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1. 发明申请

WO2018111444A1 MEDICAL IMPLANT SELECTION PROTOCOL 审中-公开
公开(公告)号：WO2018111444A1
公开(公告)日：2018-06-21
申请号：PCT/US2017/060496
申请日：2017-11-08
申请人： QUALCOMM INCORPORATED
发明人： HE, Linhai , ALCALA, Osvaldo , SHELLHAMMER, Stephen Jay , NEWHAM, Adam Edward
IPC分类号： A61N1/372 , A61N1/05 , A61B5/00 , H04L1/16 , H04W72/04 , H04W74/00
CPC分类号： A61N1/37288 , A61B5/0031 , A61B5/0478 , A61B5/076 , A61B5/6868 , A61N1/05 , A61N1/0529 , A61N1/36025 , A61N1/36082 , A61N1/37205 , A61N1/37223 , A61N1/37235 , H04L1/1614 , H04W72/044 , H04W74/006
摘要： Techniques provided herein are directed toward providing a selection protocol that can be used in such biological measurement and stimulation systems to select only a portion of the medical implants for reporting during a particular system cycle. In particular, the interrogator device can send the first message that defines a group to the medical implants, then send a second message with the identifier of the group to trigger communications with the medical implants of that group.

2. 发明申请

WO2018094232A1 METHODS AND SYSTEMS FOR NEURAL STIMULATION VIA VISUAL, AUDITORY AND PERIPHERAL NERVE STIMULATIONS 审中-公开
公开(公告)号：WO2018094232A1
公开(公告)日：2018-05-24
申请号：PCT/US2017062335
申请日：2017-11-17
申请人： COGNITO THERAPEUTICS INC
发明人： MALCHANO ZACHARY JOHN HAMBRECHT , WILLIAMS MARTIN WARREN
IPC分类号： A61N1/36
CPC分类号： A61M21/00 , A61B3/113 , A61B5/024 , A61B5/0482 , A61B5/0484 , A61B5/0496 , A61B5/05 , A61B5/16 , A61B5/163 , A61B5/168 , A61B5/4836 , A61B5/4848 , A61B5/6803 , A61M2021/0027 , A61M2021/0044 , A61M2021/0072 , A61M2205/3375 , A61N1/0456 , A61N1/36025 , A61N1/36092 , A61N1/36132 , A61N5/0618 , A61N2005/0626 , A61N2005/0627 , A61N2005/0629 , A61N2005/0648 , A61N2005/0652 , A61N2005/0663 , A61N2005/0667 , G02C11/10 , G02C2200/10 , H05B37/0227
摘要： Systems and methods of the present disclosure are directed to systems and methods for treating cognitive dysfunction in a subject in need thereof. The system can include a light source and a speaker. A visual neural stimulation system provides, via the light source, visual stimulation having a first value of a first parameter. An auditory neural stimulation system provides, via the speaker, audio stimulation having a second value of the second parameter. A stimuli orchestration component selects, for a first time interval, one of the visual stimulation or the audio stimulation to vary based on a policy, selects, for the first time interval, the other of the visual stimulation or the audio stimulation to keep constant based on the policy, and provides causes the one of the visual neural stimulation system or the auditory neural stimulation system to vary the one of the visual stimulation or the audio stimulation.

3. 发明申请

WO2017193118A1 SYSTEM AND DEVICE FOR GENERATING AN ELECTRIC FIELD FOR THERAPEUTIC PURPOSES 审中-公开
标题翻译：用于产生治疗目的的电场的系统和装置
公开(公告)号：WO2017193118A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/031499
申请日：2017-05-08
申请人： TAL MEDICAL
发明人： MADDEN, Michael , SKVARKA, Jan , GODDARD, Alex , BHARDWAJ, Jason , PANDE, Atule , SAWCHAK, Sharon , MILLER, Andrew
IPC分类号： A61N1/04 , A61N1/36
CPC分类号： A61N1/0456 , A61N1/0484 , A61N1/36021 , A61N1/36025
摘要： A therapy device, comprising: a helmet configured to be worn on a head of a user, the helmet comprising an inner surface to contact the user,,ill outer surface, and a volume located between the inner and outer surfaces; a conductive element within the volume; and an electrical connection connected to the conductive element and configured to be further connected to a source of electrical current; wherein the conductive element is configured to create a magnetic field when an electrical current is passed therethrough, the magnetic field to induce an electric field within the head of the user.
摘要翻译：治疗装置，其包括：头盔，其被配置成佩戴在使用者的头部上，所述头盔包括用于接触使用者的内表面，外表面以及位于内侧和外表面; 体积内的导电元件; 以及电连接件，所述电连接件连接到所述导电元件并且被配置为进一步连接到电流源; 其中所述导电元件被配置成当电流通过时产生磁场，所述磁场在所述使用者的头部内感应出电场。

