专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2018144445A1 METHODS FOR TREATING HEMATOLOGICAL CANCER AND THE USE OF BIOMARKERS AS A PREDICTOR FOR RESPONSIVENESS TO TREATMENT COMPOUNDS 审中-公开
公开(公告)号：WO2018144445A1
公开(公告)日：2018-08-09
申请号：PCT/US2018/015923
申请日：2018-01-30
申请人： CELGENE CORPORATION
发明人： GANDHI, Anita , TROTTER, Matthew William, Burnell , RISUENO-PEREZ, Alberto , TOWFIC, Fadi, George
IPC分类号： C40B30/04 , G01N33/50 , G01N33/574
CPC分类号： G01N33/57407 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N33/5094 , G01N33/57426 , G01N2800/52
摘要： A method for predicting the responsiveness of a patient having a hematological cancer to a treatment compound, comprising obtaining a biological sample from the patient having the hematological cancer; determining the expression level of one, two, three, four, five, or more genes; and comparing the expression level of the one, two, three, four, five, or more genes in the biological sample with a reference expression level of the same genes, wherein the treatment compound is 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)- piperidine-2,6-dione (lenalidomide), 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)- piperidine-2,6-dione (Compound A), or a stereoisomer, pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or a polymorph thereof.

2. 发明申请

WO2017186129A1 METHODS OF PERSONALIZED MICROFILTRATION TO DETECT CELLS FROM BLOOD 审中-公开
标题翻译：个人化微滤法检测血液细胞的方法
公开(公告)号：WO2017186129A1
公开(公告)日：2017-11-02
申请号：PCT/CN2017/082043
申请日：2017-04-26
申请人： THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
发明人： LEE, Yi-Kuen , ZHAO, Cong , RIAZ, Kashif
IPC分类号： C12N5/078 , C12N5/09 , C12M1/34 , C12M1/12
CPC分类号： A61B5/150755 , C12M47/04 , C12N5/0694 , G01N15/1031 , G01N33/5094 , G01N33/574
摘要： The present application provides a Capillary number-based method of isolating circulating rare cells from a blood sample from a subject using filtration parameters determined based on the measurement of hemorheological parameters of the sample. The present application also provides a method for determining filtration parameters in a microfluidic elasto-filtration process for isolating circulating rare cells from a blood sample from a subject. The present application further provides a device for isolating circulating rare cells from a blood sample from a subject and a non-transitory computer storage medium for performing methods described in the present application.
摘要翻译：本申请提供了一种基于毛细管数的方法，其使用基于样品的血液流变学参数测量确定的过滤参数从受试者的血液样品中分离循环稀有细胞。本申请还提供了一种用于确定微流体弹性过滤工艺中的过滤参数的方法，用于从受试者的血液样品中分离循环稀有细胞。本申请还提供了用于从受试者的血液样品中分离循环稀有细胞的装置和用于执行本申请中描述的方法的非暂时性计算机存储介质。

3. 发明申请

WO2017161182A1 SUBCELLULAR LOCALIZATION OF TARGET ANALYTES 审中-公开
标题翻译：目标分析的细胞局部化
公开(公告)号：WO2017161182A1
公开(公告)日：2017-09-21
申请号：PCT/US2017/022802
申请日：2017-03-16
申请人： BECKMAN COULTER, INC.
发明人： BRITTAIN, George , GULNIK, Sergei
IPC分类号： G01N33/50
CPC分类号： G01N33/58 , G01N15/1459 , G01N33/5094 , G01N2015/1486 , G01N2458/10
摘要： The present invention provides methods of determining and quantifying the subcellular localization of an analyte within a sample of cells by using at least two permeabilizing reagents.
摘要翻译：本发明提供了通过使用至少两种透化剂来确定和量化细胞样品内的分析物的亚细胞定位的方法。

