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1. 发明申请

WO02078046A3 MASS SPECTROMETRY METHOD AND APPARATUS 审中-公开
标题翻译：质谱法和装置
公开(公告)号：WO02078046A3
公开(公告)日：2003-02-13
申请号：PCT/GB0201373
申请日：2002-03-20
申请人： THERMO FINNIGAN LLC , MAKAROV ALEXANDER , HARDMAN MARK E , SCHWARTZ JAE C , SENKO MICHAEL W
发明人： MAKAROV ALEXANDER , HARDMAN MARK E , SCHWARTZ JAE C , SENKO MICHAEL W
IPC分类号： G01N27/62 , H01J49/06 , H01J49/40 , H01J49/42 , H01J49/28 , H01J49/48
CPC分类号： H01J49/4225 , B82Y30/00 , H01J49/423 , H01J49/425
摘要： A mass spectrometer (10) comprises an ion source (12) which generates nebulized ions which enter an ion cooler (20) via an ion source block (16). Ions within a window of m/z of interest are extracted via a quadrupole mass filter (24) and passed to a linear trap (30). Ions are trapped in a potential well in the linear trap (30) and are bunched at the bottom of the potential well adjacent an exit segment (50). Ions are gated out of the linear trap (30) into an electrostatic ion trap (130) and are detected by a secondary electron multiplier (10). By bunching the ions in the linear trap (30) prior to ejection, and by focussing the ions in time of flight (TOF) upon the entrance of the electrostatic trap (130), the ions arrive at the electrostatic trap (130) as a convolution of short, energetic packets of similar m/z. Such packets are particularly suited to an electrostatic trap because the FWHM of each packet's TOF distribution is less than the period of oscillation of those ions in the electrostatic trap.
摘要翻译：质谱仪（10）包括离子源（12），其产生经由离子源块（16）进入离子冷却器（20）的雾化离子。通过四极质量过滤器（24）提取感兴趣的m / z窗口内的离子，并将其传递到线性阱（30）。离子被捕获在线性阱（30）中的势阱中，并且在邻近出口段（50）的势阱的底部聚束。离子从线性阱（30）门控成静电离子阱（130），并由二次电子倍增器（10）检测。通过在喷射之前聚束线性捕集阱（30）中的离子，并且在静电捕获器（130）的入口处通过聚焦离子在飞行时间（TOF），离子作为静电捕获器（130）到达静电捕获器130 短的，有活力的类似m / z的包的卷积。由于每个分组的TOF分布的FWHM小于静电阱中的那些离子的振荡周期，所以这样的分组特别适用于静电阱。

2. 发明申请

WO2002078046A2 MASS SPECTROMETRY METHOD AND APPARATUS 审中-公开
标题翻译：质谱法和装置
公开(公告)号：WO2002078046A2
公开(公告)日：2002-10-03
申请号：PCT/GB2002/001373
申请日：2002-03-20
申请人： THERMO FINNIGAN LLC , MAKAROV, Alexander , HARDMAN, Mark, E. , SCHWARTZ, Jae, C. , SENKO, Michael, W.
发明人： MAKAROV, Alexander , HARDMAN, Mark, E. , SCHWARTZ, Jae, C. , SENKO, Michael, W.
IPC分类号： H01J49/00
CPC分类号： H01J49/4225 , B82Y30/00 , H01J49/423 , H01J49/425
摘要： A mass spectrometer (10) comprises an ion source (12) which generates nebulized ions which enter an ion cooler (20) via an ion source block (16). Ions within a window of m/z of interest are extracted via a quadrupole mass filter (24) and passed to a linear trap (30). Ions are trapped in a potential well in the linear trap (30) and are bunched at the bottom of the potential well adjacent an exit segment (50). Ions are gated out of the linear trap (30) into an electrostatic ion trap (130) and are detected by a secondary electron multiplier (10). By bunching the ions in the linear trap (30) prior to ejection, and by focussing the ions in time of flight (TOF) upon the entrance of the electrostatic trap (130), the ions arrive at the electrostatic trap (130) as a convolution of short, energetic packets of similar m/z. Such packets are particularly suited to an electrostatic trap because the FWHM of each packet's TOF distribution is less than the period of oscillation of those ions in the electrostatic trap.
摘要翻译：质谱仪（10）包括离子源（12），其产生经由离子源块（16）进入离子冷却器（20）的雾化离子。通过四极质量过滤器（24）提取感兴趣的m / z窗口内的离子，并将其传递到线性阱（30）。离子被捕获在线性阱（30）中的势阱中，并且在邻近出口段（50）的势阱的底部聚束。离子从线性阱（30）门控成静电离子阱（130），并由二次电子倍增器（10）检测。通过在喷射之前聚束线性捕集阱（30）中的离子，并且在静电捕获器（130）的入口处通过聚焦离子在飞行时间（TOF），离子作为静电捕获器（130）到达静电捕获器130 短的，有活力的类似m / z的包的卷积。由于每个分组的TOF分布的FWHM小于静电阱中的那些离子的振荡周期，所以这样的分组特别适用于静电阱。

3. 发明申请

WO2006116335A1 LEADING EDGE/TRAILING EDGE TOF DETECTION 审中-公开
标题翻译：领先边缘/追踪边缘TOF检测
公开(公告)号：WO2006116335A1
公开(公告)日：2006-11-02
申请号：PCT/US2006/015515
申请日：2006-04-21
申请人： THERMO FINNIGAN LLC , HARDMAN, Mark, E. , EARLEY, Lee , LAND, Adrian
发明人： HARDMAN, Mark, E. , EARLEY, Lee , LAND, Adrian
IPC分类号： B01D59/44
CPC分类号： H01J49/0036 , H01J49/025 , H01J49/40
摘要： Disclosed are a time-of-flight mass spectrometer and signal processing electronics. The signal processing electronics include a plurality of time-to-digital converters configured to receive signal pulses from the same detector anode within the time-of-flight mass spectrometer. The signal processing electronics are further configured to differentiate, and compensate for, those signal pulses caused by the detection of more than one ion. Differentiation and compensation are achieved by using the time-to-digital converters to detect the leading and trailing edges of a signal pulse. The time difference between the detection of the leading edge and detection of the trailing edge is indicative of whether or not the signal pulse was generated by the detection of more than one ion.
摘要翻译：披露了飞行时间质谱仪和信号处理电子学。信号处理电子器件包括多个时间 - 数字转换器，其被配置为在飞行时间质谱仪内接收来自相同检测器阳极的信号脉冲。信号处理电子器件还被配置为区分并补偿由多于一个离子的检测引起的那些信号脉冲。通过使用时间 - 数字转换器来检测信号脉冲的前沿和后沿来实现差分和补偿。前沿检测与后沿检测之间的时间差表示通过检测多于一个离子是否产生了信号脉冲。

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