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1. 发明申请

WO2017009790A1 ENHANCING MICROALGAL METABOLISM OF XYLOSE 审中-公开
标题翻译：增强XYLOSE的微量代谢
公开(公告)号：WO2017009790A1
公开(公告)日：2017-01-19
申请号：PCT/IB2016/054185
申请日：2016-07-13
申请人： MARA RENEWABLES CORPORATION
发明人： MERKX-JACQUES, Alexandra , WOODHALL, David , SCAIFE, Mark , ARMENTA, Roberto E. , MUISE, Denise , RASMUSSEN, Holly , BENJAMIN, Jeremy
IPC分类号： C12N1/11 , C07K14/40 , C11C1/00 , C12N15/31 , C12N15/54 , C12N15/61
CPC分类号： C12N9/92 , C07K14/40 , C07K2319/21 , C12N9/1205 , C12Y207/01017 , C12Y503/01005
摘要： Provided herein are recombinant microorganisms having two or more copies of a nucleic acid sequence encoding xylose isomerase, wherein the nucleic acid encoding the xylose isomerase is an exogenous nucleic acid. Optionally, the recombinant microorganisms include at least one nucleic acid sequence encoding a xylulose kinase and/or at least one nucleic acid sequence encoding a xylose transporter. The provided recombinant microorganisms are capable of growing on xylose as a carbon source.
摘要翻译：本文提供了具有两个或更多拷贝的编码木糖异构酶的核酸序列的重组微生物，其中编码木糖异构酶的核酸是外源核酸。任选地，重组微生物包括编码木酮糖激酶和/或编码木糖转运蛋白的至少一个核酸序列的至少一个核酸序列。所提供的重组微生物能够在作为碳源的木糖上生长。

2. 发明申请

WO2015069796A1 METHODS FOR ENGINEERING SUGAR TRANSPORTER PREFERENCES 审中-公开
标题翻译：工程糖运输方式优先
公开(公告)号：WO2015069796A1
公开(公告)日：2015-05-14
申请号：PCT/US2014/064168
申请日：2014-11-05
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： ALPER, Hal , YOUNG, Eric
IPC分类号： C07K14/40 , C12N1/19 , C12N15/09 , C12P7/10
CPC分类号： C07K14/40 , C07K14/39 , C12P7/10 , Y02E50/16
摘要： Provided herein are compositions and methods useful for transporting xylose, arabinose and other monosaccharides, into a yeast cell.
摘要翻译：本文提供了可用于将木糖，阿拉伯糖和其它单糖转运到酵母细胞中的组合物和方法。

3. 发明申请

WO2014081673A2 ENGINEERING PLANTS FOR EFFICIENT UPTAKE AND UTILIZATION OF UREA TO IMPROVE CROP PRODUCTION 审中-公开
标题翻译：工程植物有效利用和利用乌拉圭来提高作物生产
公开(公告)号：WO2014081673A2
公开(公告)日：2014-05-30
申请号：PCT/US2013070603
申请日：2013-11-18
申请人： PIONEER HI BRED INT , GUPTA RAJEEV , HOU ZHENGLIN , LOUSSAERT DALE F , SHEN BO , WOOD L KENT
发明人： GUPTA RAJEEV , HOU ZHENGLIN , LOUSSAERT DALE F , SHEN BO , WOOD L KENT
IPC分类号： C12N15/82 , C07K14/195 , C07K14/37 , C07K14/415
CPC分类号： C12N15/8243 , A01G1/001 , C05C9/00 , C07K14/195 , C07K14/32 , C07K14/335 , C07K14/35 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/395 , C07K14/40 , C07K14/405 , C07K14/415 , C12N9/80 , C12N15/8261 , Y02A40/146
摘要： The present disclosure provides polynucleotides and related polypeptides related to urea uptake. The disclosure provides genomic sequences for urea transporter, urease and glutamine synthetase genes. Urea transporters, urease and glutamine synthetase are responsible for controlling nitrogen utilization efficiency in plants. Urea transporter, urease or glutamine synthetase sequences are provided for improving grain yield and plant growth. The disclosure further provides recombinant expression cassettes, host cells and transgenic plants.
摘要翻译：本公开提供了与尿素摄取相关的多核苷酸和相关多肽。本公开提供了尿素转运蛋白，脲酶和谷氨酰胺合成酶基因的基因组序列。尿素转运蛋白，脲酶和谷氨酰胺合成酶负责控制植物的氮利用效率。提供尿素转运蛋白，脲酶或谷氨酰胺合成酶序列用于改善谷物产量和植物生长。本公开进一步提供重组表达盒，宿主细胞和转基因植物。

