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1. 发明申请

WO2012041918A3 PROCESS FOR THE MANUFACTURE OF HYDROGEN PEROXIDE 审中-公开
公开(公告)号：WO2012041918A3
公开(公告)日：2012-04-05
申请号：PCT/EP2011/066893
申请日：2011-09-28
申请人： SOLVAY SA , DESMEDT, Frédérique Jacqueline , HODGE, Philip , JANSSENS, Francine
发明人： DESMEDT, Frédérique Jacqueline , HODGE, Philip , JANSSENS, Francine
IPC分类号： C01B15/023 , C07C46/00 , C07C46/06 , C07C50/18
摘要： The present invention relates to a process for the preparation of aqueous hydrogen peroxide from the anthraquinone (AO) loop process, comprising using at least one alkylanthraquinone of formula (I) wherein -R1, R2 and R3 are chosen from H, methyl radical, isopropyl radical, n-propyl radical, and tert-amyl radical, and -at least two of the three groups R1, R2 and R3 are different from H and are different from each other.

2. 发明申请

WO2007017168A1 PROCESS FOR THE PREPARATION OF UBIHYDROQUINONES AND UBIQUINONES 审中-公开
标题翻译：制备UBIHYDROQUINONES和UBIQUINONES的方法
公开(公告)号：WO2007017168A1
公开(公告)日：2007-02-15
申请号：PCT/EP2006/007645
申请日：2006-08-02
申请人： DSM IP ASSETS B.V. , AQUINO, Fabrice , BONRATH, Werner , BOHRER, Patrick , HUGENTOBLER, Max , NETSCHER, Thomas , RADSPIELER, Alexander
发明人： AQUINO, Fabrice , BONRATH, Werner , BOHRER, Patrick , HUGENTOBLER, Max , NETSCHER, Thomas , RADSPIELER, Alexander
IPC分类号： C07C46/06 , C07C50/28 , C07C41/30 , C07C43/23
CPC分类号： C07C46/02 , C07C41/30 , C07C50/28 , C07C43/215 , C07C43/23
摘要： A process for the preparation of ubihydroquinones and ubiquinones by condensation of a prenol or isoprenol with a hydroquinone or derivative thereof in the presence of 0.005 - 1.0 mol% of a catalyst which is a Broensted-acid, a Lewis-acid from the group consisting of a derivative of Bi or In or an element of group 3 of the periodic table of the elements, a heteropolyacid, an NH- or a CH-acidic compound, and optionally oxidizing the ubihydroquinone obtained.
摘要翻译：一种在0.005-1.0摩尔％的催化剂（Broensted-acid），路易斯酸（Lewis酸）的存在下，由Prenol或异戊二烯醇与氢醌或其衍生物缩合制备二氢醌和泛醌的方法， Bi或In的衍生物或元素周期表第3族的元素，杂多酸，NH-或CH-酸性化合物，以及任选地氧化所获得的二氢醌。

