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1. 发明申请

WO1997039767A1 METHODS FOR INDUCING BONE FORMATION 审中-公开
标题翻译：诱导骨形成的方法
公开(公告)号：WO1997039767A1
公开(公告)日：1997-10-30
申请号：PCT/US1997006892
申请日：1997-04-18
申请人： ZYMOGENETICS, INC. , UNIVERSITY OF WASHINGTON
发明人： ZYMOGENETICS, INC. , UNIVERSITY OF WASHINGTON , DURNAM, Diane, M. , KUIJPER, Joseph, L. , WEIGLE, David, S. , LIU, Chung, C.
IPC分类号： A61K38/22
CPC分类号： C12N5/0654 , A61K35/12 , A61K38/2264 , C12N2501/355 , C12N2502/076
摘要： Methods for inducing bone formation using ob protein are disclosed. The methods can be used for treating osteoporosis, repairing fractures, dental defects, resectioning due to oncogenesis and elongation of the growth plate/long bone. In addition, the methods can be used for ex vivo therapy and reinfused into a mammal.
摘要翻译：公开了使用ob蛋白诱导骨形成的方法。该方法可用于治疗骨质疏松症，修复骨折，牙齿缺损，由于肿瘤发生和生长板/长骨伸长引起的切除。此外，该方法可用于离体治疗并再灌注到哺乳动物中。

2. 发明申请

WO1997027286A1 METHODS FOR USING THE OBESE GENE AND ITS GENE PRODUCT TO STIMULATE HEMATOPOIETIC DEVELOPMENT 审中-公开
标题翻译：使用OBESE基因及其基因产物刺激致病性发展的方法
公开(公告)号：WO1997027286A1
公开(公告)日：1997-07-31
申请号：PCT/US1997000767
申请日：1997-01-21
申请人： PROGENITOR, INC.
发明人： PROGENITOR, INC. , SNODGRASS, H., Ralph , CIOFFI, Joseph , ZUPANCIC, Thomas, J. , SHAFER, Alan, W. , MIKHAIL, Adel, A. , BARUT, Bruce, A.
IPC分类号： C12N05/00
CPC分类号： C12N5/0645 , A61K38/2264 , A61K48/00 , C07K14/5759 , C07K14/715 , C12N5/0641 , C12N5/0647 , C12N2501/125 , C12N2501/14 , C12N2501/355 , C12N2506/02
摘要： The present invention relates to the expression of various forms of a novel receptor in hematopoietic and endothelial cells. A variant form of this receptor has been detected in brain cells and shown to bind to the obese gene product, leptin. In particular, the present invention relates to methods of using leptin to stimulate the growth and development of receptor-positive hematopoietic and endothelial cells in vitro and in vivo. In addition, this receptor is selectively expressed in hematopoietic progenitor cells with long-term repopulating potential. Thus, agents that specifically bind to this receptor may be used to identify and isolate progenitor cells for a variety of clinical applications.
摘要翻译：本发明涉及造血和内皮细胞中各种形式的新型受体的表达。已经在脑细胞中检测到该受体的变体形式，并显示其结合肥胖基因产物瘦蛋白。特别地，本发明涉及在体外和体内使用瘦素刺激受体阳性造血和内皮细胞的生长和发育的方法。此外，该受体在具有长期复制潜力的造血祖细胞中选择性表达。因此，特异性结合该受体的药剂可用于鉴定和分离各种临床应用的祖细胞。

