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1. 发明申请

WO2006044840A3 SOLUBLE ZCYTOR21, ANTI-ZCYTOR21 ANTIBODIES AND BINDING PARTNERS AND METHODS OF USING IN INFLAMMATION 审中-公开
公开(公告)号：WO2006044840A3
公开(公告)日：2006-04-27
申请号：PCT/US2005/037332
申请日：2005-10-18
申请人： ZYMOGENETICS, INC. , GAO, Zeren , KUESTNER, Rolf, E. , APPLEBY, Mark, W. , LEWIS, Katherine, E. , MCKERNAN, Patricia, A. , OKADA, Shannon, L. , TAFT, David, W. , KUIJPER, Joseph, L. , JASPERS, Stephen, R. , LEVIN, Steven, D.
发明人： GAO, Zeren , KUESTNER, Rolf, E. , APPLEBY, Mark, W. , LEWIS, Katherine, E. , MCKERNAN, Patricia, A. , OKADA, Shannon, L. , TAFT, David, W. , KUIJPER, Joseph, L. , JASPERS, Stephen, R. , LEVIN, Steven, D.
IPC分类号： C07K14/715
摘要： The present invention relates ZcytoR21 antagonists, such as soluble receptors and anti-ZcytoR21 antibodies, that are useful in blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17C. IL-17C is a cytokine that is involved in inflammatory processes and human disease. ZcytoR21 is a receptor for IL-17C. The present invention includes soluble ZcytoR21, anti-ZcytoR21 antibodies and binding partners, as well as methods for antagonizing IL-17C using such soluble receptors, antibodies and binding partners.

2. 发明申请

WO2007047738A1 IL-17C ANTAGONISTS AND METHODS OF USING THE SAME 审中-公开
标题翻译： IL-17C拮抗剂及其使用方法
公开(公告)号：WO2007047738A1
公开(公告)日：2007-04-26
申请号：PCT/US2006/040663
申请日：2006-10-18
申请人： ZYMOGENETICS, INC. , GAO, Zeren, , KUESTNER, Rolf, E. , APPLEBY, Mark, W. , LEWIS, Katherine, E. , MCKERNAN, Patricia, A. , OKADA, Shannon, L. , TAFT, David, W. , KUIJPER, Joseph, L. , JASPERS, Stephen, R. , LEVIN, Steven, D.
发明人： GAO, Zeren, , KUESTNER, Rolf, E. , APPLEBY, Mark, W. , LEWIS, Katherine, E. , MCKERNAN, Patricia, A. , OKADA, Shannon, L. , TAFT, David, W. , KUIJPER, Joseph, L. , JASPERS, Stephen, R. , LEVIN, Steven, D.
IPC分类号： C07K14/715 , C12N15/62 , C12N15/12 , A61K38/17
CPC分类号： C07K14/7155 , A61K38/00 , C07K2319/20 , C07K2319/21 , C07K2319/30
摘要： The present invention relates IL-17RE antagonists, such as soluble receptors and anti-IL-17RE antibodies, that are useful in blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17C. IL-17C is a cytokine that is involved in inflammatory processes and human disease. IL-17RE is a receptor for IL-17C. The present invention includes soluble IL-17RE, anti-IL-17RE antibodies and binding partners, as well as methods for antagonizing IL-17C using such soluble receptors, antibodies and binding partners.
摘要翻译：本发明涉及可用于阻断，抑制，降低，拮抗或中和IL-17C活性的IL-17RE拮抗剂，例如可溶性受体和抗IL-17RE抗体。 IL-17C是涉及炎症过程和人类疾病的细胞因子。 IL-17RE是IL-17C的受体。本发明包括可溶性IL-17RE，抗IL-17RE抗体和结合配偶体，以及使用这种可溶性受体，抗体和结合配偶体拮抗IL-17C的方法。

3. 发明申请

WO2004033645A2 METHODS OF REGULATING BODY WEIGHT 审中-公开
标题翻译：调节身体重量的方法
公开(公告)号：WO2004033645A2
公开(公告)日：2004-04-22
申请号：PCT/US2003/031804
申请日：2003-10-06
申请人： ZYMOGENETICS, INC.
发明人： JASPERS, Stephen, R. , SHEPPARD, Paul, O. , BISHOP, Paul, D. , KUIJPER, Joseph, L. , DEISHER, Theresa, A.
IPC分类号： C12N
CPC分类号： C07K14/72 , A61K38/00 , A61K47/6811 , C07K14/575 , C07K14/63 , C07K16/18
摘要： The present invention relates to a method of regulating body weight, body mass, fat depositions, and circulating glucose levels, by antagonizing zsig33 peptide by binding it with an antibody.
摘要翻译：本发明涉及通过将zsig33肽与抗体结合来拮抗zsig33肽来调节体重，体重，脂肪沉积和循环葡萄糖水平的方法。

