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1. 发明申请

WO2019097536A1 QUANTUM DOT POWERED IP-10 ANTIBODY BASED KIT FOR LATENT TB AND TB ANTIGEN DETECTION 审中-公开
公开(公告)号：WO2019097536A1
公开(公告)日：2019-05-23
申请号：PCT/IN2018/050688
申请日：2018-10-25
申请人： MGM INSTITUTE OF HEALTH SCIENCES (MGMIHS), DEEMED UNIVERSITY U/S 3 OF UGC ACT, 1956
发明人： YADAV, Raman Prasad , KADAM, Sudhirchandra Nanasaheb , KADAM, Nitin Nanasaheb , BHAGIT, Amita Anant
IPC分类号： G01N33/569
CPC分类号： G01N33/5695 , C07K16/1289 , G01N33/588 , G01N2333/35 , G01N2469/10
摘要： The present invention provides an antibody quantum dot complex comprising Mycobacterium tuberculosis anti-IP10 antibody and biogenic quantum dots for detection of Latent tuberculosis (LTB) antigens and TB antigens and a process for the synthesis thereof. Further, the present invention provides a diagnostic kit comprising the anti-IP10 antibody for detection of LTBI antigens and active tuberculosis antigens, and a method of assaying the concentration of the M . tuberculosis IP-10 antigen in an individual recovering from tuberculosis or exhibiting symptoms thereof.

2. 发明申请

WO2018151938A2 COMPOSITIONS AND METHODS OF DETERMINING A LEVEL OF INFECTION IN A SUBJECT 审中-公开
公开(公告)号：WO2018151938A2
公开(公告)日：2018-08-23
申请号：PCT/US2018/016115
申请日：2018-01-31
申请人： THE METHODIST HOSPITAL
发明人： HU, Ye , LIU, Chang , MA, Xin , LI, Yaojun , HOLLAND, Steven Michael , ZHAO, Zhen , ZELAZNY, Adrian , LYON, Christopher John
IPC分类号： A61K47/69 , A61K9/51
CPC分类号： G01N33/54346 , G01N33/5695 , G01N33/6851
摘要： Provided herein are nanoparticles configured for the rapid detection of disease-specific peptides from patient samples, including blood-based samples. Also provided are methods of measuring the level of an infection by isolation and quantification of disease-specific peptides from patient samples. The nanoparticles may act as a co-matrix for matrix assisted laser desorption/ionization mass spectrometry.

3. 发明申请

WO2017143985A1 METHOD FOR DETECTING MARKER FOR ACTIVE TUBERCULOSIS 审中-公开
标题翻译：检测活动性结核病标记物的方法
公开(公告)号：WO2017143985A1
公开(公告)日：2017-08-31
申请号：PCT/CN2017/074390
申请日：2017-02-22
申请人： KEI INTERNATIONAL LIMITED , TOMORROWS IP LIMITED
发明人： CASTROP, Johannes Theodorus
IPC分类号： G01N33/50 , G01N33/92 , G01N33/543 , G01N33/569
CPC分类号： G01N33/5695
摘要： The present invention provides a method of detecting a marker for active tuberculosis, and a method for pre-treating a sample from a human or animal suspected of having active tuberculosis.
摘要翻译：本发明提供了检测活动性结核病标志物的方法，以及预处理疑似患有活动性结核病的人或动物的样品的方法。

4. 发明申请

WO2017139153A1 NOVEL ANTI-LAM AND ANTI-PIM6/LAM MONOCLONAL ANTIBODIES FOR DIAGNOSIS AND TREATMENT OF MYCOBACTERIUM TUBERCULOSIS INFECTIONS 审中-公开
标题翻译：新型抗LAM和抗PIM6 / LAM单克隆抗体诊断和治疗结核杆菌感染
公开(公告)号：WO2017139153A1
公开(公告)日：2017-08-17
申请号：PCT/US2017/016058
申请日：2017-02-01
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
发明人： PINTER, Abraham , PATEL, Deendayal , CHOUDHARY, Alok
IPC分类号： G01N33/569 , C07K16/12 , C07K16/28 , A61K39/395 , A61K39/02 , A61K39/04
CPC分类号： G01N33/5695 , C07K16/1289 , C07K2317/21 , C07K2317/622 , C07K2317/92 , G01N2333/35 , G01N2400/02 , G01N2800/44
摘要： The present invention broadly provides different compositions, kits, vectors, and methods including monoclonal antibodies directed to epitopes found within lipoarabinomannan (LAM) and phosphatidyl-myo-inositol mannoside 6 (PIM6) for the diagnosis and treatment of Mycobacterium tuberculosis infections.
摘要翻译：本发明广泛地提供了不同的组合物，试剂盒，载体和方法，包括针对在脂阿拉伯甘露聚糖（LAM）和磷脂酰肌醇 - 甘露糖苷6（PIM6）中发现的表位的单克隆抗体，用于诊断和治疗结核分枝杆菌感染。