4. 发明申请

WO2011070113A1 SOPHOROLIPID TRANSPORTER PROTEIN 审中-公开
标题翻译： SOPHOROLIPID运输蛋白
公开(公告)号：WO2011070113A1
公开(公告)日：2011-06-16
申请号：PCT/EP2010/069280
申请日：2010-12-09
申请人： UNIVERSITEIT GENT , SOETAERT, Wim , VAN BOGAERT, Inge
发明人： SOETAERT, Wim , VAN BOGAERT, Inge
IPC分类号： C07K14/40 , C12P19/12 , C12P19/44
CPC分类号： C12P19/44 , C07K14/40 , C12P19/12
摘要： The present invention relates to a transporter protein involved in the transport of sophorolipids. More specifically, it relates to a Candida bombicola sophorolipid transporter protein, and the use of this transporter to modulate the secretion and/or production of glycolipids, preferably sophorolipids in organisms, preferably in fungi.
摘要翻译：本发明涉及涉及槐糖脂运输的转运蛋白。更具体地，本发明涉及一种假丝酵母蚕豆转运蛋白，以及该转运蛋白在生物体中，优选在真菌中调节糖脂分泌和/或产生，优选槐糖脂的用途。

5. 发明申请

WO2007035930A3 GLYCOSYLATED POLYPEPTIDES PRODUCED IN YEAST MUTANTS AND METHODS OF USE THEREOF 审中-公开
标题翻译：在YEAST MUTANT中生产的糖苷多糖及其使用方法
公开(公告)号：WO2007035930A3
公开(公告)日：2007-11-29
申请号：PCT/US2006037302
申请日：2006-09-22
申请人： PROSCI INC , GENG YU , LUALLEN ROBERT JAMES
发明人： GENG YU , LUALLEN ROBERT JAMES
IPC分类号： G01N33/53
CPC分类号： C12P21/005 , A61K39/0002 , A61K39/12 , A61K39/21 , C07K14/37 , C07K14/39 , C07K14/395 , C07K14/40 , C07K16/1063 , C07K16/14 , C07K16/2851 , C07K16/44 , C07K2319/40 , C12N2740/16034
摘要： The invention provides various high mannose glycosylated polypeptides that are useful in a vaccine formulations. The invention also provides methods for making such glycosylated polypeptides and its uses in eliciting HIV-neutralizing antibodies.
摘要翻译：本发明提供可用于疫苗制剂的各种高甘露糖糖基化多肽。本发明还提供了制备这样的糖基化多肽的方法及其在引发HIV-中和抗体中的用途。

