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1. 发明申请

WO2010121638A1 RECOVERY OF VITAMIN K3 FROM MOTHER LIQUOR 审中-公开
标题翻译：维生素K3从母液中恢复
公开(公告)号：WO2010121638A1
公开(公告)日：2010-10-28
申请号：PCT/EP2009/008877
申请日：2009-12-11
申请人： LONZA LTD , BICKER, Markus , BIERSTEDT, Anja , AMOUZEGAR, Kamyad , MAHDAVI, Behzad , ST-AMANT, Guy
发明人： BICKER, Markus , BIERSTEDT, Anja , AMOUZEGAR, Kamyad , MAHDAVI, Behzad , ST-AMANT, Guy
IPC分类号： C07C46/10 , C07C50/12
CPC分类号： C07C46/10 , C07C50/12
摘要： The present invention discloses a process for the recovery of Menadione from spent mother liquor containing a Menadione Bisulfite derivative, whereby the pH of the mother liquor is increased.
摘要翻译：本发明公开了一种从含有Menadione亚硫酸氢盐衍生物的废母液中回收Menadione的方法，由此母液的pH增加。

2. 发明申请

WO1993018208A1 INDIRECT CERIUM MEDIATED ELECTROSYNTHESIS 审中-公开
标题翻译：间接的介质电泳法
公开(公告)号：WO1993018208A1
公开(公告)日：1993-09-16
申请号：PCT/CA1993000037
申请日：1993-02-01
申请人： HYDRO-QUEBEC
发明人： HYDRO-QUEBEC , HARRISON, Stephen
IPC分类号： C25B01/00
CPC分类号： C25B1/00 , B82Y30/00 , C07C45/28 , C07C46/04 , Y02P20/125 , C07C50/12
摘要： An integrated process for oxidizing aromatic and alkyl aromatic compounds to form carbonyl containing reaction products comprising the reaction of quadravalent cerium with a reactant stream containing an aromatic or alkyl aromatic compound and using a high degree of mixing, followed by the electrolytic regeneration of the reduced cerium ion in a cell (A) under near turbulent or turbulent flow conditions at high solution velocities relative to the anode. The preferred cell structure for accomplishing the electrolysis utilizes a turbulence promoting anode arrangement which allows for the analyte to flows past the anode under the conditions mentioned, and a reduced area cathode whereby the anode and cathode compartments need not be separated by an ion exchange membrane.

3. 发明申请

WO2018145660A1 一种2-甲基-1,4-萘醌的全连续流合成工艺审中-公开
公开(公告)号：WO2018145660A1
公开(公告)日：2018-08-16
申请号：PCT/CN2018/076323
申请日：2018-02-11
申请人：上海惠和化德生物科技有限公司
发明人：马兵 , 马陈雷 , 刘学 , 潘帅
IPC分类号： C07C46/04 , C07C50/10
CPC分类号： C07C46/02 , C07C46/04 , C07C50/10 , C07C50/12
摘要：本发明涉及一种2-甲基-1,4-萘醌的全连续流合成工艺以及实现该工艺的一体化连续流反应器，所述的合成工艺以2-甲基萘、乳化剂溶液、重铬酸钠溶液、硫酸溶液为原料，所述的合成工艺在一体化连续流反应器中进行，在所述一体化连续流反应器的进料口不间断加入2-甲基萘、乳化剂溶液、重铬酸钠溶液、硫酸溶液，连续经过瞬态乳化过程和氧化过程，在所述一体化连续流反应器出料口不间断得到2-甲基-1,4-萘醌，反应时间等于或小于700s。本工艺是一种快速、安全、高效、通用性强和易于大规模生产的2-甲基-1,4-萘醌的连续合成工艺。

