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1. 发明申请

WO2006129083A2 MULTIPLE ION INJECTION IN MASS SPECTROMETRY 审中-公开
标题翻译：多重离子注入大量光谱
公开(公告)号：WO2006129083A2
公开(公告)日：2006-12-07
申请号：PCT/GB2006/001976
申请日：2006-05-31
申请人： THERMO FINNIGAN LLC , MAKAROV, Alexander, Alekseevich , LANGE, Oliver , HORNING, Stevan, Roy
发明人： MAKAROV, Alexander, Alekseevich , LANGE, Oliver , HORNING, Stevan, Roy
IPC分类号： H01J49/42
CPC分类号： H01J49/0009 , H01J49/0031 , H01J49/004 , H01J49/14 , H01J49/4265
摘要： This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analysed. A method of mass spectrometry is provided comprising the sequential steps of: accumulating in an ion store a sample of one type of ions to be analysed; accumulating in the ion store a sample of another type of ions to be analysed; and mass analysing the combined samples of the ions.; wherein the method comprises accumulating the sample of the one type of ions and/or the sample of another type of ions to achieve a target number of ions based on the results of a previous measurement of the respective type of ions.
摘要翻译：本发明涉及在质谱分析的至少一个阶段中包括离子捕获的质谱。具体地说，尽管不是排他地，本发明涉及分析前体离子和碎片离子的串联质谱法。提供了一种质谱法，其包括以下顺序步骤：在离子存储中积聚待分析的一种类型离子的样品; 在离子存储中积聚待分析的另一种类型的离子的样品; 并对离子的组合样品进行质量分析; 其中所述方法包括累积所述一种类型离子的样品和/或另一类型离子的样品，以根据先前测量相应类型离子的结果来实现目标数目的离子。

2. 发明申请

WO2005124821A3 RF POWER SUPPLY FOR A MASS SPECTROMETER 审中-公开
标题翻译：射频电源用于质谱仪
公开(公告)号：WO2005124821A3
公开(公告)日：2006-12-07
申请号：PCT/GB2005002444
申请日：2005-06-21
申请人： THERMO FINNIGAN LLC , MAKAROV ALEXANDER ALEKSEEVICH , DENISOV EDUARD V , KHOLOMEEV ALEXANDER
发明人： MAKAROV ALEXANDER ALEKSEEVICH , DENISOV EDUARD V , KHOLOMEEV ALEXANDER
IPC分类号： H01J49/42 , H01J49/02
CPC分类号： H01J49/0031 , H01J49/022 , H01J49/36 , H01J49/423 , H01J49/427
摘要： The present invention provides a radio frequency (RF) power supply in a mass spectrometer. The power supply provides an RF signal to electrodes of a storage device to create a trapping field. Such ion storage devices are often used to store ions prior to ejection to a subsequent mass analyser. The RF field is usually collapsed prior to ion ejection. The present invention provides a RF power supply comprising: a RF signal supply, a coil arranged to receive the signal provided by the RF signal supply and to provide an output RF signal for supply to electrodes of an ion storage device, and a shunt including a switch operative to switch between a first open position and a second closed position in which the shunt including a switch operative to switch between a first open position and a second closed position in which the shunt shorts the coil output.
摘要翻译：本发明提供质谱仪中的射频（RF）电源。电源向存储设备的电极提供RF信号以产生捕获场。这种离子存储装置通常用于在离开之前存储离子到随后的质量分析器。射频场通常在离子喷射之前倒塌。本发明提供一种RF电源，包括：RF信号电源，被布置成接收由RF信号电源提供的信号的线圈，并提供用于供应到离子存储装置的电极的输出RF信号，以及包括开关，其操作以在第一打开位置和第二关闭位置之间切换，其中所述分流器包括可操作地在第一打开位置和第二关闭位置之间切换的开关，在所述第一打开位置和所述第二关闭位置之间所述分流器使所述线圈输出