6. 发明申请

WO2006121895A3 PHARMACEUTICAL COMPOSITIONS AND METHODS TO VACCINATE AGAINST DISSEMINATED CANDIDIASIS AND OTHER INFECTIOUS AGENTS 审中-公开
标题翻译：药物组合物和抗肿瘤药物和其他感染性药物的方法
公开(公告)号：WO2006121895A3
公开(公告)日：2007-06-07
申请号：PCT/US2006017482
申请日：2006-05-04
申请人： LOS ANGELES BIOMED RES INST , EDWARDS JR JOHN E , FILLER SCOTT G , SHEPPARD DONALD C , IBRAHIM ASHRAF , FU YUE , SPELLBERG BRAD J , YEAMAN MICHAEL
发明人： EDWARDS JR JOHN E , FILLER SCOTT G , SHEPPARD DONALD C , IBRAHIM ASHRAF , FU YUE , SPELLBERG BRAD J , YEAMAN MICHAEL
IPC分类号： A61K39/00 , A61K38/00
CPC分类号： A61K39/0002 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/40 , C07K16/14
摘要： The invention provides a vaccine including an isolated AIs protein family member having cell adhesion activity, or an immunogenic fragment thereof, with an adjuvant in a pharmaceutically acceptable medium. The invention also provides a method of treating or preventing hematogenously disseminated or mucocutaneous candidiasis. The method includes administering an immunogenic amount of a vaccine an isolated AIs protein family member having cell adhesion activity, or an immunogenic fragment thereof, in a pharmaceutically acceptable medium. A method of treating or preventing disseminated candidiasis also is provided that includes administering an effective amount of an isolated AIs protein family member having cell adhesion activity, or an functional fragment thereof, to inhibit the binding or invasion of Candida to a host cell or tissue. The AIs protein family member can be derived from a Candida strain selected from the group consisting of Candida albicans, Candida krusei, Candida tropicalis, Candida glabrata and Candida parapsilosis and the AIs protein family member includes AIs Ip, Als3p, Als5p, AlsÌp, Als7p or Als9p. Also provided is a method of treating or preventing Staphylococcus aureus infections. The method includes administering an immunogenic amount of a vaccine an isolated AIs protein family member having cell adhesion activity, or an immunogenic fragment thereof, in a pharmaceutically acceptable medium.
摘要翻译：本发明提供一种包含具有细胞粘附活性的分离的AIs蛋白家族成员或其免疫原性片段的疫苗，其在药学上可接受的培养基中与佐剂一起使用。本发明还提供了治疗或预防血液性弥漫性或粘膜皮肤念珠菌病的方法。该方法包括在药学上可接受的培养基中施用免疫原性量的具有细胞粘附活性的分离的AIs蛋白质家族成员或其免疫原性片段。还提供了治疗或预防弥漫性念珠菌病的方法，其包括施用有效量的具有细胞粘附活性的分离的AIs蛋白质家族成员或其功能片段，以抑制念珠菌与宿主细胞或组织的结合或侵入。 AIs蛋白质家族成员可以衍生自选自白色念珠菌，克罗斯假丝酵母，热带假丝酵母，光滑假丝酵母和副假丝酵母的念珠菌菌株，AIs蛋白家族成员包括AIs Ip，Als3p，Als5p，AlsIp，Als7p或 Als9p。还提供了治疗或预防金黄色葡萄球菌感染的方法。该方法包括在药学上可接受的培养基中施用免疫原性量的具有细胞粘附活性的分离的AIs蛋白质家族成员或其免疫原性片段。