4. 发明申请

WO2011017519A3 INHIBITORS OF METHIONINE AMINOPEPTIDASES AND METHODS OF TREATING DISORDERS 审中-公开
标题翻译：蛋氨酸氨基肽酶抑制剂和治疗疾病的方法
公开(公告)号：WO2011017519A3
公开(公告)日：2011-06-30
申请号：PCT/US2010044547
申请日：2010-08-05
申请人： UNIV JOHNS HOPKINS , LIU JUN O , OLALEYE OMONIKE ARIKE , BHAT SHRIDHAR
发明人： LIU JUN O , OLALEYE OMONIKE ARIKE , BHAT SHRIDHAR
IPC分类号： C07C50/12 , A61K31/122 , A61P35/00 , C07D215/04 , C07D275/04
CPC分类号： C07C50/12 , C07D277/42 , C07D277/44 , C07D277/46 , C07D277/84 , C07D295/116 , C07D513/04
摘要： The invention is directed towards novel naphthoquinone and naphthothiazole compounds, and methods of treating disorders related to MetAP, including tuberculosis and bacterial infection, using various naphthoquinone, hydroxyquinonline, and naphthothiazole compounds.
摘要翻译：本发明涉及新颖的萘醌和萘并噻唑化合物，以及使用各种萘醌，羟基喹啉和萘并噻唑化合物治疗与MetAP有关的疾病，包括结核和细菌感染的方法。

5. 发明申请

WO2013121873A1 ビアリール化合物の製造方法审中-公开
标题翻译：二元化合物的生产方法
公开(公告)号：WO2013121873A1
公开(公告)日：2013-08-22
申请号：PCT/JP2013/051838
申请日：2013-01-29
申请人：国立大学法人名古屋大学
发明人：石原　一彰 , ウヤヌク　ムハメット
IPC分类号： C07C41/30 , C07C43/23 , C07C46/06 , C07C50/06 , C07C50/12 , C07B61/00
CPC分类号： C07C41/30 , C07C46/06 , C07C43/23 , C07C50/06 , C07C50/12
摘要：　本発明のビアリール化合物の製造方法は、テトラブチルアンモニウムヨージド、及びｔｅｒｔ－ブチルヒドロペルオキシド又は過酸化水素の存在下、フェノール又はナフトールを反応させる工程を包含する。
摘要翻译：这种联芳基化合物的制备方法包括在四丁基碘化铵和叔丁基过氧化氢或过氧化氢的存在下苯酚或萘酚反应的步骤。

6. 发明申请

WO2011085945A1 YIELD-EFFICIENT PROCESS FOR THE PRODUCTION OF HIGHLY PURE 2-METHYL-1,4-NAPHTHOQUINONE AND ITS DERIVATIVES 审中-公开
标题翻译：用于生产高纯度2-甲基-1,4-萘醌及其衍生物的有效方法
公开(公告)号：WO2011085945A1
公开(公告)日：2011-07-21
申请号：PCT/EP2011/000024
申请日：2011-01-06
申请人： LONZA LTD , AMOUZEGAR, Kamyab , MAHDAVI, Behzad , LANGEVIN, Mathieu , DIDIER, Charles , LIEB, Alexander
发明人： AMOUZEGAR, Kamyab , MAHDAVI, Behzad , LANGEVIN, Mathieu , DIDIER, Charles , LIEB, Alexander
IPC分类号： C07C46/04
CPC分类号： C07C46/04 , C07C46/08 , C07C50/12
摘要： The present invention discloses a process for the production of 2-methyl-1,4-naphthoquinone and its bisulfite adducts, comprising the following steps: a) oxidizing 2-methyl-naphthalene (2-MNA) to achieve an organic phase containing 2-methyl-naphthoquinone (2-MNQ) and 6-methyl-naphthoquinone (6-MNQ); b) subjecting said organic phase to treatment with an aqueous solution of a bisulfite salt to extract preferentially the 6-MNQ isomer from the organic phase; c) separating said organic phase from the aqueous phase; d) subjecting the organic phase of process step c) to a second bisulfitation step with an aqueous solution of a bisulfite salt, resulting in an organic phase containing 2-MNA and trace amounts of 2-MNQ and an aqueous phase containing 2-MSB and trace amounts of 6-MSB; e) optionally removing interfering bisulfite ions from the aqueous phase of process step c); f) raising the pH of the aqueous phase from step c) or e) to higher than 8,5 in the presence of a solvent resulting in an organic phase containing 2-MNQ; g) combining the organic phase from step f) with the organic phase being treated in the process step d); h) recycling the organic phase from step d) back to step a) to be used as solvent for the oxidation reaction of 2-MNA.
摘要翻译：本发明公开了一种2-甲基-1,4-萘醌及其亚硫酸氢盐加合物的制备方法，包括以下步骤：a）氧化2-甲基 - 萘（2-MNA）以获得含2- 甲基萘醌（2-MNQ）和6-甲基萘醌（6-MNQ）; b）使用亚硫酸氢盐水溶液对所述有机相进行处理，从有机相中优先提取6-MNQ异构体; c）将所述有机相与水相分离; d）使工艺步骤c）的有机相与亚硫酸氢盐水溶液进行第二次双硫化步骤，得到含有2-MNA和痕量2-MNQ的有机相和含有2-MSB的水相和痕量6-MSB; e）任选地从工艺步骤c）的水相中除去干扰亚硫酸氢盐离子; f）在溶剂存在下将水相的pH从步骤c）或e）提高到高于8.5，导致含有2-MNQ的有机相; g）将步骤f）中的有机相与方法步骤d）中待处理的有机相结合; h）将步骤d）中的有机相回收至步骤a）以用作2-MNA的氧化反应的溶剂。

