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1. 发明申请

WO1998003671A1 PROCESS FOR PREPARING DOCOSAHEXAENOIC ACID AND DOCOSAPENTAENOIC ACID 审中-公开
标题翻译：制备丙二酸和DOCOSAPENTAENOIC酸的方法
公开(公告)号：WO1998003671A1
公开(公告)日：1998-01-29
申请号：PCT/JP1997001946
申请日：1997-06-06
申请人： NAGASE BIOCHEMICALS, LTD. , SUNTORY LIMITED , TANAKA, Satohiro , YAGUCHI, Toshiaki , SHIMIZU, Sakayu , SOGO, Tsutomu , FUJIKAWA, Shigeaki
发明人： NAGASE BIOCHEMICALS, LTD. , SUNTORY LIMITED
IPC分类号： C12P07/64
CPC分类号： C12P7/6427 , A23D9/007 , A23K20/158 , A23L33/12 , C11C1/045 , C12P7/6472 , C12R1/645 , C12R1/89
摘要： A process for preparing lipids which contain docosahexaenoic acid (DHA) and/or docosapentaenoic acid (DPA) is disclosed. The process includes the steps of cultivating in a medium a microorganism which belongs to the genus Ulkenia having the ability to produce DHA and/or DPA and recovering the lipids from the culture. The process may further include the step of separating DHA and/or DPA from the lipids.
摘要翻译：公开了一种制备含有二十二碳六烯酸（DHA）和/或二十二碳五烯酸（DPA）的脂质的方法。该方法包括在培养基中培养属于具有产生DHA和/或DPA的能力的乌尔肯尼亚属的微生物并从培养物中回收脂质的步骤。该方法还可以包括从脂质中分离DHA和/或DPA的步骤。

2. 发明申请

WO1996026288A1 A METHOD FOR THE ISOLATION AND PURIFICATION OF LIPID CELL-WALL COMPONENTS 审中-公开
标题翻译：一种用于分离和纯化脂肪细胞壁组件的方法
公开(公告)号：WO1996026288A1
公开(公告)日：1996-08-29
申请号：PCT/GB1996000416
申请日：1996-02-22
申请人： BROWN, Keith, Edwin, Frank , ADCOCK INGRAM LIMITED , VERSCHOOR, Jan, Andrianus
发明人： BROWN, Keith, Edwin, Frank , ADCOCK INGRAM LIMITED
IPC分类号： C12P07/64
CPC分类号： C12P7/6409 , A61K39/04 , C07K16/1289 , C12P7/6436 , C12P7/6463 , C12P7/649 , G01N33/5695 , Y02E50/13
摘要： A method, using a multi-phasic solvent system, for the simultaneous purification and separation of different classes of compounds, which may be cell-wall components or derivatives or analogues thereof which may be extracted from a culture of the relevant cells or which may be synthesized. The cell-wall components may be lipid cell-wall components of microbial origin which can be separated from contaminating material as a group.
摘要翻译：一种使用多相溶剂系统同时纯化和分离不同类别化合物的方法，其可以是细胞壁组分或其衍生物或类似物，其可以从相关细胞的培养物中提取或可能是合成。细胞壁组分可以是微生物来源的脂质细胞壁组分，其可以作为一组与污染物质分离。

3. 发明申请

WO1993020225A1 PROCESS FOR PRODUCING DOCOSAHEXAENOIC ACID 审中-公开
标题翻译：生产苯醚二酸的方法
公开(公告)号：WO1993020225A1
公开(公告)日：1993-10-14
申请号：PCT/JP1993000402
申请日：1993-03-31
申请人： KAWASAKI STEEL CORPORATION , TAKEUCHI, Daizo; , Lizuka, Tokio; , UEHARA, Kenichi;
发明人： KAWASAKI STEEL CORPORATION
IPC分类号： C12P07/64
CPC分类号： C12P7/6427 , C12P7/6472 , C12R1/89
摘要： A process for producing docosahexaenoic acid by subjecting Crypthecodinium cohnii, one of marine microalgae, to liquid shake culture, liquid submerged aerobic spinner culture and/or aerobic spinner culture in the presence of a surfactant and/or a defoamer; and a process for producing docosahexaenoic acid by subjecting Crypthecodinium cohnii ATCC30021 strain to liquid shake culture, liquid submerged aerobic spinner culture and/or aerobic spinner culture.
摘要翻译：通过在表面活性剂和/或消泡剂存在下，使海洋微藻之一的Crypthecodinium cohnii进行液体摇动培养，液体浸没需氧旋转培养和/或需氧旋转培养来生产二十二碳六烯酸的方法; 以及通过使Crypthecodinium cohnii ATCC30021菌株进行液体振荡培养，液体浸没有氧旋转培养和/或有氧旋转培养来生产二十二碳六烯酸的方法。