7. 发明申请

WO2006121895A2 PHARMACEUTICAL COMPOSITIONS AND METHODS TO VACCINATE AGAINST DISSEMINATED CANDIDIASIS AND OTHER INFECTIOUS AGENTS 审中-公开
标题翻译：药物组合物和抗肿瘤药物和其他感染性药物的方法
公开(公告)号：WO2006121895A2
公开(公告)日：2006-11-16
申请号：PCT/US2006/017482
申请日：2006-05-04
申请人： LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER , EDWARDS, Jr., John, E. , FILLER, Scott, G. , SHEPPARD, Donald, C. , IBRAHIM, Ashraf , FU, Yue , SPELLBERG, Brad, J. , YEAMAN, Michael
发明人： EDWARDS, Jr., John, E. , FILLER, Scott, G. , SHEPPARD, Donald, C. , IBRAHIM, Ashraf , FU, Yue , SPELLBERG, Brad, J. , YEAMAN, Michael
IPC分类号： A61K39/00 , C12N1/18
CPC分类号： A61K39/0002 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/40 , C07K16/14
摘要： The invention provides a vaccine including an isolated AIs protein family member having cell adhesion activity, or an immunogenic fragment thereof, with an adjuvant in a pharmaceutically acceptable medium. The invention also provides a method of treating or preventing hematogenously disseminated or mucocutaneous candidiasis. The method includes administering an immunogenic amount of a vaccine an isolated AIs protein family member having cell adhesion activity, or an immunogenic fragment thereof, in a pharmaceutically acceptable medium. A method of treating or preventing disseminated candidiasis also is provided that includes administering an effective amount of an isolated AIs protein family member having cell adhesion activity, or an functional fragment thereof, to inhibit the binding or invasion of Candida to a host cell or tissue. The AIs protein family member can be derived from a Candida strain selected from the group consisting of Candida albicans, Candida krusei, Candida tropicalis, Candida glabrata and Candida parapsilosis and the AIs protein family member includes AIs Ip, Als3p, Als5p, AlsÌp, Als7p or Als9p. Also provided is a method of treating or preventing Staphylococcus aureus infections. The method includes administering an immunogenic amount of a vaccine an isolated AIs protein family member having cell adhesion activity, or an immunogenic fragment thereof, in a pharmaceutically acceptable medium.
摘要翻译：本发明提供一种包含具有细胞粘附活性的分离的AIs蛋白家族成员或其免疫原性片段的疫苗，其在药学上可接受的培养基中与佐剂一起使用。本发明还提供了治疗或预防血液性弥漫性或粘膜皮肤念珠菌病的方法。该方法包括在药学上可接受的培养基中施用免疫原性量的具有细胞粘附活性的分离的AIs蛋白质家族成员或其免疫原性片段。还提供了治疗或预防弥漫性念珠菌病的方法，其包括施用有效量的具有细胞粘附活性的分离的AIs蛋白质家族成员或其功能片段，以抑制念珠菌与宿主细胞或组织的结合或侵入。 AIs蛋白质家族成员可以衍生自选自白色念珠菌，克罗斯假丝酵母，热带假丝酵母，光滑假丝酵母和副假丝酵母的念珠菌菌株，AIs蛋白家族成员包括AIs Ip，Als3p，Als5p，AlsIp，Als7p或 Als9p。还提供了治疗或预防金黄色葡萄球菌感染的方法。该方法包括在药学上可接受的培养基中施用免疫原性量的具有细胞粘附活性的分离的AIs蛋白质家族成员或其免疫原性片段。

8. 发明申请

WO2005021789A1 POLYPEPTIDES INVOLVED IN FUNGAL BIOFILM FORMATION AND POLYNUCLEOTIDES ENCODING SAME AND USES THEREOF 审中-公开
标题翻译：参与真菌生物膜形成的多肽和编码其的多核苷酸及其用途
公开(公告)号：WO2005021789A1
公开(公告)日：2005-03-10
申请号：PCT/IB2004/003022
申请日：2004-08-30
申请人： INSTITUT PASTEUR , D'ENFERT, Christophe, Didier , GARCIA-SANCHEZ, Susana , COTTIER, Fabien , IRAQUI, Ismaïl , GHIGO, Jean-Marc , JANBON, Guilhem
发明人： D'ENFERT, Christophe, Didier , GARCIA-SANCHEZ, Susana , COTTIER, Fabien , IRAQUI, Ismaïl , GHIGO, Jean-Marc , JANBON, Guilhem
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6895 , A61K39/00 , C07K14/40 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to a purified polypeptide, and the polynucleotide encoding same, naturally involved in fungal biofilm formation. More specifically, the polypeptide of the present invention is overexpressed in a fungus during biofilm growth compared to planktonic growth. The present invention also relates to a method for identifying compounds that inhibit such polypeptides as well as for identifying compounds that, affect biofilm formation; and use of such compounds in compositions and methods for the prevention and the treatment of biofilm forming fungus-associated diseases, such as those caused by Candida albicans.
摘要翻译：本发明涉及天然参与真菌生物膜形成的纯化多肽和编码该多肽的多核苷酸。更具体地说，与浮游生长相比，本发明的多肽在生物膜生长期间在真菌中过表达。本发明还涉及鉴定抑制这些多肽的化合物以及鉴定影响生物膜形成的化合物的方法。以及这些化合物在组合物和方法中的用途，用于预防和治疗生物膜形成真菌相关疾病，例如由白色念珠菌引起的疾病。

