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1. 发明申请

WO2017021909A1 NEUROMODULATION DEVICE 审中-公开
标题翻译：神经修复装置
公开(公告)号：WO2017021909A1
公开(公告)日：2017-02-09
申请号：PCT/IB2016/054687
申请日：2016-08-03
申请人： GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED , DUKE UNIVERSITY
发明人： FAMM, Hans Jakob Kristoffer , GRILL, Warren Murray , HOKANSON, James Arthur , LANGDALE, Christopher Lawrence , SRIDHAR, Arun
IPC分类号： A61N1/05 , A61N1/18 , A61N1/32 , A61N1/36 , A61N1/372
CPC分类号： A61N1/36007 , A61F7/00 , A61F7/10 , A61N1/36057 , A61N1/37211 , A61N5/0622 , A61N7/00 , A61N2007/0026
摘要： The present invention provides improved devices, systems and methods to provide for control of bladder function. Aspects of the present disclosure relate to an apparatus, system and/or a method for modulating the neural activity of afferent fibres of the pelvic nerve to bladder function. In one aspect, the disclosure relates to the use of pharmaceutical compositions in patients undergoing neuromodulation therapy.
摘要翻译：本发明提供改进的装置，系统和方法来提供膀胱功能的控制。本公开的方面涉及用于调节盆腔神经到传入膀胱功能的传入纤维的神经活动的装置，系统和/或方法。一方面，本公开涉及药物组合物在进行神经调节治疗的患者中的用途。

2. 发明申请

WO2016168485A1 AN IMPLANTABLE NEURO-STIMULATION DEVICE 审中-公开
标题翻译：可植入神经刺激装置
公开(公告)号：WO2016168485A1
公开(公告)日：2016-10-20
申请号：PCT/US2016/027570
申请日：2016-04-14
申请人： ROBINSON, David , MANTES, Ernest
发明人： ROBINSON, David , MANTES, Ernest
IPC分类号： A61N1/05 , A61L31/00 , A61L31/14
CPC分类号： A61N1/36071 , A61N1/0504 , A61N1/0526 , A61N1/0551 , A61N1/0556 , A61N1/0558 , A61N1/36057 , A61N1/36067 , A61N1/36082 , A61N1/36128 , A61N1/36139 , A61N1/36146 , A61N1/3615 , A61N1/36178
摘要： An implantable electrical stimulation device includes an electrically conductive electrode configured for coupling with a pulse generator device and transmitting an electrical signal configured to generate a desirable electric field around a target tissue, and a porous substrate constructed of a bio-compatible and bio-survivable material having a structure that mimics extracellular matrix embedding and supporting the electrically conductive electrode. The implantable device further includes a pulse generator also embedded, enmeshed, and supported within the porous substrate.
摘要翻译：可植入电刺激装置包括导电电极，所述导电电极被配置为与脉冲发生器装置耦合并且传输被配置为在靶组织周围产生期望电场的电信号，以及由生物相容性和生物可存活材料构成的多孔基底具有模拟细胞外基质嵌入并支撑导电电极的结构。该可植入装置还包括一个脉冲发生器，它还嵌入，嵌入并支撑在多孔基底内。

