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1. 发明申请

WO2005039500A3 METHOD FOR THE PRODUCTION OF BIOACTIVE SUBSTANCES FROM THE NOVEL ACTINOMYCETE TAXON MAR2 ("Marinophilus") 审中-公开
标题翻译：从新型ACTINOMYCETE TAXON MAR2（“Marinophilus”）生产生物活性物质的方法
公开(公告)号：WO2005039500A3
公开(公告)日：2009-04-02
申请号：PCT/US2004035219
申请日：2004-10-25
申请人： UNIV CALIFORNIA , FENICAL WILLIAM H , JENSEN PAUL R , MINCER TRACY
发明人： FENICAL WILLIAM H , JENSEN PAUL R , MINCER TRACY
IPC分类号： C12N1/20 , A61K31/7048 , A61K35/74 , C07D321/00 , C07H17/08 , C12P1/00 , C12P1/06 , C12P19/62 , C12P21/04
CPC分类号： C07D321/00 , A61K31/7048 , C07H17/08 , C12P1/06 , C12R1/01
摘要： The present invention provides methods for the isolation of a new group of actinomycetes and for the identification of members of this group based on characteristic nucleotide sequences and phylogenetic analyses. This group is phylogenetically distinct from all other known actinomycetes and represents a novel genus that includes multiple new species. Members of this group can be recognized by signature MAR2 nucleotides present in their 16S rRNA gene sequences and by standard phylogenetic treeing methods.
摘要翻译：本发明提供了基于特征性核苷酸序列和系统发育分析来分离新组放线菌和鉴定该组成员的方法。该组与所有其他已知的放线菌在系统发育上是不同的，并且代表一种包括多种新物种的新颖属。该组的成员可以通过其16S rRNA基因序列中存在的签名MAR2核苷酸和标准系统发育树方法来识别。

2. 发明申请

WO2005025490A3 NOVEL POLYOL MACROLIDE ANTITUMOR-ANTIBIOTICS FROM THE NOVEL MARINE ACTINOMYCETE STRAIN CNQ140 审中-公开
标题翻译：来自新型海洋ACTINOMYCETE菌株CNQ140的新型多元醇抗肿瘤抗生素
公开(公告)号：WO2005025490A3
公开(公告)日：2007-11-01
申请号：PCT/US2004019916
申请日：2004-06-21
申请人： UNIV CALIFORNIA , FENICAL WILLIAM H , JENSEN PAUL R , KWON HAK CHEOL
发明人： FENICAL WILLIAM H , JENSEN PAUL R , KWON HAK CHEOL
IPC分类号： C07H17/08 , A61K31/665 , A61K31/70 , A61K31/7048 , A61K45/06 , C07D321/00 , C12N1/20 , C12P1/06 , C12P17/08
CPC分类号： C12P1/06 , A61K31/7048 , A61K45/06 , C07D321/00 , C07H17/08 , C12N1/20 , C12P17/08 , C12R1/01
摘要： A novel family of cyclic polyene natural products isolated from marine actinomycete strain CNQ 140 is provided. This novel strain of actinomycetes was obtained from a previously unstudied population of marine actinomycetes that reside in sediments off La Jolla, California. Compounds derived from strain CNQ 140 have been characterized as having a cyclic polyene-polyol structure; a molecular weight from about 996 to about 1010 in the core ring structure; and at least 58 carbons and at least 14 oxygens. The invention compounds have antitumor and/or anti-microbial activity.
摘要翻译：提供了从海洋放线菌株CNQ 140中分离的环状多烯天然产物的新家族。这种新型放线菌菌株是从加利福尼亚州拉霍亚（La Jolla）沉积物中存在的海洋放线菌以前未经研究的群体获得的。衍生自应变CNQ 140的化合物已被表征为具有环状多烯 - 多元醇结构; 核心环结构中分子量约996至约1010; 和至少58个碳和至少14个氧。本发明化合物具有抗肿瘤和/或抗微生物活性。

