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1. 发明申请

WO2012080268A1 ION DETECTION SYSTEM AND METHOD 审中-公开
标题翻译：离子检测系统和方法
公开(公告)号：WO2012080268A1
公开(公告)日：2012-06-21
申请号：PCT/EP2011/072634
申请日：2011-12-13
申请人： THERMO FISHER SCIENTIFIC (BREMEN) GMBH , KHOLOMEEV, Alexander , MAKAROV, Alexander
发明人： KHOLOMEEV, Alexander , MAKAROV, Alexander
IPC分类号： H01J49/02 , H01J43/00 , H01J49/40
CPC分类号： H01J49/0031 , H01J43/00 , H01J49/025 , H01J49/40
摘要： A detection system and a method for detecting ions which have been separated in a time-of-flight (TOF) mass analyser, comprising an amplifying arrangement for converting ions into packets of secondary particles and amplifying the packets of secondary particles, wherein the amplifying arrangement is arranged so that each packet of secondary particles produces at least a first output and a second output separated in time and so that during the delay between producing the first and second output the first output produced by a packet of secondary particles is used for modulating the second output produced by the same packet. An increased dynamic range of detection and protection of the detection system against intense ion pulses is thereby provided.
摘要翻译：一种用于检测在飞行时间质谱仪（TOF）质量分析仪中已分离的离子的检测系统和方法，包括用于将离子转换成二次粒子的分组并放大次级粒子的分组的放大装置，其中放大装置布置成使得每个二次粒子的分组产生至少第一输出和在时间上分离的第二输出，并且使得在产生第一和第二输出之间的延迟期间，由二次粒子的分组产生的第一输出用于调制第二个输出由同一个数据包产生。从而提供了检测系统对强离子脉冲的动态检测范围的增加。

2. 发明申请

WO2012069597A1 METHOD OF MASS SEPARATING IONS AND MASS SEPARATOR 审中-公开
标题翻译：质量分离离子和质量分离器的方法
公开(公告)号：WO2012069597A1
公开(公告)日：2012-05-31
申请号：PCT/EP2011/070961
申请日：2011-11-24
申请人： THERMO FISHER SCIENTIFIC (BREMEN) GMBH , MAKAROV, Alexander
发明人： MAKAROV, Alexander
IPC分类号： H01J49/40 , H01J49/42
CPC分类号： H01J49/40 , H01J49/406 , H01J49/4245
摘要： A method of separating ions according to their time of flight is provided comprising: a. providing an analyser comprising two opposing ion mirrors, each mirror comprising inner and outer field-defining electrode systems elongated along an analyser axis with the outer field-defining electrode system surrounding the inner field-defining electrode system and creating therebetween an analyser volume; b. injecting ions into the analyser volume or creating ions within the analyser volume so that they separate according to their time of flight as they travel along a main flight path whilst undergoing a plurality of axial oscillations in the direction of the analyser axis and a plurality of radial oscillations whilst orbiting about one or more inner field-defining electrodes; c. the plurality of axial oscillations and plurality of radial oscillations causing the separated ions to intercept an exit port after a predetermined number of orbits. Also provided is an analyser for performing the method, comprising: the two opposing ion mirrors which abut at a first plane, wherein the outer field-defining electrode system of one mirror comprises two sections, the sections abutting at a second plane, comprising a first section between the first plane and the second plane, and a second section adjacent the first section and wherein the first section has at least a portion which extends radially from the analyser axis a greater extent than an adjacent portion of the second section at the second plane.
摘要翻译：提供了根据其飞行时间分离离子的方法，其包括：a。提供包括两个相对离子反射镜的分析器，每个反射镜包括沿着分析器轴线延伸的内部和外部场限定电极系统，外部场界定电极系统围绕内部场界定义电极系统并在其间产生分析器体积; 湾将离子注入分析器体积中或在分析器体积内产生离子，使得当它们沿着主飞行路径行进时，它们根据其飞行时间分离，同时在分析器轴线的方向上经历多个轴向振荡，并且多个径向围绕一个或多个内场限定电极绕轨道运动的振荡; C。所述多个轴向振荡和多个径向振动导致分离的离子在预定数量的轨道之后拦截出口。还提供了一种用于执行该方法的分析器，包括：两个相对的离子反射镜，其在第一平面处邻接，其中一个反射镜的外场限定电极系统包括两个部分，所述部分邻接在第二平面，包括第一在第一平面和第二平面之间的部分，以及与第一部分相邻的第二部分，并且其中第一部分具有至少一个从分析器轴线径向延伸的部分比第二部分在第二平面处的相邻部分更大的范围。