4. 发明申请

WO2016174229A1 MICROFLUIDIC DROPLET DETECTION AND SORTING 审中-公开
标题翻译：微流控液滴检测和分选
公开(公告)号：WO2016174229A1
公开(公告)日：2016-11-03
申请号：PCT/EP2016/059658
申请日：2016-04-29
申请人： EUROPEAN MOLECULAR BIOLOGY LABORATORY
发明人： MERTEN, Christoph, A. , HU, Hongxing , EUSTACE, David
IPC分类号： G01N33/58 , B01L9/00 , G01N33/50
CPC分类号： B01L3/502784 , B01L3/502761 , B01L2200/0652 , G01N15/1459 , G01N15/1484 , G01N33/5094 , G01N33/58 , G01N2015/149
摘要： The present invention relates to the field of microfluidics and in particular to methods for detecting microfluidic droplets and particles within droplets, as well as sorting the droplets. These methods allow for quantifying properties and activities of the particles within the droplets. For this purpose, the invention provides microfluidic droplets comprising suitably labelled particles. The invention also provides microfluidic devices and systems having properties which make them particularly suitable for use in the methods of the invention.
摘要翻译：本发明涉及微流体领域，特别涉及用于检测液滴内的微流体液滴和颗粒的方法，以及对液滴进行分选。这些方法允许量化颗粒在液滴内的性质和活性。为此，本发明提供包含适当标记的微粒的微流体液滴。本发明还提供具有使其特别适用于本发明方法的性质的微流体装置和系统。

5. 发明申请

WO2016170187A2 BIOMARKERS FOR DETERMINING THE CLINICAL RESPONSE TO CELL THERAPY 审中-公开
标题翻译：确定细胞疗法临床反应的生物标志物
公开(公告)号：WO2016170187A2
公开(公告)日：2016-10-27
申请号：PCT/EP2016/059196
申请日：2016-04-25
申请人： TIGENIX, S.A.U
发明人： DE LA ROSA, Olga , DALEMANS, Wilfried
IPC分类号： G01N33/50 , A61K35/28
CPC分类号： G01N33/5094 , A61K35/28 , A61P19/02 , G01N33/6893 , G01N2333/705 , G01N2333/70539 , G01N2333/70578 , G01N2333/715 , G01N2333/7155 , G01N2333/7156 , G01N2800/52
摘要： The invention relates to a method for predicting the clinical response to a therapy based on the administration of mesenchymal stem cells (MSCs) in a patient suffering from an immune-mediated inflammatory disease. The invention also relates to methods of personalised medicine as well as to therapeutic uses of MSCs in a patient suffering from an immune-mediated inflammatory disease.
摘要翻译：本发明涉及用于预测患有免疫介导的炎性疾病的患者中基于间充质干细胞（MSC）的施用对治疗的临床反应的方法。本发明还涉及个体化医学的方法以及MSC在患有免疫介导的炎性疾病的患者中的治疗用途。

6. 发明申请

WO2016162827A1 POPULATION OF HUMAN LYMPHOID PRECURSORS, METHOD FOR THEIR IDENTIFICATION AND USES THEREOF 审中-公开
标题翻译：人类淋巴细胞前体人群，其鉴定方法及其用途
公开(公告)号：WO2016162827A1
公开(公告)日：2016-10-13
申请号：PCT/IB2016/051984
申请日：2016-04-07
申请人： UNIVERSITA' DEGLI STUDI DI GENOVA
发明人： DE MARIA, Andrea , MORETTA, Lorenzo , BOZZANO, Federica , MARRAS, Francesco
IPC分类号： C12N5/0783 , G01N33/50 , A61P37/00 , A61P43/00
CPC分类号： C12N5/0646 , C12N2501/125 , C12N2501/2307 , C12N2501/2315 , C12N2501/26 , C12N2503/00 , G01N33/5094
摘要： The present invention relates to the identification of a new cell population of human lymphoid precursors characterized by the expression of markers such as CD34, DNAM- 1 (CD226) and CXCR4, the relative method for their identification and the relative uses in the therapeutic and diagnostic field.
摘要翻译：本发明涉及鉴定人类淋巴样前体的新细胞群，其特征在于标志物如CD34，DNAM-1（CD226）和CXCR4的表达，其鉴定的相对方法和治疗和诊断中的相对用途领域。

