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1. 发明申请

WO2013190392A3 DIELECTRIC STRAP WAVEGUIDES, ANTENNAS, AND MICROWAVE DEVICES 审中-公开
标题翻译：电介质波导波导，天线和微波器件
公开(公告)号：WO2013190392A3
公开(公告)日：2014-03-13
申请号：PCT/IB2013001973
申请日：2013-06-21
申请人： UNIV MANITOBA
发明人： RASHIDIAN ATABAK , SHAFAI LOTFOLLAH , KLYMYSHYN DAVID M , ALIGODARZ MOHAMMADREZA TAYFEH
IPC分类号： H01P1/00
CPC分类号： H01P3/081 , H01P1/20 , H01P1/2002 , H01P3/16 , H01P5/087 , H01P5/184 , H01P5/188 , H01P11/006 , H01Q9/0485
摘要： A new class of antennas and microwave components are introduced. In this approach a high-permittivity dielectric film is applied (i.e. printed) on a dielectric substrate, which may be grounded. By changing the shape of the high-permittivity film, different microwave devices (e.g. waveguides, filters, couplers, and antennas) are produced. By changing the size and permittivity of the high-permittivity film and dielectric substrate, these elements are designed at different frequencies for different applications. Highly-efficient microwave devices can result due to the absence of surface currents.
摘要翻译：引入了一类新型的天线和微波元件。在这种方法中，将高介电常数介质膜施加（即印刷）在可以接地的电介质基板上。通过改变高介电常数膜的形状，产生不同的微波器件（例如波导，滤波器，耦合器和天线）。通过改变高介电常数薄膜和电介质基片的尺寸和介电常数，这些元件在不同的应用中被设计在不同的频率上。由于没有表面电流，可以产生高效的微波器件。

2. 发明申请

WO2013005134A2 IMAGING USING PROBES 审中-公开
标题翻译：使用探针进行成像
公开(公告)号：WO2013005134A2
公开(公告)日：2013-01-10
申请号：PCT/IB2012053228
申请日：2012-06-26
申请人： UNIV MANITOBA , OSTADRAHIMI MAJID , LOVETRI JOE , SHAFAI LOTFOLLAH
发明人： OSTADRAHIMI MAJID , LOVETRI JOE , SHAFAI LOTFOLLAH
CPC分类号： G01N22/00 , A61B5/0507 , G01S13/89
摘要： Methods and systems may image an object of interest using one or more probes. More specifically, such exemplary methods and systems may deliver electromagnetic energy (e.g., microwave energy) using a transmitting antenna to the object while activating a probe to interact with the scattered field and sampling the resulting scattered field using one or more receiving antennas. The sampled electromagnetic energy may then be used to reconstruct an image of the object.
摘要翻译：方法和系统可以使用一个或多个探针对感兴趣的对象成像。更具体地，这样的示例性方法和系统可以使用发射天线将电磁能（例如，微波能量）递送到物体，同时激活探针以与散射场相互作用并且使用一个或多个接收天线对所得到的散射场进行采样。采样的电磁能量然后可以被用来重建物体的图像。

3. 发明申请

WO2012024083A9 OXATHIAZINE AND DITHIINE OXIDES AS INHIBITORS OF SULFHYDRYL-DEPENDENT BIOMOLECULES 审中-公开
标题翻译：作为巯基依赖性生物分子抑制剂的硫嘌呤和酪氨酸氧化物
公开(公告)号：WO2012024083A9
公开(公告)日：2012-10-04
申请号：PCT/US2011046355
申请日：2011-08-03
申请人： CHEMTURA CORP , UNIV MANITOBA , CHEE GAIK-LEAN , BROUWER WALTER G , OSIKA EWA , HASINOFF BRIAN B , BREWER A DAVID
发明人： CHEE GAIK-LEAN , BROUWER WALTER G , OSIKA EWA , HASINOFF BRIAN B , BREWER A DAVID
IPC分类号： C07D291/06 , A61K31/385 , A61K31/54 , A61P35/00 , C07D339/08
CPC分类号： C07D291/06 , A61K31/385 , A61K31/54 , C07D339/08
摘要： Novel derivatives of dihydro-l,4,2-oxathiazine and dihydro-l,4-dithiine oxides, more particularly, novel derivatives of dihydro-l,4,2-oxathiazine and dmydro-l,4-dithiine oxides that target cysteine residues of biomolecules of pharmacological importance are provided as pharmaceutically useful compounds, for example, as anticancer, antiinfectious, antigastric acid secretion, antiosteoporosic, and antiinflammatory agents.
摘要翻译：二氢-1,4,2-氧杂噻嗪和二氢-1,4-二硫杂环己烯氧化物的新衍生物，更具体地说是靶向半胱氨酸残基的二氢-1,4,2-氧杂噻嗪和二氢-1,4-二硫基氧化物的新衍生物提供药理学重要性的生物分子作为药学上有用的化合物，例如，作为抗癌剂，抗感染剂，抗胃酸分泌剂，抗骨质疏松剂和抗炎剂。

