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1. 发明申请

WO2002078046A2 MASS SPECTROMETRY METHOD AND APPARATUS 审中-公开
标题翻译：质谱法和装置
公开(公告)号：WO2002078046A2
公开(公告)日：2002-10-03
申请号：PCT/GB2002/001373
申请日：2002-03-20
申请人： THERMO FINNIGAN LLC , MAKAROV, Alexander , HARDMAN, Mark, E. , SCHWARTZ, Jae, C. , SENKO, Michael, W.
发明人： MAKAROV, Alexander , HARDMAN, Mark, E. , SCHWARTZ, Jae, C. , SENKO, Michael, W.
IPC分类号： H01J49/00
CPC分类号： H01J49/4225 , B82Y30/00 , H01J49/423 , H01J49/425
摘要： A mass spectrometer (10) comprises an ion source (12) which generates nebulized ions which enter an ion cooler (20) via an ion source block (16). Ions within a window of m/z of interest are extracted via a quadrupole mass filter (24) and passed to a linear trap (30). Ions are trapped in a potential well in the linear trap (30) and are bunched at the bottom of the potential well adjacent an exit segment (50). Ions are gated out of the linear trap (30) into an electrostatic ion trap (130) and are detected by a secondary electron multiplier (10). By bunching the ions in the linear trap (30) prior to ejection, and by focussing the ions in time of flight (TOF) upon the entrance of the electrostatic trap (130), the ions arrive at the electrostatic trap (130) as a convolution of short, energetic packets of similar m/z. Such packets are particularly suited to an electrostatic trap because the FWHM of each packet's TOF distribution is less than the period of oscillation of those ions in the electrostatic trap.
摘要翻译：质谱仪（10）包括离子源（12），其产生经由离子源块（16）进入离子冷却器（20）的雾化离子。通过四极质量过滤器（24）提取感兴趣的m / z窗口内的离子，并将其传递到线性阱（30）。离子被捕获在线性阱（30）中的势阱中，并且在邻近出口段（50）的势阱的底部聚束。离子从线性阱（30）门控成静电离子阱（130），并由二次电子倍增器（10）检测。通过在喷射之前聚束线性捕集阱（30）中的离子，并且在静电捕获器（130）的入口处通过聚焦离子在飞行时间（TOF），离子作为静电捕获器（130）到达静电捕获器130 短的，有活力的类似m / z的包的卷积。由于每个分组的TOF分布的FWHM小于静电阱中的那些离子的振荡周期，所以这样的分组特别适用于静电阱。

2. 发明申请

WO2015003799A1 TIME-OF-FLIGHT MASS SPECTROMETERS WITH CASSINI REFLECTOR 审中-公开
标题翻译：具有CASSINI反射器的飞行时间质谱仪
公开(公告)号：WO2015003799A1
公开(公告)日：2015-01-15
申请号：PCT/EP2014/001872
申请日：2014-07-08
申请人： BRUKER DALTONIK GMBH
发明人： KÖSTER, Claus
IPC分类号： H01J49/40 , H01J49/42
CPC分类号： H01J49/405 , H01J49/425
摘要： The invention relates to embodiments of high-resolution time-of- flight (TOF) mass spectrometers with special reflectors. The invention provides reflectors with ideal energy and solid angle focusing, based on Cassini ion traps, and proposes that a section of the flight path of the TOF mass spectrometers takes the form of a Cassini reflector. It is particularly favorable to make the ions fly through this Cassini reflector in a TOF mass spectrometer at relatively low energies, with kinetic energies of below one or two kiloelectronvolts. This results in a long, mass-dispersive passage time in addition to the time of flight of the other flight paths, without increasing the energy spread, angular spread or temporal distribution width of ions of the same mass. It is also possible to place several Cassini reflectors in series in order to extend the mass-dispersive time of flight. Several TOF mass spectrometers for axial as well as orthogonal ion injection with Cassini reflectors are presented.
摘要翻译：本发明涉及具有特殊反射器的高分辨率时间飞行（TOF）质谱仪的实施例。本发明提供了基于卡西尼离子阱的具有理想能量和立体角度聚焦的反射器，并且提出了TOF质谱仪的飞行路径的一部分采取卡西尼反射器的形式。特别有利的是使离子以相当低的能量在TOF质谱仪中飞过该卡西尼反射器，动能低于一或两千伏电压。这导致除了其他飞行路径的飞行时间之外的长的，质量分散的通过时间，而不增加相同质量的离子的能量扩散，角度扩展或时间分布宽度。也可以将几个卡西尼反射器串联放置，以延长飞行的质量分散时间。介绍了几种TOF质谱仪进行轴向和正交离子注入与卡西尼反射镜。