9. 发明申请

WO2002103019A1 異種eRF3間のプリオン化の感染に関与するペプチド审中-公开
标题翻译：参与异源ERF3的诱导
公开(公告)号：WO2002103019A1
公开(公告)日：2002-12-27
申请号：PCT/JP2002/005031
申请日：2002-05-24
申请人：東京大学総長が代表する日本国 , 中村義一 , 中屋敷徹
发明人：中村義一 , 中屋敷徹
IPC分类号： C12N15/31
CPC分类号： C07K14/395 , C07K14/39 , C07K14/40
摘要： An eRF3 which can prionize a heterogenous eRF3; and an eRF3 which can be prionized by a heterogenous eRF3. Use of the same in screening an inhibitor for th einfection with an abnormal PrP, detecting an abnormal PrP, constructing an abnormal PrP and screening a substance whereby an abnormal PrP may be restored into a normal PrP.
摘要翻译：可以朊病毒异源eRF3的eRF3; 和可以通过异源eRF3朊病毒的eRF3。使用相同的方法筛选一种具有异常PrP的感染抑制剂，检测异常PrP，构建异常PrP并筛选物质，从而使异常PrP恢复到正常的PrP。

10. 发明申请

WO0222825A9 THE C. ALBICANS TEC1 GENE (CATEC1) AND THE CODED TEC1P PROTEIN 审中-公开
标题翻译：白色念珠菌TEC1 GEN（CATEC1）和编码Tec1p PROTEIN
公开(公告)号：WO0222825A9
公开(公告)日：2002-09-19
申请号：PCT/EP0110596
申请日：2001-09-13
申请人： FRAUNHOFER GES FORSCHUNG , UNIV FRIEDRICH ALEXANDER ER , SCHROEPPEL KLAUS , TAYLOR BRAD N , SCHWEIZER ANJA , RUPP STEFFEN
发明人： SCHROEPPEL KLAUS , TAYLOR BRAD N , SCHWEIZER ANJA , RUPP STEFFEN
IPC分类号： A61K39/00 , A61K48/00 , C07K14/40 , C12N1/15 , C12N1/21 , C12N15/31 , C12N15/80 , A61K39/395 , C07K16/14 , C12N15/11 , C12N15/70 , C12Q1/68 , G01N33/53 , G01N33/68
CPC分类号： C07K14/40 , A61K39/00 , A61K48/00 , A61K2039/505 , A61K2039/523 , C12N15/80
摘要： The invention relates to nucleotide sequences which code for proteins which modulate the virulence of pathogenic fungal strains, to vectors containing these sequences, to host cells having these nucleotide sequences or these vectors, to proteins which modulate the virulence of pathogenic fungal strains, especially the transcription factor CaTEC1 of Candida albicans, to inhibitors thereof, especially antibodies which target these virulence-modifying proteins, to methods for producing the proteins and inhibitors, to methods for the diagnosis and therapy of diseases which are associated with a Candida infection and to diagnostic and pharmaceutical compositions containing the nucleotide sequences, proteins, host cells and/or antibodies.
摘要翻译：本发明涉及的核苷酸编码致病真菌菌株的毒力序列编码调节蛋白，含有这些序列的载体，宿主细胞包括这些核苷酸序列或载体，致病真菌菌株的调节蛋白，特别是白色念珠菌的转录因子CaTEC1，其抑制剂，尤其是抗体的毒力这是针对这些virulenzmodulierenden蛋白，用于制备蛋白和抑制剂，诊断和其与一个念珠菌感染中的上下文相关的疾病治疗的方法，以及诊断和药物组合物包括核苷酸序列，蛋白质，宿主细胞和方法/ 或抗体。

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