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1. 发明申请

WO2017079699A1 MULTIPLEX HIGH-RESOLUTION DETECTION OF MICRO-ORGANISM STRAINS, RELATED KITS, DIAGNOSTICS METHODS AND SCREENING ASSAYS 审中-公开
标题翻译：微生物菌株的多重高分辨率检测，相关试剂盒，诊断方法和筛选试验
公开(公告)号：WO2017079699A1
公开(公告)日：2017-05-11
申请号：PCT/US2016/060730
申请日：2016-11-04
申请人： THE BROAD INSTITUTE, INC. , THE GENERAL HOSPITAL CORPORATION , HUNG, Deborah , JOHNSON, Eachan , POULSEN, Brad
发明人： HUNG, Deborah , JOHNSON, Eachan , POULSEN, Brad
IPC分类号： A61K38/16 , A61K38/17 , A61K38/43 , A61K39/02
CPC分类号： A61K39/02 , C07K14/21 , C07K14/35 , C12N15/00 , C12Q1/18
摘要： The present invention relates to multiplex high-resolution detection of micro-organism strains. It provides kits, diagnostics methods and screening assays.
摘要翻译：本发明涉及微生物菌株的多重高分辨率检测。它提供试剂盒，诊断方法和筛选分析。

2. 发明申请

WO2017067964A1 P. AERUGINOSA PCRV-LINKED ANTIGEN VACCINES 审中-公开
标题翻译： P. AERUGINOSA PCRV-连接的抗原疫苗
公开(公告)号：WO2017067964A1
公开(公告)日：2017-04-27
申请号：PCT/EP2016/075048
申请日：2016-10-19
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A.
发明人： FERON, Christiane Marie-Paule Simone Jeanne , KEMMLER, Stefan Jochen , KOWARIK, Michael Thomas , QUEBATTE, Julien Laurent
IPC分类号： A61K39/104 , A61K39/385 , C07K14/21 , A61P31/04 , A61K39/00
CPC分类号： A61K39/104 , A61K39/385 , A61K45/06 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/6068 , A61K2039/6087 , A61K2039/64 , C07K14/21 , C07K2319/00 , Y02A50/47
摘要： The present invention discloses a conjugate comprising an antigen (for example a saccharide antigen) covalently linked to a Pseudomonas aeruginosa PcrV carrier protein comprising an amino acid sequence which is at least 80% identical to the sequence of SEQ ID NO:1-4, wherein the antigen is linked (either directly or through a linker) to an amino acid residue of the P. aeruginosa PcrV carrier protein. The invention also discloses Pseudomonas aeruginosa PcrV proteins that contain glycosylation site consensus sequences.
摘要翻译：本发明公开了包含与铜绿假单胞菌PcrV载体蛋白共价连接的抗原（例如糖抗原）的缀合物，所述抗原包含与SEQ ID NO：1的序列至少80％相同的氨基酸序列其中抗原连接（直接或通过接头）至铜绿假单胞菌PcrV载体蛋白的氨基酸残基。本发明还公开了含有糖基化位点共有序列的铜绿假单胞菌PcrV蛋白质。

3. 发明申请

WO2016196383A1 VACCINE COMPOSITIONS AGAINST PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME AND PORCINE CIRCOVIRUS ASSOCIATED DISEASES 审中-公开
标题翻译：烟草组合物对磷酸盐生殖因子和呼吸道综合征和猪血友病相关疾病的影响
公开(公告)号：WO2016196383A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/034858
申请日：2016-05-27
申请人： REBER GENETICS CO., LTD. , HEALTHBANKS BIOTECH USA INC.
发明人： CHIEN, Yu-Hsin , TSAI, Meng-Ju , LAI, Pao-Yen , CHOU, Wei-I , CHANG, Hsiu-Kang
IPC分类号： A61K39/02 , A61K39/10 , A61K39/104
CPC分类号： A61K39/12 , A61K2039/70 , C07K14/005 , C07K14/21 , C07K2319/04 , C07K2319/095 , C07K2319/55 , C07K2319/74 , C12N2750/10022 , C12N2750/10034 , C12N2770/10022 , C12N2770/10034
摘要： A fusion protein comprising an antigen-presenting cell (APC)-binding domain or a CD91 receptor-binding domain, a translocation peptide, a fusion antigen, an endoplasmic reticulum retention sequence, and optionally a nuclear export signal is disclosed. The fusion antigen comprises a porcine reproductive and respiratory syndrome virus (PRRSV) ORF7 antigen, a PRRSV ORF1b antigen, a PRRSV ORF6 antigen, and a PRRSV ORF5 antigen. The fusion protein is useful for inducing antigen-specific cell-mediated and humoral responses.
摘要翻译：公开了包含抗原呈递细胞（APC）结合结构域或CD91受体结合结构域，易位肽，融合抗原，内质网保留序列和任选的核导出信号的融合蛋白。融合抗原包括猪繁殖与呼吸综合征病毒（PRRSV）ORF7抗原，PRRSV ORF1b抗原，PRRSV ORF6抗原和PRRSV ORF5抗原。融合蛋白可用于诱导抗原特异性细胞介导的和体液应答。

