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1. 发明申请

WO2011049312A3 HIGH THROUGHPUT OLIGONUCLEOTIDE SYNTHESIZER 审中-公开
标题翻译：高通量寡核苷酸合成仪
公开(公告)号：WO2011049312A3
公开(公告)日：2011-10-13
申请号：PCT/KR2010006933
申请日：2010-10-11
申请人： BIONEER CORP , PARK HAN OH , PARK HAN EE , SONG GU YOUNG , LEE YANG WON , JANG DAE JIN
发明人： PARK HAN OH , PARK HAN EE , SONG GU YOUNG , LEE YANG WON , JANG DAE JIN
IPC分类号： C12M1/36 , C12Q1/68 , G01N35/00
CPC分类号： B01J19/0046 , B01J2219/00317 , B01J2219/00319 , B01J2219/00328 , B01J2219/00412 , B01J2219/00585 , B01J2219/00689 , B01J2219/00722 , C40B60/14
摘要： There is provided a high throughput oligonucleotide synthesizer used for the chemical synthesis of oligo DNA/RNA or protein in which a high throughput oligonucleotide synthesizer in which one or more synthetic reactor modules (plate) with hundreds or thousands of individual synthetic reactors are installed, a reagent valve for inputting a reagent required to synthesis into each of the individual synthetic reactors is mounted, the synthetic reactor modules are moved and arranged to match valve nozzles (inlets), and the reagents are divisionally provided to the individual synthetic reactors in sequence in accordance with sequence information (arrangement) which is inputted by a user to chemically synthesize oligo DNA/RNA or protein with a reactive microparticle media in the synthetic reactor module, in an automation synthesizer used for the chemical synthesis of oligo DNA/RNA or protein.
摘要翻译：提供了用于化学合成寡DNA / RNA或蛋白质的高通量寡核苷酸合成仪，其中安装了一个或多个具有数百或数千个独立合成反应器的合成反应器模块（板）的高通量寡核苷酸合成仪，用于将合成所需要的试剂输入到每个单独的合成反应器中的试剂阀被安装，合成反应器模块被移动并布置成与阀门喷嘴（入口）匹配，并且试剂按照顺序依次分别提供给单独的合成反应器在用于寡核苷酸DNA / RNA或蛋白质的化学合成的自动化合成仪中，由用户输入用于在合成反应器模块中用反应性微粒介质化学合成寡聚DNA / RNA或蛋白质的序列信息（排列）。