3. 发明申请

WO2013076307A2 HIGH DUTY CYCLE ION SPECTROMETER 审中-公开
标题翻译：高占空比离子光度计
公开(公告)号：WO2013076307A2
公开(公告)日：2013-05-30
申请号：PCT/EP2012/073640
申请日：2012-11-26
申请人： THERMO FISHER SCIENTIFIC (BREMEN) GMBH
发明人： MAKAROV, Alexander Alekseevich
CPC分类号： H01J49/10 , G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/0481 , H01J49/06 , H01J49/063 , H01J49/401 , H01J49/4215 , H01J49/423 , H01J49/425 , H01J49/426 , H01J49/427 , H01J49/4295
摘要： An ion spectrometer is provided, comprising: an ion source, arranged to generate ions continuously with a first range of mass to charge ratios; and an ion trap, arranged to receive ions from the ion source along an axis, and to eject ions with a second range of mass to charge ratios orthogonally to that axis, the second range of mass to charge ratios being narrower than the first range of mass to charge ratios. In some embodiments, ions generated by the ion source continuously flow into the ion trap. Additionally or alternatively, ion optics receive ions ejected from the ion trap and cool the ions without substantial fragmentation. An ion analyser receives ions ejected from the ion trap or ion optics and separates the ions in accordance with at least one characteristic of the ions.
摘要翻译：提供了一种离子光谱仪，包括：离子源，被布置成以第一质量与电荷比例连续地产生离子; 以及离子阱，被布置成沿着轴接收离子源的离子，并且以与该轴正交的质量与第二质量范围的质量与电荷的比例排出离子，质荷比的第二范围比第一范围的质荷比。在一些实施例中，由离子源产生的离子连续地流入离子阱。另外或替代地，离子光学器件接收从离子阱排出的离子并且冷却离子而不会明显碎裂。离子分析仪接收从离子阱或离子光学器件喷出的离子，并根据离子的至少一种特性分离离子。

4. 发明申请

WO2007000587A3 MULTI-ELECTRODE ION TRAP 审中-公开
标题翻译：多电极离子阱
公开(公告)号：WO2007000587A3
公开(公告)日：2008-03-27
申请号：PCT/GB2006002361
申请日：2006-06-27
申请人： THERMO FINNIGAN LLC , MAKAROV ALEXANDER ALEKSEEVICH
发明人： MAKAROV ALEXANDER ALEKSEEVICH
IPC分类号： H01J49/42
CPC分类号： H01J49/282 , H01J49/0009 , H01J49/0031 , H01J49/22 , H01J49/424 , H01J49/425
摘要： This invention relates generally to multi-reflection electrostatic systems, and more particularly to improvements in and relating to the Orbitrap electrostatic ion trap. A method of operating an electrostatic ion trapping device having an array of electrodes operable to mimic a single electrode is proposed, the method comprising determining three or more different voltages that, when applied to respective electrodes of the plurality of electrodes, generate an electrostatic trapping field that approximates the field that would be generated by applying a voltage to the single electrode, and applying the three or more so determined voltages to the respective electrodes. Further improvements lie in measuring a plurality of features from peaks with different intensities from one or more collected mass spectra to derive characteristics, and using the measured characteristics to improve the voltages to be applied to the plurality of electrodes.
摘要翻译：本发明一般涉及多反射静电系统，更具体地涉及Orbitrap静电离子阱的改进和涉及。提出了一种操作具有可操作以模拟单个电极的电极阵列的静电离子捕获装置的方法，所述方法包括确定当施加到所述多个电极中的各个电极时产生静电捕获场的三个或更多个不同的电压其近似于将通过向单个电极施加电压而产生的场，以及将三个或更多个如此确定的电压施加到各个电极。进一步的改进在于从具有不同强度的峰与一个或多个收集的质谱测量多个特征以导出特性，并且使用测量的特性来改善施加到多个电极的电压。