4. 发明申请

WO2011156904A3 METHOD AND APPARATUS FOR RETROPERFUSION 审中-公开
标题翻译：回收方法和装置
公开(公告)号：WO2011156904A3
公开(公告)日：2012-02-02
申请号：PCT/CA2011000704
申请日：2011-06-14
申请人： UNIV MANITOBA , ZHANG LI , HUSSAIN FARRUKH
发明人： ZHANG LI , HUSSAIN FARRUKH
IPC分类号： A61M1/36 , A61F2/958 , A61M1/10 , A61M25/00
CPC分类号： A61M25/0075 , A61M1/36 , A61M1/3613 , A61M5/16881 , A61M25/0074 , A61M25/10 , A61M39/227 , A61M39/228 , A61M2025/1059 , A61M2025/1072
摘要： The present invention relates to apparatus for retroperfusion of tissues and organs. The apparatus comprises a catheter with a proximal end for engaging a supply of the fluid medium, and a distal end having an expandable-contractible chamber for installation into suitable vessels or organs. The expandable-contractible chamber comprises a conduit element having a fluid- filled hollow wall defining a lumen. The conduit element has a first deformable inner-facing section approximate a proximal end of the conduit and a second deformable inner-facing section approximate a distal end of the conduit element. Controlled application of a pressure at a proximal end of the conduit element causes deformation of the conduit into the lumen at its distal end thereby occluding the flow of fluid medium through the catheter. Controlled release of the pressure releases deformation of the fluid-filled conduit at its distal end thereby unblocking the flow of the fluid medium through the catheter.
摘要翻译：本发明涉及组织器官的后灌注装置。该装置包括具有用于接合流体介质的供给的近端的导管，以及具有用于安装到合适的血管或器官中的可扩张收缩室的远端。可扩张收缩室包括具有限定内腔的流体填充中空壁的导管元件。导管元件具有近似于导管的近端的第一可变形内壁部分和近似于导管元件的远端的第二可变形内表面部分。在导管元件的近端受到控制的压力导致导管在其远端处进入内腔，从而阻塞通过导管的流体介质的流动。压力的控制释放释放了流体填充管道在其远端处的变形，从而解除流体介质通过导管的流动。

5. 发明申请

WO2011154791A2 SYSTEM AND METHODS OF ACOUSTICAL SCREENING FOR OBSTRUCTIVE SLEEP APNEA DURING WAKEFULNESS 审中-公开
标题翻译：阻塞性睡眠呼吸障碍的声学筛查系统与方法
公开(公告)号：WO2011154791A2
公开(公告)日：2011-12-15
申请号：PCT/IB2011001119
申请日：2011-05-24
申请人： UNIV MANITOBA , MOUSSAVI ZAHRA , MONTAZERI AMAN
发明人： MOUSSAVI ZAHRA , MONTAZERI AMAN
CPC分类号： A61B5/4818 , A61B5/0803 , A61B5/0826 , A61B5/6822 , A61B5/6823 , A61B5/6832 , A61B5/70 , A61B5/7264 , A61B7/003 , A61B7/04 , A61B2562/0204 , G16H50/20
摘要： A system and methods using tracheal sound intensity variations to screen patients suspected of obstructive sleep apnea during wakefulness. The system includes a mechanism positioning the patient and a sound input device attached to a recording device to receive breathing sound signals. A signal conditioning component amplifies and filters the breathing sound signals, and an analog to digital component digitizes the signals. A detecting component detects onsets of respiratory phases, and a separating component separates inspiratory sound signals and expiratory sound signals from the breathing sound signals. A segmenting component segments the inspiratory and expiratory phase signals into a short duration of overlapping windows, and a collection characteristic extraction component obtains characteristics from each window. A calculation component performs statistical analysis to reduce the number of significant characteristics and classify the patient as OSA or non-OSA and predicts severity of the OSA as one of mild, moderate and severe.
摘要翻译：一种系统和方法，使用气管声音强度变化来筛查怀疑在睡眠期间阻塞性睡眠呼吸暂停的患者。该系统包括定位患者的机构和附接到记录装置的声音输入装置以接收呼吸声音信号。信号调理部件放大并过滤呼吸声音信号，并且模拟数字分量对信号进行数字化。检测部件检测呼吸相位的开始，分离部件将呼吸声信号和呼气声信号与呼吸声信号分离。分段组件将吸气和呼气相位信号分成短时间的重叠窗口，并且收集特征提取组件从每个窗口获得特征。计算组件执行统计分析以减少重要特征的数量并将患者分类为OSA或非OSA，并将OSA的严重程度预测为轻度，中度和重度之一。

