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1. 发明申请

WO02077183A2 IDENTIFICATION OF ESSENTIAL GENES IN MICROORGANISMS 审中-公开
标题翻译：鉴定微生物中的基因
公开(公告)号：WO02077183A2
公开(公告)日：2002-10-03
申请号：PCT/US0209107
申请日：2002-03-21
申请人： ELITRA PHARMACEUTICALS INC , WANG LIANGSU , ZAMUDIO CARLOS , MALONE CHERYL , HASELBECK ROBERT , OHLSEN KARI L , ZYSKIND JUDITH W , WALL DANIEL , TRAWICK JOHN D , CARR GRANT J , YAMAMOTO ROBERT , FORSYTH R ALLYN , XU H HOWARD
发明人： WANG LIANGSU , ZAMUDIO CARLOS , MALONE CHERYL , HASELBECK ROBERT , OHLSEN KARI L , ZYSKIND JUDITH W , WALL DANIEL , TRAWICK JOHN D , CARR GRANT J , YAMAMOTO ROBERT , FORSYTH R ALLYN , XU H HOWARD
IPC分类号： C07K14/195 , C07K14/20 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/235 , C07K14/24 , C07K14/245 , C07K14/25 , C07K14/255 , C07K14/26 , C07K14/265 , C07K14/285 , C07K14/295 , C07K14/30 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/34 , C07K14/35 , C07K14/355 , C07K14/37 , C07K14/38 , C07K14/40 , C12N
CPC分类号： C07K14/212 , C07K14/195 , C07K14/20 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/235 , C07K14/24 , C07K14/245 , C07K14/25 , C07K14/255 , C07K14/26 , C07K14/265 , C07K14/285 , C07K14/295 , C07K14/30 , C07K14/31 , C07K14/315 , C07K14/3156 , C07K14/32 , C07K14/33 , C07K14/34 , C07K14/35 , C07K14/355 , C07K14/37 , C07K14/38 , C07K14/40
摘要： The sequences of antisense nucleic acids which inhibit the proliferation of prokaryotes are disclosed. Cell-based assays which employ the antisense nucleic acids to identify and develop antibiotics are also disclosed. The antisense nucleic acids can also be used to identify proteins required for proliferation, express these proteins or portions thereof, obtain antibodies capable of specifically binding to the expressed proteins, and to use those expressed proteins as a screen to isolate candidate molecules for rational drug discovery programs. The nucleic acids can also be used to screen for homologous nucleic acids that are required for proliferation in cells other than Staphylococcus aureus, Salmonella typhimurium, Klebsiella pneumoniae, and Pseudomonas aeruginosa. The nucleic acids of the present invention can also be used in various assay systems to screen for proliferation required genes in other organisms.
摘要翻译：公开了抑制原核生物增殖的反义核酸序列。还公开了使用反义核酸鉴定和开发抗生素的基于细胞的测定法。反义核酸也可以用于鉴定增殖所需的蛋白质，表达这些蛋白质或其部分，获得能够特异性结合表达的蛋白质的抗体，并使用那些表达的蛋白质作为筛选来分离用于合理药物发现的候选分子程式。核酸也可用于筛选除金黄色葡萄球菌，鼠伤寒沙门氏菌，肺炎克雷伯菌和铜绿假单胞菌以外的细胞中增殖所需的同源核酸。本发明的核酸还可以用于各种测定系统以筛选其它生物体中所需的增殖基因。

2. 发明申请

WO2006111743A2 IDENTIFYING LANTIBIOTIC GENE CLUSTERS AND NOVEL LANTIBIOTIC GENES 审中-公开
标题翻译：鉴定生物基因群和新生土生物基因
公开(公告)号：WO2006111743A2
公开(公告)日：2006-10-26
申请号：PCT/GB2006001429
申请日：2006-04-20
申请人： PLANT BIOSCIENCE LTD , DODD HELEN , GASSON MICHAEL JOHN , MAYER MELINDA , NARBAD ARJAN
发明人： DODD HELEN , GASSON MICHAEL JOHN , MAYER MELINDA , NARBAD ARJAN
IPC分类号： C12Q1/68 , C07K14/355 , C07K14/36 , C12P1/06
CPC分类号： C07K14/36 , C12Q1/689
摘要： This invention provides a method for discovery of new lantibiotic pathways by mining available sequence information and by exploiting conserved regions in lantibiotic biosynthetic enzymes to design probes and PCR primers for analysis of un-studied organisms. We have found that lantibiotic biosynthetic enzymes are broadly distributed in Gram-positive. New pathways are being cloned and sequenced and their lantibiotic products are being defined and disclosed.
摘要翻译：本发明提供了一种通过挖掘可获得的序列信息和通过利用羊毛硫抗生素生物合成酶中的保守区域来设计探针和PCR引物来分析未研究的生物体的方法来发现新的羊毛硫抗生素途径。我们发现羊毛硫素生物合成酶广泛分布在革兰氏阳性菌中。正在克隆和测序新的途径，并且定义和披露其羊毛硫抗生素产品。

