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1. 发明申请

WO2018089975A1 IMPLANTABLE ELECTRODES COMPRISING MECHANICALLY ANCHORED BIOCOMPATIBLE HYDROGELS 审中-公开
标题翻译：包含机械固定的生物相容性水凝胶的可植入电极
公开(公告)号：WO2018089975A1
公开(公告)日：2018-05-17
申请号：PCT/US2017/061461
申请日：2017-11-14
申请人： VERILY LIFE SCIENCES LLC
发明人： YAO, Huanfen , KAM, Kimberly , OTTS, Daniel
IPC分类号： A61N1/05
CPC分类号： A61B5/6846 , A61B5/05 , A61B2562/046 , A61B2562/125 , A61N1/05 , A61N1/0526 , A61N1/0541 , A61N1/0553
摘要： Biomaterials, such as hydrogels, can be mechanically secured to electrodes of an implantable device, such as electrodes made of noble metals. The hydrogel can be mechanically secured via anchoring features of the electrode. Anchoring features can include apertures, voids, textures, or other patterns created in or on the electrode. The hydrogel can incorporate into the anchoring features to mechanically hold the hydrogel against the electrode. The anchoring features, by being located in or on the electrode, can further increase the surface area of the electrode that is exposed to the hydrogel, which can facilitate the conduction of electrical signals between the electrode and surrounding biological tissue. The substrate supporting the electrode can include additional anchoring features that further assist in mechanically securing the hydrogel.
摘要翻译：可以将生物材料如水凝胶机械固定到可植入装置的电极，例如由贵金属制成的电极。水凝胶可以通过电极的锚固特征机械地固定。锚定特征可以包括在电极中或其上形成的孔，空隙，纹理或其他图案。水凝胶可以并入锚定特征中以机械地将水凝胶保持在电极上。锚定特征通过位于电极中或电极上可以进一步增加暴露于水凝胶的电极的表面积，这可以促进电极与周围生物组织之间的电信号的传导。支撑电极的基底可以包括另外的锚定特征，其进一步有助于机械固定水凝胶。

2. 发明申请

WO2017120023A1 TRANSCUTANEOUS ELECTROSTIMULATOR AND METHODS FOR ELECTRIC STIMULATION 审中-公开
标题翻译：经皮电刺激器和电刺激方法
公开(公告)号：WO2017120023A1
公开(公告)日：2017-07-13
申请号：PCT/US2016/067525
申请日：2016-12-19
申请人： NERVANA, LLC
发明人： CARTLEDGE, Richard , CARTLEDGE, Daniel , BRANNON, Ami , KERMIT, Falk , MAYBACK, Gregory, L.
IPC分类号： A61M21/00 , A61M21/02 , A61N1/00 , A61N1/04 , A61N1/05 , A61N1/18 , A61N1/32 , A61N1/36 , A61N1/372 , H04R1/10
CPC分类号： A61N1/36014 , A61M21/00 , A61M21/02 , A61N1/00 , A61N1/04 , A61N1/0456 , A61N1/0472 , A61N1/0476 , A61N1/05 , A61N1/0526 , A61N1/18 , A61N1/32 , A61N1/36 , A61N1/36021 , A61N1/36036 , A61N1/372 , H04R1/10 , H04R1/1008 , H04R1/1016
摘要： An electrostimulation device includes a computer generating an electrostimulation generator control signal and outputting a music signal, a transcutaneous electrostimulation generator, an electronic signal conduit, and an electrode coupler. The generator receives the generator control signal and the music signal, generates a nerve electrostimulation signal dependent upon the generator control signal, and outputs the nerve electrostimulation signal at the stimulation output and the music signal at an audio output. The coupler fits in an ear canal, has a speaker connected to the audio output to output the music signal into the ear canal when worn, and has electrostimulation electrodes conductively connected to the stimulation output through the electronic signal conduit to receive the nerve electrostimulation signal and positioned to contact tissue within the canal to transcutaneously apply the nerve electrostimulation signal thereto. The coupler supplies the nerve electrostimulation signal while music outputs from the speaker.
摘要翻译：电刺激装置包括产生电刺激发生器控制信号并输出音乐信号的计算机，经皮电刺激发生器，电子信号导管和电极耦合器。发生器接收发生器控制信号和音乐信号，根据发生器控制信号产生神经电刺激信号，并且在音频输出端输出刺激输出处的神经电刺激信号和音乐信号。该耦合器装配在耳道中，具有连接到音频输出的扬声器以在佩戴时将音乐信号输出到耳道中，并且具有通过电子信号导管传导地连接到刺激输出以接收神经电刺激信号的电刺激电极和定位成接触管内的组织以经皮向其施加神经电刺激信号。耦合器提供神经电刺激信号，同时从扬声器输出音乐。

