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1. 发明申请

WO1995021920A1 HEMATOPOIETIC PROTEIN AND MATERIALS AND METHODS FOR MAKING IT 审中-公开
标题翻译： HEMATOPOIETIC蛋白质及其制备方法
公开(公告)号：WO1995021920A1
公开(公告)日：1995-08-17
申请号：PCT/US1994008806
申请日：1994-08-05
申请人： ZYMOGENETICS, INC. , UNIVERSITY OF WASHINGTON
发明人： ZYMOGENETICS, INC. , UNIVERSITY OF WASHINGTON , HOLLY, Richard, D. , LOK, Si , FOSTER, Donald, C. , HAGEN, Frederick, S. , KAUSHANSKY, Kenneth , KUIJPER, Joseph, L. , LOFTON-DAY, Catherine , OORT, Pieter, J. , BURKHEAD, Steven, K.
IPC分类号： C12N15/19
CPC分类号： G01N33/5055 , A61K38/196 , C07K14/705 , C07K14/715 , C12N5/0642 , C12N2501/145 , C12N2501/22 , G01N33/5005 , G01N33/5008 , G01N33/5088 , G01N33/5094
摘要： Hematopoietic proteins and polypeptide fragments thereof are provided, including proteins and polypeptides from mice and humans. Also provided are DNA molecules encoding the proteins and polypeptides, as well as vectors and cells useful in their production. Antibodies that bind to an epitope on the proteins are also provided. The proteins and polypeptides are useful for in vivo and ex vivo therapy, and as reagents for cell culture and investigation of cell proliferation and development.
摘要翻译：提供了造血蛋白及其多肽片段，包括来自小鼠和人的蛋白质和多肽。还提供了编码蛋白质和多肽的DNA分子，以及可用于其生产的载体和细胞。还提供了与蛋白质上的表位结合的抗体。蛋白质和多肽可用于体内和离体治疗，以及作为细胞培养和细胞增殖和发育调查的试剂。

2. 发明申请

WO2005113001A1 METHODS OF TREATING CANCER USING IL-21 AND MONOCLONAL ANTIBODY THERAPY 审中-公开
标题翻译：使用IL-21和单克隆抗体治疗癌症治疗方法
公开(公告)号：WO2005113001A1
公开(公告)日：2005-12-01
申请号：PCT/US2005/019126
申请日：2005-05-20
申请人： ZYMOGENETICS, INC. , KINDSVOGEL, Wayne, R. , HUGHES, Steven, D. , HOLLY, Richard, D. , CLEGG, Christopher, H. , FOSTER, Donald, C. , JOHNSON, Rebecca, A. , HEIPEL, Mark, D. , SIVAKUMAR, Pallavur, V.
发明人： KINDSVOGEL, Wayne, R. , HUGHES, Steven, D. , HOLLY, Richard, D. , CLEGG, Christopher, H. , FOSTER, Donald, C. , JOHNSON, Rebecca, A. , HEIPEL, Mark, D. , SIVAKUMAR, Pallavur, V.
IPC分类号： A61K39/395
CPC分类号： C07K16/32 , A61K38/20 , A61K39/395 , A61K39/39558 , C07K16/2818 , C07K16/2896 , C07K2317/732 , A61K2300/00
摘要： Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies.
摘要翻译：描述了通过用IL-21共同施用治疗性单克隆抗体来治疗癌症的方法。可以使用的示例性单克隆抗体是利妥昔单抗，曲妥珠单抗和抗CTLA-4抗体。联合治疗的增强的抗肿瘤剂对于单克隆治疗顽固性，用单克隆抗体治疗后复发或增强的IL-21抗肿瘤作用降低与使用单克隆抗体治疗相关的毒性的患者群体特别有用。

3. 发明申请

WO1992020811A2 CLONING AND EXPRESSION OF HUMAN ISLET GLUTAMIC ACID DECARBOXYLASE AUTOANTIGEN 审中-公开
标题翻译：克隆和表达人类胰岛素酸乳酸脱羧酶自身抗体
公开(公告)号：WO1992020811A2
公开(公告)日：1992-11-26
申请号：PCT/US1992004079
申请日：1992-05-14
申请人： ZYMOGENETICS, INC. , THE BOARD OF REGENTS OF THE UNIVERSITY OF ...
发明人： ZYMOGENETICS, INC. , THE BOARD OF REGENTS OF THE UNIVERSITY OF ... , LERNMARK, Ake , KARLSEN, Allen, E. , GRUBIN, Catherine, E. , HAGOPIAN, William , O'HARA, Patrick, J. , FOSTER, Donald, C.
IPC分类号： C12P19/34
CPC分类号： C12N9/88 , A61K38/00 , C07K16/40
摘要： Human pancreatic islet cell glutamic acid decarboxylase (GAD), an autoantigen involved in the development of insulin-dependent diabetes mellitus (IDDM), has been cloned, sequenced and expressed by recombinant means. Recombinant human islet cell GAD polypeptides and antibodies specific to the GAD polypeptides can be used in methods of diagnosis and treatment, including use in immunoadsorptive therapy and the induction of immune tolerance.
摘要翻译：人胰岛细胞谷氨酸脱羧酶（GAD）是参与胰岛素依赖型糖尿病（IDDM）发展的自身抗原，已被克隆，测序并用重组方法表达。重组人胰岛细胞GAD多肽和对GAD多肽特异性的抗体可用于诊断和治疗的方法，包括用于免疫吸收治疗和诱导免疫耐受。