3. 发明申请

WO2006111743A9 IDENTIFYING LANTIBIOTIC GENE CLUSTERS AND NOVEL LANTIBIOTIC GENES 审中-公开
标题翻译：鉴定生物基因群和新生土生物基因
公开(公告)号：WO2006111743A9
公开(公告)日：2007-04-05
申请号：PCT/GB2006001429
申请日：2006-04-20
申请人： PLANT BIOSCIENCE LTD , DODD HELEN , GASSON MICHAEL JOHN , MAYER MELINDA , NARBAD ARJAN
发明人： DODD HELEN , GASSON MICHAEL JOHN , MAYER MELINDA , NARBAD ARJAN
IPC分类号： C12Q1/68 , C07K14/355 , C07K14/36 , C12P1/06
CPC分类号： C07K14/36 , C12Q1/689
摘要： This invention provides a method for discovery of new lantibiotic pathways by mining available sequence information and by exploiting conserved regions in lantibiotic biosynthetic enzymes to design probes and PCR primers for analysis of un-studied organisms. We have found that lantibiotic biosynthetic enzymes are broadly distributed in Gram-positive. New pathways are being cloned and sequenced and their lantibiotic products are being defined and disclosed.
摘要翻译：本发明提供了一种通过挖掘可获得的序列信息和通过利用羊毛硫抗生素生物合成酶中的保守区域来设计探针和PCR引物来分析未研究的生物体的方法来发现新的羊毛硫抗生素途径。我们发现羊毛硫素生物合成酶广泛分布在革兰氏阳性菌中。正在克隆和测序新的途径，并且定义和披露其羊毛硫抗生素产品。

4. 发明申请

WO2006052787A3 LIQUEFACTION OF STARCH-CONTAINING MATERIAL 审中-公开
标题翻译：含淀粉材料的液化
公开(公告)号：WO2006052787A3
公开(公告)日：2006-08-31
申请号：PCT/US2005040098
申请日：2005-11-04
申请人： NOVOZYMES NORTH AMERICA INC , ICM INC , BHARGAVA SWAPNIL , KOHL SCOTT DENNIS
发明人： BHARGAVA SWAPNIL , KOHL SCOTT DENNIS
IPC分类号： A61K38/43 , A61K38/46 , C12N9/00 , C12N9/14 , C12N9/28 , C12N9/30 , C12N9/54 , C12N9/62 , C12P1/02 , C12P1/04 , C12P1/06 , C12P7/06 , C12P7/08
CPC分类号： C12P19/14 , C12P7/10 , Y02E50/16 , Y02E50/17
摘要： The present invention relates to method of liquefying starch-containing material, wherein starch-containing material is subjected to a bacterial alpha-amylase at (a) a temperature around 50-80°C for 10-180 minutes, followed by (b) treatment at a higher temperature than used in step (a) for 1-60 minutes.
摘要翻译：本发明涉及液化含淀粉材料的方法，其中含淀粉材料在（a）约50-80℃的温度下经受10-180分钟的细菌α-淀粉酶，接着（b）处理在比步骤（a）中使用的时间更高的温度下进行1-60分钟。

5. 发明申请

WO02101051A3 GENES AND PROTEINS FOR THE BIOSYNTHESIS OF ANTHRAMYCIN 审中-公开
标题翻译：氨基酸生物合成的基因和蛋白质
公开(公告)号：WO02101051A3
公开(公告)日：2003-04-10
申请号：PCT/CA0200864
申请日：2002-06-11
申请人： ECOPIA BIOSCIENCES INC , STAFFA ALFREDO , FARNET CHRIS M
发明人： STAFFA ALFREDO , FARNET CHRIS M
IPC分类号： C07K14/36 , C12N1/21 , C12N15/31 , C12N15/52 , C12N15/63 , C12P1/06
CPC分类号： C12N15/52 , C07K14/36
摘要： Genes and proteins involved in the biosynthesis of benzodiazepines by microorganisms, including the genes and proteins forming the biosynthetic loci for the benzodiazepine anthramycin from Streptomyces refuineus subsp. thermotolerans. The genes and proteins allow direct manipulation of benzodiazepines and related chemical structures via chemical engineering of the enzymes involved in the biosynthesis of anthramycin.
摘要翻译：参与苯并二氮杂类生物合成的基因和蛋白质，包括从链霉菌（Streptomyces refuineus subsp。）中形成苯并二氮杂蒽环霉素生物合成基因座的基因和蛋白质。 thermotolerans。基因和蛋白质可以通过化学工程来参与蒽环霉素的生物合成来直接操作苯并二氮杂类和相关的化学结构。