6. 发明申请

WO2011124986A3 POLYOL MODIFIED AMINOGLYCOSIDE-LIPID CONJUGATES 审中-公开
标题翻译：多元醇改性氨基丁糖 - 脂质结合物
公开(公告)号：WO2011124986A3
公开(公告)日：2011-12-15
申请号：PCT/IB2011001226
申请日：2011-04-05
申请人： UNIV MANITOBA , SCHWEIZER FRANK , SMRITILEKHA BERA , ZHANEL GEORGE
发明人： SCHWEIZER FRANK , SMRITILEKHA BERA , ZHANEL GEORGE
IPC分类号： C07H15/00 , A61K31/7036 , A61P31/04 , C07H13/02 , C07H13/12 , C07H15/04 , C07H15/12 , C07H15/18
CPC分类号： C07H15/224 , C07H17/04
摘要： In some aspects, the present invention provides aminoglycoside derivatives thereof that exhibit antibacterial activity. In some aspects, the aminoglycoside derivatives comprise compounds consisting of (a) an ammoglycoside group and (b) at least one hydrophobic carbamate and alkoxy group to the primary or secondary hydroxy position of the aminolvcoside group and salts thereof. Additionally, methods of treating and preventing bacterial infections using the aminoglycoside derivatives are also provided
摘要翻译：在某些方面，本发明提供具有抗菌活性的氨基糖苷衍生物。在一些方面，氨基糖苷衍生物包含由（a）氨基甙基和（b）氨基甙基的伯或仲羟基位置的至少一个疏水氨基甲酸酯和烷氧基及其盐组成的化合物。此外，还提供了使用氨基糖苷衍生物治疗和预防细菌感染的方法

7. 发明申请

WO2009072002A3 BISPHENOLS IN CANCER THERAPY 审中-公开
标题翻译：癌症治疗中的双酚
公开(公告)号：WO2009072002A3
公开(公告)日：2011-05-05
申请号：PCT/IB2008003818
申请日：2008-09-15
申请人： UNIV MANITOBA , HASINOFF BRIAN B , LIANG HONG
发明人： HASINOFF BRIAN B , LIANG HONG
IPC分类号： C07C317/22 , A61K31/09 , A61K31/10 , A61K31/137 , A61P35/00 , C07C47/575 , C07C217/58 , C07C323/20 , C12N5/00 , C12N9/90 , C12N9/99
CPC分类号： A61K31/11 , A61K31/085 , A61K31/095 , A61K31/10 , A61K31/137 , A61K45/06 , A61K2300/00
摘要： The present invention generally relates to anticancer agents and methods of treating cancer. The anticancer agents described herein comprise a bisphenol core and generally act as topoisomerase II inhibitors, though their anticancer activity may be related to other mechanisms as well. The bisphenols discussed therein may also protect certain cells against detrimental effects of topoisomerase II poisons.
摘要翻译：本发明一般涉及抗癌剂和治疗癌症的方法。本文所述的抗癌剂包含双酚核心，并且通常用作拓扑异构酶II抑制剂，尽管它们的抗癌活性也可能与其它机制有关。其中讨论的双酚还可以保护某些细胞免受拓扑异构酶II毒物的不利影响。