4. 发明申请

WO2017139243A1 METHOD AND SYSTEM FOR IMPROVING PROVISION OF ELECTRICAL STIMULATION 审中-公开
标题翻译：提高电刺激条件的方法和系统
公开(公告)号：WO2017139243A1
公开(公告)日：2017-08-17
申请号：PCT/US2017/016776
申请日：2017-02-07
申请人： HALO NEURO, INC.
发明人： WINGEIER, Brett , RAZEK, Shawn , BABCOCK, Kevin , FINEBERG, Alan , LOWENBERG, Rich , WOLBER, Patrick
IPC分类号： A61N1/36 , A61N1/04 , A61N1/372
CPC分类号： A61N1/36025 , A61N1/0456 , A61N1/0472 , A61N1/08 , A61N1/36031 , A61N1/36034 , A61N2001/083
摘要： A method and system for providing stimulation to a user, the method including: transitioning a stimulation device from a baseline state to a first impedance monitoring state; during the first impedance monitoring state, guiding, an adjustment of a position of the stimulation device at a head region of the user to satisfy a first impedance criterion; upon satisfaction of the first impedance criterion, transitioning the stimulation device from the first impedance monitoring state to a stimulation regime that comprises a second monitoring state having a second criterion; upon detection of failure to satisfy the second criterion, transitioning the stimulation device from the stimulation regime to the first impedance monitoring state; and upon detecting that a third impedance criterion of the first impedance monitoring state is satisfied, transitioning the stimulation device from the first impedance monitoring state to the stimulation regime.
摘要翻译：一种用于向用户提供刺激的方法和系统，所述方法包括：将刺激设备从基线状态转变到第一阻抗监测状态; 在所述第一阻抗监测状态期间，引导所述刺激设备在所述用户的头部区域的位置的调整以满足第一阻抗标准; 在满足所述第一阻抗标准之后，将所述刺激设备从所述第一阻抗监测状态转变到包括具有第二标准的第二监测状态的刺激机制; 在检测到不满足所述第二标准的故障时，将所述刺激设备从所述刺激状态转换到所述第一阻抗监控状态; 并且在检测到第一阻抗监测状态的第三阻抗标准被满足时，将刺激设备从第一阻抗监测状态转换到刺激方案。

5. 发明申请

WO2017105930A1 SYSTEMS AND METHODS FOR NON-INVASIVE TREATMENT OF HEAD PAIN 审中-公开
标题翻译：用于非侵入性治疗头痛的系统和方法
公开(公告)号：WO2017105930A1
公开(公告)日：2017-06-22
申请号：PCT/US2016/065216
申请日：2016-12-06
申请人： SULLIVAN, Michael J. , CLARK, Bryan Allen , HUSS, John , ARCAND, Benjamin Y. , SHETAKE, Jai , BEVERLIN II, Bryce Calvin
发明人： SULLIVAN, Michael J. , CLARK, Bryan Allen , HUSS, John , ARCAND, Benjamin Y. , SHETAKE, Jai , BEVERLIN II, Bryce Calvin
IPC分类号： A61N1/36 , A61N2/00 , A61N2/02 , A61F7/00 , A61H23/00 , A61N5/06 , A61N7/00
CPC分类号： A61N1/36021 , A61B5/0022 , A61F7/00 , A61H23/00 , A61H23/0245 , A61H2201/0192 , A61H2201/10 , A61H2201/1604 , A61H2201/165 , A61H2201/50 , A61H2201/5007 , A61H2201/5043 , A61H2201/5046 , A61H2201/5048 , A61H2201/5097 , A61H2205/021 , A61H2205/023 , A61H2205/024 , A61H2230/06 , A61H2230/10 , A61H2230/20 , A61H2230/25 , A61H2230/50 , A61H2230/60 , A61N1/20 , A61N1/28 , A61N1/36025 , A61N2/006 , A61N2/008 , A61N2/02 , A61N7/00 , A61N2005/0647 , A61N2007/0026
摘要： Systems and methods for non-invasive management of head pain are disclosed. The system includes a headgear configured to be worn on a patient's head. The headgear can include a base and an extension coupled to the base, and a number of therapy devices removably or adjustably attached to the base or the extension. The therapy devices can deliver various modes of therapeutic energy at respective target sites on the head, including neuromodulation of peripheral pain pathways and/or the cerebral cortex, and therapy modalities to facilitate or enhance the neuromodulation effects. The system can include a portable device that enables the user to control the therapy devices on the headgear. The user can use the portable device to optionally access a web-based repository to acquire information about headgear usage from other users, and use that information to guide the programming of the therapy devices.
摘要翻译：公开了用于无创治疗头痛的系统和方法。该系统包括配置成佩戴在患者头部上的头盔。头带可以包括基部和连接到基部的延伸部，以及多个可移除地或可调整地连接到基部或延伸部的治疗装置。治疗装置可以在头部上的各个目标部位递送各种治疗能量模式，包括外周疼痛通路和/或大脑皮质的神经调节，以及促进或增强神经调节作用的治疗形式。该系统可以包括使用户能够控制头带上的治疗设备的便携式设备。用户可以使用便携式设备来可选地访问基于网络的储存库以从其他用户获取关于头饰使用的信息，并且使用该信息来指导治疗设备的编程。