4. 发明申请

WO2003060090A3 NOVEL CYTOKINE ZCYTOR17 LIGAND 审中-公开
公开(公告)号：WO2003060090A3
公开(公告)日：2003-07-24
申请号：PCT/US2003/001984
申请日：2003-01-21
申请人： ZYMOGENETICS, INC.
发明人： SPRECHER, Cindy, A. , KUIJPER, Joseph, L. , DASOVICH, Maria, M. , GRANT, Francis, J. , HAMMOND, Angela, K. , NOVAK, Julia, E. , GROSS, Jane, A. , DILLON, Stacey, R.
IPC分类号： C12N5/10
摘要： The present invention relates to zcytor171ig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor171ig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo . The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

5. 发明申请

WO2004003140A2 CYTOKINE RECEPTOR ZCYTOR17 MULTIMERS 审中-公开
标题翻译：细胞因子受体ZCYTOR17 MULTIMERS
公开(公告)号：WO2004003140A2
公开(公告)日：2004-01-08
申请号：PCT/US2003/001983
申请日：2003-01-21
申请人： ZYMOGENETICS, INC.
发明人： SPRECHER, Cindy, A. , GAO, Zeren , KUIJPER, Joseph, L. , DASOVICH, Maria, M. , GRANT, Francis, J. , PRESNELL, Scott, R. , WHITMORE, Theodore, E. , HAMMOND, Angela, K. , NOVAK, Julia, E. , GROSS, Jane, A. , DILLON, Stacey, R.
IPC分类号： C12N
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
摘要翻译：公开了新的多肽组合，编码多肽的多核苷酸，以及相关的组合物和方法，用于含有Zcytor17的多聚体或异二聚体细胞因子受体，其可用作新的细胞因子拮抗剂，以及用于检测刺激造血细胞增殖和/或发育的配体的方法，淋巴和骨髓细胞体外和体内。本发明还包括用于产生多聚体或异二聚体细胞因子受体的方法，其用途及其抗体。

6. 发明申请

WO1994005789A1 GLUCAGON RECEPTORS 审中-公开
标题翻译： GLUCAGON受体
公开(公告)号：WO1994005789A1
公开(公告)日：1994-03-17
申请号：PCT/US1993008174
申请日：1993-08-30
申请人： ZYMOGENETICS, INC.
发明人： ZYMOGENETICS, INC. , KINDSVOGLE, Wayne, R. , JELINEK, Laura, J. , SHEPPARD, Paul, O. , GRANT, Francis, J. , KUIJPER, Joseph, L. , FOSTER, Donald, C. , LOK, Si , O'HARA, Patrick, J.
IPC分类号： C12N15/12
CPC分类号： C07K14/723 , A61K38/00 , C07K14/72 , C07K2319/00 , C07K2319/02 , C12Q1/66 , G01N33/74 , G01N2333/605 , G01N2333/72
摘要： The present invention provides isolated DNA molecules comprising a DNA segment encoding a glucagon receptor. Also provided are DNA constructs comprising a first DNA segment encoding a glucagon receptor operably linked to additional DNA segments required for the expression of the first DNA segment, as well as host cells containing such DNA constructs. The present invention also provides amethod for detecting the presence of glucagon antagonists, comprising the steps of (a) exposing a compound in the presence of a glucagon agonist to a recombinant glucagon receptor coupled to a response pathway under conditions and for time sufficient to allow binding of the compound to the receptor and an associated response through the pathway, and (b) detecting a reduction in the stimulation of the response pathway resulting from the binding of the compound to the glucagon receptor, relative to the stimulation of the response pathway by the glucagon agonist alone and therefrom determining the presence of a glucagon antagonist.
摘要翻译：本发明提供了分离的DNA分子，其包含编码胰高血糖素受体的DNA区段。还提供了DNA构建体，其包含编码与第一DNA片段表达所需的另外DNA片段可操作地连接的胰高血糖素受体的第一DNA片段，以及含有该DNA构建体的宿主细胞。本发明还提供了检测胰高血糖素拮抗剂的存在的方法，其包括以下步骤：（a）在有足够的条件和足以允许结合的时间内将化合物在胰高血糖素激动剂存在下暴露于与响应途径偶联的重组胰高血糖素受体化合物与受体的相关反应和通过该途径的相关应答，以及（b）检测由化合物与胰高血糖素受体的结合产生的反应途径的刺激相对于由胰高血糖素激动剂单独和由此决定胰高血糖素拮抗剂的存在。