4. 发明申请

WO1991007498A1 PROCESS FOR THE HETEROTROPHIC PRODUCTION OF PRODUCTS WITH HIGH CONCENTRATIONS OF OMEGA-3 HIGHLY UNSATURATED FATTY ACIDS 审中-公开
标题翻译：欧米加-3高度不饱和脂肪酸高浓度异味生产方法
公开(公告)号：WO1991007498A1
公开(公告)日：1991-05-30
申请号：PCT/US1990006375
申请日：1990-11-05
申请人： PHYCOTECH, INC.
发明人： PHYCOTECH, INC. , BARCLAY, William, R.
IPC分类号： C12P07/64
CPC分类号： C12P7/6427 , A23K10/16 , A23K20/158 , A23K50/00 , A23K50/10 , A23K50/75 , A23K50/80 , A23L11/07 , A23L13/00 , A23L13/43 , A23L13/50 , A23L15/20 , A23L17/00 , A23L17/40 , A23L19/09 , A23L25/30 , A23L29/065 , A23L33/12 , A61K31/20 , A61K31/202 , C11B1/10 , C12N1/14 , C12P7/6445 , C12P7/6472 , Y02A40/818 , Y10S435/946
摘要： A process for the heterotrophic or predominantly heterotrophic production of whole-celled or extracted microbial products with a high concentration of omega-3 highly unsaturated fatty acids, producible in an aerobic culture under controlled conditions using biologically pure cultures of heterotrophic single-celled fungi microorganisms of the order Thraustochytriales. The harvested whole-cell microbial product can be added to processed foods as a nutritional supplement, or to fish and animal feeds to enhance the omega-3 highly unsaturated fatty acid content of products produced from these animals. The lipids containing these fatty acids can also be extracted and used in nutritional, pharmaceutical and industrial applications.
摘要翻译：异源营养或主要异养生产具有高浓度的ω-3高度不饱和脂肪酸的全细胞或提取的微生物产物的方法，可在受控条件下在有氧培养物中生产，使用异养单细胞真菌微生物的生物纯纯培养物命令Thraustochytriales。收获的全细胞微生物产品可以添加到作为营养补充剂的加工食品中，或者添加到鱼和动物饲料中以增强由这些动物产生的产品的ω-3高度不饱和脂肪酸含量。含有这些脂肪酸的脂质也可以用于营养，制药和工业应用。

5. 发明申请

WO1986003518A1 PROCESS FOR PRODUCING FATTY ACIDS, PARTICULARLY 'gamma'-LINOLENIC ACID FROM TETRAHYMENA, PRODUCTS OBTAINED THEREBY AND MEDICINAL OR ALIMENTARY PREPARATION CONTAINING 'gamma'-LINOLENIC ACID OR DERIVATIVES THEREOF AS PLATELET ANTI-AGGREGATION AGENT 审中-公开
标题翻译：用于生产脂肪酸的方法，特别是来自四氢叶酸的γ-亚磺酸，由其获得的产品和药物或制剂，其含有γ-氨基酸或其衍生物作为抗菌聚集剂
公开(公告)号：WO1986003518A1
公开(公告)日：1986-06-19
申请号：PCT/BE1985000020
申请日：1985-11-25
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE ... , UNIVERSITE CATHOLIQUE DE LOUVAIN , FACULTE DES SCIENCES AGRONOMIQUES DE L'ETAT , DEVIS, Raymond , SALIBA, Rachad , THONART, Philippe , ARTOIS, Claude , DIVE, Daniel , GUILLAUME, Jean
发明人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE ... , UNIVERSITE CATHOLIQUE DE LOUVAIN , FACULTE DES SCIENCES AGRONOMIQUES DE L'ETAT
IPC分类号： C12P07/64
CPC分类号： C12P7/6427 , A23L33/12 , A61K31/20 , C12P7/6436 , C12P7/6472
摘要： The process for producing fatty acids is characterized in that it comprises at least the following steps: production of ciliated protozan tetrahymena in an appropriate nutricious medium and-extraction of total fatty acids of tetrahymena. The invention also relates to total fatty acids thus obtained, as well as to the gamma-linolenic acid or the dihomo-gamma-linolenic acid and their derivatives as well as to medicinal or alimentary preparations containing them as platelet anti-aggregation agent or anti-thrombotic agent.