3. 发明申请

WO2005096342A2 METHOD AND APPARATUS FOR ION FRAGMENTATION BY ELECTRON CAPTURE 审中-公开
标题翻译：电子捕获离子分离的方法和装置
公开(公告)号：WO2005096342A2
公开(公告)日：2005-10-13
申请号：PCT/GB2005001198
申请日：2005-03-29
申请人： THERMO FINNIGAN LLC , MAKAROV ALEXANDER ALEKSEEVICH , DENISOV EDUARD V , JUNG GERHARD
发明人： MAKAROV ALEXANDER ALEKSEEVICH , DENISOV EDUARD V , JUNG GERHARD
IPC分类号： H01J49/04 , H01J37/00
CPC分类号： H01J49/0054
摘要： The present invention relates to a method and apparatus for ion fragmentation by electron capture. The present invention provides a method of generating fragment ions by electron capture, comprising; directing ions to be fragmented into a fragmentation chamber of a mass spectrometer into a fragmentation chamber of a mass spectrometer arrangement; trapping at least some of the ions to be fragmented in at least one direction of the fragmentation chamber by using a magnetic field, the ions being trapped within a volume V; generating an electron beam using an electron source located away from the volume V; irradiating the trapped ions in the volume V with the electrons generated by the electron source in the presence of the said magnetic field, so as to cause dissociation; and ejecting the resultant fragment ions from the fragmentation chamber for subsequent analysis at a different location away from the fragmentation chamber.
摘要翻译：本发明涉及一种通过电子捕获进行离子碎片化的方法和装置。本发明提供了一种通过电子捕获产生碎片离子的方法，包括：将离子分散成质谱仪的碎裂室进入质谱仪布置的碎裂室; 通过使用磁场捕获在碎裂室的至少一个方向上被分段的至少一些离子，离子被捕获在体积V内; 使用远离体积V的电子源产生电子束; 在存在所述磁场的情况下用电子源产生的电子照射体积V中的被俘获的离子，以引起解离; 并将所得的碎片离子从碎裂室排出，以便在远离碎裂室的不同位置进行后续分析。

4. 发明申请

WO2004083805A2 OBTAINING TANDEM MASS SPECTROMETRY DATA FOR MULTIPLE PARENT IONS IN AN ION POPULATION 审中-公开
标题翻译：在离子人群中获得多个离子的离子质谱数据
公开(公告)号：WO2004083805A2
公开(公告)日：2004-09-30
申请号：PCT/GB2004/001174
申请日：2004-03-19
申请人： THERMO FINNIGAN LLC , MAKAROV, Alexander, Alekseevich , SYKA, John, Edward, Philip
发明人： MAKAROV, Alexander, Alekseevich , SYKA, John, Edward, Philip
IPC分类号： G01N
CPC分类号： H01J49/063 , H01J49/004 , H01J49/423
摘要： This invention relates to tandem mass spectrometry and, in particular, to tandem mass spectrometry using a linear ion trap and a time of flight detector to collect mass spectra to form a MS/MS experiment. The accepted standard is to store and mass analyze precursor ions in the ion trap before ejecting the ions axially to a collision cell for fragmentation before mass analysis of the fragments in the time of flight detector. This invention makes use of orthogonal ejection of ions with a narrow range of m/z values to produce a ribbon beam of ions that are injected into the collision cell. The shape of this beam and the high energy of the ions are accommodated by using a planar design of collision cell. Ions are retained in the ion trap during ejection so that successive narrow ranges may be stepped through consecutively to cover all precursor ions of interest.
摘要翻译：本发明涉及串联质谱法，特别涉及使用线性离子阱和飞行时间检测器的串联质谱法来收集质谱以形成MS / MS实验。所接受的标准是在离子阱中存储和质量分析前体离子，然后在飞行时间内对碎片进行质量分析之前，将离子轴向排列到碰撞池进行碎裂。本发明利用具有窄范围m / z值的离子的正交喷射来产生注入到碰撞池中的带状离子束束。通过使用碰撞池的平面设计来容纳该束的形状和离子的高能量。在喷射期间离子被保留在离子阱中，使得连续的窄范围可以连续地步进以覆盖所有感兴趣的前体离子。

5. 发明申请

WO2012152950A1 MASS ANALYSER 审中-公开
标题翻译：质量分析仪
公开(公告)号：WO2012152950A1
公开(公告)日：2012-11-15
申请号：PCT/EP2012/058941
申请日：2012-05-14
申请人： THERMO FISHER SCIENTIFIC (BREMEN) GMBH , DENISOV, Eduard V. , KHOLOMEEV, Alexander , HAUSCHILD, Jan-Peter , MAKAROV, Alexander Alekseevich
发明人： DENISOV, Eduard V. , KHOLOMEEV, Alexander , HAUSCHILD, Jan-Peter , MAKAROV, Alexander Alekseevich
IPC分类号： H01J49/42
CPC分类号： H01J49/26 , H01J49/425 , Y10T29/49117
摘要： A mass analyser comprises: an electrical field generator, providing a time-varying electric field for injection of ions to be analysed, excitation of ions to be analysed or both; first and second detection electrodes, each of which receives a respective voltage pickup due to the time-varying electric field and provides a respective detection signal based on a respective image current at the detection electrode; and a differential amplifier, providing an output based on the difference between the detection signal for the first detection electrode and the detection signal for the second detection electrode. It may also be provided that the electrical field generator comprises at least one field generating electrode without a spatially symmetrical counterpart and the capacitance between each field generating electrode and the first detection electrode is substantially the same as the capacitance between that field generating electrode and the second detection electrode.
摘要翻译：质量分析器包括：电场发生器，提供用于注入要分析的离子的时变电场，要分析的离子的激发或两者; 第一和第二检测电极，每个检测电极由于时变电场而接收相应的电压拾取器，并且基于检测电极处的各自的图像电流提供相应的检测信号; 以及差分放大器，基于第一检测电极的检测信号和第二检测电极的检测信号之间的差提供输出。还可以提供的是，电场发生器包括至少一个没有空间对称的场产生电极，并且每个场产生电极和第一检测电极之间的电容与该场产生电极和第二检测电极之间的电容基本相同检测电极。