5. 发明申请

WO2017077493A1 CORE ELEMENTS FOR POINT OF CARE DIAGNOSIS OF TUBERCULOSIS 审中-公开
标题翻译：结核病诊断点的核心要素
公开(公告)号：WO2017077493A1
公开(公告)日：2017-05-11
申请号：PCT/IB2016/056643
申请日：2016-11-04
申请人： UNIVERSITY OF PRETORIA , CSIR
发明人： VERSCHOOR, Jan, Adrianus , OKEKE, Ikechukwu, Emmanuel , KALOMBO, Lonji , LEMMER, Yolandy
IPC分类号： G01N33/543 , G01N33/569
CPC分类号： G01N33/54346 , G01N33/5438 , G01N33/5695 , G01N2333/35 , G01N2469/20 , G01N2800/12
摘要： The invention provides a method of diagnosing tuberculosis by using a novel antibody biomarker capturing vehicle, activating a screen-printed electrode using chemical and mechanical polishing, and immobilising mycolic acid antigen biomarkers on the activated electrode. The novel antibody biomarker capturing vehicle is produced by introducing isolated mycolic acid antigens of tuberculous mycobacterial origin onto an outer surface of a nanoparticle such that the mycolic acid antigens are presented as antibody biomarker capturing agents. The solvent resistant screen-printed electrode is activated by both chemically and mechanically polishing the electrode. The mycolic acid antigens are immobilised on the activated electrode by incubating the activated electrode with a mycolic acid-dimethylformamide solution to allow mycolic acid antigens to adsorb onto the activated electrode.
摘要翻译：本发明提供了一种通过使用新型抗体生物标志物捕获媒介物，使用化学和机械抛光活化丝网印刷电极，并将霉菌酸抗原生物标志物固定在活化电极上来诊断结核病的方法。通过将结核分枝杆菌来源的分离的霉菌酸抗原引入纳米颗粒的外表面来产生新型抗体生物标志物捕获媒介物，使得霉菌酸抗原作为抗体生物标志物捕获剂呈现。通过化学和机械抛光电极激活耐溶剂丝网印刷电极。通过将活化的电极与霉菌酸 - 二甲基甲酰胺溶液一起孵育，使分枝菌酸抗原固定在活化电极上，使霉菌酸抗原吸附到活化电极上。

6. 发明申请

WO2017055494A1 MYCOBACTERIA PRE-ANALYTIC REAGENT 审中-公开
标题翻译： MYCOBACTERIA预分析试剂
公开(公告)号：WO2017055494A1
公开(公告)日：2017-04-06
申请号：PCT/EP2016/073332
申请日：2016-09-29
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE MOLECULAR SYSTEMS, INC.
发明人： JOHNSON, Jenny A. , MEHTA, Rochak
IPC分类号： G01N33/569 , G01N1/28 , G01N1/38
CPC分类号： C12N1/20 , G01N1/38 , G01N33/5695
摘要： A pre-analytic reagent is provided for liquefaction of a sputum sample and complete inactivation of one or more Mycobacteria, e.g., Mycobacterium tuberculosis (MTB) suspected of being contained in the sputum sample at room temperature. The pre-analytic reagent may include one or more of each of: a chaotropic agent, a chelator, a reducing agent, a detergent, and acetic acid. The pre-analytic reagent can be configured to be effective to liquefy the sputum sample and completely inactivate the Mycobacteria suspected to be contained therein.
摘要翻译：提供预分析试剂以液化痰样品，并在室温下完全灭活一种或多种分枝杆菌，例如疑似包含在痰样品中的结核分枝杆菌（Mycobacterium tuberculosis，MTB）。预分析试剂可以包括以下各项中的一种或多种：离液剂，螯合剂，还原剂，洗涤剂和乙酸。预分析试剂可以配置为有效地液化痰样品并完全灭活怀疑含有的分枝杆菌。

7. 发明申请

WO2016175708A1 NOVEL DESIGN OF ENZYME-LINKED IMMUNSORBENT ASSAY PLATES AND SYSTEMS AND METHODS OF USE THEREOF 审中-公开
标题翻译：酶联免疫测定板和系统的新颖设计及其使用方法
公开(公告)号：WO2016175708A1
公开(公告)日：2016-11-03
申请号：PCT/SG2016/050204
申请日：2016-05-03
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： MANI, Vigneshwaran , SINGHAL, Amit , DE LIBERO, Gennaro
IPC分类号： G01N33/53
CPC分类号： G01N33/54386 , B01L3/5023 , B01L2300/08 , B01L2300/087 , B01L2300/0877 , B01L2300/161 , G01N33/5304 , G01N33/5695 , G01N33/6863 , G01N33/6866 , G01N33/6869 , G01N2333/35 , G01N2333/525 , G01N2333/55 , G01N2333/57 , G01N2800/60
摘要： The present disclosure refers to an enzyme-linked immunosorbent assay (ELISA) plate comprising at least one row of reaction chambers, wherein the reaction chambers in the same row are in fluid communication with each other. Also enclosed is a system for detecting one or more target analytes comprising an ELISA plate as described herein, a plurality of magnetic beads and a magnet configured to cooperate with the magnetic beads. Also encompassed is a method of performing an ELISA assay which comprises of moving magnetic beads through subsequent reaction chambers, wherein the reaction chambers are alternatingly filled with a non-aqueous liquid, such as silicone oil, and aqueous ELISA reagents.
摘要翻译：本公开涉及包含至少一排反应室的酶联免疫吸附测定（ELISA）板，其中同一行中的反应室彼此流体连通。还包括用于检测包含如本文所述的ELISA板的一种或多种靶分析物的系统，多个磁珠和配置为与磁珠配合的磁体。还包括进行ELISA测定的方法，其包括将磁珠移动通过随后的反应室，其中反应室交替填充非水液体，例如硅油，以及含水的ELISA试剂。

