专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2016122986A1 SYSTEMS, COMPOSITIONS, AND METHODS OF LIPID PANEL TEST CONTROLS UTILIZING PARTICLES THAT MIMIC HEMATOCRIT 审中-公开
标题翻译：使用MIMIC HEMATOCRIT颗粒的脂质板测试控制系统，组合物和方法
公开(公告)号：WO2016122986A1
公开(公告)日：2016-08-04
申请号：PCT/US2016/014575
申请日：2016-01-22
申请人： POLYMER TECHNOLOGY SYSTEMS, INC.
发明人： HUGHES, Gary L. , MOSKOWITZ, Keith , PATWARDHAN, Aniruddha
IPC分类号： G01N33/50
CPC分类号： G01N33/96 , G01N2496/10
摘要： A calibration sample includes serum/plasma having a known level of a first analyte and a plurality of particles that mimic the characteristics of red blood cells.
摘要翻译：校准样品包括具有已知水平的第一分析物和模拟红细胞特征的多个颗粒的血清/血浆。

2. 发明申请

WO2005036164A1 REFERENCE CONTROL FOR OPTICAL MEASUREMENT OF NUCLEATED RED BLOOD CELLS OF A BLOOD SAMPLE 审中-公开
标题翻译：血液样品的核红细胞的光学测量参考控制
公开(公告)号：WO2005036164A1
公开(公告)日：2005-04-21
申请号：PCT/US2004/032168
申请日：2004-09-30
申请人： BECKMAN COULTER, INC.
发明人： LI, Yi , ORTIZ, Nery , YOUNG, Carole, J. , GALVEZ, Santiago
IPC分类号： G01N31/00
CPC分类号： G01N15/1459 , G01N33/56972 , G01N33/80 , G01N33/96 , G01N2015/0073 , G01N2015/1062 , G01N2015/1486 , G01N2015/1493 , G01N2496/10 , Y10T436/10 , Y10T436/101666
摘要： Reference control compositions and the method of use are disclosed for measurement of nucleated red blood cells, which includes one set of synthetic spherical particles having a mean particle diameter ranging from 6.2 µm to 6.8 µm and a refractive index from 1.58 to 1.62 monodispersed in an aqueous suspension medium. The synthetic spherical particles have optical properties simulating optical properties of nucleated red blood cells as measured by optical measurements. The reference control composition can further include a second set of the synthetic spherical particles having optical properties simulating optical properties of white blood cells. Further disclosed is a reference control system which includes a series of reference control compositions, each having an amount of one type of synthetic spherical particles which have optical properties simulating the optical properties of nucleated red blood cells having a specific cell maturity.
摘要翻译：公开了参考对照组合物和使用方法用于测量有核红细胞，其包括一组平均粒径范围为6.2μm至6.8μm的合成球形颗粒和单分散在水性中的折射率为1.58至1.62 悬浮介质。合成球形颗粒具有通过光学测量测量的模拟有核红细胞的光学性质的光学性质。参考对照组合物可进一步包括具有模拟白细胞光学性质的光学性质的第二组合成球形颗粒。进一步公开了一种参考控制系统，其包括一系列参考控制组合物，每个参考对照组合物具有一定量的一种类型的合成球形颗粒，其具有模拟具有特定细胞成熟度的有核红细胞的光学性质的光学性质。

3. 发明申请

WO2017108765A1 ELECTROCHEMICAL BLOOD MIMICKING FLUID 审中-公开
标题翻译：电化学血液模拟液
公开(公告)号：WO2017108765A1
公开(公告)日：2017-06-29
申请号：PCT/EP2016/081890
申请日：2016-12-20
申请人： CILAG GMBH INTERNATIONAL
发明人： MACFIE, Gavin
IPC分类号： C12Q1/00 , G01N27/327
CPC分类号： C12Q1/006 , G01N27/3274 , G01N33/96 , G01N2496/10
摘要： A fluid mimicking electrochemical properties of blood includes a base fluid and particles dispersed in the base fluid. The fluid has rheological properties that mimic blood, and the dispersion of the particles may be maintained for a range of hematocrit equivalent levels. In addition, a method for preparing a blood mimicking fluid for use with an electrochemical biosensor includes dispersing particles into a base fluid, and introducing an analyte that is compatible with the electrochemical biosensor into the base fluid. Further, a method of testing an electrochemical biosensor includes the steps of obtaining a blood mimicking fluid having a predetermined concentration of the analyte and having rheological and electrochemical properties in combination mimicking blood, assaying the blood mimicking fluid to measure an analyte concentration, and comparing the measured analyte concentration and the predetermined analyte concentration.
摘要翻译：模拟血液电化学特性的流体包括基液和分散在基液中的颗粒。该流体具有模拟血液的流变性质，并且可以保持一定范围的血细胞比容等效水平的颗粒分散。另外，用于制备供电化学生物传感器使用的血液模拟流体的方法包括将颗粒分散到基础流体中，并将与电化学生物传感器相容的分析物引入到基础流体中。此外，测试电化学生物传感器的方法包括以下步骤：获得具有预定浓度的分析物并且具有模拟血液的流变学和电化学性质的血液模拟流体，分析血液模拟流体以测量分析物浓度，以及比较测量的分析物浓度和预定的分析物浓度。

