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1. 发明申请

WO2015185600A1 ROTATABLE CARTRIDGE FOR PROCESSING AND ANALYZING A BIOLOGICAL SAMPLE 审中-公开
标题翻译：可旋转的加工和分析生物样品的盒子
公开(公告)号：WO2015185600A1
公开(公告)日：2015-12-10
申请号：PCT/EP2015/062337
申请日：2015-06-03
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： BOEHM, Christoph , LUTZ, Sascha , SPINKE, Jürgen
IPC分类号： B01L3/00 , G01N35/00 , G01N1/38 , G01N35/10
CPC分类号： B01L3/50273 , B01L3/502723 , B01L3/502738 , B01L2200/04 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2300/043 , B01L2300/044 , B01L2300/0654 , B01L2300/0672 , B01L2300/0803 , B01L2300/087 , B01L2300/0883 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , B01L2400/0694 , G01N1/38 , G01N35/00069 , G01N35/1016 , G01N2035/00247 , G01N2035/00257 , G01N2035/1032 , G01N2035/1034
摘要： The invention provides for a cartridge (300) for an automatic analyzer (1100), wherein the cartridge is operable for being spun around a rotational axis (102). The cartridge comprises: a fluid chamber (104) for receiving a fluid (307), an aliquoting chamber (108), a first duct (106) connecting the fluid chamber and the aliquoting chamber, a metering chamber (112) operable for causing fluid to fill the metering chamber using capillary action, a second duct (110) connecting the metering chamber with the aliquoting chamber, and a vent (128). The vent is connected to the metering chamber. The vent is nearer to the rotational axis than the metering chamber. The metering chamber has side walls (204) and a central region (206). The side walls taper away from the central region, wherein capillary action next to the side walls of the metering chamber is greater than in the central region of the metering chamber. The second duct comprises a duct entrance (114) in the aliquoting chamber. The second duct further comprises a duct exit (116) in the metering chamber wherein the duct exit is closer to the rotational axis than the duct entrance. The second duct is operable for causing fluid to flow to the metering chamber using capillary action. The cartridge further comprises a downstream fluidic element (122) connected to the metering chamber via a valve (121) and a fluidic structure (336) for processing a biological sample into the processed biological sample. The fluidic structure comprises a measurement structure (344, 1110) for enabling measurement of the processed biological sample, wherein the fluidic structure is configured for receiving the biological sample.
摘要翻译：本发明提供了一种用于自动分析仪（1100）的盒（300），其中盒可操作以围绕旋转轴线（102）旋转。墨盒包括：用于接收流体（307）的流体室（104），等分试样室（108），连接流体室和等分试样室的第一管道（106），可操作以使流体以使用毛细管作用填充计量室，将计量室与等分室连接的第二管道（110）和通气孔（128）。通风口连接到计量室。通风口比计量室更靠近旋转轴线。计量室具有侧壁（204）和中心区域（206）。侧壁从中心区域逐渐变细，其中靠近计量室的侧壁的毛细作用大于在计量室的中心区域。第二管道包括等分室中的管道入口（114）。第二管道还包括在计量室中的管道出口（116），其中管道出口比管道入口更靠近旋转轴线。第二管道可操作以使流体使用毛细管作用流到计量室。墨盒还包括经由阀（121）连接到计量室的下游流体元件（122）和用于将生物样品处理成经处理的生物样品的流体结构（336）。流体结构包括用于能够测量经处理的生物样品的测量结构（344,1110），其中流体结构被配置为用于接收生物样品。