6. 发明申请

WO2009091456A3 MASS SPECTROMETER WITH LOOPED ION PATH 审中-公开
标题翻译：带循环离子通道的质谱仪
公开(公告)号：WO2009091456A3
公开(公告)日：2011-07-28
申请号：PCT/US2008085734
申请日：2008-12-05
申请人： THERMO FINNIGAN LLC , KOVTOUN VIATCHESLAV V , MAKAROV ALEXANDER ALEKSEEVICH
发明人： KOVTOUN VIATCHESLAV V , MAKAROV ALEXANDER ALEKSEEVICH
IPC分类号： H01J49/00
CPC分类号： H01J49/0081 , H01J49/062
摘要： A mass spectrometer includes at least one ion selector, at least one collision cell, and an ion path switching device arranged to define a looped ion path around which ions derived from a sample may be sent multiple times (without reversal of ion travel) in order to effect a desired number of isolation/fragmentation cycles for MSn analysis. When the desired number of isolation/fragmentation cycles have been completed, the ion path switching device directs the ions to a detector or a separate mass analyzer for acquisition of a mass spectrum.
摘要翻译：质谱仪包括至少一个离子选择器，至少一个碰撞池和离子路径切换装置，该离子路径切换装置被设置成限定循环的离子路径，围绕该离子路径从样品衍生的离子可以顺次多次发射（不反转离子行程）以实现MSn分析所需数量的分离/分段循环。当所需数量的隔离/破碎循环已经完成时，离子路径切换装置将离子引导到用于获取质谱的检测器或单独的质量分析器。

7. 发明申请

WO2008046594A2 MULTI-CHANNEL DETECTION 审中-公开
标题翻译：多通道检测
公开(公告)号：WO2008046594A2
公开(公告)日：2008-04-24
申请号：PCT/EP2007/008985
申请日：2007-10-17
申请人： THERMO FISHER SCIENTIFIC (BREMEN) GMBH , MAKAROV, Alexander, Alekseevich
发明人： MAKAROV, Alexander, Alekseevich
CPC分类号： H01J49/406 , H01J49/004 , H01J49/025 , H01J49/061 , H01J49/408
摘要： A mass spectrometer and method of mass spectrometry wherein charged particles in a beam undergo multiple changes of direction. A detection arrangement detects a first portion of the charged particle beam, and provides a first output based upon the intensity of the detected first portion of the charged particle beam. The detection arrangement detects a second portion of the charged particle beam that has travelled a greater path length through the mass spectrometer than the first portion of the charged particle beam, and provides a second output based upon the detected second portion of the charged particle beam. A controller adjusts the parameters of the charged particle beam and/or the detection arrangement, based upon the first output of the detection arrangement, so as to adjust the second output of the detection arrangement.
摘要翻译：质谱仪和质谱法，其中束中的带电粒子经历多个方向改变。检测装置检测带电粒子束的第一部分，并且基于所检测到的带电粒子束的第一部分的强度提供第一输出。检测装置检测带电粒子束的第二部分，该第二部分已经比通过质谱仪行进了比带电粒子束的第一部分更大的路径长度，并且基于检测到的带电粒子束的第二部分提供第二输出。控制器基于检测装置的第一输出来调整带电粒子束和/或检测装置的参数，以便调整检测装置的第二输出。

8. 发明申请

WO2006129083A3 MULTIPLE ION INJECTION IN MASS SPECTROMETRY 审中-公开
标题翻译：多重离子注入大量光谱
公开(公告)号：WO2006129083A3
公开(公告)日：2007-10-25
申请号：PCT/GB2006001976
申请日：2006-05-31
申请人： THERMO FINNIGAN LLC , MAKAROV ALEXANDER ALEKSEEVICH , LANGE OLIVER , HORNING STEVAN ROY
发明人： MAKAROV ALEXANDER ALEKSEEVICH , LANGE OLIVER , HORNING STEVAN ROY
IPC分类号： H01J49/42
CPC分类号： H01J49/0009 , H01J49/0031 , H01J49/004 , H01J49/14 , H01J49/4265
摘要： This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analysed. A method of mass spectrometry is provided comprising the sequential steps of: accumulating in an ion store a sample of one type of ions to be analysed; accumulating in the ion store a sample of another type of ions to be analysed; and mass analysing the combined samples of the ions.; wherein the method comprises accumulating the sample of the one type of ions and/or the sample of another type of ions to achieve a target number of ions based on the results of a previous measurement of the respective type of ions.
摘要翻译：本发明涉及在质谱分析的至少一个阶段中包括离子捕获的质谱。具体地说，尽管并非排他地，本发明涉及分析前体离子和碎片离子的串联质谱法。提供了一种质谱法，其包括以下顺序步骤：在离子存储中积聚待分析的一种类型离子的样品; 在离子存储中积聚待分析的另一种类型的离子的样品; 并对离子的组合样品进行质量分析; 其中所述方法包括基于先前测量各种类型离子的结果累积一种类型离子的样品和/或另一类型离子的样品以实现目标数目的离子。

