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1. 发明申请

WO2010056740A1 METHOD OF CORRECTION OF PARTICLE INTERFERENCE TO HEMOGLOBIN MEASUREMENT 审中-公开
标题翻译：校正粒子干扰测定法的方法
公开(公告)号：WO2010056740A1
公开(公告)日：2010-05-20
申请号：PCT/US2009/064021
申请日：2009-11-11
申请人： BECKMAN COULTER, INC. , ZHANG, Shuliang , LU, Jiuliu , ZHENG, Min , GRACE, Eric, M. , LI, Jing , LAVERNIA, Maritza , BRITTON, Ted, W.
发明人： ZHANG, Shuliang , LU, Jiuliu , ZHENG, Min , GRACE, Eric, M. , LI, Jing , LAVERNIA, Maritza , BRITTON, Ted, W.
IPC分类号： G01N33/72
CPC分类号： G01N33/721 , G01N33/491 , Y10T436/10 , Y10T436/101666 , Y10T436/25 , Y10T436/25125
摘要： A method of correction of particle interference to hemoglobin measurement of a blood sample on a hematology analyzer is provided. The method includes mixing an aliquot of a blood sample with a lytic reagent to lyse red blood cells and forming a sample mixture; measuring absorbance of the sample mixture at a predetermined wavelength of a hemoglobin chromogen formed in the sample mixture, and obtaining an apparent hemoglobin concentration of the blood sample using obtained absorbance; measuring concentration and size of cellular particles remaining in the sample mixture; removing contribution of the cellular particles to the apparent hemoglobin concentration using the concentration and the size of the cellular particles to obtain a corrected hemoglobin concentration of the blood sample; and reporting the corrected hemoglobin concentration of the blood sample.
摘要翻译：提供了一种在血液分析仪上校正血液样品血红蛋白测量的粒子干扰的方法。该方法包括将血样的等分试样与裂解试剂混合以溶解红细胞并形成样品混合物; 测量在样品混合物中形成的血红蛋白色原子的预定波长处的样品混合物的吸光度，并使用所获得的吸光度获得血液样品的表观血红蛋白浓度; 测量残留在样品混合物中的细胞颗粒的浓度和尺寸; 使用细胞颗粒的浓度和大小去除细胞颗粒对表观血红蛋白浓度的贡献，以获得血液样品的校正血红蛋白浓度; 并报告血样的校正血红蛋白浓度。

2. 发明申请

WO2010019960A2 FLOW CYTOMETRY-BASED SYSTEMS AND METHODS FOR DETECTING MICROBES 审中-公开
标题翻译：基于流动细胞计数的系统和用于检测微生物的方法
公开(公告)号：WO2010019960A2
公开(公告)日：2010-02-18
申请号：PCT/US2009/054071
申请日：2009-08-17
申请人： LITMUS RAPID-B LLC , BUZATU, Dan, A. , WILKES, Jon, G. , MOSKAL, Ted, A. , NEVIUS, Bill , TAYLOR, Jason, T. , TUCKER, Randal, K. , MILLER, Melinda , RAMSANOOP, Shawn
发明人： BUZATU, Dan, A. , WILKES, Jon, G. , MOSKAL, Ted, A. , NEVIUS, Bill , TAYLOR, Jason, T. , TUCKER, Randal, K. , MILLER, Melinda , RAMSANOOP, Shawn
IPC分类号： C12Q1/02 , C12M1/34 , G01N33/52 , G01N35/08
CPC分类号： C12Q1/04 , C12Q1/06 , G01N1/38 , G01N15/1012 , G01N15/1434 , G01N15/1459 , G01N21/6486 , G01N33/569 , G01N33/56911 , G01N2001/028 , G01N2015/1402 , G01N2201/06113 , G01N2201/127 , Y02A50/58 , Y10T436/101666
摘要： In various embodiments, the present disclosure describes methods and systems for detecting microbes in a sample. The methods are generally applicable to quantifying the number of target bacteria in a sample counted from a detection region of a flow cytometer histogram. The detection methods can be employed in the presence of other microorganisms and other non-target microbe components to selectively quantify the amount of a target microbe. The methods are advantageous over those presently existing for testing of foodstuffs and diagnostic evaluation in their speed, accuracy and ease of use. Various swab collection devices and kits useful for practicing the present disclosure are also described herein.
摘要翻译：在各种实施例中，本公开描述了用于检测样本中的微生物的方法和系统。这些方法通常适用于量化从流式细胞仪直方图的检测区域计数的样品中的目标细菌的数量。检测方法可以用于存在其他微生物和其他非目标微生物组分以选择性定量目标微生物的量。这些方法比目前用于食品检测和诊断评估的方法在速度，准确性和易用性方面具有优势。这里还描述了用于实施本公开的各种拭子收集装置和试剂盒。