7. 发明申请

WO2015172076A1 NAPHTHAQUINONE METHYLTRANSFERASE INHIBITORS AND USES THEREOF 审中-公开
标题翻译：萘醌亚甲基转移酶抑制剂及其用途
公开(公告)号：WO2015172076A1
公开(公告)日：2015-11-12
申请号：PCT/US2015/029977
申请日：2015-05-08
申请人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
发明人： LUO, Minkui , SANCHEZ, Glorymar, Ibanez , BLUM, Gil, Joseph , YANG, Li
IPC分类号： C07C50/10 , C07C50/12
CPC分类号： C07C50/12 , C07C50/14 , C07C233/32 , C07C323/22 , C07C323/30 , C07C2601/14 , C07C2602/10 , C07D215/38 , C07D217/02 , C07D243/08 , C07D295/116 , C09B13/02
摘要： Provided herein are compounds of (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, and prodrugs thereof. Also provided are pharmaceutical compositions and methods involving the inventive compounds for the treatment of proliferative diseases (e.g., cancer (e.g., leukemia, breast cancer, melanoma, metastatic cancer) and diseases associated with inappropriate SET8 activity. Also provided are methods for inhibiting SET8 and methods for labelling SET8.
摘要翻译：本文提供了（I）化合物及其药学上可接受的盐，溶剂合物，水合物，多晶型物，共晶体，互变异构体，立体异构体和前药。还提供了涉及用于治疗增殖性疾病（例如，癌症（例如，白血病，乳腺癌，黑素瘤，转移性癌症）和与不适当的SET8活性相关的疾病的本发明化合物的药物组合物和方法。还提供了用于抑制SET8和 SET8标签的方法。

8. 发明申请

WO2011017519A2 INHIBITORS OF METHIONINE AMINOPEPTIDASES AND METHODS OF TREATING DISORDERS 审中-公开
标题翻译：甲氨酸氨基转移酶的抑制剂和治疗疾病的方法
公开(公告)号：WO2011017519A2
公开(公告)日：2011-02-10
申请号：PCT/US2010/044547
申请日：2010-08-05
申请人： THE JOHNS HOPKINS UNIVERSITY , LIU, Jun O. , OLALEYE, Omonike Arike , BHAT, Shridhar
发明人： LIU, Jun O. , OLALEYE, Omonike Arike , BHAT, Shridhar
IPC分类号： C07C50/12 , C07D275/04 , C07D215/04 , A61K31/122 , A61P35/00
CPC分类号： C07C50/12 , C07D277/42 , C07D277/44 , C07D277/46 , C07D277/84 , C07D295/116 , C07D513/04
摘要： The invention is directed towards novel naphthoquinone and naphthothiazole compounds, and methods of treating disorders related to MetAP, including tuberculosis and bacterial infection, using various naphthoquinone, hydroxyquinonline, and naphthothiazole compounds.
摘要翻译：本发明涉及新型萘醌和萘并噻唑化合物，以及使用各种萘醌，羟基醌纶和萘并噻唑化合物治疗与MetAP相关的疾病，包括结核病和细菌感染的方法。