7. 发明申请

WO2003060090A2 NOVEL CYTOKINE ZCYTOR17 LIGAND 审中-公开
标题翻译：新奇的CYTOKINE ZCYTOR17 LIGAND
公开(公告)号：WO2003060090A2
公开(公告)日：2003-07-24
申请号：PCT/US2003/001984
申请日：2003-01-21
申请人： ZYMOGENETICS, INC.
发明人： SPRECHER, Cindy, A. , KUIJPER, Joseph, L. , DASOVICH, Maria, M. , GRANT, Francis, J. , HAMMOND, Angela, K. , NOVAK, Julia, E. , GROSS, Jane, A. , DILLON, Stacey, R.
IPC分类号： C12N
CPC分类号： C07K16/24 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K14/52 , C07K2317/24
摘要： The present invention relates to zcytor171ig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor171ig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译：本发明涉及zcytor171ig多核苷酸，多肽和抗zcytor17抗体分子。 zcytor171ig是一种新型细胞因子。多肽可用于刺激免疫系统的方法，体外和体内造血细胞的增殖和/或发育。本发明还包括生产蛋白质的方法，用途及其抗体。

8. 发明申请

WO2002000721A8 CYTOKINE RECEPTOR ZCYTOR17 审中-公开
公开(公告)号：WO2002000721A8
公开(公告)日：2002-01-03
申请号：PCT/US2001/020484
申请日：2001-06-26
申请人： ZYMOGENETICS, INC.
发明人： SPRECHER, Cindy, A. , PRESNELL, Scott, R. , GAO, Zeren , WHITMORE, Theodore, E. , KUIJPER, Joseph, L. , MAURER, Mark, F.
IPC分类号： C07K14/715
摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo . Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo . The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

9. 发明申请

WO1997039767A1 METHODS FOR INDUCING BONE FORMATION 审中-公开
标题翻译：诱导骨形成的方法
公开(公告)号：WO1997039767A1
公开(公告)日：1997-10-30
申请号：PCT/US1997006892
申请日：1997-04-18
申请人： ZYMOGENETICS, INC. , UNIVERSITY OF WASHINGTON
发明人： ZYMOGENETICS, INC. , UNIVERSITY OF WASHINGTON , DURNAM, Diane, M. , KUIJPER, Joseph, L. , WEIGLE, David, S. , LIU, Chung, C.
IPC分类号： A61K38/22
CPC分类号： C12N5/0654 , A61K35/12 , A61K38/2264 , C12N2501/355 , C12N2502/076
摘要： Methods for inducing bone formation using ob protein are disclosed. The methods can be used for treating osteoporosis, repairing fractures, dental defects, resectioning due to oncogenesis and elongation of the growth plate/long bone. In addition, the methods can be used for ex vivo therapy and reinfused into a mammal.
摘要翻译：公开了使用ob蛋白诱导骨形成的方法。该方法可用于治疗骨质疏松症，修复骨折，牙齿缺损，由于肿瘤发生和生长板/长骨伸长引起的切除。此外，该方法可用于离体治疗并再灌注到哺乳动物中。

10. 发明申请

WO1995021920A1 HEMATOPOIETIC PROTEIN AND MATERIALS AND METHODS FOR MAKING IT 审中-公开
标题翻译： HEMATOPOIETIC蛋白质及其制备方法
公开(公告)号：WO1995021920A1
公开(公告)日：1995-08-17
申请号：PCT/US1994008806
申请日：1994-08-05
申请人： ZYMOGENETICS, INC. , UNIVERSITY OF WASHINGTON
发明人： ZYMOGENETICS, INC. , UNIVERSITY OF WASHINGTON , HOLLY, Richard, D. , LOK, Si , FOSTER, Donald, C. , HAGEN, Frederick, S. , KAUSHANSKY, Kenneth , KUIJPER, Joseph, L. , LOFTON-DAY, Catherine , OORT, Pieter, J. , BURKHEAD, Steven, K.
IPC分类号： C12N15/19
CPC分类号： G01N33/5055 , A61K38/196 , C07K14/705 , C07K14/715 , C12N5/0642 , C12N2501/145 , C12N2501/22 , G01N33/5005 , G01N33/5008 , G01N33/5088 , G01N33/5094
摘要： Hematopoietic proteins and polypeptide fragments thereof are provided, including proteins and polypeptides from mice and humans. Also provided are DNA molecules encoding the proteins and polypeptides, as well as vectors and cells useful in their production. Antibodies that bind to an epitope on the proteins are also provided. The proteins and polypeptides are useful for in vivo and ex vivo therapy, and as reagents for cell culture and investigation of cell proliferation and development.
摘要翻译：提供了造血蛋白及其多肽片段，包括来自小鼠和人的蛋白质和多肽。还提供了编码蛋白质和多肽的DNA分子，以及可用于其生产的载体和细胞。还提供了与蛋白质上的表位结合的抗体。蛋白质和多肽可用于体内和离体治疗，以及作为细胞培养和细胞增殖和发育调查的试剂。

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