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1. 发明申请

WO2016010596A3 PROCESS FOR GENERATING COOL FLAME AND FLAMELESS FUEL OXIDATION USING NON-EQUILIBRIUM PLASMA ACTIVATION 审中-公开
标题翻译：使用非平衡等离子体激活产生冷却火焰和无燃料燃料氧化的方法
公开(公告)号：WO2016010596A3
公开(公告)日：2016-04-14
申请号：PCT/US2015024248
申请日：2015-04-03
申请人： UNIV PRINCETON
发明人： JU YIGUANG , WON SANG HEE , SUN WEIQI
IPC分类号： F23D14/20 , C10L1/10 , C10L10/14 , F02M25/12 , F23D14/46
CPC分类号： C10L10/00 , F23C99/001 , F23C2900/99001 , F23C2900/99005 , F23J7/00 , F23K2401/10 , F23L7/007 , Y02E20/342 , Y02E20/344
摘要： An exemplary embodiment can be an exemplary method, which can include, for example, generating a cool flame(s) using a plasma-assisted combustion, and maintaining the cool flame(s). The cool flame(s) can have a temperature below about 1050 Kelvin, which can be about 700 Kelvin. The cool flame(s) can be further generated using a heated counterflow burning arrangement and a an ozone generating arrangement. The heated counterflow burning arrangement can include a liquid fuel vaporization arrangement. The ozone generating arrangement can include a micro plasma dielectric barrier discharge arrangement. The plasma-assisted combustion can be generated using (i) liquid n-heptane, (i) heated nitrogen, and (iii) ozone.
摘要翻译：示例性实施例可以是示例性方法，其可以包括例如使用等离子体辅助燃烧产生冷焰并保持冷却火焰。冷却的火焰的温度可以低于约1050开尔文，其可以是大约700开尔文。可以使用加热的逆流燃烧装置和臭氧发生装置进一步产生冷焰。加热的逆流燃烧装置可以包括液体燃料蒸发装置。臭氧发生装置可以包括微等离子体介质阻挡放电装置。可以使用（i）液体正庚烷，（i）加热的氮气和（iii）臭氧来产生等离子体辅助燃烧。

2. 发明申请

WO2015153381A3 DECARBOXYLATIVE CROSS-COUPLING AND APPLICATIONS THEREOF 审中-公开
标题翻译：脱羧交叉耦合及其应用
公开(公告)号：WO2015153381A3
公开(公告)日：2015-12-10
申请号：PCT/US2015023195
申请日：2015-03-27
申请人： UNIV PRINCETON
发明人： MACMILLAN DAVID W C , ZUO ZHIWEI
IPC分类号： C25B3/10
CPC分类号： C07D403/04 , C07C17/363 , C07C29/00 , C07C29/62 , C07C41/22 , C07C45/65 , C07C211/27 , C07C269/06 , C07C319/20 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D207/06 , C07D207/08 , C07D209/14 , C07D211/08 , C07D265/30 , C07D295/023 , C07D307/12 , C07D401/04 , C07C22/08 , C07C23/10 , C07C23/18 , C07C271/24 , C07C271/18 , C07C271/22 , C07C323/43 , C07C49/80 , C07C33/46 , C07C43/225 , C07C49/807 , C07C49/784 , C07C49/84 , C07C49/792 , C07C49/813
摘要： Methods described herein enable the production of numerous molecular species through decarboxylative cross-coupling via use of photoredox and transition metal catalysts. For example, methods described herein enable the production of numerous molecular species through decarboxylative cross-coupling via use of photoredox and transition metal catalysts. A method described herein, in some embodiments, comprises providing a reaction mixture including a photoredox catalyst, a transition metal catalyst, a coupling partner and a substrate having a carboxyl group. The reaction mixture is irradiated with a radiation source resulting in cross-coupling of the substrate and coupling partner via a mechanism including decarboxylation, wherein the coupling partner is selected from the group consisting of a substituted aromatic compound and a substituted aliphatic compound.
摘要翻译：本文所述的方法能够通过使用光氧化还原和过渡金属催化剂通过脱羧交叉偶联产生许多分子物质。例如，本文描述的方法能够通过使用光氧化还原和过渡金属催化剂通过脱羧交叉偶联产生许多分子物质。在一些实施方案中，本文所述的方法包括提供包含光氧化还原催化剂，过渡金属催化剂，偶联配偶体和具有羧基的底物的反应混合物。用辐射源照射反应混合物，导致底物和偶联配偶体经由包括脱羧基的机制交叉偶联，其中偶联伴侣选自取代的芳族化合物和取代的脂族化合物。