7. 发明申请

WO2016084850A1 造血幹細胞を減少させる組成物およびその製造方法审中-公开
标题翻译：用于减少血浆干细胞的组合物及其生产方法
公开(公告)号：WO2016084850A1
公开(公告)日：2016-06-02
申请号：PCT/JP2015/083088
申请日：2015-11-25
申请人：国立大学法人東京大学
发明人：中内　啓光 , 山崎　聡 , 田矢　祐規
IPC分类号： A61K45/06 , A61K31/198 , A61K31/70 , A61K33/00 , A61P3/02 , A61P43/00 , C12N5/0789 , C12Q1/04
CPC分类号： A61K31/198 , A23L33/30 , A23L33/40 , A23V2002/00 , A61K31/70 , A61K33/00 , A61K35/28 , A61K45/06 , A61K2035/124 , A61P3/02 , A61P43/00 , C12Q1/04 , G01N33/5094
摘要：課題：本発明は、動物（特にヒト）体内の造血幹細胞を低減または除去する際に、放射線照射の代替となる手法を提供する。解決手段：バリンを実質的に含まない、経静脈栄養剤または経腸栄養剤。
摘要翻译：问题：本发明提供了当减少或消除动物（特别是人）体内的造血干细胞时用作辐射的替代物的技术。解决方案：基本上不含缬氨酸的肠外营养物或肠内营养素。

8. 发明申请

WO2015150423A1 METHOD FOR SEMEN ANALYSIS 审中-公开
标题翻译：分析方法
公开(公告)号：WO2015150423A1
公开(公告)日：2015-10-08
申请号：PCT/EP2015/057110
申请日：2015-03-31
申请人： FERTIPRO N.V.
发明人： COMHAIRE, Sven , COMHAIRE, Björn , EERTMANS, Frank , BOGAERT, Veerle
IPC分类号： G01N33/50 , G01N33/52 , G01N33/68 , G01N33/72
CPC分类号： G01N33/725 , G01N33/5091 , G01N33/5094 , G01N33/52 , G01N33/689
摘要： The present invention relates to methods for detecting leukocytes in semen samples and a kit for performing these methods. The methods comprise staining of leukocytes on the basis of peroxidase activity.
摘要翻译：本发明涉及用于检测精液样品中白细胞的方法和用于进行这些方法的试剂盒。该方法包括基于过氧化物酶活性染色白细胞。

9. 发明申请

WO2014161606A1 IDENTIFYING PATIENT RESPONSE TO S1P RECEPTOR MODULATOR ADMINISTRATION 审中-公开
标题翻译：鉴定患者对S1P受体调节剂的作用
公开(公告)号：WO2014161606A1
公开(公告)日：2014-10-09
申请号：PCT/EP2013/058226
申请日：2013-04-19
申请人： NOVARTIS AG , BORELL, Hubert , GARDIN, Anne , JIN, Yi , LEGANGNEUX, Eric , UFER, Mike
发明人： BORELL, Hubert , GARDIN, Anne , JIN, Yi , LEGANGNEUX, Eric , UFER, Mike
IPC分类号： G01N33/50 , C12Q1/68 , G01N33/569
CPC分类号： C07D205/04 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , G01N33/5094 , G01N33/56972 , G01N2800/52
摘要： The invention provides a method of assessing the appropriate therapeutic dose of 1-{4- [1-(4-cyclohexyl-3-trifluoromethyl-benzyloxyimino)-ethyl]-2-ethyl-benzyl}-azetidine-3- carboxylic acid to administer to a patient in need thereof, comprising the steps of: (i) testing whether or not the patient has the poor metabolizer genotype; and (ii) if the patient does not have the poor metaboliser genotype, administering -{4-[1-(4-cyclohexyl-3-trifluoromethyl-benzyloxyimino)-ethyl]-2-ethyl- benzyl}-azetidine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof, to the patient at the standard therapeutic dose; and (iii) if the patient does have the poor metaboliser genotype, either (a) administering 1-{4-[1-(4-cyclohexyl-3-trifluoromethyl-benzyloxyimino)- ethyl]-2-ethyl-benzyl}-azetidine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof, to the patient at a therapeutic dose below that of the standard therapeutic dose; or (b) not administering 1-{4-[1-(4-cyclohexyl-3-trifluoromethyl- benzyloxyimino)-ethyl]-2-ethyl-benzyl}-azetidine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof, to the patient.
摘要翻译：本发明提供了评估1- {4- [1-（4-环己基-3-三氟甲基 - 苄氧基亚氨基） - 乙基] -2-乙基 - 苄基} - 氮杂环丁烷-3-羧酸的合适治疗剂量的方法，包括以下步骤：（i）测试患者是否具有不良代谢基因型; 给予 - {4- [1-（4-环己基-3-三氟甲基 - 苄氧基亚氨基） - 乙基] -2-乙基 - 苄基} - 氮杂环丁烷-3-羧酸，并且（ii）如果患者不具有差的代谢基因型，酸或其药学上可接受的盐以标准治疗剂量给予患者; （iii）如果患者确实具有差的代谢基因型，则（a）给予1- {4- [1-（4-环己基-3-三氟甲基 - 苄氧亚氨基） - 乙基] -2-乙基 - 苄基} - 氮杂环丁烷 -3-羧酸或其药学上可接受的盐以低于标准治疗剂量的治疗剂量给予患者; 或（b）不给予1- {4- [1-（4-环己基-3-三氟甲基 - 苄氧基亚氨基） - 乙基] -2-乙基 - 苄基} - 氮杂环丁烷-3-羧酸或其药学上可接受的盐，给病人