6. 发明申请

WO0176612A8 METHOD FOR PRODUCING NEMATOCIDAL COMPOSITION BY HEAT TREATING A pH-ADJUSTED FERMENTATION BROTH 审中-公开
标题翻译：通过热处理pH调节发酵豆生产杀虫组合物的方法
公开(公告)号：WO0176612A8
公开(公告)日：2002-06-20
申请号：PCT/US0111699
申请日：2001-04-10
申请人： VALENT BIOSCIENCES CORP , WARRIOR PREM , HEIMAN DANIEL F , REHBERGER LINDA A , JOHNSON RONALD E , HANSEN JAMES R , MCVICKER KEVIN A
发明人： WARRIOR PREM , HEIMAN DANIEL F , REHBERGER LINDA A , JOHNSON RONALD E , HANSEN JAMES R , MCVICKER KEVIN A
IPC分类号： C12P1/02 , A01N61/00 , A01N63/00 , A01N63/02 , A61K35/66 , A61K35/74 , A61K36/06 , A61K36/062 , C12N1/20 , C12P1/00 , C12P1/04 , C12P1/06 , A61K35/84
CPC分类号： A61K35/74 , A01N63/02 , A61K35/742 , A61K36/06 , A61K36/062 , C12P1/02 , C12P1/04
摘要： The present invention is directed to a method for producing a new nematocidal composition particularly useful against plant parasitic nematodes and also a process to prevent damage resulting from nematode infestation. The method for production of the composition involves heating a pH-adjusted fermentation broth of microorganisms to a temperature of at least about 100 DEG C for at least about 15 minutes. Preferably, the microorganism is Gibberella fujikuroi, Streptomyces erythraeus, Bacillus sphaericus, Bacillus thuringiensis or Fusarium moniliforme .
摘要翻译：本发明涉及一种用于生产特别适用于植物寄生线虫的新型杀线虫组合物的方法，还涉及一种防止线虫侵袭引起的损害的方法。制备组合物的方法包括将pH调节的微生物发酵液加热到至少约100℃的温度至少约15分钟。优选地，微生物是赤霉病，红链霉菌，球形芽孢杆菌，苏云金芽孢杆菌或镰孢镰刀菌。

7. 发明申请

WO00058482A2 TRANSDUCING PHAGES 审中-公开
标题翻译：传输机构
公开(公告)号：WO00058482A2
公开(公告)日：2000-10-05
申请号：PCT/US2000/007771
申请日：2000-03-23
IPC分类号： C12N15/09 , C12N1/21 , C12N7/00 , C12N15/76 , C12P1/06 , C12R1/465 , C12R1/92
CPC分类号： C12R1/465 , C12N15/76 , C12R1/91
摘要： The present invention is directed to isolated transducing phages, methods of isolating transducing phages, and methods of using transducing phages including, for instance, transferring at least one nucleic acid fragment from a donor microbe to a recipient microbe, and producing a secondary metabolite from a microbe. The transducing phages typically have a broad host range, and transduce microbes in the Order Actinomycetales, in particular in the Family Streptomycetaceae, including Streptomyces coelicolor, Streptomyces lividans, Streptomyces venezuelae, Streptomyces avermitilis, and Saccharopolyspora erythraea. The transducing phages can be specialized transducing phages or generalized transducing phages.
摘要翻译：本发明涉及分离的转导噬菌体，分离转导噬菌体的方法，以及使用转导性噬菌体的方法，包括例如将至少一种核酸片段从供体微生物转移至受体微生物，以及从微生物。转导噬菌体通常具有广泛的宿主范围，并且在放线菌纲中转导微生物，特别是在家族链霉菌科，包括天蓝色链霉菌（Streptomyces coelicolor），变形链霉菌（Streptomyces lividans），维生素链霉菌（Streptomyces venezuelae），阿维链霉菌（Streptomyces avermitilis）和糖酵母（Saccharopolyspora erythraea）中。转导噬菌体可以是专门的转化噬菌体或广泛转导的噬菌体。