2. 发明申请

WO2006054964A1 PREPARATION AND CHARACTERIZATION OF FORMULATIONS IN A HIGH THROUGHPUT MODE 审中-公开
标题翻译：高通量模式中制剂的制备和表征
公开(公告)号：WO2006054964A1
公开(公告)日：2006-05-26
申请号：PCT/US2004/037735
申请日：2004-11-12
申请人： METTLER-TOLEDO , BYSOUTH, Stephen, Robert , HITE, Sidney, Wilson , BOHARA, Amrish , NETTLETON-HAMMOND, John, Henry , BERGSTROM, Karin, Ingegard , LANDHAM, Rowena , LUKKARI, Ingrid, Gunborg
发明人： BYSOUTH, Stephen, Robert , HITE, Sidney, Wilson , BOHARA, Amrish , NETTLETON-HAMMOND, John, Henry , BERGSTROM, Karin, Ingegard , LANDHAM, Rowena , LUKKARI, Ingrid, Gunborg
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/00319 , B01J2219/00344 , B01J2219/00484 , B01J2219/00495 , B01J2219/00549 , B01J2219/00585 , B01J2219/00596 , B01J2219/00689 , B01J2219/00691 , B01J2219/00693 , B01J2219/00695 , B01J2219/00756 , B02C2017/065 , G01N35/0099 , G01N35/028 , G01N2035/00326
摘要： The invention is an automated robotic system for the production and testing of formulations at a very high throughput. It is an integrated system of hardware and software capable of preparing and evaluating hundreds of emulsions per day. The system can formulate aqueous solutions (SL), oil in water emulsions (EW), suspo-emulsions (SE), micro capsule suspensions (CS), micro-emulsions (ME), and suspension concentrates (SC) at the 1 ml to 25 ml scale. The system can process emulsions rapidly in an automated way and enable very flexible formulation recipes to be introduced. The system allows chemists to generate experimental samples of varying recipe and method to be conducted in parallel with projected throughput of up to 1200 formulations processed and characterized per day. Materials and consumables can be distributed from storage storage systems to the work stations where dispensing of ingredients in various states can be performed, including solids, liquids, gels, pastes, suspensions and waxes. The emulsions formed can be characterized using methods including phase diagnosis, turbidity analysis, viscosity and particle sizing using automated test equipment. An integrated module can also perform Tank Mix Compatibility testing in high throughput mode. The modular system allows future processes and tests to be added, either to a station, or as a new station. The software capability includes tracking of processes from start to finish and the integration of analytical data with the as-designed and as-formulated experimental results.
摘要翻译：本发明是一种用于以非常高的产量生产和测试制剂的自动化机器人系统。它是一个硬件和软件的集成系统，能够每天准备和评估数百种乳液。该系统可以配制水溶液（SL），水包油乳剂（EW），悬浮乳液（SE），微胶囊悬浮液（CS），微乳液（ME）和悬浮浓缩物（SC） 25毫升规模。该系统可以以自动化的方式快速处理乳液，并且能够引入非常灵活的配方配方。该系统允许化学家生成具有不同配方和方法的实验样品，与每天处理和表征的高达1200种配方的预计产量并行进行。材料和消耗品可以从存储储存系统分配到工作站，在这些工作站可以进行各种状态的成分的分配，包括固体，液体，凝胶，糊剂，悬浮液和蜡。可以使用包括相位诊断，浊度分析，使用自动测试设备的粘度和颗粒尺寸的方法来表征所形成的乳液。集成模块还可以在高吞吐量模式下进行Tank Mix Compatibility测试。模块化系统允许将未来的过程和测试添加到站点或作为新站点。软件功能包括从开始到完成的过程跟踪，以及分析数据的集成以及设计和配置的实验结果。

3. 发明申请

WO2003004159A1 METHOD TO DISTRIBUTE LIQUIDS CONTAINING MOLECULES IN SOLUTION AND TO DEPOSIT SAID MOLECULES ON SOLID SUPPORTS, AND RELATIVE DEVICE 审中-公开
标题翻译：分配溶液中含有分子的液体和在固体支持物上沉积分子的方法以及相关设备
公开(公告)号：WO2003004159A1
公开(公告)日：2003-01-16
申请号：PCT/IB2002/002535
申请日：2002-07-02
申请人： UNIVERSITA' DEGLI STUDI DI UDINE , FIRRAO, Giuseppe
发明人： FIRRAO, Giuseppe
IPC分类号： B01L3/00
CPC分类号： B01L3/5085 , B01J2219/00319 , B01J2219/00497 , B01J2219/00664 , C40B60/14
摘要： Method and device to distribute at least a sample of liquid containing molecules in solution, and to deposit and bind the molecules to solid supports. The method provides to use at least two supports (12; 112) which have been previously equipped with at least a through hole (11) and to arrange them one on top of the other so that the respective holes (11) are aligned so as to define a containing channel (13). The method then provides to distribute the sample of liquid inside the containing channel (13) using a surface inside the holes (11) as a site for depositing, localizing and binding the molecules in solution in the sample of liquid.
摘要翻译：在溶液中分配至少含有分子的液体样品的方法和装置，并将分子沉积并结合到固体支持物上。该方法提供了使用至少两个预先装有至少一个通孔（11）的支撑件（12; 112），并将它们一个放置在另一个的顶部上，使得相应的孔（11）对准，以便以定义包含通道（13）。该方法然后提供使用孔（11）内部的表面分布在容纳通道（13）内的液体样品作为用于沉积，定位和结合液体样品中的溶液中的分子的位点。