2. 发明申请

WO2013134742A3 MICRO-TUBE PARTICLES FOR MICROFLUIDIC ASSAYS AND METHODS OF MANUFACTURE 审中-公开
标题翻译：用于微流控测定的微管颗粒和制造方法
公开(公告)号：WO2013134742A3
公开(公告)日：2014-01-23
申请号：PCT/US2013030054
申请日：2013-03-08
申请人： CYVEK INC
发明人： PUTNAM MARTIN A , BRANCIFORTE JEFFREY T , STANWOOD CHARLES O , TU JANE M
IPC分类号： B01L3/00 , B01J19/00 , G01N35/00
CPC分类号： G01N1/28 , B01J19/0046 , B01J2219/00468 , B01J2219/00511 , B01J2219/0052 , B01J2219/00522 , B01J2219/0054 , B01J2219/00585 , B01J2219/00691 , B01J2219/00725 , B01J2219/0074 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/027 , B01L2200/0689 , B01L2200/16 , B01L2300/0636 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0638 , B01L2400/0655 , B32B37/0076 , B81C3/001 , G01N35/00029 , G01N2001/002 , G01N2035/00148 , G01N2035/00158 , G01N2035/00247
摘要： A microfluidic assay device that defines a micro-fluidic flow channel (44) having a flow axis, in which a series of discrete, axially-spaced apart, transparent hollow flow elements (32) are secured in fixed position, each flow element having at least one axially-extending flow passage through its interior, assay capture agent fixed to the interior surface of the elements for capture of an analyte in liquid flowing through the interior of the flow elements, the device constructed to enable light to be transmitted out of the elements for reading of fluorescence from captured analyte, wherein: the exterior axially-extending surfaces of the flow elements are free of active capture agent, while at least part of the interior surfaces carry deposits of active capture agent exposed to flow through the elements.
摘要翻译：一种限定具有流动轴线的微流体流动通道（44）的微流体测定装置，其中一系列离散的，轴向间隔开的透明中空流动元件（32）固定在固定位置，每个流动元件具有至少一个轴向延伸的通过其内部的流动通道，测定捕获剂固定到元件的内表面，用于捕获流过流动元件内部的液体中的分析物，该装置构造成使得光能够从用于从捕获的分析物读取荧光的元件，其中：流动元件的外部轴向延伸的表面没有活性捕获剂，而至少部分内表面携带暴露于流过元件的活性捕获剂的沉积物。

3. 发明申请

WO2013134744A3 MICROFLUIDIC ASSAY ASSEMBLIES AND METHODS OF MANUFACTURE 审中-公开
标题翻译：微流检测装置及其制造方法
公开(公告)号：WO2013134744A3
公开(公告)日：2014-01-09
申请号：PCT/US2013030056
申请日：2013-03-08
申请人： CYVEK INC
发明人： PUTNAM MARTIN A
IPC分类号： B01L3/00 , B01J19/00 , B81C3/00 , G01N35/00
CPC分类号： G01N1/28 , B01J19/0046 , B01J2219/00468 , B01J2219/00511 , B01J2219/0052 , B01J2219/00522 , B01J2219/0054 , B01J2219/00585 , B01J2219/00691 , B01J2219/00725 , B01J2219/0074 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/027 , B01L2200/0689 , B01L2200/16 , B01L2300/0636 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0638 , B01L2400/0655 , B32B37/0076 , B81C3/001 , G01N35/00029 , G01N2001/002 , G01N2035/00148 , G01N2035/00158 , G01N2035/00247
摘要： In assembling a portion of a microfluidic device by conducting bonding action by contacting faces of opposed bondable materials, one comprising a flexible sheet, the method, while maintaining continual contact of the faces in a region R1 until bonding is completed, of employing repeated make-and-break-contact manufacturing protocol on a second region R2 of the contacted faces of the bondable materials, thereby over time neutralizing the tendency for permanent bonds to form in that region R2, thus to enable making and breaking actuated movements of the second region R2 of the flexible sheet relative to the portion of the other material that it opposes.
摘要翻译：在通过使相对的可接合材料的表面接触而组装一部分微流体装置时，其中一个包括柔性片，该方法在保持区域R1中的表面的连续接触直到接合完成之前，在可接合材料的接触面的第二区域R2上的断裂接触制造方案，由此随着时间的推移中和在该区域R2中形成永久接合的趋势，从而能够使第二区域R2的致动运动的柔性片相对于其所反对的其他材料的部分。

4. 发明申请

WO2013134744A2 MICROFLUIDIC ASSAY ASSEMBLIES AND METHODS OF MANUFACTURE 审中-公开
标题翻译：微流检测装置及其制造方法
公开(公告)号：WO2013134744A2
公开(公告)日：2013-09-12
申请号：PCT/US2013/030056
申请日：2013-03-08
申请人： CYVEK, INC
发明人： PUTNAM, Martin A.
IPC分类号： B81C3/00
CPC分类号： G01N1/28 , B01J19/0046 , B01J2219/00468 , B01J2219/00511 , B01J2219/0052 , B01J2219/00522 , B01J2219/0054 , B01J2219/00585 , B01J2219/00691 , B01J2219/00725 , B01J2219/0074 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/027 , B01L2200/0689 , B01L2200/16 , B01L2300/0636 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0638 , B01L2400/0655 , B32B37/0076 , B81C3/001 , G01N35/00029 , G01N2001/002 , G01N2035/00148 , G01N2035/00158 , G01N2035/00247
摘要： In assembling a portion of a microfluidic device by conducting bonding action by contacting faces of opposed bondable materials, one comprising a flexible sheet, the method, while maintaining continual contact of the faces in a region R1 until bonding is completed, of employing repeated make-and-break-contact manufacturing protocol on a second region R2 of the contacted faces of the bondable materials, thereby over time neutralizing the tendency for permanent bonds to form in that region R2, thus to enable making and breaking actuated movements of the second region R2 of the flexible sheet relative to the portion of the other material that it opposes.
摘要翻译：在通过使相对的可接合材料的表面接触而组装一部分微流体装置时，其中一个包括柔性片，该方法在保持区域R1中的表面的连续接触直到接合完成之前，在可接合材料的接触面的第二区域R2上的断裂接触制造方案，由此随着时间的推移中和在该区域R2中形成永久接合的趋势，从而能够使第二区域R2的致动运动的柔性片相对于其所反对的其他材料的部分。

