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1. 发明申请

WO2019123144A1 VITAMIN K2 COMPOSITIONS FOR THE TREATMENT OF DRUG INDUCED NEUROPATHY 审中-公开
公开(公告)号：WO2019123144A1
公开(公告)日：2019-06-27
申请号：PCT/IB2018/060038
申请日：2018-12-13
申请人： SYNERGIA LIFE SCIENCES PVT. LTD.
发明人： MEHTA, Dilip , VAIDYA, Ashok , VAIDYA, Rama , DOUND, Yogesh , DE SOUZA, Anselm
IPC分类号： A61K31/22 , A61P25/02 , A61P35/00 , C07C50/12 , C07C50/14
摘要： The present invention provides the use of vitamin K2 compositions for the treatment of drug- induced neuropathy. More particularly it is related to the use of vitamin K2-7 compositions for the treatment of drug- induced peripheral neuropathy caused by the drugs used for the treatment of multiple myeloma.

2. 发明申请

WO2010121638A1 RECOVERY OF VITAMIN K3 FROM MOTHER LIQUOR 审中-公开
标题翻译：维生素K3从母液中恢复
公开(公告)号：WO2010121638A1
公开(公告)日：2010-10-28
申请号：PCT/EP2009/008877
申请日：2009-12-11
申请人： LONZA LTD , BICKER, Markus , BIERSTEDT, Anja , AMOUZEGAR, Kamyad , MAHDAVI, Behzad , ST-AMANT, Guy
发明人： BICKER, Markus , BIERSTEDT, Anja , AMOUZEGAR, Kamyad , MAHDAVI, Behzad , ST-AMANT, Guy
IPC分类号： C07C46/10 , C07C50/12
CPC分类号： C07C46/10 , C07C50/12
摘要： The present invention discloses a process for the recovery of Menadione from spent mother liquor containing a Menadione Bisulfite derivative, whereby the pH of the mother liquor is increased.
摘要翻译：本发明公开了一种从含有Menadione亚硫酸氢盐衍生物的废母液中回收Menadione的方法，由此母液的pH增加。

3. 发明申请

WO0008495A3 ANTIPROLIFERATIVE NAPHTHOQUINONES, DERIVATIVES, COMPOSITIONS, AND USES THEREOF 审中-公开
标题翻译：抗增殖性萘酚醌，衍生物，组合物及其用途
公开(公告)号：WO0008495A3
公开(公告)日：2000-05-25
申请号：PCT/US9917863
申请日：1999-08-06
申请人： UNIV PITTSBURGH
发明人： CARR BRIAN I , WILCOX CRAIG S , KERNS JEFFREY K
IPC分类号： A61P35/00 , C07C43/225 , C07C46/00 , C07C46/02 , C07C50/24 , C07C205/46 , C07C233/33 , C07C323/22 , C07C50/12 , A61K31/05 , A61K31/055 , A61K31/06 , A61K31/10 , A61K31/122 , C07C50/14 , C07C205/25 , C07C205/26 , C07C323/21
CPC分类号： C07C323/22 , C07C43/225 , C07C46/00 , C07C46/02 , C07C50/24 , C07C205/46 , C07C233/33
摘要： The present invention provides a compound selected from the group consisting of (I), (II), and (III), wherein R and R are the same or different and are each H, C1-C3 alkyl, phosphate, or C1-C3 alkyl carboxylate; R and R are the same or different and are each H, a halogen, A-Z, S-Z, S-A-Z, N(B)-Z, N(B)-A-Z, O-Z, or O-A-Z, wherein: A is a C1-C20 linear or branched saturated or unsaturated alkyl, haloalkyl, arylalkyl, cycloalkylalkyl, heterocycloalkyl, hydroxyalkyl, alkoxyalkyl, thioalkyl, carboxyalkyl, carboalkoxyalkyl, carboxyaminoalkyl, a 5- to 6-membered ring carbohydrate or the corresponding acyclic analog thereof, peptidyl, or aminoalkyl diradical; B is H or C1-C6 alkyl; Z is H, aryl, heterocyclic, or a heteroatom-containing functional group; and R -R are the same or different and are each H, a halogen, heterocyclic, Z as defined above, A-Z as defined above, or heteroatom-containing functional group, provided that R -R are not all H, useful as cellular growth inhibitors.
摘要翻译：本发明提供选自（I），（II）和（III）的化合物，其中R 1和R 4相同或不同并且各自为H，C 1 -C 3烷基，磷酸酯或羧酸C1-C3烷基酯; R 2和R 3相同或不同并且各自为H，卤素，AZ，SZ，SAZ，N（B）-Z，N（B）-AZ，OZ或OAZ，其中：A C 1 -C 20直链或支链饱和或不饱和烷基，卤代烷基，芳基烷基，环烷基烷基，杂环烷基，羟基烷基，烷氧基烷基，硫代烷基，羧基烷基，羰基烷氧基烷基，羧基氨基烷基，5-6元环碳水化合物或其相应的无环类似物，，或氨基烷基二基; B是H或C 1 -C 6烷基; Z是H，芳基，杂环或含杂原子的官能团; 和R 5 -R 8相同或不同，并且各自为H，卤素，如上定义的杂环，Z，如上定义的AZ或含杂原子的官能团，条件是R 5 -R 8不全为H，可用作细胞生长抑制剂。

