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1. 发明申请

WO2011071912A1 LABEL-FREE CELLULAR MANIPULATION AND SORTING VIA BIOCOMPATIBLE FERROFLUIDS 审中-公开
标题翻译：通过生物化学反应器进行免疫细胞操纵和分选
公开(公告)号：WO2011071912A1
公开(公告)日：2011-06-16
申请号：PCT/US2010/059270
申请日：2010-12-07
申请人： YALE UNIVERSITY , KOSER, Hur
发明人： KOSER, Hur
IPC分类号： G01N33/49 , B03C1/32
CPC分类号： G01N15/1056 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L2200/0636 , B01L2200/0652 , B01L2300/06 , B01L2300/0848 , B03C1/023 , B03C1/23 , B03C1/253 , B03C1/288 , B03C1/32 , B03C2201/18 , B03C2201/24 , B03C2201/26 , C12M47/04 , C12N13/00 , G01N2015/0065 , G01N2015/1006 , G01N2015/1081
摘要： A device for separating a sample of cells suspended in a bio-compatible ferrofluid is described The device includes a microfluidic channel having a sample inlet, at least one output, and a length between the sample inlet and the at least one output, wherein a sample can be added to the sample inlet and flow along the length to the at least one outlet The device includes a plurality of electrodes, and further includes a power source for applying a current to the plurality of electrodes to create a magnetic field pattern along the length of the microfluidic channel The present invention also includes a method of using said device for separating at least one cell type.
摘要翻译：描述了用于分离悬浮在生物相容性铁磁流体中的细胞样品的装置。该装置包括具有样品入口，至少一个输出和样品入口与至少一个输出之间的长度的微流体通道，其中样品可以被添加到样品入口并沿着长度流动到至少一个出口。装置包括多个电极，并且还包括用于向多个电极施加电流以产生沿着长度的磁场图案的电源的微流体通道本发明还包括使用所述装置分离至少一种细胞类型的方法。

2. 发明申请

WO2006102437A2 POWER HARVESTING SCHEME BASED PIEZOELECTRICITY AND NONLINEAR DEFLECTIONS 审中-公开
标题翻译：基于功率收集方案的压电和非线性偏移
公开(公告)号：WO2006102437A2
公开(公告)日：2006-09-28
申请号：PCT/US2006/010447
申请日：2006-03-23
申请人： YALE UNIVERSITY , KOSER, Hur , ZHANG, Nian
发明人： KOSER, Hur , ZHANG, Nian
IPC分类号： H01L41/04
CPC分类号： H01L41/1136 , B60C23/0411 , H02N2/186
摘要： An energy harvesting device and a method of using the energy harvesting device to generate an electrical charge are described. The energy harvesting device comprises a mass and at least two tethers, at least one of which comprises a piezoelectric material that is mechanically stressable upon deflection of the at least two tethers. Each of the tethers comprises a first end coupled to the mass and a second end coupled to a reference structure, and the tethers are arranged about the mass such that the mass is moveable within a straightline path relative to the reference. The movement of the mass causes the deflection of the tethers, resulting in the generation of an electric charge. The device is preferably operable at the microscale.
摘要翻译：描述了能量收集装置和使用能量收集装置产生电荷的方法。能量收集装置包括质量块和至少两个系绳，其中至少一个系统包括在至少两个系绳的偏转时机械应力的压电材料。系绳中的每一个包括联接到质量块的第一端和联接到参考结构的第二端，并且系绳围绕质量块布置，使得质量块能够在相对于参考物的直线路径内移动。质量的运动导致系绳的偏转，导致产生电荷。该装置优选在微尺度下可操作。