3. 发明申请

WO2014197096A3 ASSAY ENHANCEMENT BY SELECTIVE DEPOSITION AND BINDING ON AMPLIFICATION STRUCTURES 审中-公开
标题翻译：选择性沉积和结合放大结构的测定增强
公开(公告)号：WO2014197096A3
公开(公告)日：2015-01-29
申请号：PCT/US2014029979
申请日：2014-03-15
申请人： UNIV PRINCETON
发明人： CHOU STEPHEN Y
IPC分类号： G01N21/63 , G01N21/27
CPC分类号： G01N21/658 , B29C33/424 , B29C33/56 , B29C37/0003 , B29C59/02 , B29C59/026 , B29C2059/023 , B29K2995/0005 , G01N21/648 , G01N21/6486 , G03F7/0002
摘要： This disclosure provides, among other things, a method for enhancing detection of an analyte that is bound to a substrate comprising a signal amplification layer on a surface of the substrate, wherein the signal amplification layer comprises high-amplification regions and low-amplification regions, and the high-amplification regions amplify signals at said surface more than the low-amplification regions. The method comprises selectively masking the low-amplification regions of the substrate, thereby increasing the probability that an analyte will bind to a high-amplification region and be detected.
摘要翻译：本公开尤其提供了一种用于增强结合到包含在衬底的表面上的信号放大层的衬底的衬底的检测的方法，其中信号放大层包括高放大区域和低放大区域，并且高放大区域比所述低放大区域放大所述表面处的信号。该方法包括选择性地掩蔽底物的低放大区域，从而增加分析物将结合到高放大区域并被检测的可能性。

4. 发明申请

WO2014197097A3 PLASMONIC NANOCAVITY ARRAY SENSORS FOR ANALYTE DETECTION ENHANCEMENT AND METHODS FOR MAKING AND USING OF THE SAME 审中-公开
标题翻译：用于分析物检测增强的等离子体纳米阵列传感器及其制造和使用的方法
公开(公告)号：WO2014197097A3
公开(公告)日：2015-01-22
申请号：PCT/US2014030108
申请日：2014-03-16
申请人： UNIV PRINCETON
发明人： CHOU STEPHEN Y , CHEN HAO
IPC分类号： G01N21/65 , G01N27/26 , G03F7/00
CPC分类号： G01N21/658 , B29C33/424 , B29C33/56 , B29C37/0003 , B29C59/02 , B29C59/026 , B29C2059/023 , B29K2995/0005 , G01N21/648 , G01N21/6486 , G03F7/0002
摘要： This disclosure provides, among other things, a nanosensor for sensing an analyte. In some embodiments the nanosensor comprises (a) a substrate; (b) a signal amplification layer comprising: (i) a substantially continuous metallic backplane on the substrate; (ii) one or a plurality of pillars extending from the metallic backplane or from the substrate through holes in the backplane; and (iii) a metallic disk on top of the pillar, wherein at least one portion of the edge of the disk is separated from the metallic backplane; and (c) a capture agent that specifically binds to the analyte, wherein the capture agent is linked to the surface of the signal amplification layer; wherein the nanosensor amplifies a light signal from an analyte, when the analyte is bound to the capture agent. Methods for fabricating the nanosensor and methods for using the nanosensor are also provided.
摘要翻译：本公开尤其提供了用于感测分析物的纳米传感器。在一些实施方案中，纳米传感器包括（a）基底; （b）信号放大层，包括：（i）在所述衬底上的基本上连续的金属背板; （ii）一个或多个支柱，从所述金属背板或从所述基板穿过所述背板中的孔延伸; 和（iii）在所述柱的顶部上的金属盘，其中所述盘的边缘的至少一部分与所述金属背板分离; 和（c）特异性结合分析物的捕获剂，其中捕获剂与信号放大层的表面连接; 其中当分析物结合到捕获剂时，纳米传感器放大来自分析物的光信号。还提供了制造纳米传感器的方法和使用纳米传感器的方法。