4. 发明申请

WO2019157163A1 TARGETING OCULAR DISEASES WITH NOVEL APE1/REF-1 INHIBITORS 审中-公开
公开(公告)号：WO2019157163A1
公开(公告)日：2019-08-15
申请号：PCT/US2019/017023
申请日：2019-02-07
申请人： INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
发明人： KELLEY, Mark R. , CORSON, Timothy W.
IPC分类号： C07C50/12 , A61K31/122 , A61P35/00 , C07C50/06
摘要： [(2E)-2-[(3-methoxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methylidene]-N,N-diethylpentanamide] (APX2009) and (2E)-2-[(3-methoxy-1,4-dioxo-1,4-dihydronapthalen -2-yl)methylidene]-N-methoxypentanamide] (APX2014) for inhibiting ocular diseases are disclosed herein.

5. 发明申请

WO2013121873A1 ビアリール化合物の製造方法审中-公开
标题翻译：二元化合物的生产方法
公开(公告)号：WO2013121873A1
公开(公告)日：2013-08-22
申请号：PCT/JP2013/051838
申请日：2013-01-29
申请人：国立大学法人名古屋大学
发明人：石原　一彰 , ウヤヌク　ムハメット
IPC分类号： C07C41/30 , C07C43/23 , C07C46/06 , C07C50/06 , C07C50/12 , C07B61/00
CPC分类号： C07C41/30 , C07C46/06 , C07C43/23 , C07C50/06 , C07C50/12
摘要：　本発明のビアリール化合物の製造方法は、テトラブチルアンモニウムヨージド、及びｔｅｒｔ－ブチルヒドロペルオキシド又は過酸化水素の存在下、フェノール又はナフトールを反応させる工程を包含する。
摘要翻译：这种联芳基化合物的制备方法包括在四丁基碘化铵和叔丁基过氧化氢或过氧化氢的存在下苯酚或萘酚反应的步骤。

6. 发明申请

WO01026482A1 POLYCYCLIC QUINONE AND IONOPHORE COMPOSITION FOR THE SYNERGISTIC REDUCTION OF METHANE FORMATION IN RUMINANT ANIMALS 审中-公开
标题翻译：用于消灭动物中甲烷形成的协同减少的多环喹啉和离子组合物
公开(公告)号：WO01026482A1
公开(公告)日：2001-04-19
申请号：PCT/US2000/027822
申请日：2000-10-10
IPC分类号： A23K1/16 , A23K1/17 , A23K1/18 , C07C50/18 , C07H19/01 , C07C50/08 , C07C50/12
CPC分类号： C07H19/01 , A23K20/111 , A23K20/195 , A23K50/10 , C07C50/18 , Y02P60/56
摘要： A composition, preferably used to reduce methane formation in a ruminant, wherein the composition is a combination of a polycyclic quinone compound and an ionophore compound.
摘要翻译：一种组合物，优选用于减少反刍动物中的甲烷形成，其中组合物是多环醌化合物和离子载体化合物的组合。