3. 发明申请

WO02050007A2 SUBSTITUTED STILBENES AND THEIR REACTIONS 审中-公开
标题翻译：取代的STILBENES及其反应
公开(公告)号：WO02050007A2
公开(公告)日：2002-06-27
申请号：PCT/GB2001/005702
申请日：2001-12-20
IPC分类号： A61P35/00 , C07C43/215 , C07C43/23 , C07C46/06 , C07C50/30 , C07C205/35 , C07C205/37 , C07C205/44 , C07C271/22 , C07D213/68 , C07F7/18 , A61K31/09 , A61K31/12 , A61K31/215 , A61K31/27 , A61K31/44 , C07C50/28
CPC分类号： C07F7/1852 , C07C43/215 , C07C43/23 , C07C46/06 , C07C50/30 , C07C205/35 , C07C205/37 , C07C205/44 , C07C271/22 , C07D213/68
摘要： The present invention relates to stilbene and quinone compounds related to combretastatin A-4 and their use as anticancer compounds and prodrugs. The compounds include those with an alkyl group on the double bond of cis or trans-stilbenes, compounds with one or more (and preferably 2 or 3) alkyl group substituents on the stilbene A ring, compounds with an alkoxy group other than methoxy at position 3, 4, and/or 5 of the stilbene A ring, compounds (or prodrugs) in which BOC amino acid esters are formed with the phenolic hydroxyl at the 3-position of the B ring and compounds (or prodrugs) based on a benzoquinone B ring. The present invention further relates to the photochemical reactions of stilbene compounds, either the above compounds disclosed for the first time herein or compounds based on prior art stilbenes. These reactions include the photochemical release of an active form of the compound from a prodrug conjugate and the photochemical isomerisation of the compounds, especially from a trans to cis form of compounds. The reactions can be used alone or in combination to convert inactive or comparatively less active forms of the compounds to more active forms,thereby allowing the compounds to be selectively targeted, e.g. activating them at the site of a tumour.
摘要翻译：本发明涉及与考布他汀A-4相关的芪和醌化合物及其作为抗癌化合物和前药的用途。化合物包括在顺式或反式二苯乙烯的双键上具有烷基的化合物，在二苯乙烯A环上具有一个或多个（优选2或3个）烷基取代基的化合物，位置以外的甲氧基的烷氧基的化合物 3,4或5，其中BOC氨基酸酯与B环3位上的酚羟基形成的化合物（或前药）和基于苯醌的化合物（或前药） B戒指本发明还涉及二苯乙烯化合物的光化学反应，上述化合物是本文首次公开的化合物或基于现有技术的二苯乙烯的化合物。这些反应包括来自前药缀合物的化合物的活性形式的光化学释放和化合物的光化学异构化，特别是从反式到顺式形式的化合物。反应可以单独使用或组合使用以将化合物的无活性或相对较少活性的形式转化为更具活性的形式，从而允许化合物选择性靶向。在肿瘤部位激活它们。

4. 发明申请

WO02006261A1 TOCOTRIENOLQUINONE CYCLISATION PRODUCT WITH AN ANTI-HYPERCHOLESTEROL EFFECT 审中-公开
标题翻译：具有抗HYPER胆固醇的作用Tocotrienolquinone，ZYKLISIERUNGSPRODUKTE
公开(公告)号：WO02006261A1
公开(公告)日：2002-01-24
申请号：PCT/EP2001/008163
申请日：2001-07-13
IPC分类号： A23L33/105 , A61K31/343 , A61P3/00 , A61P3/06 , A61P3/10 , A61P7/02 , A61P9/00 , A61P9/10 , C07C46/06 , C07C50/28 , C07D307/94 , C07D307/04 , A61K31/34
CPC分类号： C07D307/94 , A23L33/105
摘要： The invention relates to the use of at least one component of formula (I) wherein R , R , R and R independently represent H or C1-C6 alkyl. The invention also relates to the use of a compound of formula (I) for medical purposes.
摘要翻译：本发明涉及使用式（I）的至少一种化合物，其中R <1>，R <2>，R <3>和R <4>独立地是H或C1-C6烷基彼此; 以及使用用于医疗用途的式（I）。

