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1. 发明申请

WO2014204311A1 TWO-PHASE ELECTROEXTRACTION FROM MOVING PHASES 审中-公开
标题翻译：来自移动相的两相电解质
公开(公告)号：WO2014204311A1
公开(公告)日：2014-12-24
申请号：PCT/NL2014/050405
申请日：2014-06-19
申请人： UNIVERSITEIT LEIDEN
发明人： SCHOONEN, Jan-Willem , LINDENBURG, Peter , VAN DUINEN, Vincent , OEDIT, Amar , VULTO, Paul , HANKEMEIER, Thomas
IPC分类号： G01N1/40 , B01L3/00 , B01D11/04
CPC分类号： B01D11/0419 , B01D11/0496 , B01L3/502776 , B01L2200/0636 , B01L2300/0645 , G01N1/40 , G01N2001/4038 , G01N2001/4072
摘要： The present invention relates to a process for the electro extraction of molecules from a moving fluid donor phase into an acceptor phase, comprising the steps of: providing an electrically conductive donor phase moving at a first flow velocity and in electrically conductive contact with a first electrode, providing an electrically conductive acceptor phase in direct contact and immiscible with the donor phase, in electrically conductive contact with a second electrode;and providing a supporting or confining phase guide pattern to keep a defined interface between donor phase and acceptor phase, and (d) applying an electrical field between the first and the second electrode.
摘要翻译：本发明涉及一种将分子从移动的液体给体相电解提取到受体相中的方法，包括以下步骤：提供以第一流速移动并与第一电极导电接触的导电供体相提供与供体相直接接触并不与其混溶的导电受体相，与第二电极导电接触;以及提供支撑或约束相导向图以保持供体相和受体相之间的界定，和（d ）在第一和第二电极之间施加电场。

2. 发明申请

WO2009048533A3 REACTIONS WITHIN MICROFLUIDIC CHANNELS 审中-公开
标题翻译：微流通道中的反应
公开(公告)号：WO2009048533A3
公开(公告)日：2009-10-08
申请号：PCT/US2008011457
申请日：2008-10-03
申请人： HARVARD COLLEGE , STONE HOWARD A , RISTENPART WILLIAM D , WAN JIANDI
发明人： STONE HOWARD A , RISTENPART WILLIAM D , WAN JIANDI
IPC分类号： B01J19/00 , B01L3/00
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/0086 , B01J2219/00889 , B01J2219/00891 , B01J2219/00957 , B01J2219/0097 , B01J2219/00986 , B01L3/502776 , B01L2300/0867 , B01L2400/0487 , G01N1/38 , G01N2001/4072
摘要： The present invention generally relates to microfluidics and, in particular, to microfluidic systems useful for determining reactions. In one aspect, two or more fluids are introduced into a microfluidic channel, and are allowed to come into contact. At or near the interface between the fluids, reactants contained within the fluids may react. By determining the reaction rate between the reactants with respect to position within the microfluidic channel, information about the reaction between the reactants can be obtained. The reaction rate may be determined, for instance, by measuring the rate of reaction at two or more points within the channel. In some cases, e.g., if the reaction rate can be determined optically or visually, the channel may be imaged and the image analyzed to determine the reaction rate. As a non-limiting example of a reaction, the reactants may be an enzyme and a substrate, and by determining reaction rates within the channel, Michaelis-Menten kinetics (or other reaction kinetics) of the enzymatic reaction may be determined. It should be understood, however, that other reactions besides Michaelis-Menten kinetics and/or enzymatic reactions may also be determined, including other catalytic or chemical reactions, and the like. The reaction profiles may be linear or non-linear, e.g., second order, third order, etc.
摘要翻译：本发明一般涉及微流体，特别涉及用于确定反应的微流体系统。在一个方面，将两种或更多种流体引入微流体通道，并允许其接触。在液体之间或界面附近，流体中包含的反应物可能会发生反应。通过确定反应物相对于微流体通道内的位置的反应速率，可以获得关于反应物之间的反应的信息。反应速率可以例如通过测量通道内两个或多个点处的反应速率来确定。在一些情况下，例如，如果反应速率可以光学上或视觉上确定，则可以对通道进行成像，并分析图像以确定反应速率。作为反应的非限制性实例，反应物可以是酶和底物，并且通过确定通道内的反应速率，可以确定酶反应的Michaelis-Menten动力学（或其他反应动力学）。然而，应当理解，还可以确定除Michaelis-Menten动力学和/或酶反应之外的其它反应，包括其它催化或化学反应等。反应曲线可以是线性的或非线性的，例如二阶，三阶等

