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1. 发明申请

WO2011045113A3 COMPETITIVE EXCLUSION COMPOSITION AND METHODS 审中-公开
标题翻译：竞争排除组合和方法
公开(公告)号：WO2011045113A3
公开(公告)日：2012-07-19
申请号：PCT/EP2010062423
申请日：2010-08-25
申请人： PLANT BIOSCIENCE LTD , HORN NICOLA , LEE ANDREW , NARBAD ARJAN , SHEARMAN CLAIRE , WEGMANN UDO
发明人： HORN NICOLA , LEE ANDREW , NARBAD ARJAN , SHEARMAN CLAIRE , WEGMANN UDO
IPC分类号： C12N15/52 , A23K1/00 , A23L1/30 , C07K14/335
CPC分类号： C12N15/52 , A23K10/16 , A23K10/18 , A23K50/75 , A23L33/135 , A23V2002/00 , A23Y2220/00 , C12R1/225 , A23V2200/3204
摘要： The present invention relates to compositions, including live organisms, nucleic acid and amino acid sequences, constructs and cells comprising these, which are used to competitively exclude pathogenic organisms from the alimentary canals of vertebrates to achieve prophylaxis or therapeutic effects.
摘要翻译：本发明涉及组合物，包括活生物体，核酸和氨基酸序列，构建体和包含它们的细胞，其用于从脊椎动物的消化道中竞争性排除病原生物体以达到预防或治疗效果。

2. 发明申请

WO2010007441A3 PHOSPHOPEPTIDES AND USE OF THE SAME 审中-公开
标题翻译：磷酸盐及其用途
公开(公告)号：WO2010007441A3
公开(公告)日：2011-01-20
申请号：PCT/GB2009050876
申请日：2009-07-16
申请人： PLANT BIOSCIENCE LTD , HOLT CARL , CLEGG ROGER
发明人： HOLT CARL , CLEGG ROGER
IPC分类号： C07K14/47 , A61K9/50 , A61K9/51 , A61P9/08 , A61P9/10 , C07K14/52 , C12P21/02
CPC分类号： C12P9/00 , A61K9/5169 , A61K47/64 , C07K14/4732 , C07K14/52
摘要： The present application relates to methods of providing thermodynamically stable calcium phosphate nanoclusters and uses thereof.
摘要翻译：本申请涉及提供热力学稳定的磷酸钙纳米簇的方法及其用途。

3. 发明申请

WO2010001119A3 USE OF GLUCOSINOLATES FROM CRUCIFEROUS PLANTS IN MODIFYING EXTRACELLULAR SIGNALLING PROTEINS 审中-公开
标题翻译：来自抗坏血酸植物的葡萄糖苷在改良细胞信号蛋白中的应用
公开(公告)号：WO2010001119A3
公开(公告)日：2011-01-06
申请号：PCT/GB2009001648
申请日：2009-07-01
申请人： PLANT BIOSCIENCE LTD , MITHEN RICHARD , TRAKA MARIA
发明人： MITHEN RICHARD , TRAKA MARIA
IPC分类号： A61K36/00 , A61K36/31 , A61P35/00
CPC分类号： A61K36/31 , A61K31/26 , A61K31/7028 , A61K45/06 , A61K2300/00
摘要： The invention relates to methods and compositions for the post-translational modification of extracellular signalling proteins by dietary phytochemicals and related compounds, including,, but not limited to one or more of the following phytochemicals: sulforaphane, erucin, sativin, iberin, ß-phenylethylisothiocyanate (PE-ITC)5 3- methylthiopropyl isothiocyanate. The invention further relates to assays for determining suitable phytochemicals for modifying extracellular signalling proteins. In addition the present invention relates to use of combinations of the phytochemicals isothiocyanataes and procyanidins, as well as methods of modifying plants to increase the levels of 3-methylthiopropyl glucosinolate therein.
摘要翻译：本发明涉及通过膳食植物化学物质和相关化合物对细胞外信号传导蛋白进行翻译后修饰的方法和组合物，包括但不限于一种或多种以下植物化学物质：萝卜硫素，芥子素，维生素，伊比林，异硫氰酸苯乙酯（PE-ITC）5 3-甲硫基丙基异硫氰酸酯。本发明还涉及用于确定适合的植物化学物质用于修饰细胞外信号传导蛋白的测定法。此外，本发明涉及植物化学物质异硫氰酸酯和原花青素的组合的使用，以及修饰植物以增加其中的3-甲硫基丙基硫代葡萄糖苷酸的水平的方法。