3. 发明申请

WO2016112398A1 PATIENT REMOTE AND ASSOCIATED METHODS OF USE WITH A NERVE STIMULATION SYSTEM 审中-公开
标题翻译：患者远程和相关的使用神经刺激系统的方法
公开(公告)号：WO2016112398A1
公开(公告)日：2016-07-14
申请号：PCT/US2016/012918
申请日：2016-01-11
申请人： AXONICS MODULATION TECHNOLOGIES, INC. , SCHROEDER, Dennis , SCHMID, Eric
发明人： SCHROEDER, Dennis , SCHMID, Eric , JIANG, Guangqiang , WOOCK, John
IPC分类号： A61N1/05 , A61N1/08 , A61N1/36
CPC分类号： A61N1/37247 , A61N1/36057 , A61N1/36128 , A61N1/36132 , A61N1/36142 , A61N1/36146 , A61N1/37211 , A61N1/37235 , A61N1/37241
摘要： A neurostimulation system having an external or an implantable pulse generator programmed to innervate a specific nerve or group of nerves in a patient through an electrode as a mode of treatment, having a patient remote that wirelessly communicates with the pulse generator to increase stimulation, decrease stimulation, and provide indications to a patient regarding the status of the neurostimulation system. The patient remote can allow for adjustment of stimulation power within a clinically effective range and for turning on and turning off the pulse generator. The patient remote and neurostimulation system can also store a stimulation level when the pulse generator is turned off and automatically restore the pulse generator to the stored stimulation level when the pulse generator is turned on.
摘要翻译：具有外部或可植入脉冲发生器的神经刺激系统，该外部或可植入脉冲发生器被编程为通过电极作为治疗方式通过电极来支配患者中的特定神经或神经组，患者远程与脉冲发生器无线通信以增加刺激，减少刺激并且向患者提供关于神经刺激系统的状态的指示。患者远程可以允许在临床有效范围内调整刺激功率，并且用于打开和关闭脉冲发生器。患者远程和神经刺激系统还可以在脉冲发生器关闭时存储刺激水平，并且当脉冲发生器接通时，将脉冲发生器自动恢复到存储的刺激水平。

4. 发明申请

WO2016094728A1 APPARATUS AND METHOD FOR TREATING HEADACHES 审中-公开
标题翻译：装置和治疗方法
公开(公告)号：WO2016094728A1
公开(公告)日：2016-06-16
申请号：PCT/US2015/065108
申请日：2015-12-10
申请人： SPR THERAPEUTICS, LLC
发明人： BOGGS, Joseph W., II , WONGSARNPIGOON, Amorn
IPC分类号： A61N1/00 , A61N1/05 , A61N1/36
CPC分类号： A61N1/0551 , A61N1/08 , A61N1/36017 , A61N1/36057 , A61N1/36075 , A61N1/36132
摘要： The present disclosure generally relates to a system for treating headaches and other pain associated with the occipital nerves. More particularly, the disclosure relates to a system of treating pain by selectively activating specific nerve fibers with a single, fault-resistant contact situated proximate to, but not in direct contact with, portions of one or more the occipital nerves. Additional measures ensure the lead does not migrate or fracture, resulting in long-lasting pain relief.
摘要翻译：本公开总体上涉及用于治疗与枕骨神经相关的头痛和其它疼痛的系统。更具体地说，本公开内容涉及一种通过选择性地激活特定神经纤维来治疗疼痛的系统，其具有位于一个或多个枕骨神经的部分附近而不是与其直接接触的单一的抗断层接触。额外的措施确保铅不会迁移或骨折，导致持久的疼痛缓解。

5. 发明申请

WO2016054559A1 SYSTEMS AND METHODS FOR NEUROSTIMULATION THERAPY 审中-公开
标题翻译：神经系统治疗的系统和方法
公开(公告)号：WO2016054559A1
公开(公告)日：2016-04-07
申请号：PCT/US2015/053807
申请日：2015-10-02
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： WANG, Jeffrey , SHERRY, John, Edward
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/0551 , A61N1/36007 , A61N1/36057 , A61N1/37247
摘要： The present disclosure pertains to methods, devices and systems for neurological regulation. The methods, devices and systems described herein are useful, for example, in the treatment of conditions of the bladder such as overactive bladder.
摘要翻译：本公开涉及用于神经调节的方法，装置和系统。本文描述的方法，装置和系统可用于例如膀胱状况的治疗，例如膀胱活动过度。

6. 发明申请

WO2016039768A1 NERVE CUFF ELECTRODE FOR NEUROMODULATION IN LARGE HUMAN NERVE TRUNKS 审中-公开
标题翻译： NERVE CUFF电极用于大型人类神经束神经修复
公开(公告)号：WO2016039768A1
公开(公告)日：2016-03-17
申请号：PCT/US2014/055374
申请日：2014-09-12
申请人： NEUROS MEDICAL, INC
发明人： FANG, Zi-Ping , SHAH, Nemath, Syed
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/36071 , A61N1/0556 , A61N1/0558 , A61N1/36057 , A61N1/361 , A61N1/36146 , A61N1/36153 , A61N1/36157 , A61N1/36171
摘要： A durable nerve cuff electrode for achieving block of an action potential in a large diameter nerve.
摘要翻译：一种持久的神经袖带电极，用于在大直径神经中实现阻滞动作电位。