3. 发明申请

WO2012041963A3 METHOD AND APPARATUS FOR IMPROVING THE THROUGHPUT OF A CHARGED PARTICLE ANALYSIS SYSTEM 审中-公开
标题翻译：用于改善充电粒子分析系统的方法和装置
公开(公告)号：WO2012041963A3
公开(公告)日：2012-05-24
申请号：PCT/EP2011066986
申请日：2011-09-29
申请人： THERMO FISHER SCIENT BREMEN , MAKAROV ALEXANDER , GIANNAKOPULOS ANASTASSIOS
发明人： MAKAROV ALEXANDER , GIANNAKOPULOS ANASTASSIOS
IPC分类号： H01J49/06
CPC分类号： H01J49/0027 , H01J49/0031 , H01J49/06 , H01J49/062
摘要： A method of increasing ion throughput within an accumulator, an energy lift and a pulsed ion extractor, operated in that order upon a batch of ions, comprising the steps of: firstly loading a batch of ions into the accumulator; secondly changing the electrical potential of the energy lift to raise the energy of the batch of ions contained therein; and thirdly ejecting the batch of ions from the pulsed ion extractor; and wherein: the energy lift is a separate device from the accumulator and the pulsed ion extractor, and whilst changing the electrical potential in the second step a fresh batch of ions is loaded into the accumulator and/or a previous batch of ions is prepared for ejection in the pulsed ion extractor; or the energy lift is incorporated into the pulsed ion extractor and whilst changing the electrical potential in the second step a fresh batch of ions is loaded into the accumulator; or the energy lift is incorporated into the accumulator and whilst changing the electrical potential in the second step a previous batch of ions is prepared for ejection in the pulsed ion extractor. A charged particle analyzer system is also provided.
摘要翻译：一种增加蓄电池内的离子通量的方法，能量提升和脉冲离子提取器，其以一批离子的顺序操作，包括以下步骤：首先将一批离子加载到蓄电池中; 二次改变能量升高的电位，以提高其中所含的一批离子的能量; 第三次从脉冲离子提取器中排出一批离子; 并且其中：所述能量提升是与所述蓄能器和所述脉冲离子提取器分离的装置，并且在第二步骤中改变电位的同时，将新批次的离子装载到所述储存器中和/或先前批次的离子准备在脉冲离子提取器中喷射; 或者能量提升被并入到脉冲离子提取器中，并且在第二步骤中改变电势的同时，将新批次的离子加载到蓄电池中; 或者能量提升被并入蓄能器中，并且在第二步骤中改变电位的同时，准备先前的一批离子以在脉冲离子提取器中喷射。还提供带电粒子分析仪系统。