3. 发明申请

WO2008148028A2 METHODS AND APPARATUSES FOR SEPARATING BIOLOGICAL PARTICLES 审中-公开
标题翻译：分离生物颗粒的方法和装置
公开(公告)号：WO2008148028A2
公开(公告)日：2008-12-04
申请号：PCT/US2008/064747
申请日：2008-05-23
申请人： APPLERA CORPORATION , LIU, Yingjie
发明人： LIU, Yingjie
IPC分类号： B01D35/06 , B01D35/30 , B03C1/01 , B03D1/00
CPC分类号： B03C1/32 , B01L3/502753 , B01L2400/0409 , B01L2400/043 , B01L2400/0487 , G01N1/4055 , G01N2001/4072
摘要： Methods and apparatuses for separating biological particles are provided.
摘要翻译：提供了用于分离生物颗粒的方法和装置。

4. 发明申请

WO2005108958A1 MICROFLUIDIC PRECONDITIONING OF (BIO) FLUIDS FOR REAGENT-FREE INFRARED CLINICAL ANALYSIS AND DIAGNOSTICS 审中-公开
标题翻译：用于无菌红细胞临床分析和诊断的（生物）流体的微流体预处理
公开(公告)号：WO2005108958A1
公开(公告)日：2005-11-17
申请号：PCT/CA2005/000687
申请日：2005-05-05
申请人： NATIONAL RESEARCH COUNCIL OF CANADA , MANSFIELD, Colin , SHAW, Anthony
发明人： MANSFIELD, Colin , SHAW, Anthony
IPC分类号： G01N21/35
CPC分类号： G01N21/35 , G01N21/03 , G01N2001/4016 , G01N2001/4072
摘要： A number of reagent-free infrared spectroscopic diagnostic and analytical methods have been established previously, making use of dry biofluid films. For example, this approach has successfully measured high concentration analytes of serum and urine. However, a number of low concentration diagnostically relevant analytes presently elude detection by infrared spectroscopy. 'This is due in part to their relatively low concentration and in part to spectral interference by other strongly absorbing constituents. The applicability of the technique would be broadened substantially if it were possible to separate and concentrate, lower concentration analytes, e.g. serum creatinine and urine proteins, from the obscuring presence of relatively high concentration compounds. The invention disclosed achieves this is through microfluidic sample preconditioning based upon laminar fluid diffusion interfaces. Preferential separation of certain low concentration serum and urine analytes of clinical interest that presently lie just below the threshold of detection by infrared spectroscopy is provided.
摘要翻译：以前已经建立了许多无试剂的红外光谱诊断和分析方法，利用干燥的生物流体膜。例如，这种方法已成功测量血清和尿液的高浓度分析物。然而，许多低浓度诊断相关分析物目前无法通过红外光谱检测。 “这部分归因于它们的相对较低的浓度，部分是由于其他强吸收成分的光谱干扰。如果可以分离和浓缩，降低浓度的分析物，例如，可以将该技术的适用性显着扩大。血清肌酐和尿蛋白，来自相对高浓度化合物的模糊存在。所公开的发明通过基于层流扩散界面的微流体样品预处理实现了这一点。提供目前正在低于红外光谱检测阈值的临床兴趣的某些低浓度血清和尿液分析物的优先分离。

5. 发明申请

WO2014195662A1 SEPARATION AND ANALYSIS SYSTEMS AND METHODS 审中-公开
标题翻译：分离与分析系统与方法
公开(公告)号：WO2014195662A1
公开(公告)日：2014-12-11
申请号：PCT/GB2013/052891
申请日：2013-11-05
申请人： BLACKTRACE HOLDINGS LIMITED
发明人： KOULMAN, Albert
IPC分类号： B01D11/04 , G01N33/34 , G01N1/42 , G01N33/40 , G01N33/68
CPC分类号： G01N30/34 , B01D11/04 , B01L3/502738 , B01L3/502784 , B01L2200/0631 , B01L2200/0673 , B01L2300/0816 , B01L2400/0487 , B01L2400/0622 , B01L2400/0638 , G01N30/7233 , G01N35/08 , G01N2001/4072 , H01J49/165
摘要： Disclosed is an extraction and analysis system and method. The system comprises a separation apparatus, a liquid-liquid extraction apparatus and an analysis apparatus. The liquid-liquid extraction apparatus is configured to receive a substantially continuous inlet flow of a first liquid from the separation apparatus, the first liquid carrying a mixture of components including an analyte. The liquid-liquid extraction apparatus is operable to receive a second liquid for contact with the first liquid, the second liquid being substantially immiscible with the first liquid. This provides partitioning of the analyte and/or another component carried by the first liquid preferentially into the second liquid substantially continuously. Subsequently the first and second liquids are separated substantially continuously. The system further comprises an outlet flow conduit operable substantially continuously to conduct the analyte, in a corresponding flow of said first or second liquid, to the analysis apparatus for substantially continuous analysis.
摘要翻译：公开了一种提取和分析系统及方法。该系统包括分离装置，液 - 液萃取装置和分析装置。液体 - 液体提取装置被配置为接收来自分离装置的第一液体的基本上连续的入口流，第一液体承载包括分析物的组分的混合物。液体 - 液体提取装置可操作以接收与第一液体接触的第二液体，第二液体与第一液体基本上不混溶。这提供了基本上连续地将分析物和/或由第一液体承载的另一组分优先分配到第二液体中。随后第一和第二液体基本连续分离。该系统还包括一个输出流管道，其可操作性地连续地将分析物在所述第一或第二液体的相应流中传导至分析装置，用于基本上连续的分析。