4. 发明申请

WO2010019372A1 REFERENCE CONTROL FOR CELL BY CELL ANALYSIS 审中-公开
标题翻译：细胞分析参考控制
公开(公告)号：WO2010019372A1
公开(公告)日：2010-02-18
申请号：PCT/US2009/051679
申请日：2009-07-24
申请人： BECKMAN COULTER, INC.
发明人： VAN AGTHOVEN, Andreas , MALERGUE, Fabrice
IPC分类号： G01N33/48
CPC分类号： A61K35/407 , G01N33/721 , G01N33/96 , G01N2333/805 , G01N2496/10 , Y10T436/101666 , Y10T436/107497
摘要： A reference control for cell by cell analysis on flow cytometric analyzers contains cellular analogs made of permeated blood cells containing therein aggregated intracellular proteins and preserved antigenic sites thereof, having cellular membrane permeable to antibodies and a suspension medium. The reference control is frozen after being prepared and thawed prior to use. The cellular analogs further contain a fluorescence marker therein. Further disclosed are a method of making the reference control and a method using the reference control, as an internal or stand-alone control, for measurements of cellular hemoglobin and cellular hemoglobin variant of a blood sample.
摘要翻译：用于流式细胞分析仪的细胞分析的参考对照包含由其中含有聚集的细胞内蛋白质和其保留的抗原位点的透过血细胞制成的细胞类似物，其具有可抗抗体的细胞膜和悬浮介质。参考对照在使用前准备并解冻后冷冻。细胞类似物还含有荧光标记物。进一步公开的是进行参考控制的方法和使用参考对照作为血液样品的细胞血红蛋白和细胞血红蛋白变体的测量作为内部或独立控制的方法。

5. 发明申请

WO1996034291A1 QUALITY CONTROL METHOD OF HEMATOLOGY INSTRUMENTS 审中-公开
标题翻译： HEMATOLOGY仪器质量控制方法
公开(公告)号：WO1996034291A1
公开(公告)日：1996-10-31
申请号：PCT/US1996005941
申请日：1996-04-29
申请人： COULTER INTERNATIONAL CORP.
发明人： COULTER INTERNATIONAL CORP. , YOUNG, Carole
IPC分类号： G01N33/96
CPC分类号： G01N33/96 , G01N15/1012 , G01N15/12 , G01N33/5094 , G01N33/92 , G01N2496/05 , G01N2496/10
摘要： A method of quality control to diagnose the cause of a malfunction of an instrument. The method uses measurements of the physical property of a sample to diagnose the cause of a malfunction of an instrument. The spatial position of a control product sample is analysed. Alternatively, the spatial position of a statistically significant number of patient blood samples can be used. The method enables the monitoring of an instrument for problems associated with debris and noise caused by red cell lysis inefficiency; instrument reagents pump volume settings; instrument laser alignments; instrument gain settings; and flow noise caused by partial plugs, residual plugs or other flow problems. The method provides a more specific indication of the type and cause of an instrument malfunctioning than non specific flagging is provided by prior art methods.
摘要翻译：一种用于诊断仪器故障原因的质量控制方法。该方法使用样品的物理性质的测量来诊断仪器故障的原因。分析对照产品样品的空间位置。或者，可以使用统计学上显着数量的患者血液样本的空间位置。该方法能够监测仪器与由红细胞裂解无效率引起的碎片和噪声相关的问题; 仪器试剂泵体积设置; 仪器激光对准仪器增益设置; 和由部分插头，残留插头或其他流量问题引起的流动噪声。该方法提供了比现有技术方法提供的非特定标记的仪器故障的类型和原因的更具体的指示。