5. 发明申请

WO2014146115A3 COMPOSITE NANOPARTICLE STRUCTURES FOR CHEMICAL AND BIOLOGICAL SENSING 审中-公开
标题翻译：用于化学和生物传感的复合纳米晶体结构
公开(公告)号：WO2014146115A3
公开(公告)日：2014-12-31
申请号：PCT/US2014031099
申请日：2014-03-18
申请人： UNIV PRINCETON
发明人： CHOU STEPHEN Y , DING WEI
IPC分类号： B32B9/00
CPC分类号： G01N21/658 , B29C33/424 , B29C33/56 , B29C37/0003 , B29C59/02 , B29C59/026 , B29C2059/023 , B29K2995/0005 , G01N21/648 , G01N21/6486 , G03F7/0002
摘要： Described herein is a nanoparticle that enhances the interaction of the nanoparticle and/or a molecule/material deposited on the surface of the nanoparticle with light, comprising a pair of stacked metallic disks separated by a non-metallic spacer, wherein: (a) the dimensions of the disks and spacer are smaller than the wavelength of the light; and (b) the nanoparticle enhance the light interaction at least three times greater than that an individual metallic disk. Methods for making the nanoparticle and methods for using the nanoparticle in a variety of assays are also provided.
摘要翻译：本文描述了增强纳米颗粒和/或沉积在纳米颗粒表面上的分子/材料与光的相互作用的纳米颗粒，其包括由非金属间隔物分隔的一对堆叠金属盘，其中：（a）盘和间隔物的尺寸小于光的波长; 和（b）纳米颗粒增强光相互作用比单个金属盘至少三倍。还提供了制备纳米颗粒的方法和在多种测定中使用纳米颗粒的方法。

6. 发明申请

WO2013191779A2 METHOD, APPARATUS, AND SYSTEM TO REDUCE NEUTRON PRODUCTION IN SMALL CLEAN FUSION REACTORS 审中-公开
标题翻译：方法，装置和系统，以减少中小企业在小清洁熔融反应器生产
公开(公告)号：WO2013191779A2
公开(公告)日：2013-12-27
申请号：PCT/US2013033767
申请日：2013-03-25
申请人： PRINCETON SATELLITE SYSTEMS INC , UNIV PRINCETON
发明人： COHEN SAMUEL A
IPC分类号： G21B1/05
CPC分类号： G21B1/052 , Y02E30/122
摘要： The invention is for a system and method to reduce neutron production from a deuterum-helium-3 (D-3He) fueled, steady-state, small nuclear fusion reactor. The reactor employs a field- reversed configuration (FRC) magnetic confinement scheme and an odd-parity rotating magnetic field (RMFo) that produces periodic, co-streaming, energetic ion beams which heat the plasma. This is accomplished through radio-frequency (RF) heating, which can effectively heat and maintain the plasma. Use of this method will lessen damage to and activation of reactor components and, in doing so, can advance the development of fusion reactors for electrical, power and propulsion applications by alleviating the need for both nuclear-materials and tritium- breeding-technology testing programs.
摘要翻译：本发明是用于减少来自氘 - 氦-3（D-3He）燃料的稳态小型核聚变反应堆的中子产生的系统和方法。电抗器采用场反转配置（FRC）磁约束方案和奇偶校验旋转磁场（RMFo），其产生加热等离子体的周期性，共流式能量离子束。这通过射频（RF）加热实现，其可以有效地加热和维持等离子体。使用这种方法将减少反应堆部件的损坏和激活，并且通过减轻对核材料和氚技术测试程序的需要，可以推进电力，电力和推进应用的聚变反应堆的发展。