6. 发明申请

WO2011042509A2 APPARATUS AND PROCESSES FOR GENERATING VARIABLE CONCENTRATION OF SOLUTES IN MICRODROPLETS 审中-公开
标题翻译：用于在微型存储器中产生可变浓度溶液的装置和过程
公开(公告)号：WO2011042509A2
公开(公告)日：2011-04-14
申请号：PCT/EP2010/065034
申请日：2010-10-07
申请人： UNIVERSITE DE STRASBOURG , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , MILLER, Oliver Jon , FRENZ, Lucas , GRIFFITHS, Andrew David , MERTEN, Christoph , EL HARRAK, Abdeslam
发明人： MILLER, Oliver Jon , FRENZ, Lucas , GRIFFITHS, Andrew David , MERTEN, Christoph , EL HARRAK, Abdeslam
IPC分类号： B01F3/08 , B01F13/00 , B01F15/04 , B01L3/00
CPC分类号： G01N1/28 , B01F3/0807 , B01F13/0062 , B01F13/0093 , B01F15/0404 , B01L3/502784 , B01L2300/0816 , B01L2300/0867 , B01L2400/0478 , B01L2400/0487 , G01N1/38 , G01N35/085 , G01N2001/4072
摘要： The present invention relates to systems and methods for generating microdroplets with varying concentrations of a particular solute from a solution at fixed concentration.
摘要翻译：本发明涉及用于从固定浓度的溶液产生具有不同浓度的特定溶质的微滴的系统和方法。

7. 发明申请

WO2008016414A2 APPARATUS AND METHOD FOR CONTINUOUS PARTICLE SEPARATION 审中-公开
标题翻译：用于连续颗粒分离的装置和方法
公开(公告)号：WO2008016414A2
公开(公告)日：2008-02-07
申请号：PCT/US2007013130
申请日：2007-05-31
申请人： UNIV PRINCETON , INGLIS DAVID , DAVIS JOHN , AUSTIN ROBERT , STURM JAMES
发明人： INGLIS DAVID , DAVIS JOHN , AUSTIN ROBERT , STURM JAMES
IPC分类号： B01D29/00
CPC分类号： G01N33/54366 , B01L3/502753 , B01L3/502761 , B01L2200/0652 , B01L2300/0864 , B01L2300/0867 , B01L2400/0472 , B01L2400/086 , G01N35/025 , G01N2001/4072 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/149 , G01N2035/00465
摘要： The invention is directed to an apparatus and a method of separating particles, such as cells, from a heterogeneous fluid, such as blood, where the particles have a large range of sizes.
摘要翻译：本发明涉及一种从非均质流体例如血液中分离诸如细胞的颗粒的装置和方法，其中颗粒具有很大的尺寸范围。