5. 发明申请

WO2013134741A2 METHODS AND SYSTEMS FOR MANUFACTURE OF MICROARRAY ASSAY SYSTEMS, CONDUCTING MICROFLUIDIC ASSAYS, AND MONITORING AND SCANNING TO OBTAIN MICROFLUIDIC ASSAY RESULTS 审中-公开
标题翻译：用于制造微阵列分析系统的方法和系统，进行微流体分析，以及监测和扫描以获得微流体分析结果
公开(公告)号：WO2013134741A2
公开(公告)日：2013-09-12
申请号：PCT/US2013/030053
申请日：2013-03-08
申请人： CYVEK, INC.
发明人： PUTNAM, Martin, A. , BRANCIFORTE, Jeffrey, T. , STANWOOD, Charles, O.
IPC分类号： B01L3/00
CPC分类号： G01N1/28 , B01J19/0046 , B01J2219/00468 , B01J2219/00511 , B01J2219/0052 , B01J2219/00522 , B01J2219/0054 , B01J2219/00585 , B01J2219/00691 , B01J2219/00725 , B01J2219/0074 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/027 , B01L2200/0689 , B01L2200/16 , B01L2300/0636 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0638 , B01L2400/0655 , B32B37/0076 , B81C3/001 , G01N35/00029 , G01N2001/002 , G01N2035/00148 , G01N2035/00158 , G01N2035/00247
摘要： A method of flowing a fluid with a tracer in a microfluidic channel of an assay device and detecting the tracer for determining the channel location or condition of the channel.
摘要翻译：在测定装置的微流体通道中用示踪剂流动流体并检测示踪剂以确定通道的位置或条件的方法。

6. 发明申请

WO2013134740A1 METHODS AND SYSTEMS FOR EPI-FLUORESCENT MONITORING AND SCANNING FOR MICROFLUIDIC ASSAYS 审中-公开
标题翻译：用于微流感测定的荧光显微镜和扫描的方法和系统
公开(公告)号：WO2013134740A1
公开(公告)日：2013-09-12
申请号：PCT/US2013/030052
申请日：2013-03-08
申请人： CYVEK, INC.
发明人： PUTNAM, Martin, A. , BRANCIFORTE, Jeffrey T. , STANWOOD, Charles O.
IPC分类号： B01J19/00 , G01N35/00 , B01L3/00
CPC分类号： G01N1/28 , B01J19/0046 , B01J2219/00468 , B01J2219/00511 , B01J2219/0052 , B01J2219/00522 , B01J2219/0054 , B01J2219/00585 , B01J2219/00691 , B01J2219/00725 , B01J2219/0074 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/027 , B01L2200/0689 , B01L2200/16 , B01L2300/0636 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0638 , B01L2400/0655 , B32B37/0076 , B81C3/001 , G01N35/00029 , G01N2001/002 , G01N2035/00148 , G01N2035/00158 , G01N2035/00247
摘要： An operating and reading instrument for performing an assay employing a portable microfluidic assay cartridge, the instrument comprising a translatable table under automated control, the translatable table carrying a receiving region for the portable cartridge and carrying a port system connectible to the cartridge that includes at least one remotely automated valve carried by the translatable table, the valve arranged to apply pressurized flowable substance at selected times to the cartridge while the cartridge is on the translatable table.
摘要翻译：一种用于使用便携式微流控测定盒执行测定的操作和阅读仪器，所述仪器包括在自动控制下的可翻译工作台，所述可移动工作台承载用于所述便携式存储器的接收区域，并且携带可连接到所述盒的端口系统，所述端口系统至少包括一个远程自动化的阀，由可移动工作台承载，该阀设置成在该盒位于可平移台上时，将选定的时间加压的可流动物质施加到该盒。