4. 发明申请

WO1991009951A1 RECOMBINANT PROTEIN C WITH TRUNCATED LIGHT CHAIN 审中-公开
标题翻译：重组蛋白C与截断的轻链
公开(公告)号：WO1991009951A1
公开(公告)日：1991-07-11
申请号：PCT/US1990007617
申请日：1990-12-21
申请人： ZYMOGENETICS, INC. , TEIJIN LIMITED
发明人： ZYMOGENETICS, INC. , TEIJIN LIMITED , FOSTER, Donald, C. , HOLLY, Richard, D. , SUZUKI, Masahiko , WAKABAYASHI, Kenji , KUMAR, Anur, Ashok
IPC分类号： C12N15/57

5. 发明申请

WO1997044455A1 HEMATOPOIETIC CYTOKINE RECEPTOR 审中-公开
标题翻译：化学细胞因子受体
公开(公告)号：WO1997044455A1
公开(公告)日：1997-11-27
申请号：PCT/US1997008502
申请日：1997-05-19
申请人： ZYMOGENETICS, INC.
发明人： ZYMOGENETICS, INC. , BAUMGARTNER, James, W. , FOSTER, Donald, C. , GRANT, Francis, J. , SPRECHER, Cindy, A.
IPC分类号： C12N15/12
CPC分类号： C07K14/715 , A61K38/00 , C07K2319/00
摘要： Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular ligand-binding domain of a cell-surface receptor that is expressed at high levels in lymphoid tissue, including B-cells and T-cells. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo.
摘要翻译：公开了新型受体多肽，编码多肽的多核苷酸，以及相关组合物和方法。多肽包含细胞表面受体的细胞外配体结合结构域，其在淋巴组织（包括B细胞和T细胞）中以高水平表达。多肽可用于检测在体外和体内刺激淋巴样和骨髓细胞的增殖和/或发育的配体的方法。配体结合受体多肽也可用于在体外和体内阻断配体活性。

6. 发明申请

WO1996017062A1 LOW MOLECULAR WEIGHT THROMBOPOIETIN 审中-公开
标题翻译：低分子重量血小板计数
公开(公告)号：WO1996017062A1
公开(公告)日：1996-06-06
申请号：PCT/US1995014929
申请日：1995-11-15
申请人： ZYMOGENETICS, INC.
发明人： ZYMOGENETICS, INC. , BUDDLE, Michele, M. , DOWNEY, William , FOSTER, Donald, C. , FORSTROM, John, W. , LOK, Si , OSBORN, Sherri, G.
IPC分类号： C12N15/19
CPC分类号： C07K14/524 , A01K2217/05 , A61K38/00
摘要： Isolated mammalian thrombopoietins are disclosed. The thrombopoietins include polypeptides characterized by an amino acid sequence selected from the group consisting of (a) a sequence of amino acids as shown in SEQ ID NO:2 having an amino terminus at Ser(45) and a carboxyl terminus between Ser(208) and Asn(216), inclusive; a sequence of amino acids as shown in SEQ ID NO:4 having an amino terminus at Ser(22) and a carboxyl terminus between Arg(185) and Asn(193), inclusive; a sequence of amino acids as shown in SEQ ID NO:4 having an amino terminus at Ser(22) and a carboxyl terminus at Arg(198); a sequence of amino acids as shown in SEQ ID NO:4 having an amino terminus at Ser(22) and a carboxyl terminus at Phe(207); and allelic variants of (a)-(d). Also disclosed are isolated DNA molecules encoding these polypeptides as well as vectors, cells and methods that can be used for the production of the polypeptides.
摘要翻译：公开了分离的哺乳动物血小板生成素。血小板生成素包括以氨基酸序列为特征的多肽，所述氨基酸序列选自（a）SEQ ID NO：2所示氨基酸序列，其具有Ser（45）的氨基末端和Ser（208）之间的羧基末端，和Asn（216）（含）; 如SEQ ID NO：4所示的氨基酸序列，其具有Ser（22）的氨基末端和Arg（185）和Asn（193）之间的羧基末端（包括端值）; 如SEQ ID NO：4所示的氨基酸序列，其在Ser（22）具有氨基末端，在Arg处具有羧基末端（198）; 如SEQ ID NO：4所示的氨基酸序列，其在Ser（22）具有氨基末端，在Phe（207）具有羧基末端; 和（a） - （d）的等位变体。还公开了编码这些多肽的分离的DNA分子以及可用于产生多肽的载体，细胞和方法。

7. 发明申请

WO2002072607A3 SOLUBLE HETERODIMERIC CYTOKINE RECEPTOR 审中-公开
公开(公告)号：WO2002072607A3
公开(公告)日：2002-09-19
申请号：PCT/US2002/007214
申请日：2002-03-07
申请人： ZYMOGENETICS, INC. , CHANDRASEKHER, Yasmin, A. , NOVAK, Julia, E. , FOSTER, Donald, C. , XU, Wenfeng , JASPERS, Stephen, R.
发明人： CHANDRASEKHER, Yasmin, A. , NOVAK, Julia, E. , FOSTER, Donald, C. , XU, Wenfeng , JASPERS, Stephen, R.
IPC分类号： C07K14/00
摘要： A soluble receptor that binds to IL-20 having two polypeptide subunits, IL-22R and IL-20RB. The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.