3. 发明申请

WO2004011621A2 MULTI-STEP METHOD FOR THE DIFFERENTIATION OF INSULIN POSITIVE, GLUCOSE 审中-公开
标题翻译：多步法分化胰岛素阳性，葡萄糖
公开(公告)号：WO2004011621A2
公开(公告)日：2004-02-05
申请号：PCT/US2003/023852
申请日：2003-07-29
申请人： ES CELL INTERNATIONAL PTE LTD. , CLARKE, Diana , D'ALESSANDRO, Josephine, S. , LU, Kuanghui , WANG, Anlai
发明人： CLARKE, Diana , D'ALESSANDRO, Josephine, S. , LU, Kuanghui , WANG, Anlai
IPC分类号： C12N
CPC分类号： C12N5/0678 , A61K35/12 , C12N2500/34 , C12N2500/38 , C12N2500/60 , C12N2501/01 , C12N2501/119 , C12N2501/12 , C12N2501/16 , C12N2501/175 , C12N2501/33 , C12N2501/335 , C12N2501/355 , C12N2501/39 , C12N2501/41 , C12N2501/835 , C12N2501/91 , Y02A50/471
摘要： The present invention provides improved methods of differentiating insulin+, glucose responsive islet-like structures from insulin- cells. The invention further provides methods for using insulin+, glucose responsive islet-like structures, as well as the insulin+, glucose responsive cells which comprise said islet-like clusters.
摘要翻译：本发明提供了从胰岛素细胞分化胰岛素+，葡萄糖响应性胰岛样结构的改进方法。本发明进一步提供了使用胰岛素+，葡萄糖响应性胰岛样结构以及包含所述胰岛样簇的胰岛素+葡萄糖响应细胞的方法。

4. 发明申请

WO2008056963A1 METHOD FOR PROLIFERATING STEM CELLS WITH LEPTIN 审中-公开
标题翻译：用LEPTIN促进干细胞的方法
公开(公告)号：WO2008056963A1
公开(公告)日：2008-05-15
申请号：PCT/KR2007/005670
申请日：2007-11-12
申请人： MOON, CHANIL , YANG, Hyunwon
发明人： MOON, CHANIL , YANG, Hyunwon
IPC分类号： C12N5/06
CPC分类号： C12N5/0647 , C12N2501/355
摘要： Disclosed is a method for proliferating stem cells. The presence of leptin in a cell culture medium allows various bone marrow- or blood-derived stem cells to proliferate to a great extent without increasing in the number of subcultures. Thus, the method can reduce the time period needed to reach a predetermined amount of cells, producing economic benefits. Also, stem cells can be stably proliferated using the method, without being modified.
摘要翻译：公开了一种增殖干细胞的方法。瘦素在细胞培养基中的存在允许各种骨髓或血液来源的干细胞在很大程度上增殖，而不增加传代培养的数量。因此，该方法可以减少达到预定量的细胞所需的时间，从而产生经济效益。此外，干细胞可以使用该方法稳定增殖，而不被改变。

5. 发明申请

WO1998018486A1 USE OF LEPTIN TO STIMULATE HEMATOPOIESIS 审中-公开
标题翻译：使用LEPTIN刺激HEMATOPOIESIS
公开(公告)号：WO1998018486A1
公开(公告)日：1998-05-07
申请号：PCT/US1997018875
申请日：1997-10-24
申请人： ICOGEN CORPORATION , SEATTLE BIOMEDICAL RESEARCH INSTITUTE
发明人： ICOGEN CORPORATION , SEATTLE BIOMEDICAL RESEARCH INSTITUTE , RAO, Donald, D. , SITNICKA, Ewa , BARTELMEZ, Stephen, H. , HAGEN, Frederick, S.
IPC分类号： A61K39/00
CPC分类号： A61K38/2264 , C07K14/72 , C12N5/0647 , C12N2501/125 , C12N2501/23 , C12N2501/355 , C12N2501/39
摘要： Hematopoietic precursor cell numbers are increased by exposing the cells to leptin. The hematopoietic precursor cells, such as stem cells or progenitor cells of a lin-/c-kit+ fraction, can be separated from mature hematopoietic cells present in a blood product, such as bone marrow, prior to exposure to leptin. The number of hematopoietic stem cells in vitro can also be maintained by exposure to leptin, and primitive hematopoietic stem cells can be sustained in vitro without substantial proliferation or differentiation. Also, the IL-3 mediated stimulation of hematopoietic cells can be inhibited by treatment with leptin. A composition containing leptin is used to sustain or expand the number of hematopoietic precursor cells. These methods and compositions can be used to support the survival of stem cells during collection and processing, to mobilize stem cells to peripheral circulation, to expand progenitors in vitro, to improve bone marrow transplantation, and to increase the efficiency of gene therapy which is targeted to long term repopulating hematopoietic stem cell (LTR-HSC) populations.
摘要翻译：通过将细胞暴露于瘦素来增加造血前体细胞数目。在暴露于瘦素之前，造血前体细胞，例如lin-c-kit +级分的干细胞或祖细胞可以与存在于血液制品如骨髓中的成熟造血细胞分离。体外造血干细胞的数量也可以通过暴露于瘦素来维持，并且原始造血干细胞可以在体外维持而没有显着的增殖或分化。此外，IL-3介导的造血细胞刺激可以通过用瘦蛋白治疗来抑制。使用含有瘦蛋白的组合物来维持或扩大造血前体细胞的数量。这些方法和组合物可用于支持收集和处理期间干细胞的存活，将干细胞移动到外周循环，在体外扩增祖细胞，以改善骨髓移植，并提高靶向的基因治疗效率到长期重建造血干细胞（LTR-HSC）群体。