3. 发明申请

WO2009077678A3 METHOD FOR ADJUSTING THE CALIBRATION OF DIAGNOSIS TESTS 审中-公开
标题翻译：调整诊断试验的校准方法
公开(公告)号：WO2009077678A3
公开(公告)日：2009-09-03
申请号：PCT/FR2008001379
申请日：2008-10-02
申请人： STAGO DIAGNOSTICA , ESTEVE FREDERIC , NICOUD LYDIE
发明人： ESTEVE FREDERIC , NICOUD LYDIE
IPC分类号： G01N33/86 , G01N33/96
CPC分类号： G01N33/86 , G01N33/96 , Y10T436/101666
摘要： The invention relates to a method for adjusting either the measured signal or the activity calculated by the instrument, or a predetermined calibration curve (precalibration curve) for a medical-biology diagnosis test carried out on an instrument with precalibrated reagents, that comprises the following steps: (i) defining a standard signal or activity value for one or two calibration adjusters having a predetermined concentration or activity in a tested compound, and measuring for said adjuster(s) the deviation between the standard signal or activity value(s) and the value(s) either of the signal measured by the instrument, or of the activity value(s) calculated from the precalibration curve; and if the measured deviation has an acceptable value, (ii) adjusting the signal measured by the instrument or the values of the precalibration curve so that the value of the measured signal or the calculated activity on the precalibration curve for one or both adjusters is brought back to a signal or activity value identical to the standard signal or activity value determined in step (i) for the single adjuster or for both adjusters; (iii) applying the same adjustment as that described in (ii) to all the samples whose signal or activity is measured with said precalibrated reagents.
摘要翻译：本发明涉及一种用于调整由仪器计算的测量的信号或活性或用于在具有预校准试剂的仪器上执行的医学生物学诊断测试的预定校准曲线（预校准曲线）的方法，其包括以下步骤：（i）为在测试化合物中具有预定浓度或活性的一个或两个校准调节剂定义标准信号或活性值，并测量所述调节剂的标准信号或活性值与（一个或多个）值由仪器测量的信号或由预先校准曲线计算出的活动值（s）; 如果测得的偏差有一个可接受的值，（ii）调整仪器测量的信号或预校准曲线的数值，以使一个或两个调节器的测量信号的值或预校准曲线上计算的活动带来回到与步骤（i）中为单个调节器或两个调节器所确定的标准信号或活动值相同的信号或活动值; （iii）将与（ii）中所述相同的调节应用于所有用所述预校准试剂测量其信号或活性的样品。

4. 发明申请

WO2007121464A3 DETECTION OF CIRCULATING ENDOTHELIAL CELLS 审中-公开
标题翻译：循环内皮细胞的检测
公开(公告)号：WO2007121464A3
公开(公告)日：2008-11-20
申请号：PCT/US2007066856
申请日：2007-04-18
申请人： WELLSTAT BIOLOGICS CORP , LORENCE ROBERT M
发明人： LORENCE ROBERT M
IPC分类号： G01N33/53
CPC分类号： G01N33/56966 , G01N33/54326 , G01N33/582 , G01N2333/70596 , G01N2333/71 , G01N2333/755 , G01N2458/30 , Y10T436/101666 , Y10T436/25125 , Y10T436/25375
摘要： Endothelial cells are detected in a blood sample by enriching the endothelial cells from the blood sample followed by performing on the enriched endothelial cells an immunoassay capable of detecting antigens expressed by the endothelial cells. The immunoassay is capable of detecting antigen expressed from 300 endothelial cells per milliliter of blood. The method can be used for assaying mature circulating endothelial cells or circulating endothelial progenitor cells.
摘要翻译：通过从血液样品中富集内皮细胞，然后在富集的内皮细胞上进行能够检测由内皮细胞表达的抗原的免疫测定，在血液样品中检测内皮细胞。免疫测定能够检测每毫升血液中从300个内皮细胞表达的抗原。该方法可用于测定成熟的循环内皮细胞或循环内皮祖细胞。