3. 发明申请

WO2017100530A1 SURGICAL TOOLS AND METHODS FOR DELIVERING A NEUROSTIMULATOR INTO THE PTERYGOPALATINE FOSSA 审中-公开
标题翻译：用于将神经刺激器输送到脾脏的手术工具和方法
公开(公告)号：WO2017100530A1
公开(公告)日：2017-06-15
申请号：PCT/US2016/065757
申请日：2016-12-09
申请人： AUTONOMIC TECHNOLOGIES, INC.
发明人： LUHRS, Tom , CHENG, Alan , POWELL, Ryan , TENG, Jennifer
IPC分类号： A61N1/05 , A61B17/34 , A61N1/36
CPC分类号： A61N1/3605 , A61B17/3468 , A61N1/0526 , A61N1/0551 , A61N1/36075 , A61N1/37205
摘要： One aspect of the present disclosure includes a delivery tool configured to deliver a neurostimulator into a pterygopalatine fossa of a subject. The neurostimulator can include a body connected to an integral stimulation lead having one or more stimulating electrodes. The delivery tool can comprise a handle, an elongated shaft extending from the handle, a hub portion, and a double barrel sheath. The hub portion can be located between the shaft and a spine member that extends axially away from the hub portion. The hub portion can be sized and dimensioned to releasably mate with the neurostimulator. The double barrel sheath can be connected to the spine member. A central lumen can extend through at least a portion of the shaft and the hub portion. The central lumen can be adapted to receive a lead ejector for selective deployment of the stimulation lead from the double barrel sheath.
摘要翻译：本公开的一个方面包括递送工具，其被配置为将神经刺激器递送到受试者的翼腭窝中。神经刺激器可以包括连接到具有一个或多个刺激电极的整体刺激导线的本体。输送工具可以包括手柄，从手柄延伸的细长轴，毂部分以及双桶状护套。毂部分可以位于轴和远离毂部分轴向延伸的脊部件之间。中枢部分的尺寸和尺寸可以与神经刺激器可释放地配合。双桶套可以连接到脊柱构件。中心腔可以延伸穿过轴和毂部的至少一部分。中央内腔可以适应于接收用于从双筒护套选择性地展开刺激引线的引线引出器。

4. 发明申请

WO2016209078A2 INDUCING LUCID DREAMING 审中-公开
标题翻译：诱导幼稚园梦想
公开(公告)号：WO2016209078A2
公开(公告)日：2016-12-29
申请号：PCT/NL2016/050448
申请日：2016-06-23
申请人： RED ELK BV
发明人： KEIZER, André Willem , MULDER, Derk
IPC分类号： A61N1/04 , A61N1/36 , A61B5/048 , A61B5/16 , A61B5/00
CPC分类号： A61N1/0456 , A61B5/0476 , A61B5/048 , A61B5/165 , A61B5/4812 , A61B5/6814 , A61M21/00 , A61M2021/0072 , A61N1/0484 , A61N1/0526 , A61N1/36025
摘要： The present invention is in the field of induction of lucid dreams by Transcranial Alternating Current Stimulation (TACS). Lucid dreaming refers to a well-documented and scientifically accepted phenomenon that may occur during natural sleep. Lucid dreaming is characterized by awareness of the fact that one is dreaming, an increased chance of control over the events that are occurring within the dream and increased logical or rational thought during the dream.
摘要翻译：本发明是通过经颅交流刺激（TACS）诱导清醒梦想的领域。清醒的梦想是指在自然睡眠期间可能发生的有据可查的和科学上接受的现象。清醒的梦想的特征是意识到一个人在做梦，增加控制梦中发生的事件的机会，并增加梦想中的逻辑或理性思维。