6. 发明申请

WO2017075086A1 ELECTRODE POSITIONING SYSTEM AND METHOD 审中-公开
标题翻译：电极定位系统和方法
公开(公告)号：WO2017075086A1
公开(公告)日：2017-05-04
申请号：PCT/US2016/058919
申请日：2016-10-26
申请人： HALO NEURO, INC.
发明人： WINGEIER, Brett , BAR-OR, Tal , DAVIS, Colin , HAMMETT, Victoria , CHAO, Daniel , MARTIN, Matty
IPC分类号： A61N1/04 , A61N1/20 , A61N1/36
CPC分类号： A61N1/0476 , A61B5/6803 , A61B5/6814 , A61N1/0456 , A61N1/0492 , A61N1/36025 , H04R5/033 , H04R5/0335 , H04R2460/13
摘要： A system and method for stimulating a user, the system comprising: a set of pads configured at head regions of the user; a band having a first end coupled to a first pad of the set of pads and a second end coupled to a second pad of the set of pads; a bridge coupled the band and to an electrode during use; and a set of links, each link coupled at a first region to an interior portion of its corresponding pad, and coupled at a second region to the bridge, having an elastic modulus above a threshold modulus such that: in a first mode, displacement of the set of pads produces displacement of the electrode away from the head region of the user, and in a second mode, release of the set of pads orients protrusions of the electrode approximately normal to the head region.
摘要翻译：一种用于激励用户的系统和方法，所述系统包括：配置在所述用户的头部区域的一组打击垫; 带，所述带具有耦合到所述一组焊盘中的第一焊盘的第一端和耦合到所述一组焊盘中的第二焊盘的第二端; 在使用期间将带耦合到电极的桥; 以及一组链节，每个链节在第一区域处耦合到其相应垫的内部部分，并且在第二区域处耦合到所述桥，具有高于阈值模量的弹性模量，使得：在第一模式中，该组垫产生远离使用者头部区域的电极位移，并且在第二模式中，释放该组垫使得电极的突起与头部区域近似垂直。