4. 发明申请

WO2012041963A2 METHOD AND APPARATUS FOR IMPROVING THE THROUGHPUT OF A CHARGED PARTICLE ANALYSIS SYSTEM 审中-公开
标题翻译：用于改善充电粒子分析系统的方法和装置
公开(公告)号：WO2012041963A2
公开(公告)日：2012-04-05
申请号：PCT/EP2011/066986
申请日：2011-09-29
申请人： THERMO FISHER SCIENTIFIC (BREMEN) GMBH , MAKAROV, Alexander , GIANNAKOPULOS, Anastassios
发明人： MAKAROV, Alexander , GIANNAKOPULOS, Anastassios
IPC分类号： H01J49/06
CPC分类号： H01J49/0027 , H01J49/0031 , H01J49/06 , H01J49/062
摘要： A method of increasing ion throughput within an accumulator, an energy lift and a pulsed ion source, operated in that order upon a batch of ions, comprising the steps of: firstly loading a batch of ions into the accumulator;secondly changing the electrical potential of the energy lift to raise the energy of the batch of ions contained therein;and thirdly ejecting the batch of ions from the pulsed ion source;and wherein: the energy lift is a separate device from the accumulator and the pulsed ion source, and whilst changing the electrical potential in the second step a fresh batch of ions is loaded into the accumulator and/or a previous batch of ions is prepared for ejection in the pulsed ion source; or the energy lift is incorporated into the pulsed ion source and whilst changing the electrical potential in the second step a fresh batch of ions is loaded into the accumulator; or the energy lift is incorporated into the accumulator and whilst changing the electrical potential in the second step a previous batch of ions is prepared for ejection in the pulsed ion source. Acharged particle analyzer system is also provided.
摘要翻译：一种提高蓄能器内的离子通量，能量提升和脉冲离子源的方法，其以一批离子的顺序操作，包括以下步骤：首先将一批离子加载到蓄电池中;其次改变电位能量提升以提高其中所含的一批离子的能量;以及三次从脉冲离子源中排出一批离子;并且其中：能量提升是与蓄能器和脉冲离子源分离的装置，并且在改变在第二步骤中，将新鲜离子的电荷装载到蓄能器中和/或前一批离子被准备用于在脉冲离子源中喷射; 或者能量提升被并入到脉冲离子源中，并且在第二步骤中改变电势的同时，将新批次的离子加载到蓄能器中; 或者能量提升被并入蓄能器中，并且在第二步骤中改变电位的同时，准备先前的一批离子以在脉冲离子源中喷射。还提供了充电的粒子分析仪系统。

5. 发明申请

WO2011097180A1 MULTI-NEEDLE MULTI-PARALLEL NANOSPRAY IONIZATION SOURCE 审中-公开
标题翻译：多针多平行纳米粒子离子源
公开(公告)号：WO2011097180A1
公开(公告)日：2011-08-11
申请号：PCT/US2011/023242
申请日：2011-01-31
申请人： THERMO FINNIGAN LLC , MAKAROV, Alexander, A. , WOUTERS, Eloy, R.
发明人： MAKAROV, Alexander, A. , WOUTERS, Eloy, R.
IPC分类号： H01J49/10 , H01J49/26
CPC分类号： H01J49/167 , H01J49/0018 , Y10T29/49423 , Y10T29/49433
摘要： An electrospray ion source for a mass spectrometer includes an electrode comprising at least a first plurality of protrusions protruding from a base, each protrusion of the at least a first plurality of protrusions having a respective tip; a conduit for delivering an analyte- bearing liquid to the electrode; and a voltage source, wherein, in operation of the electrospray ion source, the analyte-bearing liquid is caused to move, in the presence of a gas or air, from the base to each protrusion tip along a respective protrusion exterior so as to form a respective stream of charged particles emitted towards an ion inlet aperture of the mass spectrometer under application of voltage applied to the electrode from the voltage source.
摘要翻译：用于质谱仪的电喷雾离子源包括电极，其包括从基底突出的至少第一多个突起，所述至少第一多个突起的每个突起具有相应的末端; 用于将分析物承载液体输送到电极的导管; 以及电压源，其中，在电喷雾离子源的操作中，使有分析物的液体在气体或空气的存在下沿着相应的突起外部从基部移动到每个突起尖端，以形成在施加从电压源施加到电极的电压下，向质谱仪的离子入口孔发射的相应的带电粒子流。