4. 发明申请

WO0178895A3 CONTAINER AND METHOD FOR HIGH VOLUME TREATMENT OF SAMPLES ON SOLID SUPPORTS 审中-公开
标题翻译：用于固体支持样品高容量处理的容器和方法
公开(公告)号：WO0178895A3
公开(公告)日：2002-08-15
申请号：PCT/US0111906
申请日：2001-04-11
申请人： DISCOVERY PARTNERS INTERNATION , NEEPER ROBERT , LILLIG JOHN , BRIDWELL JOHN , CHILDERS ALLAN
发明人： NEEPER ROBERT , LILLIG JOHN , BRIDWELL JOHN , CHILDERS ALLAN
IPC分类号： B01J19/00 , B01L3/00 , C40B50/14 , C40B60/14 , G01N35/00 , G01N35/02
CPC分类号： B01L3/5025 , B01J19/0046 , B01J2219/00295 , B01J2219/00313 , B01J2219/00315 , B01J2219/00319 , B01J2219/00351 , B01J2219/00421 , B01J2219/00423 , B01J2219/00454 , B01J2219/00461 , B01J2219/0049 , B01J2219/00495 , B01J2219/005 , B01J2219/00502 , B01J2219/00504 , B01J2219/00506 , B01J2219/0052 , B01L3/50255 , C40B50/14 , C40B60/14 , G01N35/028 , G01N2035/00495 , Y10T436/111666 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： A sample/collection container includes a plurality of wells, each for separating a sample from its solid support when solvent is dispensed into the wells and the centrifuge is activated at a low speed. Operation of the centrifuge at high speed concentrates the cleaved sample in collection wells.
摘要翻译：样品/收集容器包括多个孔，每个孔用于当将溶剂分配到孔中并且离心机以低速启动时，将样品与其固体支持物分离。离心机高速运转将切割的样品集中在收集井中。

5. 发明申请

WO02034379A1 DEVICE AND METHOD FOR CARRYING OUT SOLID PHASE EXTRACTIONS 审中-公开
标题翻译： DEVICE实施固相萃取的
公开(公告)号：WO02034379A1
公开(公告)日：2002-05-02
申请号：PCT/CH2001/000619
申请日：2001-10-16
IPC分类号： B01D11/02 , B01J19/00 , C40B60/14 , G01N1/34
CPC分类号： G01N1/405 , B01D11/0219 , B01J19/0046 , B01J2219/00283 , B01J2219/00286 , B01J2219/00308 , B01J2219/0031 , B01J2219/00319 , B01J2219/00328 , B01J2219/00351 , B01J2219/00423 , B01J2219/00452 , B01J2219/00585 , B01J2219/00596 , C40B60/14
摘要： The invention relates to a device for carrying out solid phase extractions, comprising a solid phase extraction column holder (1) and a liquid collector (2) disposed downstream thereof. The solid phase extraction column holder (1) and the liquid collector (2) can be displaced relative each other between a first relative position and a second relative position in such a way that during solid phase extraction, during which solid phase extraction columns (3) are disposed in the solid phase extraction column holder (1), in the first relative position liquid from the solid phase extraction columns (3) reaches, via first inlets (22), first receptacles (21) of the liquid collector (2), and in the second relative position liquid from the solid phase extraction columns (3) reaches, via second inlets (24), a second receptacle in the form of a trough (23). A plurality of second inlets (24) is disposed between and next to the first inlets (22). The first and second inlets are set off from one another in a regular pattern. The inventive design provides for a relatively short path of displacement of the solid phase extraction column holder between the first relative position and the second relative position.
摘要翻译：用于进行固相提取，其包括固相萃取柱支架（1）和一个在它下面的装置布置的液体接收装置（2）。固相提取柱保持器（1）和液体接收装置（2）是第一相互位置和相对的第二相对位置，以彼此，即布置在固相萃取的实践中之间移动，而在固相萃取柱支架（1）固相萃取柱（3）是，在从固相萃取柱（3）通过第一入口的第一相互位置液体（22）到液体接收装置的第一容器（21）（2）和在从通过第二入口的固相萃取柱（3）的第二相互位置液体（24）在一个槽的形式的第二收集容器（23）通过。之间和旁边的第一入口（22）的多个第二入口（24）都存在。所述第一和第二入口被布置成规则的偏移。由此，在第一相对位置和第二位置相互之间的固相萃取柱支架的位移量相对较小。