7. 发明申请

WO2014172398A1 METHOD AND APPARATUS FOR PERCUTANEOUS EPICARDIAL ABLATION OF CARDIAC GANGLIONATED PLEXI WITHOUT MYOCARDIAL INJURY 审中-公开
标题翻译：无心肌损伤的心脏复发性麻痹患者的腰椎间盘突出症的方法与装置
公开(公告)号：WO2014172398A1
公开(公告)日：2014-10-23
申请号：PCT/US2014/034255
申请日：2014-04-15
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： ASIRVATHAM, Samuel, J. , KNUDSON, Mark, B.
IPC分类号： A61B18/12 , A61N1/39 , A61N1/04
CPC分类号： A61B18/1492 , A61B2018/00363 , A61B2018/00577 , A61B2018/00642 , A61B2018/0212 , A61B2018/1266 , A61B2018/1472 , A61N1/0551 , A61N1/20 , A61N1/36057
摘要： A method and device for modulating the autonomic nervous system adjacent a pericardial space to treat cardiac arrhythmia includes a treatment source arranged to supply a treatment medium, a catheter having an end sized for insertion into the pericardial space, a medium delivery assembly having a distal end arranged to be positioned by the catheter into the pericardium, with the distal end of the delivery assembly comprising a delivery tip arranged to extend away from the distal end of the catheter into the pericardial space. A connector operatively couples the delivery tip of the medium delivery assembly to the treatment source, and the delivery tip of the medium delivery assembly including a plurality of delivery points for delivering the treatment medium at a plurality of treatment areas within the pericardial space. The device performs modulation or ablation of the autonomic nervous system at selected treatment areas within the pericardium.
摘要翻译：用于调节邻近心包空间以治疗心律失常的自主神经系统的方法和装置包括：设置成供应治疗介质的治疗源，具有尺寸用于插入心包空间的端部的导管，具有远端的介质递送组件布置成由导管定位成心包，其中输送组件的远端包括布置成远离导管的远端延伸到心包空间中的输送尖端。连接器将介质输送组件的输送末端可操作地连接到治疗源，并且介质递送组件的输送末端包括用于在心包空间内的多个治疗区域处递送治疗介质的多个递送点。该装置在心包内的选定治疗区域进行自主神经系统的调制或消融。

8. 发明申请

WO2014153219A1 DEVICES AND METHODS FOR TREATING UROLOGICAL DISORDERS 审中-公开
标题翻译：用于治疗尿路疾病的装置和方法
公开(公告)号：WO2014153219A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/029683
申请日：2014-03-14
申请人： PERRYMAN, Laura Tyler , ANDRESEN, Chad
发明人： PERRYMAN, Laura Tyler , ANDRESEN, Chad
IPC分类号： A61N1/04 , A61N1/05 , A61N1/08 , A61N1/18 , A61N1/32 , A61N1/36 , A61N1/40 , A61N1/372
CPC分类号： A61N1/37205 , A61N1/36007 , A61N1/36057 , A61N1/3756 , A61N1/3787
摘要： Some implementations provide a method for treating urological disorders in a patient, the method including: placing an introducer into a patient's body through an incision site on the patient's body, the patient suffering from an urological disorder; placing an implantable wireless device into an inner lumen of the introducer, the implantable wireless device suitable to fit into the inner lumen and configured to receive electromagnetic energy non-inductively from a source located outside the patient's body; through the inner lumen of the introducer, positioning the implantable wireless device adjacent to or near one or more excitable tissue in the patient, the one or more excitable tissue regulating a nerve activity associated with the urological disorder; and causing neural modulation of the one or more excitable tissue through one or more electrodes on the implantable wireless device.
摘要翻译：一些实施方案提供了一种用于治疗患者泌尿系统疾病的方法，所述方法包括：通过患者身体的切口部位，患有泌尿系统疾病的患者将导入者放置到患者体内; 将可植入无线设备放置在导引器的内腔中，所述可植入无线设备适于装配到内腔中，并且被配置为从位于患者身体外部的源非感应地接收电磁能; 通过引导器的内腔将可植入无线装置定位在患者体内邻近或靠近一个或多个可兴奋的组织，所述一个或多个可兴奋组织调节与泌尿系疾病相关的神经活动; 并且通过所述可植入无线设备上的一个或多个电极引起所述一个或多个可兴奋组织的神经调制。