8. 发明申请

WO99055895A1 A NEW GLUCOSE-6-PHOSPHATE TRANSLOCASE INHIBITOR L 970871 FROM AN ACTINOMYCETE SP., AND CHEMICAL DERIVATIVES THEREOF, A PROCESS FOR THE PREPARATION AND THEIR USE AS PHARMACEUTICALS 审中-公开
标题翻译：来自ACTINOMYCETE SP。的新型GLUCOSE-6-PHOSPHATE TRANSLOCASE抑制剂L 970871及其化学衍生物，制备方法及其作为药物的用途
公开(公告)号：WO99055895A1
公开(公告)日：1999-11-04
申请号：PCT/EP1999/002670
申请日：1999-04-21
IPC分类号： C12P1/06 , C12P15/00 , C12P7/00 , C12N1/20 , A61K31/00 , C12R1/04
CPC分类号： C12P15/00 , C12P1/06 , C12R1/04
摘要： The present invention relates to a novel glucose-6-phosphate translocase inhibitor L 970871, which is produced by an Actinomycete sp. (culture number HIL-007997) during fermentation, a process for its preparation, to chemical derivatives derived from compound L 970871, to the use of compound L 970871 and derivatives derived therefrom and pharmacological active substances, as medicament and, in particular, for the treatment of diabetes mellitus, and to an Actinomycete sp. HIL-007997(DSM 11993) for producing the abovementioned compound L 970871.
摘要翻译：本发明涉及一种新型的葡萄糖-6-磷酸转位酶抑制剂L 970871，其由放线菌属（Proinomycete sp。（培养物编号HIL-007997），其制备方法，衍生自化合物L 970871的化学衍生物，使用化合物L 970871及其衍生物及其药理活性物质作为药物，特别是用于治疗糖尿病，以及放线菌属（Actinomycete sp。 HIL-007997（DSM 11993），用于制备上述化合物L 970871。

9. 发明申请

WO8807580A3 BIOPHYSICALLY DERIVED ASCOMYCETES,SCHIZOMYCETES AND YEAST PREPARATION,PROCESS FOR THE MANUFACTURE THEREOF AND FODDER AND PLANT HORMONES CONTAINING THIS PREPARATION,AND USE OF THE PREPARATIONS FOR SKIN TREATMENT AND PROBIOTIC ACTIVATION 审中-公开
标题翻译：生物衍生的ASCOMYCETES，SCHIZOMYCETES和YEAST制备，其制备方法以及含有本制剂的制剂和植物HORMONES，以及使用制剂进行皮肤治疗和生物活化
公开(公告)号：WO8807580A3
公开(公告)日：1988-11-17
申请号：PCT/DE8800212
申请日：1988-03-31
申请人： SOCOP NAHRUNGSMITTEL , WANK ANNA
发明人： WANK ANNA
IPC分类号： A01N63/00 , A01N63/02 , A01N63/04 , A23C9/127 , A23C9/13 , A23K10/18 , A61K8/99 , A61K36/06 , A61K36/062 , A61K36/48 , A61P17/00 , A61Q19/00 , C05F11/08 , C12N1/16 , C12N9/58 , C12P1/00 , C12P1/06 , A23K1/00
CPC分类号： C12N9/58 , A01N63/00 , A01N63/04 , A23C9/127 , A23C9/1322 , A23K10/18 , A61K8/99 , A61K36/06 , A61K36/062 , A61K36/48 , A61K2800/782 , A61K2800/85 , A61Q19/00 , A61K2300/00
摘要： A biophysically derived yeast preparation is proposed which stimulates respiration in liver homogenate, contains an L-amino acid oxidase inhibiting factor, and exhibits excellent cicatrization properties and RES-stimulating action. The process for manufacturing the yield preparation consists in treating an initial yeast, if necessary with addition of a liquid support, until a light resuspended material is obtained, followed by a brief thermal shock treatment until gases are evolved by fermentation. In addition, fodder and plant hormone solutions containing these biophysically derived yeasts are proposed.

10. 发明申请

WO2020072908A1 BIOSYNTHESIS AND RECOVERY OF SECONDARY METABOLITES 审中-公开
公开(公告)号：WO2020072908A1
公开(公告)日：2020-04-09
申请号：PCT/US2019/054703
申请日：2019-10-04
申请人： MANUS BIO, INC.
发明人： LOVE, Aaron , GHADERI, Adel , DONALD, Jason, Eric , SANTOS, Christine, Nicole, S. , KUMARAN, Ajikumar, Parayil
IPC分类号： C12N1/20 , C12N1/26 , C12P1/04 , C12P1/06 , C12P7/00 , C12P19/00 , C12P23/00 , C12P33/00
摘要： Aspects of the invention provide methods for producing one or more secondary metabolites from microbial culture. In various embodiments, the method comprises culturing a microbial cell producing a secondary metabolite for recovery from a bioreactor medium, the medium comprising an aqueous phase and an extraction phase. The composition of the extraction phase, and the relevant amount with respect to the aqueous phase, enhances production of the secondary metabolite from microbial cells and/or enhances extracellular transfer of the metabolite.

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