3. 发明申请

WO2002085093A2 REPLIKIN PEPTIDES AND USES THEREOF 审中-公开
标题翻译：替代肽及其用途
公开(公告)号：WO2002085093A2
公开(公告)日：2002-10-31
申请号：PCT/US2002/009240
申请日：2002-03-26
申请人： BOGOCH, Samuel , BOGOCH, Elenore, S.
发明人： BOGOCH, Samuel , BOGOCH, Elenore, S.
IPC分类号： G01N33/50 , A61K31/522 , A61K38/00 , A61K39/00 , A61K39/002 , A61K39/145 , A61P31/04 , A61P31/16 , A61P33/06 , C07K14/00 , C07K14/005 , C07K14/065 , C07K14/07 , C07K14/11 , C07K14/195 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/395 , C07K14/40 , C07K14/405 , C07K14/415 , C07K14/44 , C07K14/445 , C07K14/47 , C07K14/82 , C07K16/08 , C07K16/10 , C07K16/12 , C07K16/18 , C12N15/09 , C12Q1/02 , C12Q1/04 , C12Q1/68 , C12Q1/70 , G01N33/68
CPC分类号： C07K14/47 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/005 , C07K14/195 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/415 , C07K14/44 , C07K14/445 , C12N2710/24122 , C12N2760/16122 , Y02A50/412
摘要： Peptides of influenza virus hemagglutinin protein and Plasmodium falciparum malaria antigen, antibodies specific for the peptides, influenza vaccines, malaria vaccines and methods of stimulating the immune response of a subject to produce antibodies to influenza virus or malaria are disclosed. Also disclosed are methods for formulating vaccines for influenza virus. Isolated peptides of the Bacillus anthracis anthrax Toxin Lethal factor Protein pX01-107, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Bacillus anthracis Anthrax Toxin Lethal factor Protein pX01-107 are disclosed. Also disclosed are isolated peptides of the Small Pox Virus Surface Antigen S Precursor Protein, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Small Pox Virus Surface Antigen S Precursor Protein.
摘要翻译：公开了流感病毒血凝素蛋白和恶性疟原虫疟原虫抗原，肽特异性抗体，流感疫苗，疟疾疫苗和刺激受试者的免疫应答以产生抗流感病毒或疟疾的方法的肽。还公开了用于制定用于流感病毒的疫苗的方法。炭疽芽孢杆菌炭疽毒素致死致因子蛋白质pX01-107的分离肽，对肽有特异性的抗体和刺激受试者的免疫应答以产生针对炭疽芽孢杆菌的抗体的方法 >炭疽毒素致死因子蛋白质pX01-107被公开。还公开了小型痘病毒表面抗原S前体蛋白质的分离肽，对肽具有特异性的抗体以及刺激受试者的免疫应答以产生针对小痘病毒表面抗原S前体蛋白的抗体的方法。

4. 发明申请

WO98042753A1 NOVEL ANTIPLATELET AGENT 审中-公开
标题翻译：新型抗反射剂
公开(公告)号：WO98042753A1
公开(公告)日：1998-10-01
申请号：PCT/US1998/006092
申请日：1998-03-27
IPC分类号： A61K38/00 , C07K14/355 , C07K17/00 , A61K38/16
CPC分类号： C07K14/355 , A61K38/00
摘要： This invention combines the unique antiplatelet effects of S-nitrosothiols and the antiadhesive properties of fragments of vWF in the Al domain to provide unique molecules that exploit both of these properties. Preferred molecules comprise a fragment of Al (ala444-asp730) in which arginine at position 545 is replaced by cysteine (the most frequent von Willebrand disease type 2b mutation) that has been discovered to impair platelet adhesion, and to exhibit antithrombotic activity in vivo. This cysteine residue may be S-nitrosated to produce a novel molecule that has the potential for impairing platelet adhesion as well as activation/aggregation, and such molecules form the basis of a novel therapeutic method for impairing platelet responses following vascular injury or in other thrombotic disorders according to this invention.
摘要翻译：本发明结合了S-亚硝基硫醇的独特的抗血小板作用和vWF片段在Al结构域中的抗粘附性，以提供利用这两种特性的独特分子。优选的分子包含Al（ala444-asp730）的片段，其中545处的精氨酸被已发现损伤血小板粘附的半胱氨酸（最常见的血管性血友病血型B型突变）代替，并在体内显示出抗血栓形成活性。该半胱氨酸残基可以被S-亚硝化以产生具有损害血小板粘附和活化/聚集的潜力的新分子，并且这些分子形成用于损伤血管损伤或其它血栓形成后血小板反应的新型治疗方法的基础根据本发明的病症。