6. 发明申请

WO2018210395A1 LATERAL FLOW CHROMATOGRAPHIC ASSAY FOR TUBERCULOSIS (TB) 审中-公开
公开(公告)号：WO2018210395A1
公开(公告)日：2018-11-22
申请号：PCT/EG2017/000013
申请日：2017-05-16
申请人： RAFEA, Mahmoud Abdel Wahed
发明人： RAFEA, Mahmoud Abdel Wahed
IPC分类号： G01N33/569 , G01N33/558
CPC分类号： G01N33/5695 , G01N33/558 , G01N2496/10
摘要： TB-KIT is a lateral flow chromatography assay for evaluation of TB condition in mammals whatever the affected organ or part of the body, using erythrocytes hemolysate as the sample. The primary antibodies used are prepared in animals using a purified protein extract from laboratory cultures of Mycobacterium tuberculosis complex. Conjugated primary antibodies comprise an indicator dye which is currently available in many varieties. After adding the sample to test strip, Mycobacterium's analyte are attached to conjugated antibodies forming a complex which migrate along a lateral-flow assay membrane. Eventually, the complex contacts membrane bound antibodies forming antibody-conjugated-analyte-antibody sandwich, and produce a detectable signal (Fig. No. 3). Based on concentration of analyte in the sample, one can differentiate between disease, latent infection, immune, and susceptible. Consequently, in semi-quantitative approach, one use different dilutions to diagnose the occurrence/state of disease.

7. 发明申请

WO2008061073A2 HEMATOLOGY LINEARITY CONTROL COMPOSITION SYSTEM AND METHOD OF USE 审中-公开
标题翻译：血液学线性控制组合物系统及其使用方法
公开(公告)号：WO2008061073A2
公开(公告)日：2008-05-22
申请号：PCT/US2007084477
申请日：2007-11-13
申请人： BECKMAN COULTER INC
发明人： ORTIZ NERY , GERULA THEODORE J
IPC分类号： G01N33/48 , G01N37/00
CPC分类号： G01N33/96 , G01N15/12 , G01N2015/1006 , G01N2496/10 , Y10T436/10 , Y10T436/101666
摘要： A linearity control system includes a series of linearity control compositions, each thereof includes white blood cell analogs and stabilized red blood cells in a suspension medium. The concentration of the white blood cell analogs in the series of control compositions increases from 0.2 x 10 3 to 800 x 10 3 analogs per microliter, and the concentration of the white blood cell analogs in at least one control composition is greater than 120 x 10 3 analogs per microliter. The stabilized red blood cells facilitate mono-dispersion of the white blood cell analogs in the suspension medium by gently mixing. The control compositions further include platelet analogs, or additionally include reticulocyte and/or nucleated red blood cell analogs. The linearity control system allows the verification of the reportable measurement range and linearity of the measurements of hematology analyzers for white blood cells, red blood cells and platelets in extended concentration ranges.
摘要翻译：线性控制系统包括一系列线性控制组合物，其中每一个包括悬浮介质中的白细胞类似物和稳定的红细胞。一系列对照组合物中白细胞类似物的浓度从每微升升高0.2×10 3至800×10 3个类似物，并且白血浓度至少一种对照组合物中的细胞类似物的每微升大于120×10 3个类似物。稳定的红细胞促进白细胞类似物在悬浮介质中的单分散，通过轻轻混合。对照组合物还包括血小板类似物，或另外包括网织红细胞和/或有核红细胞类似物。线性控制系统允许验证可扩展浓度范围内白细胞，红细胞和血小板的血液分析仪的可报告测量范围和线性度。

8. 发明申请

WO1991000507A1 PERFLUOROCARBONS FOR USE AS STANDARDS IN GAS PARTIAL PRESSURE MEASUREMENTS 审中-公开
标题翻译：在气体部分压力测量中作为标准使用的全氟氯烃
公开(公告)号：WO1991000507A1
公开(公告)日：1991-01-10
申请号：PCT/US1989002940
申请日：1989-07-05
申请人： LONG, David, M., Jr.
IPC分类号： G01N01/00
CPC分类号： A61K9/0026 , G01N33/96 , G01N2405/04 , G01N2496/10 , G01N2496/70
摘要： A method for calibrating an instrument used to determine the pO2 and pCO2 in the blood, comprising, introducing into the instrument a sample quantity of an emulsion comprising an aqueous phase, an oxygen-carrying fluorocarbon in an amount of 45 % to 125 % weight per volume having known stable values for pO2 and pCO2, and an effective amount of an emulsifying agent, the emulsion being biocompatible and maintaining the stable values through heat sterilization and storage for at least three months, and adjusting the calibration of the instrument to correspond to the known values of pO2 and pCO2 in the emulsion.
摘要翻译：一种用于校准用于确定血液中的pO2和pCO2的仪器的方法，包括：向所述仪器中引入样品量的包含水相的乳液，所述乳液包含含水量为45％至125％重量的含氧碳氟化合物具有已知pO2和pCO2稳定值的体积和有效量的乳化剂，该乳液是生物相容性的，并且通过热灭菌和储存保持至少三个月的稳定值，并且将仪器的校准调整为对应于乳液中已知的pO2和pCO2值。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式