4. 发明申请

WO2016186986A1 INSECTICIDAL PROTEINS AND METHODS FOR THEIR USE 审中-公开
公开(公告)号：WO2016186986A1
公开(公告)日：2016-11-24
申请号：PCT/US2016/032273
申请日：2016-05-13
申请人： PIONEER HI BRED INTERNATIONAL INC
发明人： KOZY, Heather , ORAL, Jarred , SCHELLENBERGER, Ute , WEI, Jun-Zhi , XIE, Weiping , ZHONG, Xiaohong , ZHU, Genhai
IPC分类号： C12N15/82 , C07K14/195
CPC分类号： C12N15/8242 , C07K14/21 , C07K2319/21
摘要： Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.

5. 发明申请

WO2016168709A1 DIRECTED DIFFERENTIATION OF PLURIPOTENT STEM CELLS BY BACTERIAL INJECTION OF TALEN PROTEINS 审中-公开
标题翻译：通过细菌注射TALEN蛋白质对PLUIPOTETI干细胞的指导性鉴定
公开(公告)号：WO2016168709A1
公开(公告)日：2016-10-20
申请号：PCT/US2016/027904
申请日：2016-04-15
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
发明人： JIN, Shouguang , TERADA, Naohiro , BAI, Fang
IPC分类号： A61K35/74 , A61K39/104 , C07K14/21 , C12N15/78 , C12N15/87 , C12R1/385
CPC分类号： C12N9/22 , A61K35/74 , C07K14/21 , C07K2319/80 , C12N5/0657 , C12N15/78 , C12N2501/16 , C12N2501/60 , C12N2506/02 , C12N2510/00
摘要： In some aspects, the disclosure relates to methods and compositions for delivery of proteins into mammalian cells. In some embodiments, the disclosure provides a genetically engineered bacterium that may be useful for delivery of proteins into mammalian cells. In some aspects, the disclosure relates to improved methods of bacterially-mediated protein delivery.
摘要翻译：在一些方面，本公开涉及将蛋白质递送到哺乳动物细胞中的方法和组合物。在一些实施方案中，本公开提供了可用于将蛋白质递送到哺乳动物细胞中的遗传工程化的细菌。在一些方面，本公开涉及细菌介导的蛋白质递送的改进方法。

6. 发明申请

WO2016144686A1 STRUCTURE BASED METHODS FOR MODIFICATION OF PIP-72 POLYPEPTIDES AND PIP-72 POLYPEPTIDES DERIVED THEREFROM 审中-公开
标题翻译：基于结构的PIP-72多肽和PIP-72多肽衍生物的修饰方法
公开(公告)号：WO2016144686A1
公开(公告)日：2016-09-15
申请号：PCT/US2016/020634
申请日：2016-03-03
申请人： PIONEER HI-BRED INTERNATIONAL, INC.
发明人： LIU, Lu , ORAL, Jarred Kenneth , POLAND, Brad , SCHELLENBERGER, Ute
IPC分类号： C12N15/82 , C07K14/415 , C07K14/21 , A01N65/00
CPC分类号： C07K14/21 , A01N63/02 , C12N15/8286 , Y02A40/162
摘要： Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity. Structure based methods for engineering insecticidal proteins of the disclosure to have modified physical properties are provided.
摘要翻译：提供了控制害虫的组成和方法。该方法涉及用编码杀虫蛋白的核酸序列转化生物体。特别地，核酸序列可用于制备具有杀虫活性的植物和微生物。因此，提供了转化的细菌，植物，植物细胞，植物组织和种子。组合物是杀虫的核酸和细菌物种的蛋白质。这些序列用于构建表达载体，用于随后转化为感兴趣的生物体，包括植物，作为分离其他同源（或部分同源的）基因的探针。杀虫蛋白用于控制，抑制生长或杀死鳞翅目，鞘翅目，双翅目，真菌，半翅目和线虫害虫种群并生产具有杀虫活性的组合物。提供了具有改进的物理性质的本发明的用于工程化杀虫蛋白的基于结构的方法。

7. 发明申请

WO2016049510A3 CELL-BASED TARGETED DELIVERY OF PSEUDONOMAS EXOTOXIN 审中-公开
标题翻译：基于细胞的靶向递送假单胞菌外毒素
公开(公告)号：WO2016049510A3
公开(公告)日：2016-05-19
申请号：PCT/US2015052322
申请日：2015-09-25
申请人： GEN HOSPITAL CORP
发明人： SHAH KHALID
IPC分类号： A61K48/00 , C12N15/85
CPC分类号： C07K14/21 , A61K35/28 , A61K35/30 , A61K35/545 , C07K14/5437 , C07K2319/55 , C12N2510/02 , C12N2740/16043 , C12N2840/203
摘要： Embodiments herein provide engineered mammalian cells, compositions comprising these cells and methods for targeted cancer therapy using cytotoxins derived from Pseudonomas sp. Specifically, it relates to cell-based, targeted in vivo delivery of Pseudonomas exotoxin (PE) for cancer therapy.
摘要翻译：本文中的实施方案提供工程改造的哺乳动物细胞，包含这些细胞的组合物以及使用来自假性瘤细胞的细胞毒素进行靶向癌症治疗的方法。具体而言，它涉及用于癌症治疗的基于细胞的靶向体内递送假性瘤外毒素（PE）。

