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1. 发明申请

WO0196025A3 SYSTEMS AND METHODS FOR CELL SUBPOPULATION ANALYSIS 审中-公开
标题翻译：细胞分化分析的系统和方法
公开(公告)号：WO0196025A3
公开(公告)日：2003-05-15
申请号：PCT/US0119479
申请日：2001-06-14
申请人： UNIV TEXAS , GASCOYNE PETER R C , BECKER FREDERICK F , VYKOUKAL JODY
发明人： GASCOYNE PETER R C , BECKER FREDERICK F , VYKOUKAL JODY
IPC分类号： G01N33/561 , B01D57/02 , B03C1/00 , B03C5/00 , B03C5/02 , B81B1/00 , C12M1/34 , C12Q1/02 , G01N15/02 , G01N15/10 , G01N27/06 , G01N27/447 , G01N30/00 , G01N33/48 , G01N33/543
CPC分类号： B03C5/026 , B03C5/028 , G01N15/1056 , G01N27/44786 , G01N30/0005 , G01N2015/0288 , G01N2015/1006 , G01N2015/1081
摘要： Systems, apparatuses and methods for cell isolation and analysis. Cells are introduced into a dielectrophoretic prefilter including one or more trapping electrodes configured to trap at least a portion of the cells with a dielectrophoretic force. The cells trapped from the prefilter are directed into a dielectrophoretic field-flow fractionation separator coupled to the prefilter. The cells are discriminated by balancing a dielectrophoretic force ( and optionally a magnetophoretic force) with a gravitational force to displace the cells to positions within a velocity profile in the separator. At least a portion of the cells are trapped as a function of the cells' time of emergence from the separator with two or more spiral electrode segments coupled to the separator.
摘要翻译：用于细胞分离和分析的系统，装置和方法。将细胞引入到介电电泳预过滤器中，所述介电电泳预过滤器包括一个或多个俘获电极，其被配置为用介电电泳力捕获至少一部分细胞。从预过滤器捕获的细胞被引导到耦合到预过滤器的介电泳流场分馏分离器中。通过平衡介电电泳力（和可选的磁导率）与重力来将细胞置换到分离器内的速度分布内的位置来区分细胞。细胞的至少一部分作为细胞从分离器出现的时间的函数被捕获，其中两个或更多个螺旋电极段连接到分离器。

2. 发明申请

WO02030562A1 AN INTEGRATED BIOCHIP SYSTEM FOR SAMPLE PREPARATION AND ANALYSIS 审中-公开
标题翻译：用于样品制备和分析的综合生物系统
公开(公告)号：WO02030562A1
公开(公告)日：2002-04-18
申请号：PCT/US2001/042601
申请日：2001-10-09
IPC分类号： B01L3/00 , C12N13/00 , G01N15/00 , G01N15/06 , G01N27/447 , G01N33/543 , B01J19/00 , B03C5/02 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/54373 , B01J2219/00274 , B01L3/502761 , B01L2200/0621 , B01L2200/10 , B01L2400/0415 , B01L2400/043 , B01L2400/0433 , C12N13/00 , G01N15/0656 , G01N27/44786 , G01N2015/0065 , G01N2446/00 , Y10T436/25
摘要： The invention includes a composition that is an integrated biochip system for processing and analyzing samples using sequential tasks that take place on one or more chips. The system preferably comprises one or more active chips, and can be automated. The invention also includes methods of using an integrated biochip for processing and analyzing samples. The methods include the application of a sample to the system and performing at least two sequential tasks on at least one chip surface. The method includes the use of physical forces, such as dielectrophoretic and electromagnetic forces to process and analyze samples, and includes the use of microparticles that can be coupled to sample components to be manipulated by dielectrophoretic and electromagnetic forces.
摘要翻译：本发明包括一种组合物，其是用于使用在一个或多个芯片上发生的顺序任务来处理和分析样品的集成生物芯片系统。系统优选地包括一个或多个有源芯片，并且可以是自动化的。本发明还包括使用集成生物芯片来处理和分析样品的方法。所述方法包括将样本应用于系统并且在至少一个芯片表面上执行至少两个顺序任务。该方法包括使用诸如介电电泳和电磁力的物理力来处理和分析样品，并且包括使用可以耦合到通过介电电泳和电磁力操纵的样品组分的微粒。