7. 发明申请

WO2012064954A3 SEQUENCE-SPECIFIC EXTRACTION AND ANALYSIS OF DNA-BOUND PROTEINS 审中-公开
标题翻译： DNA结合蛋白的序列特异性提取和分析
公开(公告)号：WO2012064954A3
公开(公告)日：2012-07-19
申请号：PCT/US2011060185
申请日：2011-11-10
申请人： UNIV PRINCETON , DAPPRICH JOHANNES , GARCIA BENJAMIN , LEROY GARY
发明人： DAPPRICH JOHANNES , GARCIA BENJAMIN , LEROY GARY
IPC分类号： G01N33/68 , C12Q1/68 , G01N33/15 , G01N33/53
CPC分类号： G01N33/566 , G01N33/6842 , G01N33/6875 , G01N2440/00 , G01N2500/02 , G01N2570/00
摘要： An automated protein preparation technology that may use magnetic microparticles to isolate proteins in their native state from specific genomic loci of interest via the chromatin to which they are bound is described. After extraction, the targeted proteins may be purified for downstream analysis by quantitative mass spectrometry or ELISA. The identification of DNA-bound proteins, histones and their post-translational modification is of high scientific and pharmaceutical importance due to the role of DNA-binding proteins in the causation and development of human disease; in particular, cancer.
摘要翻译：描述了一种自动化的蛋白质制备技术，该技术可以使用磁性微粒通过它们所结合的染色质将其天然状态的蛋白质从特定的目标基因组位点分离出来。提取后，可以通过定量质谱法或ELISA纯化目标蛋白质用于下游分析。 DNA结合蛋白，组蛋白及其翻译后修饰的鉴定由于DNA结合蛋白在致病和人类疾病发展中的作用而具有很高的科学和药学重要性; 特别是癌症。

8. 发明申请

WO2011005530A2 NON-CRYSTALLINE MATERIALS HAVING COMPLETE PHOTONIC, ELECTRONIC, OR PHONONIC BAND GAPS 审中-公开
标题翻译：具有完整光子，电子或PHONONIC BAND GAPS的非晶体材料
公开(公告)号：WO2011005530A2
公开(公告)日：2011-01-13
申请号：PCT/US2010039516
申请日：2010-06-22
申请人： UNIV PRINCETON , STEINHARDT PAUL J , TORQUATO SALVATORE , FLORESCU MARIAN
发明人： STEINHARDT PAUL J , TORQUATO SALVATORE , FLORESCU MARIAN
IPC分类号： C09K11/00 , G02B5/00
CPC分类号： G02B1/005 , B82Y20/00 , G01K17/00 , G01L1/24 , G01N21/17 , G02B5/3025 , G02B6/1225 , G02B6/125 , G02B27/0012 , H01L33/0058 , H01L33/0095 , H01L33/16 , Y10T29/49993
摘要： The invention provides an article of manufacture, and methods of designing and making the article. The article permits or prohibits waves of energy, especially photonic/electromagnetic energy, to propagate through it, depending on the energy band gaps built into it. The structure of the article may be reduced to a pattern of points having a hyperuniform distribution. The point-pattern may exhibit a crystalline symmetry, a quasicrystalline symmetry or may be aperiodic. In some embodiments, the point pattern exhibits no long-range order. Preferably, the point-pattern is isotropic. In all embodiments, the article has a complete, TE- and TM-optimized band-gap. The extraordinary transmission phenomena found in the disordered hyperuniform photonic structures of the invention find use in optical micro-circuitry (all-optical, electronic or thermal switching of the transmission), near- field optical probing, thermophotovoltaics, and energy-efficient incandescent sources.
摘要翻译：本发明提供了一种制造物品，以及设计和制造该物品的方法。该文章允许或禁止能量波，特别是光子/电磁能通过它传播，这取决于内置的能量带隙。制品的结构可以减少到具有超均匀分布的点的图案。点图案可以呈现出结晶对称性，准晶体对称性或者可以是非周期性的。在一些实施例中，点图案不显示长距离顺序。优选地，点图案是各向同性的。在所有实施例中，制品具有完整的TE和TM优化的带隙。在本发明的无序超均匀光子结构中发现的非凡的传输现象发现在光学微电路（传输的全光学，电子或热交换），近场光学探测，热光伏和能量效率的白炽光源中。