5. 发明申请

WO2008097719A1 HEMOLYTIC REAGENT AND METHOD FOR THE STUDY OF LEUKOCYTE SUBPOPULATIONS IN WHOLE BLOOD 审中-公开
标题翻译：全血白细胞生长因子研究的化学试剂及方法
公开(公告)号：WO2008097719A1
公开(公告)日：2008-08-14
申请号：PCT/US2008/051855
申请日：2008-01-24
申请人： IDEXX LABORATORIES, INC. , DEKA, Chiranjit , FENG, Jianwen
发明人： DEKA, Chiranjit , FENG, Jianwen
IPC分类号： G01N33/50
CPC分类号： G01N33/5094 , G01N2015/0069 , Y10T436/10 , Y10T436/101666 , Y10T436/107497 , Y10T436/108331 , Y10T436/25 , Y10T436/25125
摘要： A lytic reagent composition and methods for differential analysis of leukocytes are disclosed. In embodiments, the analysis may utilize optical measurements in flow cytometry based hematology analyzers. The reagent system includes an anionic surfactant in a hypotonic solution, an inorganic buffer to maintain the pH in a range from about 6 to about 10, and optionally a leukocyte stabilizer. The reagent system is used to lyse red blood cells and stabilize the leukocytes to enable multi-part differentiation of leukocytes in a near physiologic pH environment on a flow cytometry based hematology analyzer using axial light loss, light scatter intensity, high-numerical aperture side scatter, and time-of-flight measurements.
摘要翻译：公开了一种裂解试剂组合物和白细胞差异分析方法。在实施例中，分析可以利用基于流式细胞术的血液分析仪中的光学测量。试剂系统包括在低渗溶液中的阴离子表面活性剂，将pH保持在约6至约10范围内的无机缓冲剂和任选的白细胞稳定剂。试剂系统用于裂解红血细胞并稳定白细胞，使得在基于流式细胞仪的血液分析仪上，在近生理pH环境中白细胞多部分分化，使用轴向光损失，光散射强度，高数值孔径侧散射和飞行时间测量。

6. 发明申请

WO2007142316A1 新規なナノシリカ粒子の製造方法と用途审中-公开
标题翻译：制备新型纳米二氧化硅颗粒的方法和使用纳米二氧化硅颗粒
公开(公告)号：WO2007142316A1
公开(公告)日：2007-12-13
申请号：PCT/JP2007/061587
申请日：2007-06-07
申请人：国立大学法人徳島大学 , 中村教泰
发明人：中村教泰
IPC分类号： C08G77/06 , C09K11/06 , G01N15/00 , G01N33/48
CPC分类号： G01N33/588 , B82Y15/00 , B82Y30/00 , C08G77/02 , C08G77/06 , C08G77/28 , G01N33/585 , Y10T428/2982 , Y10T436/101666 , Y10T436/109163
摘要：メルカプトプロピルトリメトキシシラン（ＭＰＳ）、メルカプトプロピルトリエトキシシラン（ＭＰＥＳ）、メルカプトプロピルメチルジメトキシシラン（ＭＰＤＭＳ）、トリメトキシ［２－（７－オキサビシクロ［４．１．０］－ヘプト－３－イル）エチル］シラン（ＥｐｏＰＳ）、チオシシアナトプロピルトリエトキシシラン（ＴＣＰＳ）およびアクリルオキシプロピルトリメトキシシラン（ＡｃＰＳ）からなる群より選択される１種または数種のシリカ化合物を含む、歯学・医学・獣医学分野の予防薬、治療薬、診断剤、診断治療両用剤等、また、分野を問わず定性試験や定量試験用の標識体あるいはマーカー等として提供かつ利用できる、シリカ粒子が本発明によって提供される。
摘要翻译：包含至少一种选自巯基丙基三甲氧基硅烷（MPS），巯基丙基三乙氧基硅烷（MPES），巯基丙基甲基二甲氧基硅烷（MPDMS），三甲氧基[2-（7-氧杂双环[4.1.0] - 庚-3-基）乙基]硅烷（EpoPS），硫氰酸丙基三乙氧基硅烷（TCPS）和丙烯酰氧基丙基三甲氧基硅烷（AcPS）。可以提供二氧化硅颗粒并将其用作牙科，医学或兽医领域中的预防剂，治疗剂，诊断剂，诊断和治疗剂等，或作为标签，制造商等用于任何领域的定性或定量测试。