5. 发明申请

WO2021160827A2 PRODUCTION OF GLYCOSYLATED PRODUCT IN HOST CELLS 审中-公开
公开(公告)号：WO2021160827A2
公开(公告)日：2021-08-19
申请号：PCT/EP2021/053497
申请日：2021-02-12
申请人： INBIOSE N.V.
发明人： AESAERT, Sofie , BEAUPREZ, Joeri , COUSSEMENT, Pieter , DECOENE, Thomas , LANNOO, Nausicaä , PETERS, Gert , VANDEWALLE, Kristof
IPC分类号： C12P7/22 , C12N1/20 , C12N1/16 , C12N9/10 , C12P19/00 , C12P1/00 , C12N15/09 , C07K14/245 , C07K14/32 , C07K14/34 , C07K14/35 , C07K14/355 , C12N1/12 , C12N15/52 , C12N15/70 , C12N9/1048 , C12P19/02 , C12P19/04 , C12P19/12 , C12P19/18 , C12P19/26 , C12P19/44 , C12P21/005 , C12R2001/125 , C12R2001/15 , C12R2001/19 , C12R2001/32 , C12R2001/365 , C12R2001/89
摘要： The present invention is in the technical field of synthetic biology and metabolic engineering. The present invention provides engineered viable bacteria. In particular, the present invention provides viable bacteria with reduced cell wall biosynthesis additionally modified for production of glycosylated product. The present invention further provides methods of generating viable bacteria and uses thereof. Furthermore, the present invention is in the technical field of fermentation of metabolically engineered microorganisms producing glycosylated product.

6. 发明申请

WO2009024572A1 METHOD FOR THE PRODUCTION OF MODIFIED STEROID DEGRADING MICROORGANISMS AND THEIR USE 审中-公开
标题翻译：生产改性的甾体降解微生物的方法及其使用
公开(公告)号：WO2009024572A1
公开(公告)日：2009-02-26
申请号：PCT/EP2008/060844
申请日：2008-08-19
申请人： N.V. ORGANON , VAN DER GEIZE, Robert , HESSELS, Gerda , DIJKHUIZEN, Lubbert
发明人： VAN DER GEIZE, Robert , HESSELS, Gerda , DIJKHUIZEN, Lubbert
IPC分类号： C07K14/355 , C12P33/00 , C12P7/26 , C12P7/40
CPC分类号： C12N9/10 , C12N9/001 , C12P7/26 , C12P7/40 , C12P7/42 , C12P33/00
摘要： A method is described to construct genetically modified strains of steroid degrading micro-organisms wherein the method comprises inactivation of at least one gene involved in methylhexahydroindanedione propionate degradation. Strains with (multiple) inactivated steroid degrading enzyme genes according to the invention can be used in the accumulation of steroid intermediates. Accumulation products are for example 3aα-H-4α (3-'propionic acid)-7aβ- methylhexahydro-1,5-indanedione (HIP), 3-hydroxy-9,10-secoandrosta- 1,3,5(10)-thene-9,17-dione (3-HSA), 1,4-androstadiene-3,17-dione (ADD) and 3aα-H-4α(3'-propionic acid)-5α-hydroxy-7aβ-methylhexahydro-1 -indanone-δ- lactone (HIL).
摘要翻译：描述了一种构建基因修饰的类固醇降解微生物菌株的方法，其中所述方法包括使参与甲基六氢茚满酮丙酸酯降解的至少一个基因的失活。具有根据本发明的（多个）灭活的类固醇降解酶基因的菌株可用于类固醇中间体的积累。累积产物例如为3aa-H-4a（3-丙酸）-7α-甲基六氢-1,5-茚二酮（HIP），3-羟基-9,10-雄甾-1,3,5（10） - （3-HSA），1,4-雄甾二烯-3,17-二酮（ADD）和3aa-H-4a（3'-丙酸）-5α-羟基-7α-甲基六氢-1 - 茚满酮 - 内酯（HIL）。

7. 发明申请

WO2006111743A3 IDENTIFYING LANTIBIOTIC GENE CLUSTERS AND NOVEL LANTIBIOTIC GENES 审中-公开
公开(公告)号：WO2006111743A3
公开(公告)日：2006-10-26
申请号：PCT/GB2006/001429
申请日：2006-04-20
申请人： PLANT BIOSCIENCE LIMITED , DODD, Helen , GASSON, Michael, John , MAYER, Melinda , NARBAD, Arjan
发明人： DODD, Helen , GASSON, Michael, John , MAYER, Melinda , NARBAD, Arjan
IPC分类号： C12Q1/68 , C07K14/36 , C07K14/355 , C12P1/06
摘要： This invention provides a method for discovery of new lantibiotic pathways by mining available sequence information and by exploiting conserved regions in lantibiotic biosynthetic enzymes to design probes and PCR primers for analysis of un-studied organisms. We have found that lantibiotic biosynthetic enzymes are broadly distributed in Gram-positive. New pathways are being cloned and sequenced and their lantibiotic products are being defined and disclosed.