6. 发明申请

WO0170400A8 MULTIBLOCK MICRO-ARRAYS OR MACRO-ARRAYS WITH LAB-ON-A-CHIP 审中-公开
标题翻译：多芯片微阵列或大块阵列
公开(公告)号：WO0170400A8
公开(公告)日：2002-04-04
申请号：PCT/FR0100881
申请日：2001-03-22
申请人： GELI FRANCOIS
发明人： GELI FRANCOIS
IPC分类号： B01J19/00 , B01L3/00 , C40B60/14 , G01N30/46 , G01N35/00 , G01N35/10
CPC分类号： B82Y30/00 , B01J19/0046 , B01J19/0093 , B01J2219/00317 , B01J2219/00319 , B01J2219/00369 , B01J2219/00432 , B01J2219/00479 , B01J2219/00522 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00659 , B01J2219/00664 , B01J2219/00707 , B01J2219/00711 , B01J2219/0072 , B01J2219/00871 , B01L3/5025 , B01L3/502707 , B01L3/502715 , B01L2200/027 , B01L2200/028 , B01L2300/0681 , B01L2300/0816 , B01L2300/087 , B01L2300/0887 , C40B60/14 , G01N30/466 , G01N35/1065 , G01N2035/00237
摘要： The invention concerns multiblock micro-arrays or macro-arrays incorporating laboratories on chips, for use in chemical, biochemical or biological analysis or chemical or biochemical synthesis. An inventive multiblock micro-array or macro-array consists of a stack of flat elementary modules provided with parallel microchannels at their surface which emerge into the thickness and on the edge of their sides, each flat elementary module providing a line to said multiblock micro-array or macro-array. The microchannels can be provided with micro-mixers and enlarged portions, provided with molecule-fixing surface and can receive micro-columns or micro-particles or micro-spheres. The juxtaposition of the lines first set of reagents enables to perform the parallel reactions on very small volumes. Two inventive multiblock micro-arrays or macro-arrays can be orthogonally connected to cross a first set of reagents a with a second, and form a sealed chain of analysis or synthesis.
摘要翻译：本发明涉及包含芯片实验室的多块微阵列或宏阵列，用于化学，生物化学或生物分析或化学或生物化学合成。本发明的多块微阵列或宏阵列由一组平坦的基本模块组成，其平面微通道在其表面具有并入的微通道，其出现在其厚度和边缘的边缘上，每个平坦的基本模块提供到所述多块微型阵列的线，数组或宏数组。微通道可以设置有微混合器和扩大部分，具有分子固定表面，并且可以接收微柱或微粒或微球。第一组试剂的并列配置使得能够在非常小的体积上进行并行反应。两个本发明的多嵌段微阵列或宏阵列可以正交连接以跨越第一组试剂a与第二组，形成密封的分析或合成链。

7. 发明申请

WO01078895A2 CONTAINER AND METHOD FOR HIGH VOLUME TREATMENT OF SAMPLES ON SOLID SUPPORTS 审中-公开
标题翻译：用于固体支持样品高容量处理的容器和方法
公开(公告)号：WO01078895A2
公开(公告)日：2001-10-25
申请号：PCT/US2001/011906
申请日：2001-04-11
IPC分类号： B01J19/00 , B01L3/00 , C40B50/14 , C40B60/14 , G01N35/00 , G01N35/02
CPC分类号： B01L3/5025 , B01J19/0046 , B01J2219/00295 , B01J2219/00313 , B01J2219/00315 , B01J2219/00319 , B01J2219/00351 , B01J2219/00421 , B01J2219/00423 , B01J2219/00454 , B01J2219/00461 , B01J2219/0049 , B01J2219/00495 , B01J2219/005 , B01J2219/00502 , B01J2219/00504 , B01J2219/00506 , B01J2219/0052 , B01L3/50255 , C40B50/14 , C40B60/14 , G01N35/028 , G01N2035/00495 , Y10T436/111666 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： A sample/collection container includes a plurality of wells, each for separating a sample from its solid support when solvent is dispensed into the wells and the centrifuge is activated at a low speed. Operation of the centrifuge at high speed concentrates the cleaved sample in collection wells.
摘要翻译：样品/收集容器包括多个孔，每个孔用于当将溶剂分配到孔中并且离心机以低速启动时，将样品与其固体支持物分离。离心机高速运转将切割的样品集中在收集井中。

