamada , Hiroshi Matsui , Yoshihiro Aburatani , Yamato Kaminaka , Hiroshi Kubo , Hiroaki Okamoto
发明人： Yoshinobu Makino , Kiyoshi Yamada , Hiroshi Matsui , Yoshihiro Aburatani , Yamato Kaminaka , Hiroshi Kubo , Hiroaki Okamoto
IPC分类号： F02C7/00 , B23K26/24 , B23K26/28 , B23K26/38 , F23R3/00 , F23R3/06 , F23R3/42 , F02G3/00
CPC分类号： F23R3/002 , B23K26/244 , B23K26/282 , B23K26/384 , B23K26/388 , B23K26/389 , B23K26/40 , B23K2201/001 , B23K2203/26 , B23P2700/13 , F05B2260/202 , Y10T29/4932 , Y10T29/49346
摘要： Provided are a gas turbine multi-hole film-cooled combustor liner, which can be manufactured with improved accuracy in shape and position of cooling holes in a very short time, ensuring desirable buckling strength and satisfactory cooling performance. A planar flat member is curved to form a liner shell of a cylindrical shape, the cylindrical member is welded in the longitudinal direction thereof to form a cylindrical shell. Then a wavy configuration and a corrugated configuration are formed on the cylindrical shell by a hydro-bulging method, cooling holes are formed through the liner shell by laser drilling at or near wave crest portions of the wavy configuration of the liner shell, and inner rings are attached to the liner shell by resistance spot welding or vacuum brazing.
摘要翻译：本发明提供一种燃气轮机多孔薄膜冷却燃烧器衬套，能够在非常短的时间内提高冷却孔的形状和位置的精度，确保理想的翘曲强度和令人满意的冷却性能。平面平面构件弯曲以形成圆柱形的衬套，圆柱形构件沿其纵向方向焊接以形成圆柱形壳体。然后通过水力膨胀方法在圆柱形壳体上形成波状结构和波纹状结构，通过在衬套壳的波状构造的波峰部分处或附近通过激光钻孔在衬套壳体上形成冷却孔，并且内圈通过电阻点焊或真空钎焊连接到衬套外壳。

26. 发明授权

US5795769A Gene encoding interleukin-2 polypeptide, recombinant DNA carrying the gene, a living cell line possessing the recombinant DNA and method for producing interleukin-2 using the cell 失效
标题翻译：基因编码白细胞介素-2多肽，携带该基因的重组DNA，具有该重组DNA的活细胞系和使用该细胞产生白细胞介素-2的方法
公开(公告)号：US5795769A
公开(公告)日：1998-08-18
申请号：US516563
申请日：1995-08-18
申请人： Tadatsugu Taniguchi , Masami Muramatsu , Haruo Sugano , Hiroshi Matsui , Nobukazu Kashima
发明人： Tadatsugu Taniguchi , Masami Muramatsu , Haruo Sugano , Hiroshi Matsui , Nobukazu Kashima
IPC分类号： C07K14/55 , C12N15/70 , C12N15/81 , C12N15/00 , C12N15/26
CPC分类号： C07K14/55 , C12N15/70 , C12N15/81 , Y10S435/849 , Y10S930/141
摘要： A gene coded for a polypeptide which possesses interleukin-2 is isolated, and connected with a vector DNA which is capable of replicating in a procaryotic or eucaryotic cell at a position downstream of a promoter gene in the vector obtaining a recombinant DNA, with which the cell is transformed to produce interleukin-2.
摘要翻译：分离编码具有白细胞介素-2的多肽的基因，并与载体DNA连接，该载体DNA能够在原核或真核细胞中在载体中的启动子基因下游位置复制获得重组DNA，转化细胞以产生白介素-2。

27. 发明授权

US5786736A Non-reciprocal circuit element 失效
标题翻译：不可逆电路元件
公开(公告)号：US5786736A
公开(公告)日：1998-07-28
申请号：US713977
申请日：1996-09-13
申请人： Hiroki Dejima , Takashi Hasegawa , Yutaka Ishiura , Yoshikazu Chigodou , Hiroshi Matsui , Keiji Ogawa
发明人： Hiroki Dejima , Takashi Hasegawa , Yutaka Ishiura , Yoshikazu Chigodou , Hiroshi Matsui , Keiji Ogawa
IPC分类号： H01P1/387 , H01P1/383
CPC分类号： H01P1/387
摘要： A non-reciprocal circuit element which can be miniaturized while still providing a matching capacitance having a large value. A circulator, for example, has central electrodes and a multilayer substrate for forming a matching capacitance. The multilayer substrate is formed by stacking a plurality of dielectric sheets provided with central electrodes or matching capacitive electrodes with each other and integrally firing the same. The matching capacitance is formed by connecting multilayer capacitive parts which are formed by stacking a number of dielectric sheets which are each partially sandwiched by a pair of capacitive electrodes in parallel with each other. An upper surface of the multilayer substrate has a first aperture for receiving a ferrite member and a second aperture for receiving a permanent magnet in positions facing the central electrodes.
摘要翻译：一种不可逆电路元件，其可以在仍然提供具有大值的匹配电容的同时小型化。例如，循环器具有中心电极和用于形成匹配电容的多层衬底。多层基板通过将设置有中心电极或匹配的电容电极的多个电介质层叠并且一体地烧结而形成。匹配电容是通过层叠多个电介质层而形成的，所述多层电容部分通过层叠彼此平行的由一对电容电极部分夹在中间的多个电介质片而形成。多层基板的上表面具有用于接收铁氧体部件的第一孔和用于在面向中心电极的位置中接收永磁体的第二孔。