5. 发明申请

WO01068743A2 POROUS POLYMER/CARRIER SOLID PHASE REACTANTS, METHOD FOR PRODUCING SAME AND THE USE THEREOF 审中-公开
标题翻译：多孔聚合物/支固相，用于生产及其用途
公开(公告)号：WO01068743A2
公开(公告)日：2001-09-20
申请号：PCT/DE2001/001092
申请日：2001-03-15
IPC分类号： C07C29/143 , B01J20/28 , C07B39/00 , C07B61/00 , C07C17/02 , C07C17/08 , C07C17/20 , C07C17/266 , C07C17/275 , C07C17/38 , C07C33/22 , C07C45/29 , C07C45/30 , C07C45/39 , C07C45/63 , C07C45/78 , C07C46/06 , C07C49/403 , C07C205/03 , C07C247/10 , C07C253/14 , C07C255/33 , C07C331/04 , C08F2/44 , C40B50/00 , C08J
CPC分类号： C07C17/38 , B01J2219/00497 , C07B39/00 , C07B61/00 , C07B2200/11 , C07C17/02 , C07C17/08 , C07C17/202 , C07C17/266 , C07C17/275 , C07C45/29 , C07C45/292 , C07C45/298 , C07C45/30 , C07C45/63 , C07C45/78 , C07C46/06 , Y10T428/1376 , Y10T428/2982 , Y10T428/2998 , Y10T428/31855 , Y10T428/31931 , C07C19/08 , C07C49/403
摘要： Disclosed are porous polymer/carrier solid phase reactants which consist of a polymer that consists of fine particles and is situated in the pore space of porous carrier materials. Reactive groups are bound to the polymer. Said groups act as reactants in organic-chemical syntheses. Said solid phase reactants can be produced as bulk material or tubes, plates or rods, can be built in pressure sealed housings and can be used in flow-through apparatuses or microtitration fields for the synthesis of organic products. Potential active agents can be produced at high speed by using the inventive porous polymer/carrier solid phase reactants that can be flown through convectively, whereby production requires only little isolation and cleaning.
摘要翻译：中描述的多孔聚合物/载体的固相反应物，其由细碎聚合物，其存在于多孔载体材料的孔体积。在聚合物的反应性基团连接，这在有机合成化学作为反应物起作用。提到的固相反应物可作为散装材料或作为管，板或杆来制备。提到的固相反应物可以被结合到压力密封的壳体和在流通装置或Mikrotitrierfeldern用于有机产品的合成。通过使用所描述的对流流过的多孔聚合物/支持固相反应物，可以以高的速度来产生与用于分离和纯化较少的努力潜在活性物质。

6. 发明申请

WO2013121873A1 ビアリール化合物の製造方法审中-公开
标题翻译：二元化合物的生产方法
公开(公告)号：WO2013121873A1
公开(公告)日：2013-08-22
申请号：PCT/JP2013/051838
申请日：2013-01-29
申请人：国立大学法人名古屋大学
发明人：石原　一彰 , ウヤヌク　ムハメット
IPC分类号： C07C41/30 , C07C43/23 , C07C46/06 , C07C50/06 , C07C50/12 , C07B61/00
CPC分类号： C07C41/30 , C07C46/06 , C07C43/23 , C07C50/06 , C07C50/12
摘要：　本発明のビアリール化合物の製造方法は、テトラブチルアンモニウムヨージド、及びｔｅｒｔ－ブチルヒドロペルオキシド又は過酸化水素の存在下、フェノール又はナフトールを反応させる工程を包含する。
摘要翻译：这种联芳基化合物的制备方法包括在四丁基碘化铵和叔丁基过氧化氢或过氧化氢的存在下苯酚或萘酚反应的步骤。