8. 发明申请

WO2016161435A1 PEPTIDES OF M. TUBERCULOSIS FOR A SCREENING TEST FOR HIV POSITIVE PATIENTS AT HIGH-RISK FOR TUBERCULOSIS 审中-公开
标题翻译：艾滋病病毒感染者高危型流行性肺结核患者筛查结核分枝杆菌肽
公开(公告)号：WO2016161435A1
公开(公告)日：2016-10-06
申请号：PCT/US2016/025894
申请日：2016-04-04
申请人： NEW YORK UNIVERSITY
发明人： LAAL, Suman
IPC分类号： G01N33/53 , G01N33/569
CPC分类号： G01N33/5695 , G01N2333/35 , G01N2469/10 , G01N2800/26 , G01N2800/50
摘要： Provided are peptides suitable for early detection of active M. tuberculosis (Mtb) infection in immunocompromised individuals. The peptides can form complexes with antibodies directed to Mtb antigens MS, MPT51, ESAT6 or CFPIO. Also provided are methods for detected of complexes of the peptides and the antibodies. The presence of complexes aids in predicting risk in immunocompromised individuals of developing active tuberculosis.
摘要翻译：提供了适合于在免疫受损个体中早期检测活动性结核分枝杆菌（Mtb）感染的肽。肽可以与针对Mtb抗原MS，MPT51，ESAT6或CFPIO的抗体形成复合物。还提供了检测肽和抗体复合物的方法。复合物的存在有助于预防免疫功能低下的个体发展为活动性结核病的风险。

9. 发明申请

WO2016012449A1 MONOCLONAL ANTIBODY, METHOD, KIT AND USE 审中-公开
标题翻译：单克隆抗体，方法，包装和使用
公开(公告)号：WO2016012449A1
公开(公告)日：2016-01-28
申请号：PCT/EP2015/066648
申请日：2015-07-21
申请人： TBDIADIRECT AB
发明人： HAMASUR, Beston
IPC分类号： G01N33/569
CPC分类号： G01N33/5695
摘要： Methods for determining the presence of a surface polysaccharide antigen derivable from a mycobacterium, or a fragment of the antigen, a kit for performing the methods disclosed herein and use of monoclonal antibodies disclosed herein are provided. Furthermore, monoclonal antibody MAb 25 produced by the hybridoma cell line deposited under Accession No. DSM ACC3247 and/or monoclonal antibody MAb 170 produced by the hybridoma cell line deposited under Accession No. DSM ACC3246 are disclosed.
摘要翻译：提供了用于确定可从分枝杆菌或抗原片段衍生的表面多糖抗原的存在的方法，用于进行本文公开的方法的试剂盒和本文公开的单克隆抗体的用途。此外，公开了由保藏号DSM ACC3247保藏的杂交瘤细胞系产生的单克隆抗体MAb 25和/或以保藏号DSM ACC3246保藏的杂交瘤细胞系产生的单克隆抗体MAb 170。

10. 发明申请

WO2015164617A1 TUBERCULOSIS BIOMARKERS IN URINE AND USES THEREOF 审中-公开
标题翻译：尿液中的管状生物标志物及其用途
公开(公告)号：WO2015164617A1
公开(公告)日：2015-10-29
申请号：PCT/US2015/027318
申请日：2015-04-23
申请人： SOMALOGIC, INC.
发明人： OCHSNER, Urs , STERLING, David , KRAEMER, Stephen , JANJIC, Nebojsa
IPC分类号： G01N33/569 , A61K39/00
CPC分类号： G01N33/5695
摘要： The present application relates generally to biomarkers for tuberculosis infection and methods of detection thereof. In various embodiments, the invention relates to one or more biomarkers, biomarker panels, methods, devices, reagents, systems, and kits for detecting and/or characterizing tuberculosis infection in an individual from a urine sample.
摘要翻译：本申请一般涉及用于结核病感染的生物标志物及其检测方法。在各种实施方案中，本发明涉及用于检测和/或表征来自尿液样品的个体中的结核病感染的一种或多种生物标志物，生物标志物组合物，方法，装置，试剂，系统和试剂盒。

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