8. 发明申请

WO2017096414A1 MICROFLUIDIC CHIPS AND USES THEREOF 审中-公开
标题翻译：微流体芯片及其用途
公开(公告)号：WO2017096414A1
公开(公告)日：2017-06-15
申请号：PCT/AU2016/000391
申请日：2016-12-07
申请人： UNIVERSITY OF SOUTH AUSTRALIA
发明人： PRIEST, Craig Ian , KRIEL, Frederik Hermanus
IPC分类号： G01N1/40 , B01L3/00
CPC分类号： G01N1/40 , B01D11/0496 , G01N1/4055 , G01N2001/4072
摘要： A microfluidic chip suitable for use in liquid-liquid or liquid-gas phase transfer applications is disclosed. The microfluidic chip comprises a contact zone comprising a high aspect ratio channel in fluid connection with at least one liquid or gas inlet whereby, in use, at least two immiscible or partially immiscible liquid and/or gas streams exiting the at least one liquid or gas inlet flow adjacent one another and in contact with one another through the contact zone under conditions to allow transfer of at least some of a chemical entity from one stream to the other before the streams exit the high aspect ratio channel at a microchip outlet.
摘要翻译：公开了适用于液 - 液或液 - 气相转移应用的微流体芯片。微流体芯片包括接触区域，该接触区域包括与至少一个液体或气体入口流体连接的高纵横比通道，由此在使用中，离开至少一种液体或气体的至少两种不混溶或部分不混溶的液体和/或气体流入口流彼此相邻并且在允许化学实体的至少一些从一个流转移到另一个的条件下通过接触区彼此接触，然后流在微芯片出口处离开高纵横比通道。 p>

9. 发明申请

WO2011042509A3 APPARATUS AND PROCESSES FOR GENERATING VARIABLE CONCENTRATION OF SOLUTES IN MICRODROPLETS 审中-公开
标题翻译：在微波中产生溶解度变化浓度的装置和方法
公开(公告)号：WO2011042509A3
公开(公告)日：2011-06-23
申请号：PCT/EP2010065034
申请日：2010-10-07
申请人： UNIV STRASBOURG , CENTRE NAT RECH SCIENT , MILLER OLIVER JON , FRENZ LUCAS , GRIFFITHS ANDREW DAVID , MERTEN CHRISTOPH , EL HARRAK ABDESLAM
发明人： MILLER OLIVER JON , FRENZ LUCAS , GRIFFITHS ANDREW DAVID , MERTEN CHRISTOPH , EL HARRAK ABDESLAM
IPC分类号： B01F3/08 , B01F13/00 , B01F15/04 , B01L3/00
CPC分类号： G01N1/28 , B01F3/0807 , B01F13/0062 , B01F13/0093 , B01F15/0404 , B01L3/502784 , B01L2300/0816 , B01L2300/0867 , B01L2400/0478 , B01L2400/0487 , G01N1/38 , G01N35/085 , G01N2001/4072
摘要： The present invention relates to systems and methods for generating microdroplets with varying concentrations of a particular solute from a solution at fixed concentration.
摘要翻译：本发明涉及用固定浓度的溶液产生具有不同浓度的特定溶质的微滴的系统和方法。

10. 发明申请

WO1997000442A1 MICROFABRICATED DIFFERENTIAL EXTRACTION DEVICE AND METHOD 审中-公开
标题翻译：微量差异提取装置及方法
公开(公告)号：WO1997000442A1
公开(公告)日：1997-01-03
申请号：PCT/US1996010308
申请日：1996-06-14
申请人： THE UNIVERSITY OF WASHINGTON
发明人： THE UNIVERSITY OF WASHINGTON , YAGER, Paul , BRODY, James, P. , HOLL, Mark, R. , FORSTER, Fred, K. , GALAMBOS, Paul, C.
IPC分类号： G01N30/00
CPC分类号： B01D11/0492 , B01D11/0496 , B01F13/0059 , B01F13/0093 , B01F2005/0031 , B01J19/0093 , B01J2219/00783 , B01J2219/00828 , B01J2219/00889 , B01J2219/00905 , B01J2219/00952 , B01J2219/0097 , B01J2219/00995 , G01N15/06 , G01N30/0005 , G01N2001/4072 , G01N2035/00237 , Y10S366/01 , Y10T436/255
摘要： This invention provides a microfabricated extraction system and methods for extracting desired particles from a sample stream containing desired and undesired particles. The sample stream is placed in laminar flow contact with an extraction stream under conditions in which inertial effects are negligible. The contact between the two streams is maintained for a sufficient period of time to allow differential transport of the desired particles from the sample stream into the extraction stream. In a preferred embodiment the differential transport mechanism is diffusion. The extraction system of this invention coupled to a microfabricated diffusion-based mixing device and/or sensing means allows picoliter quantities of fluid to be processed or analyzed on devices no larger than silicon wafers.
摘要翻译：本发明提供了一种微加工提取系统和从含有所需和不需要的颗粒的样品流中提取所需颗粒的方法。在惯性效应可忽略的条件下，将样品流与提取流层流接触。保持两个物流之间的接触足够的时间，以便将期望的颗粒从样品流中差分输送到萃取物流中。在优选实施例中，差分传送机构是扩散。本发明的提取系统耦合到基于微制造的基于扩散的混合装置和/或感测装置允许在不大于硅晶片的装置上处理或分析皮升数量的流体。

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