7. 发明申请

WO0250007A3 SUBSTITUTED STILBENES, THEIR REACTIONS AND ANTICANCER ACTIVITY 审中-公开
标题翻译：替代的STILBENES，它们的反应和反应活动
公开(公告)号：WO0250007A3
公开(公告)日：2002-10-17
申请号：PCT/GB0105702
申请日：2001-12-20
申请人： CANCER RES VENTURES LTD , HADFIELD JOHN ANTHONY , MCGOWN ALAN THOMSON , MAYALARP STEPHEN PATRICK , LAND EDWARD JOHN , HAMBLETT IAN , GAUKROGER KEIRA , LAWRENCE NICHOLAS JAMES , HEPWORTH LUCY ANNETTE , BUTLER JOHN
发明人： HADFIELD JOHN ANTHONY , MCGOWN ALAN THOMSON , MAYALARP STEPHEN PATRICK , LAND EDWARD JOHN , HAMBLETT IAN , GAUKROGER KEIRA , LAWRENCE NICHOLAS JAMES , HEPWORTH LUCY ANNETTE , BUTLER JOHN
IPC分类号： A61P35/00 , C07C43/215 , C07C43/23 , C07C46/06 , C07C50/30 , C07C205/35 , C07C205/37 , C07C205/44 , C07C271/22 , C07D213/68 , C07F7/18 , A61K31/09 , A61K31/12 , A61K31/215 , A61K31/27 , A61K31/44 , C07C50/28
CPC分类号： C07F7/1852 , C07C43/215 , C07C43/23 , C07C46/06 , C07C50/30 , C07C205/35 , C07C205/37 , C07C205/44 , C07C271/22 , C07D213/68
摘要： The present invention relates to stilbene and quinone compounds related to combretastatin A-4 and their use as anticancer compounds and prodrugs. The compounds include those with an alkyl group on the double bond of cis or trans-stilbenes, compounds with one or more (and preferably 2 or 3) alkyl group substituents on the stilbene A ring, compounds with an alkoxy group other than methoxy at position 3, 4, and/or 5 of the stilbene A ring, compounds (or prodrugs) in which BOC amino acid esters are formed with the phenolic hydroxyl at the 3-position of the B ring and compounds (or prodrugs) based on a benzoquinone B ring. The present invention further relates to the photochemical reactions of stilbene compounds, either the above compounds disclosed for the first time herein or compounds based on prior art stilbenes. These reactions include the photochemical release of an active form of the compound from a prodrug conjugate and the photochemical isomerisation of the compounds, especially from a trans to cis form of compounds. The reactions can be used alone or in combination to convert inactive or comparatively less active forms of the compounds to more active forms,thereby allowing the compounds to be selectively targeted, e.g. activating them at the site of a tumour.
摘要翻译：本发明涉及与考布他汀A-4相关的芪和醌化合物及其作为抗癌化合物和前药的用途。化合物包括在顺式或反式二苯乙烯的双键上具有烷基的化合物，在二苯乙烯A环上具有一个或多个（优选2或3个）烷基取代基的化合物，位置以外的甲氧基的烷氧基的化合物 3,4或5，其中BOC氨基酸酯与B环3位上的酚羟基形成的化合物（或前药）和基于苯醌的化合物（或前药） B戒指本发明还涉及二苯乙烯化合物的光化学反应，上述化合物是本文首次公开的化合物或基于现有技术的二苯乙烯的化合物。这些反应包括来自前药缀合物的化合物的活性形式的光化学释放和化合物的光化学异构化，特别是从反式到顺式形式的化合物。反应可以单独使用或组合使用以将化合物的无活性或相对较少活性的形式转化为更具活性的形式，从而允许化合物选择性靶向。在肿瘤部位激活它们。

8. 发明申请

WO0168743A3 POROUS POLYMER/CARRIER SOLID PHASE REACTANTS, METHOD FOR PRODUCING SAME AND THE USE THEREOF 审中-公开
标题翻译：多孔聚合物/支固相，用于生产及其用途
公开(公告)号：WO0168743A3
公开(公告)日：2002-05-16
申请号：PCT/DE0101092
申请日：2001-03-15
申请人： KUNZ ULRICH , KIRSCHNING ANDREAS , HOFFMANN ULRICH
发明人： KUNZ ULRICH , KIRSCHNING ANDREAS , HOFFMANN ULRICH
IPC分类号： C07C29/143 , B01J20/28 , C07B39/00 , C07B61/00 , C07C17/02 , C07C17/08 , C07C17/20 , C07C17/266 , C07C17/275 , C07C17/38 , C07C33/22 , C07C45/29 , C07C45/30 , C07C45/39 , C07C45/63 , C07C45/78 , C07C46/06 , C07C49/403 , C07C205/03 , C07C247/10 , C07C253/14 , C07C255/33 , C07C331/04 , C08F2/44 , C40B50/00 , C08F8/00
CPC分类号： C07C17/38 , B01J2219/00497 , C07B39/00 , C07B61/00 , C07B2200/11 , C07C17/02 , C07C17/08 , C07C17/202 , C07C17/266 , C07C17/275 , C07C45/29 , C07C45/292 , C07C45/298 , C07C45/30 , C07C45/63 , C07C45/78 , C07C46/06 , Y10T428/1376 , Y10T428/2982 , Y10T428/2998 , Y10T428/31855 , Y10T428/31931 , C07C19/08 , C07C49/403
摘要： Disclosed are porous polymer/carrier solid phase reactants which consist of a polymer that consists of fine particles and is situated in the pore space of porous carrier materials. Reactive groups are bound to the polymer. Said groups act as reactants in organic-chemical syntheses. Said solid phase reactants can be produced as bulk material or tubes, plates or rods, can be built in pressure sealed housings and can be used in flow-through apparatuses or microtitration fields for the synthesis of organic products. Potential active agents can be produced at high speed by using the inventive porous polymer/carrier solid phase reactants that can be flown through convectively, whereby production requires only little isolation and cleaning.
摘要翻译：中描述的多孔聚合物/载体的固相反应物，其由细碎聚合物，其存在于多孔载体材料的孔体积。在聚合物的反应性基团连接，这在有机合成化学作为反应物起作用。提到的固相反应物可作为散装材料或作为管，板或杆来制备。提到的固相反应物可以被结合到压力密封的壳体和在流通装置或Mikrotitrierfeldern用于有机产品的合成。通过使用所描述的对流流过的多孔聚合物/支持固相反应物，可以以高的速度来产生与用于分离和纯化较少的努力潜在活性物质。