5. 发明申请

WO2016176668A1 BREATHING DISORDER DETECTION AND TREATMENT DEVICE AND METHODS 审中-公开
标题翻译：呼吸障碍物检测和治疗装置及方法
公开(公告)号：WO2016176668A1
公开(公告)日：2016-11-03
申请号：PCT/US2016/030325
申请日：2016-04-30
申请人： SOMTEK, INC.
发明人： ALFERNESS, Anton , CROSS, Brett , ALFERNESS, Clifton , FISCHER, Kurt , FARIS, Brian
IPC分类号： A61B5/08 , A61B5/145 , A61B7/04 , A61N1/18 , A61H1/00
CPC分类号： A61B7/003 , A61B5/08 , A61B5/0826 , A61B5/14542 , A61B5/4818 , A61B5/6817 , A61B2505/07 , A61B2562/0238 , A61N1/0456 , A61N1/0472 , A61N1/0526 , A61N1/36014 , A61N1/36036
摘要： Disclosed are systems, methods and devices for diagnosing and treating breathing disorders of humans and other mammals
摘要翻译：公开了用于诊断和治疗人类和其他哺乳动物呼吸障碍的系统，方法和装置

6. 发明申请

WO2015060927A2 IMPLANTABLE HEAD MOUNTED NEUROSTIMULATION SYSTEM FOR HEAD PAIN 审中-公开
标题翻译：用于头痛的可植入式头部神经调节系统
公开(公告)号：WO2015060927A2
公开(公告)日：2015-04-30
申请号：PCT/US2014051235
申请日：2014-08-15
申请人： SYNTILLA MEDICAL LLC
发明人： REED KENNETH LYLE , BULGER ROBERT RAYMOND
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/3787 , A61N1/0504 , A61N1/0526 , A61N1/0529 , A61N1/0551 , A61N1/36075 , A61N1/37211 , A61N1/37229 , A61N1/375
摘要： An implantable head-mounted unibody peripheral neurostimulation system is provided for implantation in the head for the purpose of treating chronic head pain, including migraine. The system may include an implantable pulse generator (IPG) from which multiple stimulating leads may extend sufficient to allow for adequate stimulation over multiple regions of the head, preferably including the frontal, parietal and occipital regions. A lead may include an extended body, along which may be disposed a plurality of surface metal electrodes, which may be sub-divided into a plurality of electrode arrays. A plurality of internal metal wires may run a portion of its length and connect the IPG's internal circuit to the surface metal electrodes. The IPG may include a rechargeable battery, an antenna, and an application specific integrated circuit. The IPG may be capable of functional connection with an external radiofrequency unit for purposes that may include recharging, diagnostic evaluation, and programming.
摘要翻译：为了治疗包括偏头痛在内的慢性头痛的目的，提供了用于植入头部的可植入头戴式一体式外周神经刺激系统。该系统可以包括植入式脉冲发生器（IPG），多个刺激引线可以从该植入式脉冲发生器延伸足以允许在头部的多个区域（优选地包括额叶，顶骨和枕叶区域）上进行足够的刺激。引线可以包括延伸主体，沿着该延伸主体可以布置多个表面金属电极，其可以被细分成多个电极阵列。多个内部金属线可以延伸其一部分长度并将IPG的内部电路连接到表面金属电极。 IPG可以包括可充电电池，天线和专用集成电路。 IPG可以与外部射频单元进行功能连接，其目的可能包括充电，诊断评估和编程。