7. 发明申请

WO98056374A1 USE OF DIKETONE TETRACYCLES DERIVATIVES, NOVEL COMPOUNDS OBTAINED AND THEIR APPLICATION IN THERAPY 审中-公开
标题翻译：使用二酮酮四环素衍生物，获得的新化合物及其在治疗中的应用
公开(公告)号：WO98056374A1
公开(公告)日：1998-12-17
申请号：PCT/FR1998/001143
申请日：1998-06-05
IPC分类号： C07D213/73 , C07D471/04 , A61K31/435 , C07C50/12
CPC分类号： C07D213/73 , C07D471/04
摘要： The invention concerns the use of teracyclic derivatives of general formula (I) in which independently of one another: R1 is a hydrogen atom, a halogen atom, a C1-C5 alkyl radical, a C1-C5 alkoxy radical or OH, a nitro radical, an amino radical, a C1-C5 amino alkyl radical, a C1-C5 amino dialkyl radical, a C1-C5 thioalkyl radical or SH; R2 is a hydrogen atom, a halogen atom, a C1-C5 alkyl radical, a C1-C5 alkoxy radical, or OH, a nitro radical, an amino radical, a C1-C5 alkyl amino radical, a C1-C5 amino dialkyl radical, a C1-C5 thioalkyl radical or SH; R3 is a hydrogen atom, a halogen atom, a C1-C5 alkyl radical, a C1-C5 alkoxy radical or OH, a nitro radical, an amino radical, a C1-C5 amino alkyl radical, a C-C amino dialkyl radical, a C1-C5 amino thioalkyl radical or SH; n and m are either equal to 0 or to 1, but not independently of each other such that if n is equal to 1 then m is equal to 0, and if n is equal to 0 then m is equal to 1, for obtaining a medicine for treating functional and organic venous insufficiency.
摘要翻译：本发明涉及通式（I）的三环衍生物的用途，其中R 1为氢原子，卤素原子，C 1 -C 5烷基，C 1 -C 5烷氧基或OH，硝基氨基，C1-C5氨基烷基，C1-C5氨基二烷基，C1-C5硫代烷基或SH; R2是氢原子，卤素原子，C1-C5烷基，C1-C5烷氧基或OH，硝基，氨基，C1-C5烷基氨基，C1-C5氨基二烷基，C 1 -C 5硫代烷基或SH; R3是氢原子，卤素原子，C1-C5烷基，C1-C5烷氧基或OH，硝基，氨基，C1-C5氨基烷基，CC氨基二烷基，C1 -C 5氨基硫代烷基或SH; n和m等于0或1，但不是彼此独立，使得如果n等于1，则m等于0，并且如果n等于0，则m等于1，以获得治疗功能性和有机静脉功能不全的药物。

8. 发明申请

WO2020068735A1 AMINO-QUINONE ANTIPOLYMERANTS AND METHODS OF USING 审中-公开
公开(公告)号：WO2020068735A1
公开(公告)日：2020-04-02
申请号：PCT/US2019/052580
申请日：2019-09-24
申请人： ECOLAB USA INC.
发明人： MASERE, Jonathan
IPC分类号： C08F2/40 , C08F12/08 , C07C7/20 , C07C50/12
摘要： Described are methods and composition for inhibiting polymerization of a monomer (e.g., styrene) composition using an aminated quinone antipolymerant, such as an aminated benzoquinone or aminated naphthoquinone antipolymerant having one or more secondary or tertiary amine group(s). The aminated quinone antipolymerant can be used with little or no nitroxyl group containing antipolymerant yet still provide excellent antipolymerant activity in a monomer-containing composition.

9. 发明申请

WO2019201820A1 OXIDATION OF ALKYLATED P-HYDROQUINONES IN AQUEOUS SOLUTIONS BY HYDROGEN PEROXIDE 审中-公开
公开(公告)号：WO2019201820A1
公开(公告)日：2019-10-24
申请号：PCT/EP2019/059589
申请日：2019-04-15
申请人： DSM IP ASSETS B.V.
发明人： BONRATH, Werner , MUELLER, Marc-André , NETSCHER, Thomas , SMUDA, Christina , ZWEIFEL, Theodor
IPC分类号： C07C46/06 , C07C50/02 , C07C50/12 , C07C50/04
摘要： The present invention relates to the oxidation of alkylated p-hydroquinones. It has been found the oxidation by aqueous hydrogen peroxide in the presence of a transition metal salt, which does not comprise any polydentate ligand bound to the metal ion, and an organic acid and water represents a particularly efficient procedure for the manufacturing of alkylated p-benzoquinones.

10. 发明申请

WO2019201819A1 OXIDATION OF ALKYLATED P-HYDROQUINONES IN AQUEOUS SOLUTIONS BY OXYGEN 审中-公开
公开(公告)号：WO2019201819A1
公开(公告)日：2019-10-24
申请号：PCT/EP2019/059588
申请日：2019-04-15
申请人： DSM IP ASSETS B.V.
发明人： BONRATH, Werner , MUELLER, Marc-André , NETSCHER, Thomas
IPC分类号： C07C46/08 , C07C50/04 , C07C50/12 , C07C50/02
摘要： The present invention relates to the oxidation of alkylated p-hydroquinones. It has been found the oxidation by oxygen or an oxygen containing gas mixture in the presence of a transition metal salt, which does not comprise any polydentate ligand bound to the metal ion, and an organic acid and water represents a particularly efficient procedure for the manufacturing of alkylated p-benzoquinones.

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