6. 发明申请

WO2016016386A1 TRANSDIFFERENTIATED TISSUE GRAFT 审中-公开
标题翻译：透析组织切片
公开(公告)号：WO2016016386A1
公开(公告)日：2016-02-04
申请号：PCT/EP2015/067546
申请日：2015-07-30
申请人： EDER, Claudia , OGON, Michael
发明人： EDER, Claudia , OGON, Michael
IPC分类号： A61L27/38 , C12N5/077 , C12N5/0793
CPC分类号： A61L27/3895 , A61L27/3645 , A61L27/3843 , A61L27/3886 , A61L2430/06 , A61L2430/38 , C12N5/0619 , C12N5/0654 , C12N5/0655 , C12N2500/25 , C12N2500/38 , C12N2500/42 , C12N2501/15 , C12N2501/355 , C12N2501/39 , C12N2506/13 , C12N2506/1384
摘要： The invention provides a method of producing a connective tissue graft suitable for correcting a connective tissue defect, comprising determining the size and shape of a tissue defect, obtaining a fat tissue from a patient modelled to fit the size and shape of the tissue defect, contacting the fat tissue with one or more connective tissue specific growth or differentiation factors; and kits for such a method.
摘要翻译：本发明提供一种生产适合于校正结缔组织缺损的结缔组织移植物的方法，包括确定组织缺损的大小和形状，从被建模以适应组织缺损的大小和形状的患者获得脂肪组织，接触具有一种或多种结缔组织特异性生长或分化因子的脂肪组织; 和用于这种方法的试剂盒。

7. 发明申请

WO2004011621A3 MULTI-STEP METHOD FOR THE DIFFERENTIATION OF INSULIN POSITIVE, GLUCOSE 审中-公开
标题翻译：用于胰岛素阳性，葡萄糖分化的多步法
公开(公告)号：WO2004011621A3
公开(公告)日：2004-07-08
申请号：PCT/US0323852
申请日：2003-07-29
申请人： ES CELL INT PTE LTD , CLARKE DIANA , D ALESSANDRO JOSEPHINE S , LU KUANGHUI , WANG ANLAI
发明人： CLARKE DIANA , D ALESSANDRO JOSEPHINE S , LU KUANGHUI , WANG ANLAI
IPC分类号： A61K35/12 , A61K35/14 , A61K35/22 , A61K35/23 , A61K35/28 , A61K35/30 , A61K35/32 , A61K35/34 , A61K35/36 , A61K35/37 , A61K35/38 , A61K35/407 , A61K35/42 , A61K35/54 , A61P1/18 , A61P3/10 , C12N5/074 , C12N5/00 , C12N5/08 , C12N5/16
CPC分类号： C12N5/0678 , A61K35/12 , C12N2500/34 , C12N2500/38 , C12N2500/60 , C12N2501/01 , C12N2501/119 , C12N2501/12 , C12N2501/16 , C12N2501/175 , C12N2501/33 , C12N2501/335 , C12N2501/355 , C12N2501/39 , C12N2501/41 , C12N2501/835 , C12N2501/91
摘要： The present invention provides improved methods of differentiating insulin+, glucose responsive islet-like structures from insulin- cells. The invention further provides methods for using insulin+, glucose responsive islet-like structures, as well as the insulin+, glucose responsive cells which comprise said islet-like clusters.
摘要翻译：本发明提供了从胰岛素 - 细胞分化胰岛素+，葡萄糖反应性胰岛样结构的改进方法。本发明还提供了使用胰岛素+，葡萄糖反应性胰岛样结构以及包含所述胰岛样簇的胰岛素+葡萄糖应答细胞的方法。

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