4. 发明申请

WO2010012972A3 NOVEL BACTERIAL CELLS AND USES THEREOF 审中-公开
标题翻译：新型细菌细胞及其用途
公开(公告)号：WO2010012972A3
公开(公告)日：2010-04-01
申请号：PCT/GB2009001433
申请日：2009-06-05
申请人： PLANT BIOSCIENCE LTD , GASSON MICHAEL , SHEARMAN CLAIRE , STENTZ REGIS
发明人： GASSON MICHAEL , SHEARMAN CLAIRE , STENTZ REGIS
IPC分类号： C07K14/195 , A23C9/12 , A61K35/74 , C12N15/74
CPC分类号： C12N15/746 , A23C19/062 , A23L27/25 , A23L33/135 , A23V2002/00 , A61K35/74 , A61K35/742 , A61K35/744 , A61K35/747 , C07K14/315 , C07K14/8103 , A23V2200/32
摘要： The present invention provides a bacterial host cell having improved cell permeability properties, the cell comprising an Orf18 gene or species homologue thereof, or a fragment or variant of the same encoding a polypeptide having the activity of the Orf18 gene product or species homologue thereof, wherein the gene, homologue, fragment or variant is under the control of an heterologous promoter (inducible or constitutively active) which permits sufficient expression of the gene, homologue, fragment or variant to increase the permeability of the cell wall. "Orf18 and the "orf18 gene" are also known as "CsiA" and the "csiA gene" respectively. In one embodiment, the host cell is a Lactococcus lactis cell in which a chromosomally-integrated Orf18 gene naturally present in the cell is inactivated. The invention further provides the use of such host cells in the production of polypeptides. In addition, the invention provides pharmaceutical compositions of the host cells and the use thereof for administering a bioactive agent to the human or animal body (for example, to the Gl tract).
摘要翻译：本发明提供具有改善的细胞渗透性的细菌宿主细胞，所述细胞包含Orf18基因或其物种同系物，或编码具有Orf18基因产物或其物种同系物的活性的多肽的片段或变体，其中基因，同源物，片段或变体在异源启动子（可诱导或组成型活性）的控制下，其允许基因，同源物，片段或变体的足够表达以增加细胞壁的通透性。 “Orf18”和“orf18基因”也分别被称为“CsiA”和“csiA”。在一个实施方案中，宿主细胞是乳酸乳球菌细胞，其中天然存在于细胞中的染色体整合的Orf18基因被灭活本发明还提供这种宿主细胞在多肽的制备中的用途。此外，本发明提供宿主细胞的药物组合物及其用于向人或动物体施用生物活性剂的用途（例如， Gl道）。

5. 发明申请

WO2008087561A8 METHODS AND COMPOSITIONS FOR MODULATING THE SIRNA AND RNA-DIRECTED-DNA METHYLATION PATHWAYS 审中-公开
标题翻译：用于调节SIRNA和RNA指导的DNA甲基化途径的方法和组合物
公开(公告)号：WO2008087561A8
公开(公告)日：2008-10-09
申请号：PCT/IB2008000954
申请日：2008-01-18
申请人： PLANT BIOSCIENCE LTD , NAVARRO LIONEL , VOINNET OLIVER
发明人： NAVARRO LIONEL , VOINNET OLIVER
IPC分类号： C12N15/09
CPC分类号： C12N9/00 , C12N15/8281
摘要： Methods to identify nucleotide sequences whose expression will enhance resistance to pathogen infection are described, as is use of such nucleotide sequences to enhance resistance with minimal side effects on development.
摘要翻译：描述了鉴定其表达将增强对病原体感染的抗性的核苷酸序列的方法，正如使用此类核苷酸序列增强抗性而对发育的副作用最小。

6. 发明申请

WO2005080579A3 TAXADIENE BIOSYNTHESIS 审中-公开
公开(公告)号：WO2005080579A3
公开(公告)日：2006-03-30
申请号：PCT/GB2005000578
申请日：2005-02-18
申请人： PLANT BIOSCIENCE LTD , FRAY RUPERT
发明人： FRAY RUPERT
IPC分类号： C12N9/00 , C12N15/82 , C12P15/00 , A01H4/00
CPC分类号： C12N15/8243 , C12N9/93 , C12P15/00
摘要： The present invention relates to the finding that plants which are deficient in geranylgeranyl diphosphate (GGDP) metabolism, in particular tomato and other carotenoid synthesising plants, are useful in the biosynthesis of taxa-4, 11-diene (taxadiene) and other paclitaxel intermediates. Methods and means of producing taxadiene and other paclitaxel intermediates using plants deficient in GGDP metabolism are provided.
摘要翻译：本发明涉及一种缺乏er牛儿基ger牛儿基二磷酸（GGDP）代谢的植物，特别是番茄和其他类胡萝卜素合成植物，可用于分类单体4,11-二烯（taxadiene）和其他紫杉醇中间体的生物合成。提供了使用缺乏GGDP代谢的植物生产三聚氰胺和其他紫杉醇中间体的方法和方法。