3. 发明申请

WO2014145765A1 SYSTEMS AND METHODS FOR BEAD-BASED ASSAYS IN FERROFLUIDS 审中-公开
标题翻译：在流感病毒中基于珠粒的测定的系统和方法
公开(公告)号：WO2014145765A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/030584
申请日：2014-03-17
申请人： ANCERA, INC.
发明人： KOSER, Hur
IPC分类号： B03C1/32 , G01N33/49 , C12M1/42
CPC分类号： G01N33/54366 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2300/06 , B01L2300/0654 , B01L2400/043 , B03C1/01 , B03C1/288 , B03C1/32 , B03C2201/18 , B03C2201/20 , B03C2201/26 , G01N15/1404 , G01N15/1459 , G01N15/1484 , G01N27/44786 , G01N33/54313 , G01N35/0098 , G01N2015/1415 , G01N2015/1486 , G01N2015/149
摘要： Some embodiments of the present disclosure are directed to systems and methods for separating, directing, and/or extracting a target molecule from a mix of molecules and may comprise a plurality of non-magnetic beads suspended in a ferro fluid, where the non-magnetic beads may be functionalized with at least one predetermined first molecule configured to bind with a target particle. A microfluidic device may be included which may comprise at least one microfluidic channel, the device configured to dynamically and/or statically receive an amount of the mix. Magnetic field means may be included and may be configured to apply a magnetic field to at least a portion of the at least one channel to exert an indirect force on the non-magnetic beads in the ferro fluid mix, and separate the non-magnetic beads from the ferrofluid. The beads may then be directed to at least one receptor region. At least one outlet may be provided which is arranged to be in communication with the at least one microfluidic channel, the at least one outlet may be configured to receive and extract the separated non-magnetic beads from the ferrofluid.
摘要翻译：本公开的一些实施方案涉及用于从分子混合物分离，引导和/或提取靶分子的系统和方法，并且可以包括悬浮在铁液中的多个非磁珠，其中非磁性珠子可以被至少一个预定的第一分子功能化，其被配置为与目标颗粒结合。可以包括微流体装置，其可以包括至少一个微流体通道，该装置被配置为动态地和/或静态地接收一定量的混合物。可以包括磁场装置并且可以被配置为将磁场施加到至少一个通道的至少一部分，以在铁液流体混合物中的非磁珠上施加间接力，并将非磁珠从铁磁流体。然后将珠子引导至至少一个受体区域。可以提供至少一个出口，其布置成与至少一个微流体通道连通，所述至少一个出口可以被配置为从铁磁流体接收和提取分离的非磁珠。

4. 发明申请

WO2008098236A2 DROPLET ACTUATOR DEVICES AND METHODS EMPLOYING MAGNETIC BEADS 审中-公开
标题翻译：刮刀致动器装置和使用磁珠的方法
公开(公告)号：WO2008098236A2
公开(公告)日：2008-08-14
申请号：PCT/US2008/053545
申请日：2008-02-11
申请人： ADVANCED LIQUID LOGIC, INC. , SISTA, Ramakrishna , PAMULA, Vamsee K. , POLLACK, Michael G. , SRINIVASAN, Vijay , ECKHARDT, Allen E.
发明人： SISTA, Ramakrishna , PAMULA, Vamsee K. , POLLACK, Michael G. , SRINIVASAN, Vijay , ECKHARDT, Allen E.
IPC分类号： G01N33/543 , B01L3/00
CPC分类号： G01N33/54326 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L3/502784 , B01L2200/025 , B01L2200/028 , B01L2200/0647 , B01L2200/0673 , B01L2200/141 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0427 , B01L2400/043 , C12M25/01 , C12M25/16 , G01N27/44717 , G01N27/44786 , G01N33/54386 , G01N35/0098 , G01N2035/1046
摘要： A method of providing a droplet in contact with a magnetically responsive bead and having a reduced quantity of a substance. The method generally includes the steps of (a) providing a droplet actuator comprising: (i) a substrate comprising electrodes arranged for conducting droplet operations on a surface; (ii) a starting droplet comprising: (1) one or more magnetically responsive beads; (2) a starting quantity of the substance; and (3) a starting volume; (b) magnetically immobilizing the one or more magnetically responsive beads at a location which is at a distance from a target droplet splitting zone; (c) conducting one or more droplet operations comprising droplet dividing operations selected to divide the combined droplet to yield a set of droplets comprising: (i) a droplet comprising substantially all of the one or more magnetically responsive beads and having a decreased quantity of the substance relative to the starting concentration; and (ii) a droplet substantially lacking the magnetically responsive beads.
摘要翻译：提供与磁响应珠接触并具有减少的物质量的液滴的方法。该方法通常包括以下步骤：（a）提供液滴致动器，其包括：（i）包括布置用于在表面上进行液滴操作的电极的基板; （ii）起始液滴，包括：（1）一个或多个磁响应珠; （2）物质的起始量; 和（3）起始体积; （b）将一个或多个磁响应珠磁性地固定在距离目标液滴分裂区一定距离的位置; （c）进行一个或多个液滴操作，其包括液滴分割操作，所述液滴分割操作被选择以分开所述组合的液滴以产生一组液滴，所述液滴包括：（i）包含基本上所有所述一个或多个磁响应珠粒并且具有减少量物质相对于起始浓度; 和（ii）基本上不含磁响应珠的液滴。