8. 发明申请

WO01046381A1 NANO-GRID MICRO REACTOR AND METHODS 审中-公开
标题翻译：纳米微反应器和方法
公开(公告)号：WO01046381A1
公开(公告)日：2001-06-28
申请号：PCT/US2000/035336
申请日：2000-12-22
IPC分类号： B01J19/00 , B01L3/00 , B81B1/00 , C12M1/34 , C40B60/14 , G01N33/50 , C12Q1/24
CPC分类号： B01L3/50853 , B01J19/0046 , B01J2219/00317 , B01J2219/00319 , B01J2219/00351 , B01J2219/00423 , B01J2219/005 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00702 , B01J2219/0072 , B01J2219/0074 , B01J2219/00743 , B01L2300/0819 , B81B1/00 , C40B60/14 , G01N33/5005
摘要： The invention provides exemplary devices and methods to facilitate the performance of assays. In one embodiment, one such device comprises a holding member (58) having a top surface, a bottom surface, and a plurality of holding locations (62) that are adapted to hold at least one article (66), such as a solid support and/or a cell. When within the holding locations, the articles (66) are preferably disposed below the top surface. A membrane (68) is positioned above the top surface of the holding member (58), and a pressure system is provided to apply positive pressure to the membrane (68) to force the membrane (68) against the top surface of the holding member (58). In this way, a seal may be provided between the holding locations (62).
摘要翻译：本发明提供了促进测定性能的示例性装置和方法。在一个实施例中，一个这样的装置包括具有顶表面，底表面和多个保持位置（62）的保持构件（58），其适于容纳至少一个物品（66），例如固体支撑件和/或细胞。当在保持位置内时，物品（66）优选地设置在顶表面下方。膜（68）位于保持构件（58）的顶表面上方，并且提供压力系统以向膜（68）施加正压以迫使膜（68）抵靠保持构件的顶表面（58）。以这种方式，可以在保持位置（62）之间设置密封件。

9. 发明申请

WO0076662A2 MICROENABLED CHEMICAL REACTION IN MICROFLUIDIC CHIPS 审中-公开
标题翻译：微流化学药剂中微量化学反应
公开(公告)号：WO0076662A2
公开(公告)日：2000-12-21
申请号：PCT/US0016056
申请日：2000-06-12
申请人： ORCHID BIOSCIENCES INC
发明人： SWENSON ROLF E , JIAN LIN , DEWITT SHEILA H
IPC分类号： B01J19/00 , B01L3/00 , C07B61/00 , C07C45/50 , C07C205/58 , C07C227/08 , C07C229/60 , C07K1/04 , C40B40/10 , C40B50/14 , C40B60/14 , B01L
CPC分类号： C07K1/047 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00319 , B01J2219/00351 , B01J2219/00353 , B01J2219/00418 , B01J2219/00454 , B01J2219/00459 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/0072 , B01J2219/00725 , B01L3/5027 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2300/0867 , B01L2300/0877 , B01L2400/0487 , C07B2200/11 , C07C45/50 , C07C201/12 , C07C227/08 , C40B40/10 , C40B50/14 , C40B60/14 , C07C229/60 , C07C205/58 , C07C47/02
摘要： A chemical process to obtain products of higher purity or in shorter time is provided by performing chemical reactions in a reactions volume less than 1 microliter. The advantages of this process are due to better mixing or heat exchanche (each 10 fold decrease in reaction volume leads to a 100-fold improvement mixing or heat exchange) or better surface to volume ratio. Better surface to volume ratio is a major factor in reactions critically dependent on surface mediated events such as heterogeneous catalysis. This increase in yield and speed of reaction can be conducted in parallel sets of reaction chambers provided by multilayer glass and silicon chips. Reagents can be added via a microfluidic chip incorporating channels and orthogonal row/column reagent delivery options. This discovery is amendable to solid supported synthesis as well as solution synthesis. Because of the better surface to volume ratio, this process is particularly useful with solid catalyst on the edges of the reaction chamber and can be used for hydrogenation, and hydroformulation. This process is demonstrated in reactions involving nucleophilic aromatic substitution on a solid support.
摘要翻译：通过在小于1微升的反应体积中进行化学反应来提供获得更高纯度或更短时间的产物的化学方法。该方法的优点是由于更好的混合或热交换（反应体积的每10倍减少导致混合或热交换改善100倍）或更好的表面与体积比。更好的表面与体积比是重要依赖于表面介导的事件（如非均相催化）的反应的主要因素。反应的产率和速度的这种增加可以由多层玻璃和硅片提供的平行的反应室组进行。可以通过结合通道和正交行/列试剂递送选项的微流控芯片添加试剂。这一发现可以修改为固体支持的合成以及溶液合成。由于表面与体积之比更好，该方法对于反应室边缘的固体催化剂特别有用，可用于氢化和加氢成型。在固体支持物上涉及亲核芳香取代的反应中证明了这一过程。