5. 发明申请

WO2006103445A2 IMPROVEMENTS RELATING TO ION TRAPPING 审中-公开
标题翻译：关于离子捕获的改进
公开(公告)号：WO2006103445A2
公开(公告)日：2006-10-05
申请号：PCT/GB2006/001170
申请日：2006-03-29
申请人： THERMO FINNIGAN LLC , MAKAROV, Alexander, Alekseevich , DENISOV, Eduard , JUNG, Gerhard , MALEK, Robert , LANGE, Oliver
发明人： MAKAROV, Alexander, Alekseevich , DENISOV, Eduard , JUNG, Gerhard , MALEK, Robert , LANGE, Oliver
IPC分类号： H01J49/42
CPC分类号： H01J49/423 , H01J49/004 , H01J49/425 , H01J49/4295
摘要： This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.
摘要翻译：本发明涉及一种捕获离子和离子捕获组件的方法。特别地，本发明在质谱仪中对离子的质量分析之前，已经将其应用于离子阱中的气体辅助捕获。本发明提供了一种捕集离子捕获组件的靶离子阱中的离子的方法，该离子捕获组件包括一系列体积排列使得离子可以从一个体积向下一个体积移动，所述体积包括目标离子阱，由此离子被允许反复通过体积，使得它们也被进入和离开目标离子阱而不被捕获。电位可用于从离子捕获组件的相应末端反射离子。任选地，潜在的井和/或气体辅助冷却可用于使离子沉淀在目标离子阱中。

6. 发明申请

WO2016118821A1 INTEGRATED HYBRID NEMS MASS SPECTROMETRY 审中-公开
标题翻译：一体化混合物质量分光光度计
公开(公告)号：WO2016118821A1
公开(公告)日：2016-07-28
申请号：PCT/US2016/014454
申请日：2016-01-22
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , THERMO FISHER SCIENTIFIC (BREMEN) GMBH
发明人： ROUKES, Michael, L. , MAKAROV, Alexander, A.
IPC分类号： H01J49/06 , H01J49/26
CPC分类号： H01J49/0013 , H01J49/0031 , H01J49/0045 , H01J49/06 , H01J49/061 , H01J49/26 , H01J49/425
摘要： A hybrid mass spectrometer comprising: an ion source for generating ions from a sample, a first mass spectral system comprising a nanoelectromechanical mass spectral (NEMS-MS) system, a second mass spectral system including at least one mass analyzer adapted to separate the charged particles according to their mass-to-charge ratios, and an integration zone coupling the first and second mass spectral systems, the integration zone including at least one directional device for controllably routing the ions to a selected one or both of the first and second mass spectral systems for analysis thereby. The second system can be an orbital electrostatic trap system. The ion beam can be electrically directed to one or the other system by ion optics. A chip with resonators can be used with cooling. Uses include analysis of large mass complexes found in biological systems, native single molecule analysis, and size and shape analysis.
摘要翻译：一种混合质谱仪，包括：用于从样品产生离子的离子源，包括纳米机电质谱（NEMS-MS）系统的第一质谱系统，包括至少一个质量分析器的第二质谱系统，所述质量分析器适于分离带电粒子根据其质荷比，以及耦合第一和第二质谱系统的积分区，该积分区包括至少一个定向装置，用于可控地将离子路由到第一和第二质谱中选定的一个或两个用于分析的系统。第二个系统可以是轨道静电捕获系统。离子束可以通过离子光学器件电导向一个或另一个系统。具有谐振器的芯片可以与冷却一起使用。用途包括生物系统中发现的大质量复合物的分析，天然单分子分析以及大小和形状分析。