7. 发明申请

WO2017072706A1 TTFIELD TREATMENT WITH OPTIMIZATION OF ELECTRODE POSITIONS ON THE HEAD BASED ON MRI-BASED CONDUCTIVITY MEASUREMENTS 审中-公开
标题翻译：基于磁共振成像电导率测量的电极位置优化TTFIELD治疗
公开(公告)号：WO2017072706A1
公开(公告)日：2017-05-04
申请号：PCT/IB2016/056495
申请日：2016-10-28
申请人： BOMZON, Zeev
发明人： BOMZON, Zeev , WENGER, Cornelia , MIRANDA, Pedro Michael Cavaleiro , URMAN, Noa , KIRSON, Eilon , WASSERMAN, Yoram , PALTI, Yoram
IPC分类号： A61N1/40 , A61N2/00 , A61N1/08 , A61N1/36
CPC分类号： A61N1/0456 , A61B5/0042 , A61B5/053 , A61B5/055 , A61N1/0476 , A61N1/08 , A61N1/32 , A61N1/36002 , A61N1/36025 , A61N1/40 , G06F19/00 , G16H50/50
摘要： When electrodes are used to impose an electric field in target tissue within an anatomic volume (e.g., to apply TTFields to treat a tumor), the position of the electrodes can be optimized by obtaining electrical conductivity measurements in an anatomic volume and generating a 3D map of the conductivity directly from the obtained electrical conductivity or resistivity measurements, without segmenting the anatomic volume into tissue types. A location of the target tissue is identified within the anatomic volume, and the positions for the electrodes are determined based on the 3D map of electrical conductivity and the position of the target tissue.
摘要翻译：当电极用于在解剖体积内的目标组织中施加电场（例如，应用TTFields治疗肿瘤）时，电极的位置可以通过获得电导率测量值解剖体积并且直接根据所获得的电导率或电阻率测量生成电导率的3D图，而不将解剖体积分成组织类型。在解剖体积内识别目标组织的位置，并且基于电导率的3D图和目标组织的位置确定电极的位置。

8. 发明申请

WO2017040739A2 SYSTEMS, DEVICES AND METHODS FOR NEUROSTIMULATION HAVING A MODULATION OF PACKETS 审中-公开
标题翻译：用于包装调制的神经细胞的系统，装置和方法
公开(公告)号：WO2017040739A2
公开(公告)日：2017-03-09
申请号：PCT/US2016/049824
申请日：2016-09-01
申请人： SCION NEUROSTIM, LLC
发明人： BLACK, Robert D. , SMITH, Lanty L. , ROGERS, Lesco L.
IPC分类号： A61N1/36 , A61F7/12
CPC分类号： A61N1/36036 , A61B6/037 , A61F7/12 , A61F2007/0005 , A61F2007/0093 , A61F2007/126 , A61N1/0456 , A61N1/0484 , A61N1/0526 , A61N1/36021 , A61N1/36025
摘要： A method of neurostimulation may include delivering an electrical signal to a plurality of electrodes connected to a patient. The electrical signal may include a plurality of spaced-apart packets of electrical pulses. The method may include modulating at least one of a quantity of the plurality of electrical pulses within ones of the plurality of packets of electrical pulses, a width in time of the plurality of electrical pulses within ones of the plurality of packets of electrical pulses, an amplitude in voltage of the plurality of electrical pulses within ones of the plurality of packets of electrical pulses, a separation in time between adjacent ones of the plurality of electrical pulses within ones of the plurality of packets of electrical pulses, and a separation in time between adjacent ones of the plurality of packets of electrical pulses to modulate the electrical signal.
摘要翻译：神经刺激的方法可以包括将电信号递送到连接到患者的多个电极。电信号可以包括多个间隔开的电脉冲分组。该方法可以包括调制多个电脉冲分组中的多个电脉冲中的多个电脉冲中的至少一个，多个电脉冲分组中的多个电脉冲的时间宽度，在多个电脉冲分组中的多个电脉冲之间的多个电脉冲的电压幅度，多个电脉冲分组之间的多个电脉冲中的相邻电脉冲之间的时间间隔，以及多个电脉冲之间的时间间隔多个电脉冲分组中的相邻的电脉冲分组以调制电信号。