8. 发明申请

WO2016046218A1 PULMONARY ADMINISTRATION OF PYOCINS FOR TREATING BACTERIAL RESPIRATORY INFECTIONS 审中-公开
标题翻译：用于治疗细菌性呼吸道感染的磷酸盐的脉冲施用
公开(公告)号：WO2016046218A1
公开(公告)日：2016-03-31
申请号：PCT/EP2015/071768
申请日：2015-09-22
申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW
发明人： WALKER, Daniel , MCCAUGHEY, Laura
IPC分类号： A61K38/16 , A61K9/00 , C07K14/21 , A61P31/04
CPC分类号： C07K14/21 , A61K9/0073 , A61K38/00 , A61K38/164
摘要： The invention relates to the treatment of bacterial respiratory infections using the bacterially-originating antibiotics known as pyocins. In particular, the invention provides the use of S-type pyocins, administered by pulmonary administration, for the treatment of such infections.
摘要翻译：本发明涉及使用称为py虫的细菌来源的抗生素治疗细菌性呼吸道感染。特别地，本发明提供了通过肺部给药施用的S型py虫的用途，用于治疗这种感染。

9. 发明申请

WO2015051199A3 MODIFIED PSEUDOMONAS EXOTOXIN A 审中-公开
标题翻译：修饰的假单胞菌外毒素A
公开(公告)号：WO2015051199A3
公开(公告)日：2015-08-27
申请号：PCT/US2014058941
申请日：2014-10-03
申请人： US HEALTH , HOFFMANN LA ROCHE , HOFFMANN LA ROCHE
发明人： PASTAN IRA H , MAZOR RONIT , ONDA MASANORI , LEE BYUNGKOOK , NIEDERFELLNER GERHARD , IMHOF-JUNG SABINE , BRINKMANN ULRICH , SCHEUER WERNER , GEORGES GUY
IPC分类号： A61K38/16 , C07K14/21 , C07K16/12
CPC分类号： C07K16/30 , A61K31/337 , A61K38/00 , A61K39/39558 , A61K47/6803 , A61K47/6829 , A61K47/6851 , A61K47/6859 , A61K47/6871 , A61K2039/505 , C07K14/21 , C07K16/1214 , C07K16/303 , C07K16/40 , C07K2317/24 , C07K2317/55 , C07K2317/624 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2319/30 , C07K2319/33 , C07K2319/50 , C07K2319/55 , A61K2300/00
摘要： The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Methods of treating or preventing cancer in a mammal, methods of inhibiting the growth of a target cell, methods of producing the PE, and methods of producing the chimeric molecule are further provided by the invention.
摘要翻译：本发明提供了包含具有一个或多个B细胞和/或T细胞表位取代的氨基酸序列的假单胞菌外毒素A（PE）。本发明进一步提供了相关的嵌合分子以及相关的核酸，重组表达载体，宿主细胞，细胞群和药物组合物。本发明进一步提供了治疗或预防哺乳动物癌症的方法，抑制靶细胞生长的方法，生产PE的方法以及生产嵌合分子的方法。

10. 发明申请

WO2015023846A2 INSECTICIDAL PROTEINS AND METHODS FOR THEIR USE 审中-公开
标题翻译：杀虫蛋白及其使用方法
公开(公告)号：WO2015023846A2
公开(公告)日：2015-02-19
申请号：PCT/US2014/051063
申请日：2014-08-14
申请人： PIONEER HI-BRED INTERNATIONAL, INC. , E. I. DUPONT DE NEMOURS & COMPANY
发明人： LIU, Lu , O'REAR, Jessica , PARK, Young Jun , ROSEN, Barbara , SCHELLENBERGER, Ute , SCHEPERS, Eric , WEI, Zun-Zhi , XIE, Weiping , YALPANI, Nasser , ZHONG, Xiaohong , ZHU, Genhai
IPC分类号： C07K14/415 , A01H5/00
CPC分类号： C12N15/8286 , A01N63/02 , C07K14/21 , C12R1/40 , Y02A40/162
摘要： Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
摘要翻译：提供了用于防治害虫的组合物和方法。该方法涉及用编码杀虫蛋白质的核酸序列转化生物体。特别地，核酸序列可用于制备具有杀虫活性的植物和微生物。因此，提供了转化的细菌，植物，植物细胞，植物组织和种子。组合物是杀虫核酸和细菌物种的蛋白质。该序列可用于构建表达载体，用于随后转化成感兴趣的生物体，包括植物，作为分离其他同源（或部分同源）基因的探针。杀虫蛋白质可用于控制，抑制鳞翅目，鞘翅目，双翅目，真菌，半翅目和线虫害虫种群的生长或杀死以及用于生产具有杀虫活性的组合物。

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