7. 发明申请

WO2012152950A1 MASS ANALYSER 审中-公开
标题翻译：质量分析仪
公开(公告)号：WO2012152950A1
公开(公告)日：2012-11-15
申请号：PCT/EP2012/058941
申请日：2012-05-14
申请人： THERMO FISHER SCIENTIFIC (BREMEN) GMBH , DENISOV, Eduard V. , KHOLOMEEV, Alexander , HAUSCHILD, Jan-Peter , MAKAROV, Alexander Alekseevich
发明人： DENISOV, Eduard V. , KHOLOMEEV, Alexander , HAUSCHILD, Jan-Peter , MAKAROV, Alexander Alekseevich
IPC分类号： H01J49/42
CPC分类号： H01J49/26 , H01J49/425 , Y10T29/49117
摘要： A mass analyser comprises: an electrical field generator, providing a time-varying electric field for injection of ions to be analysed, excitation of ions to be analysed or both; first and second detection electrodes, each of which receives a respective voltage pickup due to the time-varying electric field and provides a respective detection signal based on a respective image current at the detection electrode; and a differential amplifier, providing an output based on the difference between the detection signal for the first detection electrode and the detection signal for the second detection electrode. It may also be provided that the electrical field generator comprises at least one field generating electrode without a spatially symmetrical counterpart and the capacitance between each field generating electrode and the first detection electrode is substantially the same as the capacitance between that field generating electrode and the second detection electrode.
摘要翻译：质量分析器包括：电场发生器，提供用于注入要分析的离子的时变电场，要分析的离子的激发或两者; 第一和第二检测电极，每个检测电极由于时变电场而接收相应的电压拾取器，并且基于检测电极处的各自的图像电流提供相应的检测信号; 以及差分放大器，基于第一检测电极的检测信号和第二检测电极的检测信号之间的差提供输出。还可以提供的是，电场发生器包括至少一个没有空间对称的场产生电极，并且每个场产生电极和第一检测电极之间的电容与该场产生电极和第二检测电极之间的电容基本相同检测电极。

8. 发明申请

WO2012069596A1 METHOD OF MASS SELECTING IONS AND MASS SELECTOR 审中-公开
标题翻译：大量选择离子和大量选择剂的方法
公开(公告)号：WO2012069596A1
公开(公告)日：2012-05-31
申请号：PCT/EP2011/070960
申请日：2011-11-24
申请人： THERMO FISHER SCIENTIFIC (BREMEN) GMBH , MAKAROV, Alexander
发明人： MAKAROV, Alexander
IPC分类号： H01J49/42
CPC分类号： H01J49/405 , H01J49/4245 , H01J49/425 , H01J49/427
摘要： A method of selecting ions of interest from a beam of ions using an analyser, the method comprising: (i)providing an analyser comprising two opposing ion mirrors each mirror comprising inner and outer field-defining electrode systems elongated along an analyser axis z, each system comprising one or more electrodes, the outer system surrounding the inner; (ii)causing the beam of ions to fly through the analyser along a main flight path in the presence of an analyser field so as to undergo within the analyser at least one full oscillation in the direction of the analyser axis whilst orbiting about or oscillating between one or more electrodes of the inner field defining electrode system; (iii)providing one or more sets of electrodes adjacent the main flight path; (iv)constraining the arcuate divergence from the main flight path of ions of interest by applying one set of voltages to one or more of the sets of electrodes adjacent the main flight path when the ions of interest are in the vicinity of at least one of said one or more sets of electrodes adjacent the main flight path and applying one or more different sets of voltages to the said one or more sets of electrodes adjacent the main flight path when the ions of interest are not in the vicinity of at least one of said one or more sets of electrodes adjacent the main flight path; and: (v)ejecting the ions of interest from the analyser. Also provided is a charged particle analyser comprising the two opposing ion mirrors comprising inner and outer field-defining electrode systems elongated along an analyser axis z,; and at least one arcuate focusing lens for constraining the arcuate divergence of a beam of charged particles within the analyser whilst the beam orbits around the axis z, the analyser further comprising a disc having two faces at least partly spanning the space between the inner and outer field defining electrode systems and lying in a plane perpendicular to the axis z, the disc having resistive coating upon both faces.
摘要翻译：一种使用分析仪从离子束中选择感兴趣的离子的方法，所述方法包括：（i）提供包括两个相对的离子镜的分析器，每个反射镜包括沿着分析器轴线z伸长的内部和外部场限定电极系统，每个系统包括一个或多个电极，外部系统围绕内部; （ii）在分析仪场的存在下使离子束沿着主飞行路线飞过分析器，以便在分析仪内经历分析器轴线方向上的至少一个完整的振荡，同时在内场定义电极系统的一个或多个电极; （iii）提供邻近主飞行路径的一组或多组电极; （iv）当感兴趣的离子在所述主飞行路径中的至少一个附近时，将一组电压施加到与所述主飞行路径相邻的所述电极组中的一个或多个组合，从而限制所述目标离子的主飞行路径的弓形偏离所述一组或多组电极邻近所述主飞行路径并且当所述感兴趣的离子不在所述主飞行路径中的至少一个附近时，将所述一组或多组电压施加到与所述主飞行路径相邻的所述一组或多组电极所述一组或多组邻近主飞行路径的电极; 和（v）从分析仪喷射感兴趣的离子。还提供了一种带电粒子分析仪，其包括两个相对的离子镜，其包括沿分析器轴线z伸长的内场和外场定义电极系统; 以及至少一个弧形聚焦透镜，用于约束分析器内的带电粒子束的弓形发散，同时光束围绕轴线z绕着轴线z移动，分析器还包括具有至少部分跨越内部和外部之间的空间的两个面的盘场定义电极系统并且位于垂直于轴线z的平面中，该盘在两个面上具有电阻涂层。