28. 发明授权

US5616480A Temperature sensitive plasmid 失效
标题翻译：温度敏感质粒
公开(公告)号：US5616480A
公开(公告)日：1997-04-01
申请号：US408188
申请日：1995-03-22
申请人： Masakazu Sugimoto , Hiroyuki Kojima , Akiko Tanaka , Hiroshi Matsui , Katsuaki Sato , Tsuyoshi Nakamatsu
发明人： Masakazu Sugimoto , Hiroyuki Kojima , Akiko Tanaka , Hiroshi Matsui , Katsuaki Sato , Tsuyoshi Nakamatsu
IPC分类号： C12N15/09 , C12N1/21 , C12N9/00 , C12N9/12 , C12N15/63 , C12N15/77 , C12P13/08 , C12P13/22 , C12R1/13 , C12N1/20
CPC分类号： C12N9/00 , C12N15/77 , C12N9/12 , C12P13/08 , C12P13/22
摘要： A plasmid having a temperature-sensitive replication origin which has the following properties:a) capable of autonomous replication in Corynebacterium and being retained in Corynebacterium; and,b) when a cell containing said plasmid is cultured at 31.degree. to 37.degree. C., replication of the plasmid is inhibited and at the same time, the plasmid is removed from the cell body; and a method for performing homologous recombination in Corynebacterium using the plasmid.
摘要翻译：具有温度敏感复制起点的质粒，其具有以下性质：a）能够在棒状杆菌中自主复制并保留在棒状杆菌中; 和b）当含有所述质粒的细胞在31℃至37℃下培养时，质粒的复制被抑制，同时从细胞体中除去质粒; 以及使用该质粒在棒状杆菌中进行同源重组的方法。

29. 发明授权

US5595288A Thin switch including domed contact 失效
标题翻译：薄开关包括圆顶接触
公开(公告)号：US5595288A
公开(公告)日：1997-01-21
申请号：US444152
申请日：1995-05-18
申请人： Hiroshi Matsui , Tamotsu Yamamoto , Yukihiro Ishihara
发明人： Hiroshi Matsui , Tamotsu Yamamoto , Yukihiro Ishihara
IPC分类号： H01H13/52 , H01H11/06 , H01H13/48 , H01H1/10
CPC分类号： H01H13/48 , H01H11/06 , Y10T29/49105
摘要： A thin switch includes, (a) a rectangular insulating substrate, (b) a unitary fixed contact member comprising a T-shaped conductive thin-metal including a fixed contact, a first terminal, and a first conductive part therebetween, and (c) a movable contact member including a unitary elastic and T-shaped conductive thin-metal including a domed contact, a second terminal, and a second conductive part therebetween. The fixed contact member is placed so that the fixed contact is located roughly at the center of a surface of the insulating substrate and the first terminal is located at one edge of the insulating substrate. The first terminal is attached to the insulating substrate. The movable contact member is placed so that the domed contact is located over the fixed contact and the second terminal is located at the opposite edge of the insulating substrate. The second terminal is attached to the insulating substrate.
摘要翻译：薄型开关包括（a）矩形绝缘基板，（b）包括固定触点的T形导电薄金属，第一端子和第一导电部件之间的整体固定触头部件，（c）包括一个整体弹性和T形导电薄金属的活动接触件，它包括一个圆顶接触件，一个第二端子和一个第二导电部件。固定接触构件被放置成使得固定触点大致位于绝缘基板的表面的中心，并且第一端子位于绝缘基板的一个边缘处。第一端子连接到绝缘基板。可动接触构件被放置成使得圆顶接触件位于固定接触件上方，并且第二端子位于绝缘基板的相对边缘处。第二端子连接到绝缘基板。

30. 发明授权

US5538973A Imidazole derivative, pharmaceutical use thereof, and intermediate therefor 失效
标题翻译：咪唑衍生物，其药物用途及其中间体
公开(公告)号：US5538973A
公开(公告)日：1996-07-23
申请号：US393042
申请日：1995-02-23
申请人： Hiroshi Matsui , Shoji Kamiya , Hiroaki Shirahase , Shohei Nakamura
发明人： Hiroshi Matsui , Shoji Kamiya , Hiroaki Shirahase , Shohei Nakamura
IPC分类号： C07D521/00 , A61K31/495 , A61K31/445 , C07D401/14 , C07D403/14
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56
摘要： An imidazole derivative of the formula (I) ##STR1## wherein each symbol is as defined in the specification, or a pharmacologically acceptable salt thereof is described. A method for producing the compound or its salt, and its pharmaceutical use, particularly as an agent for the prophylaxis and treatment of the diseases induced by thromboxane A.sub.2 or histamine are described. Also, compounds of the formula (II) and (IV) ##STR2## wherein each symbol is as defined in the specification are described. The imidazole derivative and its parmacologically acceptable salt are useful as agents for the prophylaxis and treatment of the diseases induced by thromboxane A.sub.2 or histamine, and the intermediate compounds (II) and (IV) are novel compounds.
摘要翻译：其中每个符号如说明书中所定义，或其药理学上可接受的盐的式（I）的咪唑衍生物。描述了化合物或其盐的制备方法及其药物用途，特别是作为预防和治疗由血栓素A2或组胺引起的疾病的药剂。此外，描述了其中每个符号如说明书中所定义的式（II）和（IV）的化合物（IMAGE）（II）（IV）。咪唑衍生物及其分子间可接受的盐可用作预防和治疗由血栓素A2或组胺诱导的疾病的药剂，中间体化合物（II）和（IV）是新化合物。

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