9. 发明申请

WO2009100173A2 DEMETHYLATION AND INACTIVATION OF PROTEIN PHOSPHATASE 2A 审中-公开
标题翻译：蛋白磷酸酯酶2A的二甲基化和失活
公开(公告)号：WO2009100173A2
公开(公告)日：2009-08-13
申请号：PCT/US2009033143
申请日：2009-02-05
申请人： UNIV PRINCETON , SHI YIGONG , XING YONGNA
发明人： SHI YIGONG , XING YONGNA
IPC分类号： C12N9/18 , C12N15/55 , C30B29/58
CPC分类号： C12N9/18 , C40B30/02 , Y02A90/26
摘要： Embodiments of the present invention relate to atomic coordinates for PME-1 alone or in complex with PP2A, as well as methods for using these atomic coordinates to prepare inhibitors of PME-1 and/or PP2A and inhibitors prepared using such methods. Further embodiments relate to biochemical analyses of the interactions of PME-1 alone or in complex with PP2A. Further embodiments relate to compositions including mimetics and small molecules, optionally, secondary agents, which may be used to treat disorders in which PME-1 and/or PP2A activity plays a contributing role.
摘要翻译：本发明的实施方案涉及单独或与PP2A复合的PME-1的原子坐标，以及使用这些原子坐标来制备PME-1和/或PP2A的抑制剂和使用这些方法制备的抑制剂的方法。其他实施方案涉及单独或与PP2A复合的PME-1相互作用的生物化学分析。进一步的实施方案涉及包含模拟物和小分子的组合物，任选地第二药剂，其可用于治疗其中PME-1和/或PP2A活性起作用的病症。

10. 发明申请

WO2009023059A2 TREATMENT OF VIRAL INFECTIONS BY MODULATION OF HOST CELL METABOLIC PATHWAYS 审中-公开
标题翻译：通过调节宿主细胞代谢途径治疗病毒感染
公开(公告)号：WO2009023059A2
公开(公告)日：2009-02-19
申请号：PCT/US2008006959
申请日：2008-06-02
申请人： UNIV PRINCETON , SHENK THOMAS , RABINOWITZ JOSHUA D , MUNGER JOSH , BENNETT BRYSON
发明人： SHENK THOMAS , RABINOWITZ JOSHUA D , MUNGER JOSH , BENNETT BRYSON
IPC分类号： A61K31/365
CPC分类号： A61K31/7076 , A61K31/122 , A61K31/15 , A61K31/194 , A61K31/22 , A61K31/221 , A61K31/336 , A61K31/337 , A61K31/341 , A61K31/351 , A61K31/357 , A61K31/365 , A61K31/381 , A61K31/403 , A61K31/405 , A61K31/44 , A61K31/4545 , A61K31/52 , A61K31/522 , A61K31/53 , A61K31/5377 , A61K31/675 , A61K31/706 , A61K2300/00
摘要： Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets for intervention; i.e., to restore metabolic flux to disadvantage viral replication, or to further derange metabolic flux resulting in "suicide" of viral-infected cells (but not uninfected cells) in order to limit viral propagation. While any of the enzymes in the relevant metabolic pathway can be selected, pivotal enzymes at key control points in these metabolic pathways are preferred as candidate antiviral drug targets. Inhibitors of these enzymes are used to reverse, or redirect, the effects of the viral infection. Drug candidates are tested for antiviral activity using screening assays in vitro and host cells, as well as in animal models. Animal models are then used to test efficacy of candidate compounds in preventing and treating viral infections. The antiviral activity of enzyme inhibitors is demonstrated.
摘要翻译：描述了响应于病毒感染发生的某些代谢物浓度和通量的变化。所选代谢途径中的宿主细胞酶被选为干预的目标; 即恢复代谢通量以不利于病毒复制，或进一步扭曲代谢通量，导致病毒感染细胞（但不是未感染细胞）的“自杀”）以限制病毒传播。虽然可以选择相关代谢途径中的任何酶，但在这些代谢途径的关键控制点的关键酶优选作为候选抗病毒药物靶标。这些酶的抑制剂用于逆转或重定向病毒感染的作用。使用体外和宿主细胞的筛选测定以及动物模型测试候选药物的抗病毒活性。然后使用动物模型来测试候选化合物在预防和治疗病毒感染中的功效。证明酶抑制剂的抗病毒活性。

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