7. 发明申请

WO2005090599A2 METHODS AND ADAPTORS FOR ANALYZING SPECIFIC NUCLEIC ACID POPULATIONS 审中-公开
标题翻译：用于分析特异性核酸人口的方法和适配器
公开(公告)号：WO2005090599A2
公开(公告)日：2005-09-29
申请号：PCT/GB2005000989
申请日：2005-03-15
申请人： PLANT BIOSCIENCE LTD , FU GUOLIANG
发明人： FU GUOLIANG
IPC分类号： C12N15/10 , C12Q1/68
CPC分类号： C12Q1/6827 , C12N15/1034 , C12N15/1096 , C12Q1/6811 , C12Q1/6855 , C12Q2539/107 , C12Q2525/131
摘要： The invention provides a method of comparing a tester and a driver sample of nucleic, which tester sample is believed to contain a target nucleic acid not present in a driver sample, the method comprising: (a) providing tester and driver nucleic acid samples; (b) covalently attaching a first adaptor to said tester nucleic acid such as to form adaptor : tester nucleic acid complexes; (c) covalently attachning a second, different, adaptor to said driver nucleic acid such as to form adaptor: driver nucleic acid complexes; (d) combining said adaptor: tester nucleic acid complexes and said adaptor: driver nucleic acid complexes to form a combined sample; (e) subjecting said combined sample to denaturing and annealing conditions such that hybrid double-stranded adaptor: tester/adaptor: driver nucleic acid complexes are formed; (f) adding one ore more restriction enzymes capable of preferentially digesting hybrid non-target nucleic acid complexes, and incubating under restriction digestion conditions, (g) optionally repeating steps (e) and (f), (h) optionally amplifying one or more double-stranded nucleic acid complexes from step (g) using primers specific to the adaptors present in the or each complex. Also provided are related methods, and adaptors and kits for use in performing them.
摘要翻译：本发明提供了一种比较测试器和核酸驱动器样品的方法，该测试仪样品被认为含有不存在于驱动器样品中的靶核酸，该方法包括：（a）提供测试仪和驱动器核酸样品; （b）将第一衔接子共价连接到所述测试者核酸上，以形成衔接试验核酸复合物; （c）将第二不同的适配器共价连接到所述驱动器核酸，以形成适配器：驱动核酸复合物; （d）将所述适配器：测试者核酸复合物和所述衔接子组合：驱动核酸复合物以形成组合的样品; （e）对所述组合的样品进行变性和退火条件，使得形成混合双链衔接子：测试者/衔接子：驱动核酸复合物; （f）加入一个以上的能够优先消化杂合非靶核酸复合物的限制酶，并在限制性消化条件下孵育，（g）任选地重复步骤（e）和（f），（h）任选地扩增一个或多个来自步骤（g）的双链核酸复合物使用对于或每个复合物中存在的衔接子特异的引物。还提供了相关方法，以及用于执行它们的适配器和套件。

8. 发明申请

WO0105936A3 TRANSFORMATION METHOD AND TRANSGENIC PLANTS PRODUCED THEREBY 审中-公开
标题翻译：转化方法和生产的转基因植物
公开(公告)号：WO0105936A3
公开(公告)日：2004-01-29
申请号：PCT/US0019721
申请日：2000-07-18
申请人： PLANT BIOSCIENCE LTD , CHRISTOU PAUL , KOHLI AJAY
发明人： CHRISTOU PAUL , KOHLI AJAY
IPC分类号： C12N15/82 , C12N5/04 , A01H1/00 , A01H5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/63
CPC分类号： C12N15/8206 , C12N15/8201 , C12N15/8207 , C12N15/8216
摘要： This invention relates to methods for producing, at a high frequency, transgenic plants that contain little if any vector sequences, have simple integration patterns, contain few copies of the transgene at each locus, express the transgene at all stages of development and do not exhibit transgene silencing. The method comprises introducing minimal transgene expression cassettes, which are substantially or totally devoid of vector sequences, by direct DNA transfer, preferably by particle or microprojectile bombardment. This invention also relates to transformed plant cells, the transgenic plants regenerated therefrom, and subparts of the transgenic plants produced by the methods of this invention. The invention also includes all progeny and subsequent progeny (i.e., all subsequent generations) derived from primary transformants through selfing or crossing.
摘要翻译：本发明涉及用于在高频率下生产含有少量任何载体序列的转基因植物的方法，其具有简单的整合模式，在每个基因座处含有少量拷贝的转基因，在发育的所有阶段表达转基因，并且不显示转基因沉默。该方法包括通过直接DNA转移，优选通过粒子或微粒轰击引入基本上或完全没有载体序列的最小转基因表达盒。本发明还涉及转化的植物细胞，由其再生的转基因植物和通过本发明的方法生产的转基因植物的亚部分。本发明还包括通过自交或杂交从原代转化体衍生的所有后代和随后的后代（即所有后代）。