7. 发明申请

WO2006118818A3 CYANIDE-FREE LYTIC REAGENT COMPOSITION AND METHOD OF USE FOR HEMOGLOBIN AND WHITE BLOOD CELL MEASUREMENT 审中-公开
标题翻译：无氰试剂组合物及其用于HEMOGLOBIN和白细胞测量的方法
公开(公告)号：WO2006118818A3
公开(公告)日：2007-11-01
申请号：PCT/US2006015067
申请日：2006-04-21
申请人： BECKMAN COULTER INC
发明人： LANG RUSSELL F , PARRA-DIAZ DENNISSE , ORAMAS LUISA , MURZA BARBARA , MALDONADO SUSANA
IPC分类号： G01N33/72
CPC分类号： G01N33/721 , Y10T436/10 , Y10T436/101666 , Y10T436/107497 , Y10T436/25
摘要： A cyanide-free lytic reagent composition and method of use for measuring the total hemoglobin concentration and white blood cells in a blood sample are disclosed. The lytic reagent composition includes a quaternary ammonium surfactant to lyse red blood cells and release hemoglobin and a ligand to form a stable chromogen with the hemoglobin. The lytic reagent composition has a pH in a range of 3 to 10. The lytic reagent composition can also include a second quaternary ammonium surfactant. The ligand can be malic acid, malonic acid, ethylene diamine, N,N-diethylethylene diamine, N,N'-diethylethylene diamine, diethylene triamine, tetraethylene pentamine, 1,6-hexanediamine, 1,3- pentanediamine, 2-methylpentamethylenediamine, 1,2-diaminocyclohexane, 4-aminoacetophenone, bis-hexamethylenetriamine, pyridazine, or 3,6- dihyroxypyridazine.
摘要翻译：公开了一种无氰溶解试剂组合物和用于测量血液样品中总血红蛋白浓度和白细胞的方法。溶解试剂组合物包括季铵表面活性剂以溶解红细胞并释放血红蛋白和配体以与血红蛋白形成稳定的色原体。溶解试剂组合物的pH值在3至10的范围内。溶解试剂组合物还可以包括第二季铵表面活性剂。配体可以是苹果酸，丙二酸，乙二胺，N，N-二乙基乙二胺，N，N'-二乙基乙二胺，二亚乙基三胺，四亚乙基五胺，1,6-己二胺，1,3-戊二胺，2-甲基戊二胺， 1,2-二氨基环己烷，4-氨基苯乙酮，双六亚甲基三胺，哒嗪或3,6-二羟基哒嗪。