7. 发明申请

WO2012037266A3 USING BLOOD CLOT IN MICROFLUIDIC VALVING APPLICATIONS 审中-公开
标题翻译：在微流控阀门应用中使用血块
公开(公告)号：WO2012037266A3
公开(公告)日：2012-06-14
申请号：PCT/US2011051615
申请日：2011-09-14
申请人： CALIFORNIA INST OF TECHN , TAI YU-CHONG , SHI WENDIAN , GUO LUKE
发明人： TAI YU-CHONG , SHI WENDIAN , GUO LUKE
IPC分类号： G01N33/49 , G01N33/555 , G01N33/86
CPC分类号： G01N33/86 , B01L3/5027 , B01L3/502707 , B01L3/502738 , B01L2300/0816 , B01L2300/1827 , B01L2300/1861 , B01L2400/0406 , B01L2400/0442 , B01L2400/0677 , F16K99/0032 , F16K99/004 , F16K2099/0084 , G01N33/49 , G01N2035/00247 , Y10T137/0391
摘要： The present invention provides a method of forming a blood-clot microvalve by heating blood in a capillary tube of a microfluidic device. Also described are methods of modulating liquid flow in a capillary tube by forming and removing a blood-clot microvalve.
摘要翻译：本发明提供了一种通过在微流体装置的毛细管中加热血液来形成血栓微型阀的方法。还描述了通过形成和移除血凝块微阀来调节毛细管中的液体流动的方法。

8. 发明申请

WO2010141921A1 UNIVERSAL SAMPLE PREPARATION SYSTEM AND USE IN AN INTEGRATED ANALYSIS SYSTEM 审中-公开
标题翻译：通用样品制备系统及其在综合分析系统中的应用
公开(公告)号：WO2010141921A1
公开(公告)日：2010-12-09
申请号：PCT/US2010/037545
申请日：2010-06-04
申请人： INTEGENX INC. , JOVANOVICH, Stevan, B. , NIELSEN, William, D. , COHEN, David, S. , RECKNOR, Michael , VANGBO, Mattias , VAN GELDER, Ezra , MAJLOF, Lars , EL-SISSI, Omar
发明人： JOVANOVICH, Stevan, B. , NIELSEN, William, D. , COHEN, David, S. , RECKNOR, Michael , VANGBO, Mattias , VAN GELDER, Ezra , MAJLOF, Lars , EL-SISSI, Omar
IPC分类号： C02F1/40
CPC分类号： C12Q1/6806 , G01J3/4406 , G01N1/31 , G01N1/405 , G01N21/64 , G01N27/44721 , G01N27/44791 , G01N27/745 , G01N35/00029 , G01N2035/00148 , G01N2035/00247 , G01N2201/06113 , G01N2201/062 , Y10T436/11 , Y10T436/143333 , Y10T436/25 , Y10T436/2575
摘要： The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post- reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft 3 , and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.
摘要翻译：本发明提供一种可以处理原始生物样品，进行生化反应并提供分析读数的系统。例如，该系统可以从拭子中提取DNA，从DNA扩增STR基因座，并分析样品中扩增的位点和STR标记。该系统通过使用微流体组件来集成这些功能，以连接什么是宏流动功能。在一个实施方案中，该系统包括样品纯化模块，反应模块，反应后清洗模块，毛细管电泳模块和计算机。在某些实施例中，该系统包括用于执行分析物捕获的一次性盒。墨盒可以包括流体歧管，该流体歧管具有与微流体芯片配合的大流动腔室，所述微流体芯片在腔室之间引导液体。该系统适用于不超过10英尺3的外壳，可以是封闭的，便携式的和/或电池供电的系统。该系统可用于在不到4小时内从原始样品进行分析。