8. 发明申请

WO2007124588A2 A COLICINOGENIC STRAIN OF E. COLI 审中-公开
标题翻译：大肠杆菌的致病菌
公开(公告)号：WO2007124588A2
公开(公告)日：2007-11-08
申请号：PCT/CA2007000731
申请日：2007-05-01
申请人： UNIV MANITOBA , KRAUSE DENIS O , NYACHOTI MARTIN
发明人： KRAUSE DENIS O , NYACHOTI MARTIN
IPC分类号： C12N1/20 , A23K1/16 , A61K9/19 , A61K35/74 , A61P1/12
CPC分类号： A61K38/164 , A23K10/18 , A23K50/30 , A23K50/60 , A23L33/135 , A61K35/741 , C07K14/245 , C12R1/19
摘要： Described herein is the isolation of colicin-producing strains of E. coli for use as probiotic treatments for the prevention of E. coli K88+ diarrhea. These strains of E. coli, designated as UM-17, and UM-19, express a filament and produce colicin but produce no compounds toxic to the host animal and as such inhibit the growth of E. coli K88+.
摘要翻译：本文描述的是分离用于预防大肠杆菌K88 +腹泻的益生菌治疗的大肠杆菌生产菌株。这些名为UM-17和UM-19的大肠杆菌菌株表达细丝并产生大肠杆菌素，但不产生对宿主动物有毒的化合物，因此抑制大肠杆菌K88 +的生长。

9. 发明申请

WO2004092208A3 SARS-RELATED PROTEINS 审中-公开
标题翻译：与SARS相关的蛋白质
公开(公告)号：WO2004092208A3
公开(公告)日：2005-01-20
申请号：PCT/CA2004000558
申请日：2004-04-14
申请人： CA MINISTER HEALTH & WELFARE , UNIV MANITOBA , JONES STEVEN , FELDMANN HEINZ , BASTIEN NATHALIE , LI YAN , PLUMMER FRANK , ENS WERNER , STANDING KENNETH , KROKHINE OLEG , PERREAULT HELEN , TYLER SHAUN
发明人： JONES STEVEN , FELDMANN HEINZ , BASTIEN NATHALIE , LI YAN , PLUMMER FRANK , ENS WERNER , STANDING KENNETH , KROKHINE OLEG , PERREAULT HELEN , TYLER SHAUN
IPC分类号： A61K39/215 , C07K14/165 , C07K16/10
CPC分类号： C07K14/005 , C12N2770/20022
摘要： Novel proteins isolated from a patient with SARS are described.
摘要翻译：描述了从SARS患者分离的新型蛋白质。

10. 发明申请

WO2004019027A3 ULTRASONIC EVALUATION OF THE STRENGTH OF FLOUR DOUGHS 审中-公开
标题翻译：超声波评估飞行员强度
公开(公告)号：WO2004019027A3
公开(公告)日：2004-11-25
申请号：PCT/CA0301249
申请日：2003-08-21
申请人： UNIV MANITOBA , PAGE JOHN H , ELMEHDI HUSSEIN M , SCANLON MARTIN G
发明人： PAGE JOHN H , ELMEHDI HUSSEIN M , SCANLON MARTIN G
IPC分类号： G01N29/07 , G01N29/11 , G01N29/44 , G01N29/18 , G01H5/00 , G01K11/00 , G01N29/20 , G01N33/10
CPC分类号： G01N29/4427 , G01N3/40 , G01N29/07 , G01N29/11 , G01N29/326 , G01N29/346 , G01N29/348 , G01N29/4418 , G01N33/10 , G01N2203/0092 , G01N2203/0234 , G01N2291/0235 , G01N2291/0245 , G01N2291/02827 , G01N2291/02863 , G01N2291/02872 , G01N2291/02881
摘要： A method of determining dough strength and predicting doughquality is herein described. The method involves propagating an ultrasound signal through a sample of dough and determining the transit time and amplitude of the ultrasound signal, and hence the ultrasonic velocity and attenuation. These data are then used to determine dough strength and predict product quality. Measurement of dough expansion by digital photography as pressure is varied provides complementary information that is used to determine dough strength and predict product quality.
摘要翻译：本文描述了确定面团强度和预测面团质量的方法。该方法包括通过面团样品传播超声信号，并确定超声信号的传播时间和幅度，从而确定超声速度和衰减。然后将这些数据用于确定面团强度并预测产品质量。随着压力的变化，通过数字摄影测量面团膨胀提供了用于确定面团强度和预测产品质量的补充信息。

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