9. 发明申请

WO2014150553A1 METHODS AND APPARATUSES FOR REMODELING TISSUE OF OR ADJACENT TO A BODY PASSAGE 审中-公开
标题翻译：用于重组组织或与身体呼吸相关的方法和装置
公开(公告)号：WO2014150553A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/023586
申请日：2014-03-11
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： DANDLER, Andres , MATHUR, Prabodh
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B5/4064 , A61B5/6853 , A61B2018/0016 , A61B2018/0022 , A61B2018/00434 , A61B2018/00577 , A61B2018/00815 , A61B2018/00839 , A61B2090/3966 , A61B2562/12 , A61M25/10 , A61N1/0551 , A61N1/36057 , A61N1/3606
摘要： Medical devices and methods for making and using the same are disclosed. An medical device may include a medical device for renal nerve ablation. The medical device may include a catheter shaft having a distal region. An expandable balloon may be coupled to the distal region. An electrode assembly may be coupled to the balloon. The electrode assembly may include a first electrode pad including one or more electrodes. The first electrode pad may have a first lead-in edge, a first protruding edge, and a first transition region with a continuously changing curvature disposed between the first lead-in edge and the first protruding edge.
摘要翻译：公开了用于制造和使用它们的医疗装置和方法。医疗装置可以包括用于肾神经消融的医疗装置。医疗装置可以包括具有远端区域的导管轴。可扩张气囊可以联接到远端区域。电极组件可以联接到气囊。电极组件可以包括包括一个或多个电极的第一电极焊盘。第一电极焊盘可以具有设置在第一引入边缘和第一突出边缘之间的第一引入边缘，第一突出边缘和连续变化曲率的第一过渡区域。

10. 发明申请

WO2014089392A1 MINIMALLY INVASIVE IMPLANTABLE NEUROSTIMULATION SYSTEM 审中-公开
标题翻译：微型可入侵神经系统
公开(公告)号：WO2014089392A1
公开(公告)日：2014-06-12
申请号：PCT/US2013/073487
申请日：2013-12-06
申请人： MEDTRONIC, INC.
发明人： SCOTT, Erik R. , KAST, John E. , WEI, Xuan K. , SMITH, Todd V. , ANDERSON, Joel A. , PAPE, Forrest C.M. , BOURGET, Duane L. , DENISON, Timothy J. , DINSMOOR, David A. , ROLES, Randy S. , RODDY, Stephen J.
IPC分类号： A61N1/36 , A61N1/378 , A61N1/372
CPC分类号： A61B17/00234 , A61N1/02 , A61N1/05 , A61N1/0551 , A61N1/36 , A61N1/36007 , A61N1/36021 , A61N1/3605 , A61N1/36053 , A61N1/36057 , A61N1/36067 , A61N1/36071 , A61N1/36139 , A61N1/37205 , A61N1/37211 , A61N1/37223 , A61N1/37235 , A61N1/37247 , A61N1/37252 , A61N1/3727 , A61N1/375 , A61N1/3754 , A61N1/3756 , A61N1/3787 , F04C2270/0421
摘要： An external medical device generates a drive signal inductively coupled to an implantable coil from an external coil. A regulator module coupled to the implantable coil generates an output signal in response to the inductively coupled signal and a feedback signal correlated to an amplitude of the inductively coupled signal. A signal generator receives the output signal for generating a therapeutic electrical stimulation signal. The control module adjusts the drive signal in response to the feedback signal to control the electrical stimulation signal.
摘要翻译：外部医疗装置从外部线圈产生感应耦合到可植入线圈的驱动信号。耦合到可植入线圈的调节器模块响应于电感耦合信号和与电感耦合信号的振幅相关的反馈信号产生输出信号。信号发生器接收用于产生治疗性电刺激信号的输出信号。控制模块响应于反馈信号来调节驱动信号以控制电刺激信号。

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