9. 发明申请

WO2002064253A2 METHOD AND APPARATUS FOR SAMPLE INJECTION IN MICROFABRICATED DEVICES 审中-公开
标题翻译：微型装置中样品注射的方法和装置
公开(公告)号：WO2002064253A2
公开(公告)日：2002-08-22
申请号：PCT/US2002/004296
申请日：2002-02-11
申请人： MICROCHEM SOLUTIONS , LIU, Shaorong , LU, Juan
发明人： LIU, Shaorong , LU, Juan
IPC分类号： B01L3/00
CPC分类号： G01N35/1016 , B01D61/28 , B01D61/56 , B01L3/0241 , B01L3/0293 , B01L3/5025 , B01L3/502738 , B01L3/502746 , B01L2200/027 , B01L2200/0605 , B01L2300/0816 , B01L2400/0415 , B01L2400/0421 , B01L2400/0487 , B01L2400/0622 , B01L2400/065 , B81B1/004 , B81B2201/058 , G01N27/44743 , G01N27/44791 , G01N35/10 , G01N2001/4016 , G01N2030/204 , G01N2035/00158 , G01N2035/00247 , G01N2035/1032 , Y10T436/11 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： An off-column sample injection scheme for introducing samples into micro-reaction channels in microfabricated devices. In one aspect of the present invention, off-column sample injection is effected by introducing sample from a sample reservoir provided on the substrate of the microfabricated device into a reaction channel via a constricted channel or opening interface, e.g., a narrow connection-channel and/or a pinhole. In another embodiment of the present invention, off-column sample injection is effected by introducing sample from a sample reservoir that is provided outside the substrate of the microfabricated device. A through-hole is provided in the substrate to facilitate sample introduction into the reaction channel. In a further aspect of the present invention, the free-end of a capillary tube connected to the sample-channel is moved alternatively to a sample and an auxiliary solution to bring multiple samples in series to the vicinity of a reaction channel for convenient sample introduction and high-throughput assays. In another aspect of the present invention, fixed volumes of samples are metered into the reaction channel using one or more slidable blocks having at least one fixed-length sample metering channel. In another aspect of the present invention, a sample injection scheme based on injection time is implemented using relatively sliding blocks of separation channels and sample channels. In a further aspect of the present invention, separation channels are configured in relation to the slidable block in a manner that enables separations to be conducted continuously for high-throughput assays.
摘要翻译：用于将样品引入微制造装置的微反应通道的离线样品注入方案。在本发明的一个方面，离柱样品注射通过将设置在微细加工装置的基板上的样品容器的样品经由狭窄通道或开口界面（例如窄连接通道）引入反应通道而进行， /或针孔。在本发明的另一个实施方案中，通过从设置在微加工装置的基材外部的样品储存器引入样品来实现离柱样品注入。在基板中设置通孔以便于将样品引入反应通道。在本发明的另一方面，连接到样品通道的毛细管的自由端交替地移动到样品和辅助溶液中，以使多个样品串联连接到反应通道附近以方便样品引入和高通量测定。在本发明的另一方面，使用具有至少一个固定长度的样品计量通道的一个或多个可滑动块将固定体积的样品计量到反应通道中。在本发明的另一方面，使用相对滑动的分离通道和样品通道来实现基于注射时间的注射方案。在本发明的另一方面，分离通道相对于可滑动块被构造成使得能够连续进行分离以进行高通量测定。

10. 发明申请

WO0190614A3 SURFACE TENSION VALVES FOR MICROFLUIDIC APPLICATIONS 审中-公开
标题翻译：微流体应用的表面张力阀
公开(公告)号：WO0190614A3
公开(公告)日：2002-06-13
申请号：PCT/US0116673
申请日：2001-05-23
申请人： MICRONICS INC
发明人： WEIGL BERNHARD H , KLEIN GERALD L
IPC分类号： G01N33/48 , B01D11/00 , B01F5/00 , B01F13/00 , B01F13/10 , B01F15/04 , B01L3/00 , B01L7/00 , B01L9/00 , B01L99/00 , B81B1/00 , F15C5/00 , F16K99/00 , G01N1/00 , G01N35/00 , G01N35/08 , G01N37/00
CPC分类号： G01N35/1097 , B01D11/00 , B01F5/0057 , B01F13/0062 , B01F13/0093 , B01F15/0404 , B01F2005/0017 , B01F2005/0031 , B01F2013/1052 , B01L3/5027 , B01L3/50273 , B01L3/502738 , B01L3/502776 , B01L3/565 , B01L7/52 , B01L7/525 , B01L9/527 , B01L99/00 , B01L2200/0621 , B01L2200/0636 , B01L2200/0694 , B01L2300/0809 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2400/0406 , B01L2400/0481 , B01L2400/0638 , B01L2400/0655 , B01L2400/0688 , F16K99/0001 , F16K99/0017 , F16K99/0028 , F16K99/0057 , G01N2035/00158 , G01N2035/00247 , G01N2035/00514 , Y10T137/2076
摘要： A passive valve for use within microfluidic structures. Surface tension forces developed within microscale channels are used to control flow within the channels. Flow can be halted within a channel until fluid force reaches a predetermined pressure to allow the channel to open.
摘要翻译：用于微流体结构的被动阀。在微量通道内发展的表面张力用于控制通道内的流动。流体可以在通道内停止，直到流体力达到预定压力以允许通道打开。

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