10. 发明申请

WO9947922A3 VASCULARIZED PERFUSED MICROTISSUE/MICRO-ORGAN ARRAYS 审中-公开
标题翻译：加压渗透微量/微生物阵列
公开(公告)号：WO9947922A3
公开(公告)日：1999-11-04
申请号：PCT/US9905974
申请日：1999-03-18
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： GRIFFITH LINDA G , TANNENBAUM STEVEN R , POWERS MARK J , DOMANSKY KAREL , THOMPSON CHARLES D
IPC分类号： B01J19/00 , C12M1/34 , C12M3/04 , C40B60/14 , G01N33/50
CPC分类号： G01N33/5038 , B01J19/0046 , B01J2219/00286 , B01J2219/00308 , B01J2219/00313 , B01J2219/00317 , B01J2219/00319 , B01J2219/00351 , B01J2219/00376 , B01J2219/00416 , B01J2219/00585 , B01J2219/00659 , B01J2219/0072 , B33Y10/00 , B33Y80/00 , B82Y30/00 , C12M21/08 , C12M23/12 , C12M41/46 , C40B60/14 , G01N33/5008 , G01N33/502 , G01N33/5058 , G01N33/5064 , G01N33/5073
摘要： Systems including (1) a micromatrix and perfusion assembly suitable for seeding and attachment of cells within the matrix and for morphogenesis of seeded cells into complex, hierarchical tissue or organ structures, wherein the matrix includes channels or vessels through which culture medium, oxygen, or other nutrient or body fluids can be perfused while controlling gradients of nutrients and exogenous metabolites throughout the perfusion path independently of perfusion rate, and (2) sensor means for detecting changes in either cells within the matrix or in materials exposed to the cells, have been developed. Methods for making the micromatrices include micromachining, micromolding, embossing, laser drilling, and electro deposition machining. Cells can be of one or more types, either differentiated or undifferentiated. In a preferred embodiment, the matrix is seeded with a mixture of cells including endothelial cells which will line the channels to form "blood vessels", and at least one type of parenchymal cells, such as hepatocytes, pancreatic cells, or other organ cells. The system can be used to screen materials for an effect on the cells, for an effect of the cells on the materials (for example, in a manner equivalent to tissue metabolism of a drug), or to test a material on a biological that must first infect cells or tissues, such as viruses. The apparatus also can be used to provide a physiological environment for expansion of stem cells, or for enabling gene therapy in vitro.
摘要翻译：系统包括（1）微阵列和灌注组件，适合于将基质内的细胞接种和附着以及将接种细胞形态发生成复杂的分层组织或器官结构，其中基质包括培养基，氧或其他营养物质或体液可灌注，同时独立于灌注速率而在整个灌注路径中控制营养素和外源性代谢物的梯度，和（2）用于检测基质内或暴露于细胞的物质中细胞变化的传感器装置发达。制造微基体的方法包括微加工，微成型，压花，激光钻孔和电沉积加工。细胞可以是一种或多种类型，分化的或未分化的。在一个优选的实施方案中，将基质与细胞混合物接种，所述细胞混合物包括将使通道形成“血管”的内皮细胞，以及至少一种实质细胞，例如肝细胞，胰腺细胞或其他器官细胞。该系统可用于筛选材料对细胞的影响，细胞对材料的影响（例如，以等同于药物组织代谢的方式），或测试生物体上的材料首先感染细胞或组织，如病毒。该设备也可用于提供干细胞扩增的生理环境，或用于体外基因治疗。

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