9. 发明申请

WO03060136A2 D-GALACTURONATE REDUCTASE OF FRAGARIA ANANASSA AND ITS USE IN METHODS FOR INCREASING PRODUCTION OF VITAMIN C IN PLANTS 审中-公开
标题翻译： FRAGARIA ANANASSA的D-半乳糖酸还原酶及其在增加植物中维生素C生成方法中的应用
公开(公告)号：WO03060136A2
公开(公告)日：2003-07-24
申请号：PCT/GB0205818
申请日：2002-12-19
申请人： PLANT BIOSCIENCE LTD , AGIUS GUADALUPE MARIA FERNANDA , BOTELLA MESA MIGUEL ANGEL , VALPUESTA FERNANDEZ VICTORIANO
发明人： AGIUS GUADALUPE MARIA FERNANDA , BOTELLA MESA MIGUEL ANGEL , VALPUESTA FERNANDEZ VICTORIANO
IPC分类号： C12N9/04 , C12N15/82
CPC分类号： C12N9/0006 , C12N15/8243
摘要： Provided are DNA constructs that comprise a DNA molecule encoding a protein with D-galacturonate reductase activity involved in L-ascorbic acid synthesis inplant cells and a region for initiating functional transcription in plants. Preferred constructs include SEQ. ID. No. 1 or analogues thereof. The constructs have utility in increasing vitamin C production in plants, and making plants more resistant to stress. Also provided are related materials and methods for performing the invention.
摘要翻译：提供了包含编码具有参与植物细胞中L-抗坏血酸合成的D-半乳糖醛酸还原酶活性的蛋白质的DNA分子和用于在植物中启动功能性转录的区域的DNA构建体。优选的构建体包括SEQ。 ID。 1号或其类似物。该构建体可用于增加植物中的维生素C生产，并使植物对压力更具抵抗力。还提供了用于执行本发明的相关材料和方法。

10. 发明申请

WO0198479A3 PLANT RESISTANCE GENE 审中-公开
标题翻译：植物抗性基因
公开(公告)号：WO0198479A3
公开(公告)日：2002-04-18
申请号：PCT/GB0102693
申请日：2001-06-19
申请人： PLANT BIOSCIENCE LTD , XIAO SHUN YUAN , TURNER JOHN GORDON , COLEMAN MARK , ELLWOOD SIMON
发明人： XIAO SHUN YUAN , TURNER JOHN GORDON , COLEMAN MARK , ELLWOOD SIMON
IPC分类号： C07K14/415 , C12N15/82 , A01H5/00 , C12N5/10 , C12N15/29 , C12Q1/68
CPC分类号： C07K14/415 , C12N15/8237 , C12N15/8239 , C12N15/8282
摘要： Disclosed are isolated nucleic acids consisting essentially of RPW nucleotide sequences (especially RPW8 from Arabidopsis thaliana, and related homologues and other sequences e.g. from Brassica napus; B. oleracea). These encode a novel class of resistance polypeptides having an N-terminal transmembrane domain and a coiled coil domain and which is capable of recognising and activating in a plant into which said nucleic acid is introduced a specific defense response to challenge with a powdery mildew pathogen e.g. E. cichoracearum. Also provided are related products e.g. primers, polypeptides, transgenic plants having enhanced resistance, plus also processes for producing these, and methods of use.
摘要翻译：公开了基本上由RPW核苷酸序列（特别是来自拟南芥的RPW8，以及相关的同系物和其他序列，例如来自甘蓝型油菜，甘蓝）组成的分离的核酸。它们编码具有N-末端跨膜结构域和卷曲螺旋结构域的新一类抗性多肽，其能够在植物中识别和激活所述核酸引入的特异性防御反应以用白粉病病原体攻击。西红柿还提供了相关产品，例如引物，多肽，具有增强抗性的转基因植物，以及其生产方法以及使用方法。

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