9. 发明申请

WO2006103412A3 IMPROVEMENTS RELATING TO MASS SPECTROMETRY 审中-公开
标题翻译：与质谱相关的改进
公开(公告)号：WO2006103412A3
公开(公告)日：2007-09-20
申请号：PCT/GB2006001125
申请日：2006-03-29
申请人： THERMO FINNIGAN LLC , MAKAROV ALEXANDER ALEKSEEVICH , DENISOV EDUARD , JUNG GERHARD , KHOLOMEEV ALEXANDER , LANGE OLIVER
发明人： MAKAROV ALEXANDER ALEKSEEVICH , DENISOV EDUARD , JUNG GERHARD , KHOLOMEEV ALEXANDER , LANGE OLIVER
IPC分类号： H01J49/04
CPC分类号： H01J49/04
摘要： This invention relates to a mass spectrometer including a reaction cell and to a method of using such a mass spectrometer. In particular, although not exclusively, this invention relates to a tandem mass spectrometer and to tandem mass spectrometry. The invention provides a method of mass spectrometry using a mass spectrometer having a longitudinal axis, comprising guiding ions to travel along the longitudinal axis of the mass spectrometer in a forwards direction to pass through an intermediate ion store and then to enter a reaction cell, to process the ions within the reaction cell, to eject the processed ions to travel back along the longitudinal axis to enter the intermediate ion store once more, and to eject one or more pulses of the processed ions in an off-axis direction to a mass analyser.
摘要翻译：本发明涉及包括反应池的质谱仪和使用这种质谱仪的方法。特别地，尽管并非排他地，本发明涉及串联质谱仪和串联质谱法。本发明提供使用具有纵轴的质谱仪的质谱法，其包括引导离子沿着前进方向沿着质谱仪的纵向轴线行进，以通过中间离子储存器然后进入反应池，至处理反应池内的离子，以便将经处理的离子沿着纵轴排出回来，再次进入中间离子储存器，并将处理的离子的一个或多个脉冲沿离轴方向排出到质量分析器。

10. 发明申请

WO2005124821A2 RF POWER SUPPLY FOR A MASS SPECTROMETER 审中-公开
标题翻译：射频电源用于质谱仪
公开(公告)号：WO2005124821A2
公开(公告)日：2005-12-29
申请号：PCT/GB2005/002444
申请日：2005-06-21
申请人： THERMO FINNIGAN LLC , MAKAROV, Alexander, Alekseevich , DENISOV, Eduard, V. , KHOLOMEEV, Alexander
发明人： MAKAROV, Alexander, Alekseevich , DENISOV, Eduard, V. , KHOLOMEEV, Alexander
IPC分类号： H01J49/42
CPC分类号： H01J49/0031 , H01J49/022 , H01J49/36 , H01J49/423 , H01J49/427
摘要： The present invention provides a radio frequency (RF) power supply in a mass spectrometer. The power supply provides an RF signal to electrodes of a storage device to create a trapping field. Such ion storage devices are often used to store ions prior to ejection to a subsequent mass analyser. The RF field is usually collapsed prior to ion ejection. The present invention provides a RF power supply comprising: a RF signal supply, a coil arranged to receive the signal provided by the RF signal supply and to provide an output RF signal for supply to electrodes of an ion storage device, and a shunt including a switch operative to switch between a first open position and a second closed position in which the shunt including a switch operative to switch between a first open position and a second closed position in which the shunt shorts the coil output.
摘要翻译：本发明提供质谱仪中的射频（RF）电源。电源向存储设备的电极提供RF信号以产生捕获场。这种离子存储装置通常用于在离开之前存储离子到随后的质量分析器。射频场通常在离子喷射之前倒塌。本发明提供一种RF电源，包括：RF信号电源，被布置成接收由RF信号电源提供的信号的线圈，并提供用于供应到离子存储装置的电极的输出RF信号，以及包括开关，其操作以在第一打开位置和第二关闭位置之间切换，其中所述分流器包括可操作地在第一打开位置和第二关闭位置之间切换的开关，在所述第一打开位置和所述第二关闭位置中，所述分流器使所述线圈输出短路。

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