8. 发明申请

WO2020155242A1 一种突变NfpAB纳米孔、测试系统及制作方法与应用审中-公开
公开(公告)号：WO2020155242A1
公开(公告)日：2020-08-06
申请号：PCT/CN2019/076037
申请日：2019-02-25
申请人：深圳市梅丽纳米孔科技有限公司
发明人：李伟 , 周智 , 文豪
IPC分类号： G01N27/447 , C07K14/355
摘要：一种突变NfpAB纳米孔，其为由至少一个NfpA蛋白突变单体和NfpB蛋白突变单体组成的蛋白复合体，或为由至少两个NfpA与NfpB融合突变基因表达的突变单体组成的蛋白复合体。其具有与已知纳米孔不同的结构和识别位点，能用于核酸、多肽、蛋白质等多聚物的鉴定、浓度检测及测序其允许捕捉及转移单链DNA并区分腺嘌呤(A)，胸腺嘧啶(T)，胞嘧啶(C)及鸟嘌呤(G)。NfpAB突变体由两个不同单体组合而成，丰富了孔道内部的改造空间，孔道具有类似MspA的锥形孔道结构，是核酸测序的理想孔道。还公开了含有该纳米孔的测试系统、制作方法及应用，通过对纳米孔内部的工程化定点突变，调整孔道内部的电荷分布，降低核酸穿过孔道时的速度，实现了碱基精准识别。

9. 发明申请

WO2019118113A1 BIOLOGICAL UPGRADING OF HYDROCARBON STREAMS WITH DIOXYGENASES 审中-公开
公开(公告)号：WO2019118113A1
公开(公告)日：2019-06-20
申请号：PCT/US2018/060267
申请日：2018-11-12
申请人： EXXONMOBIL RESEARCH AND ENGINEERING COMPANY
发明人： SUMMERS, Zarath, M. , MARLER, David, O. , PATEL, Jay, B. , LANDUYT, Katherine, G.
IPC分类号： C10G32/00 , C07K14/195 , C07K14/21 , C07K14/355 , C12N9/02
CPC分类号： E21B43/16 , C09K8/58 , C10G32/00 , C10G2300/202 , C10G2300/205 , C10G2300/206 , C12N9/0071 , C12N9/0095 , C12N15/52 , C12Y114/12012 , C12Y118/01002
摘要： Dioxygenases and methods of biologically upgrading hydrocarbon streams, such as crude oil, using dioxygenases are provided herein. The dioxygenases can be used to remove impurities such as metals, heteroatoms, or asphaltenes from a hydrocarbon stream. In some cases, the dioxygenases can be chemically or genetically modified and can be used in different locations such as petroleum wells, pipes, reservoirs, tanks and/or reactors.

10. 发明申请

WO2006111743A9 IDENTIFYING LANTIBIOTIC GENE CLUSTERS AND NOVEL LANTIBIOTIC GENES 审中-公开
标题翻译：鉴定生物基因群和新生土生物基因
公开(公告)号：WO2006111743A9
公开(公告)日：2007-04-05
申请号：PCT/GB2006001429
申请日：2006-04-20
申请人： PLANT BIOSCIENCE LTD , DODD HELEN , GASSON MICHAEL JOHN , MAYER MELINDA , NARBAD ARJAN
发明人： DODD HELEN , GASSON MICHAEL JOHN , MAYER MELINDA , NARBAD ARJAN
IPC分类号： C12Q1/68 , C07K14/355 , C07K14/36 , C12P1/06
CPC分类号： C07K14/36 , C12Q1/689
摘要： This invention provides a method for discovery of new lantibiotic pathways by mining available sequence information and by exploiting conserved regions in lantibiotic biosynthetic enzymes to design probes and PCR primers for analysis of un-studied organisms. We have found that lantibiotic biosynthetic enzymes are broadly distributed in Gram-positive. New pathways are being cloned and sequenced and their lantibiotic products are being defined and disclosed.
摘要翻译：本发明提供了一种通过挖掘可获得的序列信息和通过利用羊毛硫抗生素生物合成酶中的保守区域来设计探针和PCR引物来分析未研究的生物体的方法来发现新的羊毛硫抗生素途径。我们发现羊毛硫素生物合成酶广泛分布在革兰氏阳性菌中。正在克隆和测序新的途径，并且定义和披露其羊毛硫抗生素产品。

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