6. 发明申请

WO2011048060A3 DETECTION APPARATUS FOR DETECTING CHARGED PARTICLES, METHODS FOR DETECTING CHARGED PARTICLES AND MASS SPECTROMETER 审中-公开
标题翻译：用于检测充电颗粒的检测装置，用于检测充电颗粒的方法和质谱仪
公开(公告)号：WO2011048060A3
公开(公告)日：2011-06-16
申请号：PCT/EP2010065658
申请日：2010-10-18
申请人： THERMO FISHER SCIENT BREMEN , MAKAROV ALEXANDER , GIANNAKOPULOS ANASTASSIOS
发明人： MAKAROV ALEXANDER , GIANNAKOPULOS ANASTASSIOS
IPC分类号： H01J49/02
CPC分类号： H01J49/025 , H01J49/40 , H01J2237/2444
摘要： The invention provides a detection apparatus for detecting charged particles comprising: a secondary particle generator for generating secondary charged particles in response to receiving incoming charged particles; a charged particle detector for receiving and detecting secondary charged particles generated by the secondary particle generator; a photon generator for generating photons in response to receiving secondary charged particles generated by the secondary particle generator; and a photon detector for detecting the photons generated by the photon generator. Also provided are a mass spectrometer comprising the detection apparatus, use of the detection apparatus in TOF mass spectrometry and a method of improving the dynamic range of detection for a TOF mass spectrometer.
摘要翻译：本发明提供一种用于检测带电粒子的检测装置，包括：二次粒子发生器，用于响应于接收进入的带电粒子产生二次带电粒子; 用于接收和检测由二次粒子发生器产生的二次带电粒子的带电粒子检测器; 光子发生器，用于响应于接收由二次粒子发生器产生的二次带电粒子产生光子; 以及用于检测由光子发生器产生的光子的光子检测器。还提供了一种质谱仪，其包括检测装置，使用TOF质谱法中的检测装置以及改进TOF质谱仪的动态检测范围的方法。

7. 发明申请

WO2009147391A2 COLLISION CELL 审中-公开
标题翻译：碰撞细胞
公开(公告)号：WO2009147391A2
公开(公告)日：2009-12-10
申请号：PCT/GB2009/001389
申请日：2009-06-03
申请人： THERMO FISHER SCIENTIFIC (BREMEN) GMBH , MAKAROV, Alexander , DENISOV, Eduard , BALSCHUN, Wilko , NOLTING, Dirk , GRIEP-RAMING, Jens
发明人： MAKAROV, Alexander , DENISOV, Eduard , BALSCHUN, Wilko , NOLTING, Dirk , GRIEP-RAMING, Jens
IPC分类号： H01J49/00
CPC分类号： H01J49/0422 , H01J49/0031 , H01J49/0045 , H01J49/0072 , H01J49/0081 , H01J49/0481 , H01J49/06 , H01J49/26 , H01J49/40
摘要： A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.
摘要翻译：提供了在质谱仪中操作充气碰撞池的方法。碰撞单元具有纵向轴线。导致离子进入碰撞池。在碰撞单元内产生捕获场，以便将离子捕获在碰撞池的捕获体积内，捕获体积由捕获场限定并沿着纵轴延伸。捕获的离子在碰撞单元中被处理，并且使用电极布置提供DC电位梯度，导致沿着捕获体积的轴向长度的所有点处的非零电场，从而使处理的离子离开碰撞细胞。沿着捕集体积的轴向长度的电场具有不大于其平均值的标准偏差。

8. 发明申请

WO2008055668A2 ION TRANSFER ARRANGEMENT 审中-公开
标题翻译：离子转移装置
公开(公告)号：WO2008055668A2
公开(公告)日：2008-05-15
申请号：PCT/EP2007009641
申请日：2007-11-07
申请人： THERMO FISHER SCIENT BREMEN , MAKAROV ALEXANDER , PESCH REINHOLD , MALEK ROBERT , KOZLOVSKIY VIACHESLAV
发明人： MAKAROV ALEXANDER , PESCH REINHOLD , MALEK ROBERT , KOZLOVSKIY VIACHESLAV
CPC分类号： H01J49/062 , H01J3/14
摘要： An ion transfer arrangement for transporting ions between higher and lower pressure regions of a mass spectrometer includes an electrode assembly (120) with a first plurality of ring electrodes (205) arranged in alternating relation with a second plurality of ring electrodes (210). The first plurality of ring electrodes (205) are narrower than the second plurality of ring electrodes (210) in a longitudinal direction, but the first plurality of ring electrodes have a relatively high magnitude voltage of a first polarity applied to them whereas the second plurality of ring electrodes (210) have a relatively lower magnitude voltage applied to them, of opposing polarity to that applied to the first set of ring electrodes (205). In this manner, ions passing through the ion transfer arrangement experience spatially alternating asymmetric electric fields that tend to focus ions away from the inner surface of the channel wall and towards the channel plane or axis of symmetry.
摘要翻译：用于在质谱仪的较高和较低压力区域之间输送离子的离子转移装置包括具有与第二多个环形电极（210）交替设置的第一多个环形电极（205）的电极组件（120）。第一多个环形电极（205）在纵向方向上比第二多个环形电极（210）窄，但是第一多个环形电极具有施加到它们的第一极性的相对高的幅度电压，而第二个多个环形电极环形电极（210）具有施加到它们的相对较低的幅度电压，与施加到第一组环形电极（205）的极性相反。以这种方式，通过离子转移装置的离子经历空间交替的不对称电场，其倾向于将离子聚焦离开通道壁的内表面并朝向通道平面或对称轴线。