8. 发明申请

WO1995023868A1 PRODUCTION OF FIBRINOGEN IN TRANSGENIC ANIMALS 审中-公开
标题翻译：在转基因动物中生产纤维蛋白
公开(公告)号：WO1995023868A1
公开(公告)日：1995-09-08
申请号：PCT/US1995002648
申请日：1995-03-01
申请人： ZYMOGENETICS, INC. , PHARMACEUTICAL PROTEINS LTD.
发明人： ZYMOGENETICS, INC. , PHARMACEUTICAL PROTEINS LTD. , GARNER, Ian , DALRYMPLE, Michael, A. , PRUNKARD, Donna, E. , FOSTER, Donald, C.
IPC分类号： C12N15/89
CPC分类号： C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2227/103 , A01K2227/105 , A01K2267/01 , C07K14/47 , C07K14/4717 , C07K14/4732 , C07K14/75 , C07K2319/00 , C12N15/87 , C12N15/89
摘要： Materials and methods for producing fibrinogen in transgenic non-human mammals are disclosed. DNA segments encoding A alpha , B beta and gamma chains of fibrinogen are introduced into the germ line of a non-human mammal, and the mammal or its female progeny produces milk containing fibrinogen expressed from the introduced DNA segments. Non-human mammalian embryos and transgenic non-human mammals carrying DNA segments encoding heterologous fibrinogen polypeptide chains are also disclosed.
摘要翻译：公开了在转基因非人哺乳动物中生产纤维蛋白原的材料和方法。将编码纤维蛋白原的α，ββ和γ链的DNA片段引入非人哺乳动物的胚系，并且哺乳动物或其雌性后代产生从引入的DNA片段表达的含有纤维蛋白原的乳。还公开了携带编码异源纤维蛋白原多肽链的DNA区段的非人哺乳动物胚胎和转基因非人哺乳动物。

9. 发明申请

WO1994012637A2 NOVEL HUMAN AMYLOID PROTEIN PRECURSOR HOMOLOGUE AND KUNITZ-TYPE INHIBITORS 审中-公开
标题翻译：新型人乳酸蛋白前体前体和昆虫型抑制剂
公开(公告)号：WO1994012637A2
公开(公告)日：1994-06-09
申请号：PCT/US1993011696
申请日：1993-12-01
申请人： ZYMOGENETICS, INC. , NOVO NORDISK A/S
发明人： ZYMOGENETICS, INC. , NOVO NORDISK A/S , SPRECHER, Cindy, A. , FOSTER, Donald, C. , NORRIS, Kjeld
IPC分类号： C12N15/15
CPC分类号： C07K14/4711 , A61K38/00 , C07K14/81
摘要： The present invention provides isolated DNA molecules comprising a DNA segment encoding a novel human amyloid protein precursor homologue and novel Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding a novel human amyloid protein precursor homologue or a novel Kunitz-type inhibitor wherein said first DNA segment is operably linked to additional DNA segments required for the expression for the first DNA segment, as well as host cells containing such DNA constructs and methods for producing proteins from the host cells.
摘要翻译：本发明提供了分离的DNA分子，其包含编码新型人淀粉样蛋白前体同系物的DNA片段和新型的Kunitz型抑制剂。还提供了包含编码新型人淀粉样蛋白前体同系物的第一DNA区段或新型Kunitz型抑制剂的DNA构建体，其中所述第一DNA区段与第一DNA区段的表达所需的另外的DNA区段可操作地连接，以及含有这种DNA构建体的宿主细胞和从宿主细胞产生蛋白质的方法。

10. 发明申请

WO1991009953A1 METHODS FOR PRODUCING HYBRID PHOSPHOLIPID-BINDING PROTEINS 审中-公开
标题翻译：生产混合磷脂结合蛋白的方法
公开(公告)号：WO1991009953A1
公开(公告)日：1991-07-11
申请号：PCT/US1990007335
申请日：1990-12-13
申请人： ZYMOGENETICS, INC.
发明人： ZYMOGENETICS, INC. , FOSTER, Donald, C.
IPC分类号： C12N15/62
CPC分类号： C12N9/647 , C07K14/4721 , C07K2319/00 , C07K2319/02
摘要： Methods are disclosed for producing hybrid phospholipid-binding proteins from eukaryotic cells. DNA constructs comprising a transcriptional promoter, at least one signal sequence and a hybrid phospholipid-binding protein coding sequence comprising at least one lipocortin lipid-binding domain joined to a gla-domainless, vitamin K-dependent protein and a transcriptional terminator are also disclosed.

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