7. 发明申请

WO2015004540A2 DYNAMIC MODIFICATION OF MODULATION THROUGHOUT A THERAPY PERIOD 审中-公开
标题翻译：在整个疗程期间进行动态调节的调节
公开(公告)号：WO2015004540A2
公开(公告)日：2015-01-15
申请号：PCT/IB2014/002291
申请日：2014-06-17
申请人： MASHIACH, Adi , MASHIACH, Itzik
发明人： MASHIACH, Adi , MASHIACH, Itzik
IPC分类号： A61N1/32
CPC分类号： A61N1/37223 , A61B5/0031 , A61B5/01 , A61B5/0488 , A61B5/11 , A61B5/113 , A61B5/4519 , A61B5/4818 , A61B5/682 , A61B5/6822 , A61B5/6833 , A61B5/6876 , A61B7/04 , A61B17/30 , A61B2560/0219 , A61B2562/16 , A61B2562/164 , A61B2562/227 , A61F5/566 , A61N1/0404 , A61N1/0456 , A61N1/0492 , A61N1/0514 , A61N1/0526 , A61N1/0553 , A61N1/36003 , A61N1/3601 , A61N1/36014 , A61N1/3605 , A61N1/36057 , A61N1/36075 , A61N1/3611 , A61N1/36117 , A61N1/36135 , A61N1/36139 , A61N1/36146 , A61N1/37229 , A61N1/3756 , A61N1/3758 , A61N1/3787 , A61N2/006 , A61N2/02 , A61N2001/37294
摘要： A device for controlling operation of a nerve-modulating implant unit from a location external to the body of the subject is provided. The device may include a flexible substrate configured for removable attachment to a subject's skin, a primary antenna disposed on the flexible substrate, and at least one processing device. The processing device may be configured to cause generation of a modulation control signal and application of the modulation control signal to the primary antenna in order to wirelessly transmit the modulation control signal to a secondary antenna on the implant unit to cause modulation of at least one nerve using energy transmitted wirelessly from the primary antenna to the secondary antenna, and cause a plurality of predetermined alterations of at least one characteristic of the modulation control signal over successive applications of the modulation control signal during a therapy period.
摘要翻译：提供了一种用于从受试者身体外部的位置控制神经调节植入物单元的操作的装置。该装置可以包括被配置为可移除地附接到对象的皮肤的柔性衬底，布置在柔性衬底上的主天线以及至少一个处理装置。处理装置可以被配置为引起调制控制信号的产生并且将调制控制信号施加到主天线以便将调制控制信号无线地发送到注入单元上的次级天线以引起对至少一个神经的调制使用从主天线到次级天线无线传输的能量，并且在治疗期间通过连续施加调制控制信号引起调制控制信号的至少一个特征的多个预定改变。

8. 发明申请

WO2014200864A1 ACCOMMODATION STIMULATION AND RECORDING DEVICE 审中-公开
标题翻译：住宿刺激和记录设备
公开(公告)号：WO2014200864A1
公开(公告)日：2014-12-18
申请号：PCT/US2014/041383
申请日：2014-06-06
申请人： UNIVERSITY OF HOUSTON SYSTEM
发明人： GLASSER, Adrian
IPC分类号： A61N1/36 , A61N1/04 , A61B3/10 , A61B5/0496 , A61B5/05
CPC分类号： A61N1/36046 , A61B3/112 , A61B5/0496 , A61B5/6821 , A61N1/0476 , A61N1/0526
摘要： Embodiments described herein generally relate to devices and methods for stimulation or recording of accommodation of an eye. Accommodation of an eye naturally occurs through contraction of the ciliary muscle. Embodiments described herein can deliver electrostimulation to the ciliary muscle through a pair of electrodes which deliver power over an area of the sclera which is both positioned above and over an area which is substantially equivalent to the surface area of the ciliary muscle. In further embodiments, electrical impulses produced by the ciliary muscle can be received by one or more electrodes positioned proximate the ciliary muscle. Thus, by embodiments described herein, accommodation of the eye can be reproducibly achieved by external stimulation of the ciliary muscle or measured based on electrical impulses generated by or in conjunction with the ciliary muscle.
摘要翻译：本文描述的实施例通常涉及用于刺激或记录眼睛适应的装置和方法。眼睛的存在通过睫状肌的收缩自然发生。本文所述的实施方案可以通过一对电极将电刺激提供给睫状肌，所述电极在位于巩膜上的区域上传递动力，所述区域位于基本上等于睫状肌表面积的区域之上和之上。在另外的实施例中，由睫状肌产生的电脉冲可以被位于睫状肌附近的一个或多个电极接收。因此，通过本文所述的实施例，可以通过外部刺激睫状肌或基于由睫状肌产生或与睫状肌一起产生的电脉冲来测量眼睛的适应度。