6. 发明申请

WO1996010643A1 METHOD OF TRANSESTERIFYING FAT OR OIL 审中-公开
标题翻译：转运脂肪或油的方法
公开(公告)号：WO1996010643A1
公开(公告)日：1996-04-11
申请号：PCT/JP1995001969
申请日：1995-09-28
申请人： FUJI OIL CO., LTD. , YAMAGUCHI, Koutaro , HUKAZAWA, Sadayuki , SHIMODA, Tadahisa , IZUMI, Tugio
发明人： FUJI OIL CO., LTD.
IPC分类号： C12P07/64
CPC分类号： C12P7/6454 , C11C3/04 , C11C3/08
摘要： A method of transesterifying fat or oil for the purpose of modifying the same and efficiently preparing target triglycerides in high concentrations. The method comprises the step of transesterifying a fat or oil with a fatty acid or a lower alcohol ester thereof in the presence of an enzyme catalyst and the step of distilling off the acid or the ester from the reaction mixture, these two steps being repeated in a number of stages, which method is characterized by leaving the fat or oil and the feedstock fatty acid or ester thereof selectively in the distillation steps preceding the one in the final stage to remain unremoved in the reaction mixture. This method serves to reduce the amount of the fatty acid or the ester to be used, to inhibit the formation of by-products, and to provide the target triglycerides in high concentrations more efficiently than the conventional multistage transesterification methods.
摘要翻译：脂肪或油的酯交换的方法是为了改变相同的方式，并且高效地制备目标甘油三酯。该方法包括在酶催化剂存在下将脂肪或油与脂肪酸或其低级醇酯进行酯交换的步骤以及从反应混合物中蒸出酸或酯的步骤，将这两个步骤重复该方法的特征在于在最终阶段之前的蒸馏步骤中选择性地留下脂肪或油和原料脂肪酸或酯，以保持未反应在反应混合物中。该方法用于减少脂肪酸或所用酯，抑制副产物的形成，并且以比常规的多级酯交换法更有效地提供高浓度的目标甘油三酯。

7. 发明申请

WO1995010626A1 METHOD FOR THE ENZYMATIC TRANSFORMATION OF TRIGLYCERIDES IN A FAT, IN PARTICULAR DAIRY FAT 审中-公开
标题翻译：在FAT，特定的乳制品中对三聚氰胺进行酶促转化的方法
公开(公告)号：WO1995010626A1
公开(公告)日：1995-04-20
申请号：PCT/FR1994001192
申请日：1994-10-14
申请人： CENTRE DE COOPERATION INTERNATIONALE EN RECHERCHE AGRONOMIQUE POUR LE DEVELOPPEMENT , INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE , GRAILLE, Jean, Emile , MONTET, Didier, Jean-Luc , OZENNE, Catherine, Lucette , LAMBERET, Gilles, François
发明人： CENTRE DE COOPERATION INTERNATIONALE EN RECHERCHE AGRONOMIQUE POUR LE DEVELOPPEMENT , INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
IPC分类号： C12P07/64
CPC分类号： C12P7/6454
摘要： A novel method for the enzymatic transformation of triglycerides in a main fat by acyl transfer, interesterification, transesterification or intrainteresterification, uses an enzymatic preparation in a reaction system containing said main fat alone or mixed with a co-substrate selected from fatty acids, fatty acid esters, from a secondary fat, or untreated secondary fat. The method is characterized specifically in that the enzymatic preparation comprises a plant latex, or a serum, or coagulum of the latter, in particular a latex of Euphorbiaceae or Caricaceae. Application particularly for enzymatic processing of dairy fat in the food industry.
摘要翻译：通过酰基转移，酯交换，酯交换或内部过氧化，在主要脂肪中酶促转化甘油三酸酯的新方法，在含有所述主要脂肪的反应体系中使用酶制剂，或者与选自脂肪酸，脂肪酸酯，二次脂肪或未经处理的次级脂肪。该方法的特征在于酶制剂包括植物胶乳，或血清或后者的凝血块，特别是大戟科或桉科的胶乳。特别适用于食品工业中乳脂肪的酶加工。