9. 发明申请

WO2011148312A2 IMPROVEMENTS RELATING TO THE CONTROL OF IONS 审中-公开
标题翻译：关于控制离子的改进
公开(公告)号：WO2011148312A2
公开(公告)日：2011-12-01
申请号：PCT/IB2011052244
申请日：2011-05-23
申请人： FASMATECH SCIENCE AND TECHNOLOGY LLC , RAPTAKIS EMMANUEL , PAPANASTASIOU DIMITRIS
发明人： RAPTAKIS EMMANUEL , PAPANASTASIOU DIMITRIS
IPC分类号： H01J49/04
CPC分类号： H01J49/067 , H01J49/34 , H01J49/40 , H01J49/425 , H01J49/426
摘要： A mass spectrometer comprises ion pulse means for producing ion pulses in a first vacuum chamber, ion trap means for receiving and trapping the ion pulses for mass analysis in a second vacuum chamber, and ion-optical lens means arranged between the ion pulse means and the ion trap means for receiving the ion pulses and outputting ions therefrom to the ion trap means. A first lens electrode and a second lens electrode collectively define an optical axis and are adapted for distributing a first electrical potential and second electrical potential therealong. Lens control means vary non-periodically with time the first electrical potential relative to the second electrical potential to control as a function of ion mass-to-charge ratio the kinetic energy of ions which have traversed the ion optical lens means. This controls the mass range of the ions receivable by the ion trap from the ion optical lens means.
摘要翻译：质谱仪包括用于在第一真空室中产生离子脉冲的离子脉冲装置，用于在第二真空室中接收和捕获用于质量分析的离子脉冲的离子阱装置，以及布置在离子脉冲装置和离子脉冲装置之间的离子 - 光学透镜装置用于接收离子脉冲并将离子从该离子阱输出到离子阱装置的离子阱装置。第一透镜电极和第二透镜电极共同限定光轴并且适于在其上分布第一电位和第二电位。透镜控制装置随时间变化，相对于第二电位的第一电位随着时间而变化，以便控制离子质量 - 荷电比例，其已经穿过离子光学透镜装置的离子的动能。这可以控制离子阱从离子光学透镜装置接收的离子的质量范围。

10. 发明申请

WO2006129109A2 IMPROVEMENTS IN AN ELECTROSTATIC TRAP 审中-公开
标题翻译：静电捕捉的改进
公开(公告)号：WO2006129109A2
公开(公告)日：2006-12-07
申请号：PCT/GB2006/002028
申请日：2006-06-05
申请人： THERMO FINNIGAN LLC , MAKAROV, Alexander , DENISOV, Eduard, V. , JUNG, Gerhard , BALSCHUN, Wilko , HORNING, Stevan, Roy
发明人： MAKAROV, Alexander , DENISOV, Eduard, V. , JUNG, Gerhard , BALSCHUN, Wilko , HORNING, Stevan, Roy
IPC分类号： H01J49/42
CPC分类号： H01J49/4245 , H01J49/0027 , H01J49/02 , H01J49/282 , H01J49/406 , H01J49/425
摘要： An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U'(r,φ,z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U'(r, φ,z) is the result of a perturbation W to an ideal field U(r, φ,z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, φ,z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than about 2 π radians over an ion detection period T m .
摘要翻译：公开了诸如轨道捕获器的静电捕获器，具有电极结构。产生形式为U'（r，f，z）的静电捕获场以捕获陷阱内的离子，使得它们经历同步振荡。捕获场U'（r，f，z）是对于理想场U（r，f，z）的扰动W的结果，其在轨道捕获的情况下例如是超对数的。扰动W可以以各种方式引入，例如通过使陷波的几何形状变形，使得其不再遵循理想场U（r，f，z）的等电位，或者通过添加失真场（电或磁性）。扰动的大小使得至少一些捕获的离子在离子检测周期T m具有大于零但小于约2p弧度的绝对相位扩展。

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