9. 发明申请

WO2007073651A1 4,5-开环二萜醌类化合物及其制备方法和应用审中-公开
公开(公告)号：WO2007073651A1
公开(公告)日：2007-07-05
申请号：PCT/CN2006/002440
申请日：2006-09-19
申请人：中国科学院上海药物研究所 , 张金生 , 邓斐 , 丁健
发明人：张金生 , 邓斐 , 丁健
IPC分类号： C07C50/12 , C07C50/14 , C07C50/38 , C07C46/00 , C07C69/16 , C07C69/353 , C07C67/08 , C07D303/32 , C07D301/14 , A61K31/122 , A61K31/222 , A61K31/336 , A61P35/00
CPC分类号： C07D303/32 , C07C46/00 , C07C50/12 , C07C50/14 , C07C50/38 , C07C67/08 , C07C69/007 , C07C69/34 , C07C69/16
摘要： Disclosed are 4,5-seco abieta diterpene quinones (i.e. saproorthoquinone derivatives) of formula A, B or C, physiological acceptable salts, preparation process and pharmaceutical compositions thereof , wherein in formula A, R 1 is CH 3 , CHO, CH 2 OH, CH 2 OAc, CH 2 OCO(CH 2 ) n CH 3 or CH 2 OCO(CH 2 ) n COOH, each of R 2 and R 3 is independently selected from the group composed of H, OH, OAc, OCO(CH 2 ) n CH 3 and OCO(CH 2 ) n COOH, or when R 1 is not CH 3 , R 2 and R 3 link together and form a three-member epoxy; in formula B, R 1 is CHO, CH 2 OH, CH 2 OAc, CH 2 OCO(CH 2 ) n CH 3 or CH 2 OCO(CH 2 ) n COOH n is an integer of from 1 to 10. Said compounds have antitumor activity. A B C

10. 发明申请

WO2002066690A2 METHOD OF PURIFICATION OF A REDOX MEDIATOR BEFORE ELECTROLYTIC REGENERATION THEREOF 审中-公开
标题翻译：在其电解再生之前，还原氧化还原剂的方法
公开(公告)号：WO2002066690A2
公开(公告)日：2002-08-29
申请号：PCT/CA2002/000095
申请日：2002-01-24
申请人： HYDRO-QUEBEC
发明人： MAHDAVI, Bezhad , HARRISON, Stephen , AMOUZEGAR, Kamyab
IPC分类号： C22B3/22
CPC分类号： C22B3/20 , C07C45/36 , C07C46/02 , C07C46/04 , Y02P10/234 , C07C47/542 , C07C50/24 , C07C50/12
摘要： A method for purifying a Redox mediator used in a chemical process of oxidation of organic compounds. The desired purification is obtained by recovering the mediator in the form of a solution and heating this solution to evaporate the volatile impurities contained in it and to oxidize the non volatile impurities into compounds which precipitate and are extracted by filtration. The purification takes place before the mediator is regenerated in the electrolysis cell. This prevents the impurities contained in the mediator solution to negatively affect the operation of this cell.
摘要翻译：一种用于净化有机化合物氧化化学过程中的氧化还原介体的方法。通过以溶液的形式回收介质并加热该溶液以蒸发其中所含的挥发性杂质并将非挥发性杂质氧化成化合物沉淀并通过过滤提取来获得所需的纯化。在电解池中再生之前进行纯化。这可以防止介质溶液中所含的杂质对该电池的操作产生负面影响。

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