8. 发明申请

WO1991016443A1 PROCESS FOR PREPARATION OF TRIGLYCERIDE AND TRIGLYCERIDE COMPOSITION 审中-公开
标题翻译：制备TRIGLYCERIDE和TRIGLYCERIDE组合物的方法
公开(公告)号：WO1991016443A1
公开(公告)日：1991-10-31
申请号：PCT/DK1991000100
申请日：1991-04-16
申请人： NOVO NORDISK A/S , LYSI HF , HARALDSSON, Gudmundur, G. , SVANHOLM, Hanne , HJALTASON, Baldur
发明人： NOVO NORDISK A/S , LYSI HF
IPC分类号： C12P07/64
CPC分类号： C12P7/6472 , C07C69/003 , C11C3/04 , C12P7/6454 , Y10S435/922
摘要： Triglyceride wherein all three fatty acids are C20+ polyunsaturated fatty acids (with at least three double bonds) is prepared by esterification of glycerol with free polyunsaturated fatty acid or its C1-4 lower alkyl ester in the presence of a lipase. The yield of triglyceride is increased and the amount of mono- and diglyceride decreased by removing water or lower alcohol formed during the reaction, by using positionally non-specific lipase, and/or by using a lipase immobilized by adsorption on a particulate, macroporous adsorbent resin of the acrylic type.
摘要翻译：其中所有三种脂肪酸都是C20 +多不饱和脂肪酸（具有至少三个双键）的甘油三酯通过甘油与游离多不饱和脂肪酸或其C1-4低级烷基酯在脂肪酶存在下酯化而制备。通过使用位置非特异性脂肪酶和/或通过使用通过吸附固定的颗粒状大孔吸附剂上的脂肪酶，甘油三酯的产率增加，并且通过除去反应期间形成的水或低级醇，降低甘油单酯和甘油二酯的量丙烯酸类树脂。

9. 发明申请

WO1991014784A1 A PROCESS FOR INCREASING THE AMOUNT OF TRIGLYCERIDE OF A FAT OR OIL 审中-公开
标题翻译：一种增加脂肪或油的甜味剂量的方法
公开(公告)号：WO1991014784A1
公开(公告)日：1991-10-03
申请号：PCT/DK1991000083
申请日：1991-03-19
申请人： NOVO NORDISK A/S , SVANHOLM, Hanne
发明人： NOVO NORDISK A/S
IPC分类号： C12P07/64
CPC分类号： C12P7/6454 , C07C69/003 , C11C3/04 , C11C3/10 , C12N11/08
摘要： Treatment of a fat or oil containing free fatty acid together with diglyceride and/or monoglyceride and/or glycerol with a positionally non-specific lipase or with lipase derived from Humicola or with lipase immobilized on a macroporous acrylic carrier leads to a much more rapid formation of triglyceride than prior-art process, and the shorter reaction time leads to less acyl migration. Treatment with lipase immobilized on a macroporous acrylic carrier promotes triglyceride formation and retards acyl migration.
摘要翻译：含有游离脂肪酸的脂肪或油与甘油二酯和/或单酸甘油酯和/或甘油与位置非特异性脂肪酶或来自Humicola的脂肪酶或固定在大孔丙烯酸载体上的脂肪酶一起处理导致更快速的形成的甘油三酸酯，而较短的反应时间导致较少的酰基迁移。固定在大孔丙烯酸载体上的脂肪酶的处理促进甘油三酯形成并延缓酰基迁移。

10. 发明申请

WO1991006661A1 LIPASE-CATALYZED IN SITU GENERATION OF MONO- AND DI-GLYCERIDES 审中-公开
标题翻译：在单糖和二甘油的发酵中进行脂肪酶催化
公开(公告)号：WO1991006661A1
公开(公告)日：1991-05-16
申请号：PCT/US1990006495
申请日：1990-11-02
申请人： ENZYTECH, INC.
发明人： ENZYTECH, INC. , ZAKS, Aleksey , IYENGAR, Radha , GROSS, Akiva
IPC分类号： C12P07/64
CPC分类号： C12Y301/01003 , A23D9/007 , A23L25/10 , A23L29/10 , C11C1/045 , C12P7/6418 , C12P7/6445 , C12P7/6454
摘要： Enzymatic modification of fats and oils results in a food-grade product that can be used as an emulsifier and/or fat replacer in foods. The modified oil is a mixture of mono-, di- and triglycerides having emulsification properties which can be added to commercial food preparations to replace all or part of the oil or fat in the food preparation.
摘要翻译：脂肪和油的酶改性产生可用作食品中的乳化剂和/或脂肪替代物的食品级产品。改性油是具有乳化性质的甘油单酯，甘油二酯和甘油三酯的混合物，其可以加入到商业食品制剂中以替代食品制剂中的全部或部分油或脂肪。

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