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    • 1. 发明申请
    • METHODS OF EVOLUTIONARY SYNTHESIS INCLUDING EMBODIED CHEMICAL SYNTHESES
    • 包括化学合成的演化合成方法
    • WO2013175240A1
    • 2013-11-28
    • PCT/GB2013/051390
    • 2013-05-24
    • THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW
    • CRONIN, Leroy
    • B01J19/00C40B60/08C40B50/04
    • B01J19/0046B01J2219/00283B01J2219/00286B01J2219/00353B01J2219/00479B01J2219/00495B01J2219/0059B01J2219/00599B01J2219/00689B01J2219/00695B01J2219/00698B01J2219/007B01J2219/00702B01J2219/00704B01J2219/00738B01J2219/00747B01J2219/00756C40B50/04C40B60/08
    • The invention provides a method for preparing a compound or a product having one or more characteristics that meet or exceed a user specification, the process comprising the step of selecting a first combination of chemical inputs, optionally together with physical inputs, and supplying those inputs to a reaction space, thereby to generate a first product; analysing one or more characteristics of the product generated; comparing the one or more characteristics against a user specification; using a genetic algorithm selecting a second combination of chemical inputs, optionally together with physical inputs, wherein the second combination differs from the first combination, and supplying those inputs to the reaction space, thereby to generate a second product; analysing one or more characteristics of the second product generated; comparing the one or more characteristics generated against the user specification; repeating the selecting and analysing steps for further individual combinations of chemical and/or physical inputs, to provide an array of products wherein the flow chemistry system operates continuously to provide the first, second and further products, thereby to identify one or more products meeting or exceeding the user specification.
    • 本发明提供了一种制备具有满足或超过用户规格的一种或多种特性的化合物或产品的方法,该方法包括选择化学输入的第一组合,可选地与物理输入一起并将这些输入提供给 反应空间,从而产生第一产物; 分析产生的产品的一个或多个特征; 将一个或多个特征与用户规范进行比较; 使用选择化学输入的第二组合的可选的物理输入的遗传算法,其中所述第二组合与所述第一组合不同,并且将所述输入提供给所述反应空间,从而产生第二乘积; 分析产生的第二产品的一个或多个特性; 比较生成的一个或多个特征与用户规范; 重复选择和分析步骤以用于化学和/或物理输入的进一步单独组合,以提供产品阵列,其中流化学系统连续操作以提供第一,第二和其他产品,由此识别一个或多个产品会议或 超过用户规格。
    • 6. 发明申请
    • MULTIFUNCTIAL MULTIREACTOR CHEMICAL SYNTHESIS INSTRUMENT
    • 多功能多功能化学合成仪器
    • WO2005105296A2
    • 2005-11-10
    • PCT/US2005/008879
    • 2005-03-16
    • AKRIBIO CORP.YOUNG, Li
    • YOUNG, Li
    • B01J19/00
    • B01J19/0046B01J2219/00283B01J2219/00308B01J2219/00344B01J2219/00353B01J2219/00389B01J2219/00416B01J2219/00481B01J2219/00493B01J2219/00495B01J2219/00585B01J2219/00599B01J2219/00689B01J2219/00695B01J2219/00698B01J2219/0072
    • A stand alone instrument for enhancing chemical and physical reactions on the "bench" level by providing a single instrument capability of performing a variety of functions on a plurality of reaction vessels at the same time (in parallel), includes heating, cooling and five other functional capabilities, and more particularly to such instruments that provide the matrix of plural functions and plural reaction vessels, with the further ability of providing real time energy balance data on each reactor. Thus, the instruments provide for any or all of heating, cooling, reflux, inert gas blanketing, vacuuming, stirring and evaporation at each reactor. (The words "reactor", "microreactor", "reaction vessel" and "vessel" are used interchangeably herein, and generally refer to bench scale flasks, beakers and other reactors used by bench chemists, biochemists, physicists, biologists, research doctors, and the like.) In some embodiments, the instruments include cooling units which uniquely rely upon phase change coolant injections. In other embodiments, the instruments include cofinger stoppers, described below. The instruments may include both the phase change coolant systems and the cofinger stopper arrangements.
    • 通过提供在多个反应容器上同时(并联)地执行各种功能的单一仪器能力,在“台”级上增强化学和物理反应的独立仪器包括加热,冷却和其他五个 更具体地涉及提供多个功能矩阵和多个反应容器的这种仪器,具有在每个反应器上提供实时能量平衡数据的进一步能力。 因此,这些仪器提供在每个反应器中的加热,冷却,回流,惰性气体覆盖,抽真空,搅拌和蒸发中的任何一种或全部。 (“反应器”,“微反应器”,“反应容器”和“容器”一词在本文中可以互换使用,通常是指台式化学家,生物化学家,物理学家,生物学家,研究医师使用的台式烧瓶,烧杯和其他反应器, 在一些实施例中,仪器包括唯一依赖于相变冷却剂注入的冷却单元。 在其他实施例中,仪器包括如下所述的cofinger塞子。 这些仪器可以包括相变冷却剂系统和共转手止动器装置。