9. 发明申请

WO2016183337A2 DEVICES FOR THERAPEUTIC NASAL NEUROMODULATION AND ASSOCIATED METHODS AND SYSTEMS 审中-公开
标题翻译：用于治疗性NASAL神经调节和相关方法和系统的装置
公开(公告)号：WO2016183337A2
公开(公告)日：2016-11-17
申请号：PCT/US2016/032132
申请日：2016-05-12
申请人： NATIONAL UNIVERSITY OF IRELAND GALWAY , QI ZHAN, Michele
发明人： QI ZHAN, Michele , TOWNLEY, David , SHIELDS, Brian , KEOGH, Ivan , FARREL, Conor
IPC分类号： A61N1/32 , A61N1/18 , A61B18/00 , A61B18/02 , A61B18/18 , A61N1/36 , A61N1/05 , A61B18/04
CPC分类号： A61B18/24 , A61B17/00234 , A61B18/02 , A61B18/1492 , A61B18/1815 , A61B2017/003 , A61B2018/00029 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00327 , A61B2018/00434 , A61B2018/00577 , A61B2018/00702 , A61B2018/00797 , A61B2018/1467 , A61B2218/002 , A61F7/123 , A61F2007/0006 , A61F2007/0054 , A61N1/0546 , A61N1/18 , A61N1/32 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N1/40 , A61N5/022 , A61N7/00 , A61N2007/0021
摘要： Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.
摘要翻译：用于治疗性鼻神经调节的装置和相关系统和方法在本文中公开。根据本技术的实施例配置的用于治疗神经调节的系统可以包括例如在轴的远端部分处的轴和治疗元件。轴可以在远低于患者的蝶腭孔的靶位置处将远端部分定位。治疗元件可以包括能量递送元件，其被配置为在人类患者的腭骨的微孔中治疗性调节神经节后副交感神经，用于治疗鼻炎或其它适应症。在其它实施方案中，治疗元件可以被配置为治疗性调节神经，其支配正面，筛骨，蝶窦和上颌窦以治疗慢性鼻窦炎。

10. 发明申请

WO2016132215A1 SYSTEMS AND METHOD FOR DETECTING, DIAGNOSING, AND/OR TREATMENT OF DISORDERS AND CONDITIONS 审中-公开
标题翻译：用于检测，诊断和/或治疗疾病和病症的系统和方法
公开(公告)号：WO2016132215A1
公开(公告)日：2016-08-25
申请号：PCT/IB2016/000222
申请日：2016-02-19
申请人： MASDAR INSTITUTE OF SCIENCE AND TECHNOLOGY
发明人： YOO, Jerald , ALTAF, Muhammad , ZHANG, Chen
IPC分类号： A61B5/0476 , A61B5/0478 , A61B5/04
CPC分类号： A61B5/4094 , A61B5/0478 , A61B5/0531 , A61B5/6814 , A61B2560/0209 , A61B2562/164 , A61N1/36025 , A61N1/36064 , G06F19/00 , G16H50/20
摘要： A SoC includes an AFE to receive a plurality of differential input channels and generate digitized data corresponding to the channels, and a classification processor configured to receive the digitized data from the AFE. The AFE includes a Dual-Channel Chopper to perform channel multiplexing of two channels while simultaneously chopping the channels, a Dual Channel Charge Recycled-AFE having an Chopper-Stabilized Capacitive-Coupled IA including bias sampling capacitors that store bias values associated with the first and second channels to enable swapping between the channel, and a DC servo loop (DSL) having a reduced setting time based on a reduction in a resistance of the pseudo-PMOS in response to engaging a system reset. The classification processor includes a Frequency-Time Division Multiplexing (FTDM) Feature Extraction (FE) engine and a Dual-Detector Architecture (D 2 A) classification processor. The FTDM-FE includes a plurality of FIFOs configured to store, in parallel, the digitized data corresponding to the channels, a plurality of BPF banks storing BPF coefficients, and a single BPF to calculate outputs of one specific bank of the BFP banks for all of the channels. The D 2 A processor receives the output from the FTDM-FE and estimates a beginning and end of a seizure using two LSVMs optimized for only sensitivity and specificity, respectively.
摘要翻译： SoC包括AFE以接收多个差分输入通道并生成与通道相对应的数字化数据，以及分类处理器，被配置为从AFE接收数字化数据。 AFE包括双通道斩波器，用于在同时斩波通道的同时切断两个通道的信道复用，具有斩波稳定电容耦合IA的双通道充电回收AFE，其包括偏置采样电容器，其存储与第一和第二通道相关联的偏置值第二通道，用于能够响应于接合系统复位而基于模拟PMOS的电阻的降低，使得能够在通道之间进行交换和具有减小的设置时间的DC伺服环路（DSL）。分类处理器包括频分复用（FTDM）特征提取（FE）引擎和双检测器架构（D2A）分类处理器。 FTDM-FE包括多个FIFO，其被配置为并行存储对应于信道的数字化数据，存储BPF系数的多个BPF组和单个BPF，以计算所有BFP组的一个特定组的输出的渠道。 D2A处理器接收FTDM-FE的输出，并分别使用针对灵敏度和特异性优化的两个LSVM来估计癫痫发作的开始和结束。

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