5. 发明申请

WO2016065073A1 SYSTEMS AND METHODS FOR SAMPLE PREPARATION, PROCESSING AND ANALYSIS 审中-公开
标题翻译：用于样品制备，加工和分析的系统和方法
公开(公告)号：WO2016065073A1
公开(公告)日：2016-04-28
申请号：PCT/US2015/056764
申请日：2015-10-21
申请人： INTEGENX INC.
发明人： KINDWALL, Alexander , PARK, Chungsoo, Charles , ILKOV, Fedor , JOVANOVICH, Stevan , KING, David , LITTLEHALE, Tristan, Robert , NILSON, David, Grant , PITTARO, Rick , SCHUEREN, Robert, A. , VANGBO, Mattias , WUNDERLE, Philip, Justus
IPC分类号： B01D59/42 , C25B11/02 , G01N27/447 , G01N27/49
CPC分类号： G01N27/44791 , B01L3/502715 , B01L7/52 , B01L2200/04 , B01L2200/10 , B01L2200/16 , B01L2300/0681 , B01L2300/0867 , B01L2300/1822 , B01L2300/1827 , B01L2400/0421 , G01N27/44704 , G01N27/44743 , G01N27/44786 , G01N27/453
摘要： The present disclosure provides systems and methods for sample preparation, processing and analysis. Also provided in the present disclosure is a fully-integrated electrophoresis cartridge which has a small footprint and configured to removably engage with the system. An electrophoresis cartridge adapted to releasably engage with a cartridge interface of a system is provided. The electrophoresis cartridge comprises: an electrophoresis assembly including: (1) an anode sub-assembly comprising an anode, (2) a cathode sub-assembly comprising a cathode; and (3) at least one electrophoresis capillary having a first end and a second end, wherein the cathode and the anode are configured to provide a voltage gradient across the first end and the second end of the at least one electrophoresis capillary.
摘要翻译：本公开提供了用于样品制备，处理和分析的系统和方法。本公开还提供了一种完全集成的电泳盒，其具有小的占地面积并且被配置为可移除地与系统接合。提供了适于与系统的盒接口可释放地接合的电泳盒。电泳盒包括：电泳组件，包括：（1）包括阳极的阳极子组件，（2）包括阴极的阴极子组件; 和（3）具有第一端和第二端的至少一个电泳毛细管，其中所述阴极和所述阳极被配置为在所述至少一个电泳毛细管的所述第一端和所述第二端提供电压梯度。