8. 发明申请

WO2007109396A2 REFERENCE CONTROL COMPOSITION CONTAINING A NUCLEATED RED BLOOD CELL COMPONENT MADE OF NON-NUCLEATED BLOOD CELLS 审中-公开
标题翻译：含有非核化血细胞制成的核红细胞成分的参考对照组合物
公开(公告)号：WO2007109396A2
公开(公告)日：2007-09-27
申请号：PCT/US2007/062670
申请日：2007-02-23
申请人： BECKMAN COULTER, INC.
发明人： ORTIZ, Nery , GERULA, Theodore, J. , SOCARRAS, Sandra
IPC分类号： G01N33/48
CPC分类号： G01N33/96 , G01N15/1012 , G01N15/12 , G01N15/147 , G01N2015/1037 , G01N2496/05 , Y10T436/10 , Y10T436/101666 , Y10T436/107497 , Y10T436/25 , Y10T436/2525
摘要： A reference control composition containing a nucleated red blood cell component and the method of making are disclosed. The reference control composition includes a nucleated red blood cell component made of fixed non-nucleated blood cells and a suspension medium. The non-nucleated blood cell has a natural cell size substantially similar to a size of nucleus of said nucleated red blood cell of said blood sample. The nucleated red blood cell component can be made of equine, ovine, bovine, feline, canine, or porcine red blood cells; and it is substantially free of nucleic acid. The reference control composition can further include a white blood cell component, a red blood cell component, a platelet component, a reticulocyte component, or combinations thereof. Further disclosed are the methods of using the reference control composition for measurement of nucleated red blood cells on a blood analyzer.
摘要翻译：公开了含有有核红细胞成分的参考对照组合物和制备方法。参考对照组合物包括由固定的非有核血细胞和悬浮介质制成的有核红细胞成分。无核血细胞具有与所述血样的所述有核红细胞的核的大小基本相似的天然细胞大小。有核红细胞成分可以由马，羊，牛，猫，犬或猪红细胞制成; 并且它基本上不含核酸。参考对照组合物可进一步包含白细胞组分，红细胞组分，血小板组分，网状细胞组分或其组合。还公开了使用参考对照组合物在血液分析仪上测量有核红细胞的方法。

9. 发明申请

WO2007084976A2 METHODS OF DETECTION OF IRON DEFICIENCY 审中-公开
标题翻译：铁缺乏检测方法
公开(公告)号：WO2007084976A2
公开(公告)日：2007-07-26
申请号：PCT/US2007/060752
申请日：2007-01-19
申请人： BECKMAN COULTER, INC.
发明人： MAGARI, Robert, T. , SIMON-LOPEZ, Ramon
IPC分类号： G01N33/72
CPC分类号： G01N33/721 , G01N33/80 , G01N2800/22 , Y10T436/101666
摘要： New diagnostic indexes and the method of use for detection of iron deficiency have been disclosed. These include a logistic function of mean cell hemoglobin (MCH) and mean cell volume (MCV), and a logistic function of mean cell hemoglobin concentration (MCHC) and MCH.
摘要翻译：已经公开了新的诊断指标和用于检测缺铁的方法。这些包括平均细胞血红蛋白（MCH）和平均细胞体积（MCV）的逻辑功能，以及平均细胞血红蛋白浓度（MCHC）和MCH的逻辑函数。

10. 发明申请

WO2006115870A3 MULTIPLEX MICROPARTICLE SYSTEM 审中-公开
标题翻译：多功能麦克风系统
公开(公告)号：WO2006115870A3
公开(公告)日：2007-07-19
申请号：PCT/US2006014361
申请日：2006-04-14
申请人： BECTON DICKINSON CO , MEHRPOUYAN MAJID , RECKTENWALD DIETHER J , VARRO RUDOLF
发明人： MEHRPOUYAN MAJID , RECKTENWALD DIETHER J , VARRO RUDOLF
IPC分类号： G01N33/543
CPC分类号： G01N33/54313 , G01N33/582 , G01N33/585 , Y10S435/973 , Y10T436/101666 , Y10T436/110833 , Y10T436/112499
摘要： Arrays of microparticle populations, each population labeled with a single fluorescent dye, are provided for use in multiplex assays. The populations form a virtual multidimensional array wherein each microparticle is identified by fluorescence intensity in two different fluorescence detection channels. The arrays are useful in a variety of assays, including multiplex, multi-analyte assays for the simultaneous detection of two or more analytes by, for example, flow cytometry, and a labeling reagents in, for example, microscopy. The use of singly-dyed microparticles to form multidimensional arrays greatly simplifies the creation of multiplex assays.
摘要翻译：提供用于多重测定的微粒群体阵列，每个群体用单个荧光染料标记。群体形成虚拟多维阵列，其中每个微粒通过两个不同荧光检测通道中的荧光强度来鉴定。阵列可用于各种测定，包括用于通过例如流式细胞术同时检测两种或多种分析物的多分析物测定和例如显微镜中的标记试剂。使用单色微粒形成多维阵列极大地简化了多重测定的创建。

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