9. 发明申请

WO01068579A1 METHOD FOR PRODUCING 1,1' BINAPHTHALENYLIDENE-4,4'-DIONES 审中-公开
标题翻译：用于生产1,1'- BINAPHTHALINYLIDEN -4,4-二酮
公开(公告)号：WO01068579A1
公开(公告)日：2001-09-20
申请号：PCT/EP2001/003045
申请日：2001-03-16
IPC分类号： C07C46/06 , C07C50/14
CPC分类号： C07C46/06 , C07C50/14
摘要： The invention relates to a method for producing 1,1' binaphthalenylidene-4,4'-diones of general formula (I), wherein R represents C1-6 alkyl, C1-6 alkoxy, phenyl, substituted phenyl, benzyl or benzyloxy; R , R , R , and R independently of one another represent hydrogen, C1-6 alkyl, C1-6 alkoxy, phenyl, substituted phenyl, benzyl or benzyloxy. Production takes place by oxidative coupling of the corresponding naphthols in the presence of a peroxide and a precious metal catalyst.
摘要翻译：本发明涉及一种用于通式的1,1'- Binaphthalinyliden -4,4'-二酮的制备（I）其中，R <1> C 1-6 Alykl，C 1-6烷氧基，苯基，取代苯基，苄基或苄氧基; [R <2>，R <3>，R <4>和R <5>独立地是氢，C 1-6烷基，C 1-6烷氧基，苯基，取代苯基，苄基或苄氧基，由相应的氧化偶合萘酚在过氧化物的存在和贵金属催化剂。

10. 发明申请

WO00023377A1 METHOD FOR PREPARING A MEL-TYPE TITANIUM SILICALITE, RESULTING PRODUCT AND USES IN CATALYSIS 审中-公开
标题翻译：制备冶金型钛酸钡的方法，催化产物和用途
公开(公告)号：WO00023377A1
公开(公告)日：2000-04-27
申请号：PCT/FR1999/002478
申请日：1999-10-13
IPC分类号： B01J29/89 , B01J29/04 , B01J32/00 , C01B37/00 , C01B37/02 , C01B39/04 , C07B61/00 , C07C37/60 , C07C46/04 , C07C46/06 , C07C50/04 , B01J29/035
CPC分类号： C07C37/60 , B01J29/04 , C01B37/005 , C07C39/08
摘要： The invention concerns a novel method for preparing MEL-type titanium silicalite, the resulting product and its different uses in the field of catalysis. The inventive method for preparing MEL-type titanium silicalite is characterised in that it consists in: impregnating an amorphous xerogel (TiO2-SiO2) comprising at least silicon and titanium elements with a solution comprising at least a structural agent and at least a mobilizer OH ; the impregnating solution comprising at least an efficient amount of a compound of the type 3,5 dimethylpiperidinium used as structural agent; heating said reaction mixture up to the zeolite crystallisation temperature; then recuperating and calcining the resulting zeolite. The zeolite crystals obtained present a morphology resulting from their preparation method.
摘要翻译：本发明涉及一种制备MEL型钛硅沸石的新方法，所得产物及其在催化领域中的不同用途。用于制备MEL型钛硅沸石的本发明的方法的特征在于：其包括至少包含硅和钛元素的无定形干凝胶（TiO 2 -SiO 2），其至少包含结构剂和至少一种活化剂OH - >; 所述浸渍溶液至少包含有效量的用作结构剂的3,5-二甲基哌啶的化合物; 将所述反应混合物加热至沸石结晶温度; 然后使所得沸石回收和煅烧。获得的沸石晶体呈现由其制备方法得到的形态。

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