3. 发明申请

WO2012057878A1 MICROFLUIDIC PROCESSING OF TARGET SPECIES IN FERROFLUIDS 审中-公开
标题翻译：目标物种在流感病毒中的微流化加工
公开(公告)号：WO2012057878A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/039516
申请日：2011-06-07
申请人： YALE UNIVERSITY , KOSER, Hur
发明人： KOSER, Hur
IPC分类号： G01N35/08 , G01N33/483 , G01N27/327 , G01N15/14 , B81B7/00
CPC分类号： B01D57/02 , B01L3/502753 , B01L3/502761 , B01L2200/0652 , B01L2300/0816 , B01L2400/0415 , B01L2400/043 , B03C1/0335 , B03C1/253 , B03C1/288 , B03C1/32 , B03C2201/18 , B03C2201/24 , B03C2201/26 , G01N15/1404 , G01N27/44786
摘要： Disclosed are systems, devices, methods, and other implementations, including a device to detect at least one target species in a sample, with the device including a microfluidic channel configured to receive the sample containing the at least one target species and a biocompatible ferrofluid in which the at least one target species is suspended, a detector to determine the at least one target species in the sample, and at least two of electrodes positioned proximate the microfluidic channel, the at least two electrodes configured to generate controllable magnetic forces in the sample containing the ferrofluid when a controllable at least one electrical current is applied to the at least two electrodes. The generated controllable magnetic forces causes the at least one target species to be directed towards the detector. Also disclosed are devices for separating target species in a ferrofluid, and for focusing target species suspended in a ferrofluid.
摘要翻译：公开了系统，装置，方法和其他实施方式，包括用于检测样品中的至少一种目标物种的装置，其中该装置包括微流体通道，微流体通道被配置为接收含有至少一种靶物种的样品和生物相容性铁磁流体至少一个目标物种悬浮在其上，检测器确定样品中的至少一个目标物种，以及位于微流体通道附近的至少两个电极，所述至少两个电极被配置为在样品中产生可控的磁力当对所述至少两个电极施加可控的至少一个电流时，所述铁磁流体包含所述铁磁流体。产生的可控磁力使得至少一个目标物种被引向检测器。还公开了用于分离铁磁流体中的目标物质和用于聚焦悬浮在铁磁流体中的目标物种的装置。

4. 发明申请

WO2006025858A2 MICROFABRICATED CELLULAR TRAPS BASED ON THREE-DIMENSIONAL MICRO-SCALE FLOW GEOMETRIES 审中-公开
标题翻译：基于三维微尺度流动几何的微细化细胞捕获
公开(公告)号：WO2006025858A2
公开(公告)日：2006-03-09
申请号：PCT/US2005/005000
申请日：2005-02-16
申请人： YALE UNIVERSITY , KOSER, Hur
发明人： KOSER, Hur
IPC分类号： B03B9/00
CPC分类号： B01F13/0061 , B01F5/06 , B01F5/0601 , B01F13/0059 , B01F13/0093 , B01F15/0404 , B01L3/5027 , B01L3/502738 , B01L3/502753 , B01L2200/0668 , B01L2300/0816 , B01L2300/0867 , B01L2300/0877 , B01L2400/0424 , B01L2400/0472 , B01L2400/0487
摘要： An improved microfluidic device and method of using the microfluidic device to measure natural motile response of a living moiety to a chemotactic agent. The invention comprises integrating microfluidic containment trenches within the microfluidic devices for cellular trapping, manipulation and real-time analysis of biological phenomena, including chemotaxis. The invention captures the design methodology for these traps, as well as the fabrication means and the associated external control mechanism that allows rapid, reversible and fully controlled changes in the chemical environment to which trapped cells are exposed.
摘要翻译：一种改进的微流体装置和使用微流体装置来测量活性部分对趋化剂的自然运动响应的方法。本发明包括将微流体密封沟槽集成在微流体装置内用于细胞捕获，操纵和实时分析生物现象，包括趋化性。本发明捕获了这些陷阱的设计方法，以及制造手段和相关的外部控制机制，其允许捕获细胞暴露于其中的化学环境的快速，可逆和完全控制的变化。

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