9. 发明申请

WO2014016700A2 IMPLANT SLEEP APNEA TREATMENT DEVICE INCLUDING AN ANTENNA 审中-公开
标题翻译：包括天线的植入式睡眠呼吸暂停治疗设备
公开(公告)号：WO2014016700A2
公开(公告)日：2014-01-30
申请号：PCT/IB2013002147
申请日：2013-07-26
申请人： MASHIACH ADI
发明人： MASHIACH ADI
IPC分类号： A61N1/36
CPC分类号： A61B17/0482 , A61N1/0526 , A61N1/0548 , A61N1/0558 , A61N1/36003 , A61N1/3601 , A61N1/3605 , A61N1/3606 , A61N1/36071 , A61N1/36075 , A61N1/3611 , A61N1/36117 , A61N1/36125 , A61N1/36132 , A61N1/36189 , A61N1/37229 , A61N1/375 , A61N1/3787 , H02J7/025 , H02J50/05 , H02J50/12 , H04B5/0031 , H04B5/0037 , H04B5/0081 , H04B5/0093 , Y10T29/49018
摘要： A sleep apnea treatment device may include a flexible carrier configured to be implanted in a body of a subject. The device may also include at least one electrode disposed on the flexible carrier, the at least one electrode being configured to modulate nerve fibers of the subject. A flexible antenna may be disposed on the flexible carrier, the flexible antenna electrically connected to the at least one electrode in a manner permitting at least some energy received by the flexible antenna to be transferred to the at least one electrode. The flexible antenna may include: at least a first conductive trace arranged on a first side of the flexible carrier, the at least a first conductive trace defining at least a first elongated space between portions thereof: and at least a second conductive trace arranged on a second side of the flexible carrier, the at least a second conductive trace defining at least a second elongated space between portions thereof, wherein the at least a first conductive trace is at least partially offset from the at least a second conductive trace such that portions of the first conductive trace overly the at least a second elongated space and wherein portions of the second conductive trace underlay the at least a first elongated space.
摘要翻译：睡眠呼吸暂停治疗装置可以包括被配置成植入到对象的身体中的柔性载体。该装置还可以包括设置在柔性载体上的至少一个电极，该至少一个电极被配置为调制受试者的神经纤维。柔性天线可以设置在柔性载体上，柔性天线以允许由柔性天线接收的至少一些能量传递到至少一个电极的方式电连接到至少一个电极。柔性天线可以包括：布置在柔性载体的第一侧上的至少第一导电迹线，所述至少第一导电迹线在其部分之间限定至少第一细长空间;以及至少第二导电迹线，所述至少第二导电迹线在其部分之间限定至少第二细长空间，其中所述至少第一导电迹线至少部分地偏离所述至少第二导电迹线，使得所述至少第二导电迹线的部分所述第一导电迹线覆盖所述至少第二细长空间，并且其中所述第二导电迹线的部分覆盖所述至少第一细长空间。

10. 发明申请

WO2013155280A1 ELECTRODES ADAPTED FOR TRANSMITTING OR MEASURING VOLTAGES THROUGH HAIR 审中-公开
标题翻译：适用于通过发胶发射或测量电压的电极
公开(公告)号：WO2013155280A1
公开(公告)日：2013-10-17
申请号：PCT/US2013/036139
申请日：2013-04-11
申请人： HECK, Sandy L.
发明人： HECK, Sandy L.
IPC分类号： A61B5/04 , A61B5/0488
CPC分类号： A61N1/0484 , A61B5/04001 , A61B5/0488 , A61B5/0492 , A61B5/6803 , A61B5/6814 , A61N1/0456 , A61N1/0476 , A61N1/0526 , A61N1/36036
摘要： An electrode that functions alone, in clusters or arrays can be used to measure and/or deliver voltages through skin covered with hair by achieving reliable skin contact. In one form, a composite metal electrode has several raised points capable of passing through hair to contact the skin directly between hairs. Electrode points are distributed evenly over a flat circular or curved base to create a composite electrode or cluster in which all electrode points electrically couple to one another and to an output device. In another form of the invention, each electrode point is connected by a separate conductor wire to a selector that evaluates the signal during use and determines which of the electrode points are to be coupled to an output device.
摘要翻译：通过实现可靠的皮肤接触，可单独使用，簇或阵列功能的电极可用于测量和/或传递通过被毛发覆盖的皮肤的电压。在一种形式中，复合金属电极具有能够穿过毛发的几个凸起点，直接在头发之间接触皮肤。电极点均匀地分布在平坦的圆形或弯曲的基底上以产生复合电极或簇，其中所有电极点彼此电耦合并输出到输出装置。在本发明的另一种形式中，每个电极点通过单独的导体线连接到选择器，该选择器在使用期间评估信号，并确定哪个电极点将被耦合到输出装置。

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