10. 发明申请

WO2014147074A1 METHOD / DEVICE FOR GENERATING A CORRECTED VALUE OF AN ANALYTE CONCENTRATION IN A SAMPLE OF A BODY FLUID 审中-公开
标题翻译：用于生成体液中样品分析浓度校正值的方法/装置
公开(公告)号：WO2014147074A1
公开(公告)日：2014-09-25
申请号：PCT/EP2014/055418
申请日：2014-03-18
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , HOENES, Joachim , RINGEMANN, Christian , WELLER, Andreas
发明人： HOENES, Joachim , RINGEMANN, Christian , WELLER, Andreas
IPC分类号： G01N33/543
CPC分类号： G01N33/5094 , G01N21/75 , G01N27/3272 , G01N27/3274 , G01N33/525 , G01N33/558 , G01N33/66
摘要： A method for detecting an analyte in a body fluid is disclosed. The method has the following steps: a) applying a sample (122) of the body fluid to a test element (120), said test element (120) comprising at least (i) a test field (128) comprising at least one test material (130) adapted to change at least one measurable property in the presence of the analyte, (ii) a capillary element (126) adapted to guide the sample (122) across said test field (128) in a flow direction (146), (iii) a first and a second measurement location (158, 160) within said test field (128), wherein the second measurement location (160) is offset from the first measurement location (158) in the flow direction (146); b) measuring the measurable property in said at least one first measurement location (158), thereby generating at least one first measurement value; c) measuring the measurable property in said at least one second measurement location (160), thereby generating at least one second measurement value; d) detecting the analyte by using an evaluation algorithm having at least two input variables, wherein (i) at least one first input variable of the at least two input variables includes an information on a difference between the first measurement value and the second measurement value, and (ii) at least one second input variable of the at least two input variables includes a measurement information on an analyte-induced change of the measurable property of the test material (130) in at least part of the test field (128).
摘要翻译：公开了一种用于检测体液中的分析物的方法。该方法具有以下步骤：a）将体液样品（122）施加到测试元件（120），所述测试元件（120）包括至少（i）包括至少一个测试的测试场（128）适于在存在分析物的情况下改变至少一个可测量性质的材料（130），（ii）适于在流动方向（146）上跨越所述测试场（128）引导样品（122）的毛细管元件（126），（iii）所述测试场（128）内的第一和第二测量位置（158,160），其中所述第二测量位置（160）在所述流动方向（146）上偏离所述第一测量位置（158）; b）测量所述至少一个第一测量位置（158）中的可测量特性，由此产生至少一个第一测量值; c）测量所述至少一个第二测量位置（160）中的可测量特性，由此产生至少一个第二测量值; d）通过使用具有至少两个输入变量的评估算法来检测分析物，其中（i）至少两个输入变量的至少一个第一输入变量包括关于第一测量值和第二测量值之间的差的信息，和（ii）所述至少两个输入变量的至少一个第二输入变量包括关于在所述测试场（128）的至少一部分中所述测试材料（130）的可测量特性的分析物引起的变化的测量信息，。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式