6. 发明申请

WO2013132344A3 SPLIT-SENSOR DIELECTROPHORETIC/MAGNETOPHORETIC CYTOMETER 审中-公开
标题翻译：分体传感器电磁/磁性测微计
公开(公告)号：WO2013132344A3
公开(公告)日：2013-10-31
申请号：PCT/IB2013000838
申请日：2013-03-11
申请人： UNIV MANITOBA
发明人： THOMSON DOUGLAS , BRIDGES GREG , BUTLER MICHAEL , NIKOLIC-JARIC MARIJA , SALIMI ELHAM , CABEL TIM , RZESZOWSKI SZYMON , FERRIER GRAHAM , BRAASCH KATRIN
IPC分类号： G01N15/10
CPC分类号： G01N15/1031 , G01N15/1056 , G01N27/44786 , G01N2015/1006 , G01N2015/1081
摘要： Embodiments of an improved sensor for dielectrophoretic cytometry are presented. In one embodiment, the sensor includes a plurality of sensor electrodes as well as an actuation electrode. Embodiments of microfluidic systems incorporating such sensor are also described. Additionally, embodiments of methods or performing cytometry analysis are also presented.
摘要翻译：提出了一种改进的介电电泳细胞计数传感器的实施例。在一个实施例中，传感器包括多个传感器电极以及致动电极。还描述了结合了这种传感器的微流体系统的实施例。此外，还提出了方法的实施方案或进行细胞分析。

7. 发明申请

WO2005072854A1 SCODAPHORESIS AND METHODS AND APPARATUS FOR MOVING AND CONCENTRATING PARTICLES 审中-公开
标题翻译：用于移动和浓缩颗粒的SCODAPHORESIS和方法和装置
公开(公告)号：WO2005072854A1
公开(公告)日：2005-08-11
申请号：PCT/CA2005/000124
申请日：2005-02-02
申请人： THE UNIVERSITY OF BRITISH COLUMBIA , MARZIALI, Andrea , WHITEHEAD, Lorne
发明人： MARZIALI, Andrea , WHITEHEAD, Lorne
IPC分类号： B01D57/02
CPC分类号： C25B7/00 , B01D57/02 , B03C5/005 , G01N27/44713 , G01N27/44734 , G01N27/44786 , G01N2001/4038
摘要： Methods and apparatus for moving and concentrating particles apply an alternating driving field and an alternating field that alters mobility of the particles. The driving field and mobility-varying field are correlated with one another. The methods and apparatus may be used to concentrate DNA or RNA in a medium, for example. Methods and apparatus for extracting particles from one medium into another involve applying an alternating driving field that causes net drift of the particles from the first medium into the second medium but no net drift of the particles in the second medium.
摘要翻译：用于移动和聚集颗粒的方法和装置施加交替的驱动场和改变粒子的迁移率的交变场。驱动场和迁移率变化场相互关联。方法和装置可以用于将DNA或RNA浓缩在培养基中，例如。用于从一种介质提取颗粒到另一种介质的方法和装置包括施加交替的驱动场，其引起颗粒从第一介质到第二介质的净漂移，但是在第二介质中没有颗粒的净漂移。

8. 发明申请

WO2014032147A1 ANALISADOR ELETROFORÉTICO POR INDUÇÃO ELETROMAGNÉTICA 审中-公开
标题翻译：电磁感应电解分析仪
公开(公告)号：WO2014032147A1
公开(公告)日：2014-03-06
申请号：PCT/BR2013/000329
申请日：2013-08-26
申请人： MANFREDI, José Félix , TEIXEIRA DUARTE, Marcelo
发明人： MANFREDI, José Félix , TEIXEIRA DUARTE, Marcelo
IPC分类号： G01N27/447 , G01N30/02
CPC分类号： G01N27/44786 , G01N27/447 , G01N27/44717
摘要： Analisador eletroforético por indução eletromagnética, o qual compreende um núcleo toroidal ferromagnético (1), ao qual é acoplado um enrolamento elétrico indutor (2), pelo qual circula corrente alternada de entrada, que induz a formação de fluxo magnético variável, confinado ao referido núcleo, que gera corrente elétrica alternada induzida no suporte (3), forçando a migração de moléculas portadoras de carga elétrica, constituintes da amostra em análise. Um injetor (4), montado numa extremidade do suporte permite a introdução da amostra, enquanto um detector (5), instalado na extremidade oposta, monitora a passagem dos componentes discretos e envia um sinal eletrônico a um microcomputador, que processa e disponibiliza os dados ao operador. A introdução de uma chave elétrica rápida (6) como um diodo, ligando as extremidades do suporte, possibilita abertura e fechamento do circuito induzido na mesma frequência da corrente alternada do indutor, resultando em movimentação das partículas num sentido único e sua consequente separação por migração diferencial.
摘要翻译：电磁感应电泳分析仪包括耦合到电感线圈（2）的铁磁环形芯（1），通过该电磁感应线圈（2）流入限制于上述芯的可变磁流的形成的输入交流电，产生交流电流在支撑体（3）中，从被分析的样品中取出带电荷的分子的迁移。安装在支架一端的注射器（4）能够插入样品，而安装在相对端的检测器（5）监测分立组件的运动，并向处理数据的微型计算机发送电子信号并使操作员可以使用它。插入诸如二极管的快速电气开关（6），连接支撑件的端部，使感应电路以与电感器中的交流电流相同的频率打开和关闭，导致颗粒沿单个方向移动并因此由差异迁移分离。