9. 发明申请

WO2007122379A2 METHOD OF ION ABUNDANCE AUGMENTATION IN A MASS SPECTROMETER 审中-公开
标题翻译：离子扩散方法在质谱仪中的应用
公开(公告)号：WO2007122379A2
公开(公告)日：2007-11-01
申请号：PCT/GB2007/001362
申请日：2007-04-13
申请人： THERMO FINNIGAN LLC , MAKAROV, Alexander
发明人： MAKAROV, Alexander
CPC分类号： H01J49/42 , H01J49/0031 , H01J49/0045
摘要： A method of improving the detection limits of a mass spectrometer by: generating sample ions from an ion source; storing the sample ions in a first ion storage device; ejecting the stored ions into an ion selection device; selecting and ejecting ions of a chosen mass to charge ratio out of the ion selection device; storing the ions ejected from the ion selection device in a second ion storage device without passing them back through the ion selection device; repeating the preceding steps so as to augment the ions of the said chosen mass to charge ratio stored in the second ion storage device; and transferring the augmented ions of the said chosen mass to charge ratio back to the first ion storage device for subsequent analysis.
摘要翻译：一种通过以下步骤改进质谱仪的检测限的方法：从离子源产生样品离子; 将样品离子存储在第一离子存储装置中; 将所储存的离子喷射到离子选择装置中; 从所述离子选择装置中选择和排出所选择的质荷比的离子; 将从所述离子选择装置喷出的离子存储在第二离子存储装置中，而不将其返回通过所述离子选择装置; 重复前述步骤，以便增加存储在第二离子存储装置中的所选择的质荷比的离子; 以及将所述选择的质量与充电比例的增强离子转移回到第一离子存储装置，用于随后的分析。

10. 发明申请

WO2006129083A2 MULTIPLE ION INJECTION IN MASS SPECTROMETRY 审中-公开
标题翻译：多重离子注入大量光谱
公开(公告)号：WO2006129083A2
公开(公告)日：2006-12-07
申请号：PCT/GB2006/001976
申请日：2006-05-31
申请人： THERMO FINNIGAN LLC , MAKAROV, Alexander, Alekseevich , LANGE, Oliver , HORNING, Stevan, Roy
发明人： MAKAROV, Alexander, Alekseevich , LANGE, Oliver , HORNING, Stevan, Roy
IPC分类号： H01J49/42
CPC分类号： H01J49/0009 , H01J49/0031 , H01J49/004 , H01J49/14 , H01J49/4265
摘要： This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analysed. A method of mass spectrometry is provided comprising the sequential steps of: accumulating in an ion store a sample of one type of ions to be analysed; accumulating in the ion store a sample of another type of ions to be analysed; and mass analysing the combined samples of the ions.; wherein the method comprises accumulating the sample of the one type of ions and/or the sample of another type of ions to achieve a target number of ions based on the results of a previous measurement of the respective type of ions.
摘要翻译：本发明涉及在质谱分析的至少一个阶段中包括离子捕获的质谱。具体地说，尽管不是排他地，本发明涉及分析前体离子和碎片离子的串联质谱法。提供了一种质谱法，其包括以下顺序步骤：在离子存储中积聚待分析的一种类型离子的样品; 在离子存储中积聚待分析的另一种类型的离子的样品; 并对离子的组合样品进行质量分析; 其中所述方法包括累积所述一种类型离子的样品和/或另一类型离子的样品，以根据先前测量相应类型离子的结果来实现目标数目的离子。

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