9. 发明申请

WO2013132344A2 SPLIT-SENSOR DIELECTROPHORETIC/MAGNETOPHORETIC CYTOMETER 审中-公开
标题翻译：分裂传感器电分析/磁性细胞计数器
公开(公告)号：WO2013132344A2
公开(公告)日：2013-09-12
申请号：PCT/IB2013/000838
申请日：2013-03-11
申请人： UNIVERSITY OF MANITOBA
发明人： THOMSON, Douglas , BRIDGES, Greg , BUTLER, Michael , NIKOLIC-JARIC, Marija , SALIMI, Elham , CABEL, Tim , RZESZOWSKI, Szymon , FERRIER, Graham , BRAASCH, Katrin
IPC分类号： G01N15/10
CPC分类号： G01N15/1031 , G01N15/1056 , G01N27/44786 , G01N2015/1006 , G01N2015/1081
摘要： Embodiments of an improved sensor for dielectrophoretic cytometry are presented. In one embodiment, the sensor includes a plurality of sensor electrodes as well as an actuation electrode. Embodiments of microfluidic systems incorporating such sensor are also described. Additionally, embodiments of methods or performing cytometry analysis are also presented.
摘要翻译：介绍了用于介电泳细胞计量术的改进传感器的实施例。在一个实施例中，传感器包括多个传感器电极以及致动电极。还描述了包含这种传感器的微流体系统的实施例。此外，还介绍了方法的实施方案或进行细胞计数分析。

10. 发明申请

WO2012057878A1 MICROFLUIDIC PROCESSING OF TARGET SPECIES IN FERROFLUIDS 审中-公开
标题翻译：目标物种在流感病毒中的微流化加工
公开(公告)号：WO2012057878A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/039516
申请日：2011-06-07
申请人： YALE UNIVERSITY , KOSER, Hur
发明人： KOSER, Hur
IPC分类号： G01N35/08 , G01N33/483 , G01N27/327 , G01N15/14 , B81B7/00
CPC分类号： B01D57/02 , B01L3/502753 , B01L3/502761 , B01L2200/0652 , B01L2300/0816 , B01L2400/0415 , B01L2400/043 , B03C1/0335 , B03C1/253 , B03C1/288 , B03C1/32 , B03C2201/18 , B03C2201/24 , B03C2201/26 , G01N15/1404 , G01N27/44786
摘要： Disclosed are systems, devices, methods, and other implementations, including a device to detect at least one target species in a sample, with the device including a microfluidic channel configured to receive the sample containing the at least one target species and a biocompatible ferrofluid in which the at least one target species is suspended, a detector to determine the at least one target species in the sample, and at least two of electrodes positioned proximate the microfluidic channel, the at least two electrodes configured to generate controllable magnetic forces in the sample containing the ferrofluid when a controllable at least one electrical current is applied to the at least two electrodes. The generated controllable magnetic forces causes the at least one target species to be directed towards the detector. Also disclosed are devices for separating target species in a ferrofluid, and for focusing target species suspended in a ferrofluid.
摘要翻译：公开了系统，装置，方法和其他实施方式，包括用于检测样品中的至少一种目标物种的装置，其中该装置包括微流体通道，微流体通道被配置为接收含有至少一种靶物种的样品和生物相容性铁磁流体至少一个目标物种悬浮在其上，检测器确定样品中的至少一个目标物种，以及位于微流体通道附近的至少两个电极，所述至少两个电极被配置为在样品中产生可控的磁力当对所述至少两个电极施加可控的至少一个电流时，所述铁磁流体包含所述铁磁流体。产生的可控磁力使得至少一个目标物种被引向检测器。还公开了用于分离铁磁流体中的目标物质和用于聚焦悬浮在铁磁流体中的目标物种的装置。

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