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1. 发明申请

WO2019071150A1 A FUSION PROTEIN FOR TARGETED THERAPY OF AUTOIMMUNE DISEASE 审中-公开
公开(公告)号：WO2019071150A1
公开(公告)日：2019-04-11
申请号：PCT/US2018/054645
申请日：2018-10-05
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION
发明人： CHEN, Mingnan , ZHAO, Peng , WANG, Peng
IPC分类号： A61K47/68 , C07K16/28
CPC分类号： C07K14/78 , A61K9/0019 , A61K9/1075 , A61K9/51 , A61K38/164 , A61K38/39 , A61K39/0011 , A61K39/001111 , A61K39/39 , A61K39/3955 , A61K47/34 , A61K2039/505 , A61K2039/54 , A61K2039/55555 , A61K2039/585 , A61K2039/876 , A61P35/00 , C07K14/36 , C07K16/2818 , C07K2317/565 , C07K2317/622 , C07K2319/20 , C07K2319/21 , C07K2319/30
摘要： Disclosed herein, are fusion proteins comprising a targeting moiety, a plasma protein binding domain, and a toxin or biological variant thereof. Also described herein, are method of administering the fusion protein to patients with an autoimmune disease.

2. 发明申请

WO2018094076A1 PEPTIDES AND ANTIBODIES FOR DETECTING CHANGES IN ALZHEIMER'S DISEASE BRAIN AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2018094076A1
公开(公告)日：2018-05-24
申请号：PCT/US2017/062057
申请日：2017-11-16
申请人： SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
发明人： RUOSLAHTI, Erkki , MANN, Aman , SCODELLER, Pablo , HUSSAIN, Sazid
IPC分类号： A61K38/00 , A61K39/395 , A61P25/28
CPC分类号： A61P25/28 , A61K38/00 , A61K2039/505 , C07K7/06 , C07K16/22 , C07K2319/20 , C07K2319/60 , C07K2319/61 , G01N33/6896 , G01N2500/10 , G01N2800/2821
摘要： The present invention is based on the seminal discovery of a panel of targeting peptides and antibodies that can recognize AD brains at different stages of the disease, starting from early to advanced stage. The peptide probes described here are unique in the field and can be expected to advance understanding on early neurodegenerative changes associated with AD and improve the therapeutic outcomes by early detection and intervention in AD. Further, the invention provides antibodies that can be used to treat AD.

3. 发明申请

WO2017112784A1 SPYCATCHER AND SPYTAG: UNIVERSAL IMMUNE RECEPTORS FOR T CELLS 审中-公开
标题翻译： SPYCATCHER和SPYTAG：T细胞的通用免疫受体
公开(公告)号：WO2017112784A1
公开(公告)日：2017-06-29
申请号：PCT/US2016/068055
申请日：2016-12-21
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： POWELL, Daniel , TSOURKAS, Andrew
IPC分类号： A61K35/12 , C12N5/10
CPC分类号： A61K35/12 , A61K35/15 , A61K35/17 , A61K2039/515 , C07K14/7051 , C07K14/70521 , C07K2319/02 , C07K2319/03 , C07K2319/20 , C07K2319/40
摘要： The invention provides compositions and methods for adoptive T cell therapy in treating a variety of disorders including cancer, infections, and autoimmune disorders. In one embodiment, the invention provides a universal immune receptor that comprises a protein or peptide tag, such as a SpyCatcher or a SpyTag moiety, bound to an extracellular hinge region, a transmembrane domain, and an intracellular domain for T cell activation.
摘要翻译：本发明提供用于过继性T细胞疗法治疗多种病症（包括癌症，感染和自身免疫性病症）的组合物和方法。在一个实施方案中，本发明提供了通用免疫受体，其包含与细胞外铰链区，跨膜结构域和细胞内结构域结合的用于T细胞活化的蛋白或肽标签，例如SpyCatcher或SpyTag部分。 p>

4. 发明申请

WO2017083491A2 METHODS OF PRODUCING AND PURIFYING MATRIX-BINDING FUSION PROTEINS BY ION-EXCHANGE CHROMATOGRAPHY 审中-公开
标题翻译：离子交换色谱法生产和纯化基质结合融合蛋白的方法
公开(公告)号：WO2017083491A2
公开(公告)日：2017-05-18
申请号：PCT/US2016/061284
申请日：2016-11-10
申请人： PROTEOTHERA, INC.
发明人： PATWARI, Parth
IPC分类号： C07K1/22
CPC分类号： C07K1/22 , C07K2319/20
摘要： The invention provides methods of producing and purifying fusion proteins containing a domain capable of binding one or more extracellular matrix components, such as heparin and chondroitin sulfate, by cation-exchange chromatography.
摘要翻译：本发明提供了通过阳离子交换色谱法生产和纯化含有能够结合一种或多种细胞外基质组分（如肝素和硫酸软骨素）的结构域的融合蛋白的方法。

5. 发明申请

WO2017055587A1 REKOMBINANTE HERSTELLUNG VON PEPTIDEN 审中-公开
标题翻译：肽重组生产
公开(公告)号：WO2017055587A1
公开(公告)日：2017-04-06
申请号：PCT/EP2016/073479
申请日：2016-09-30
申请人： BASF SE , BASF S.A. CONDOMINIO ROCHAVERÁ, TORRE CRYSTAL
发明人： FELLE, Max Fabian , SCHWALB, Carsten , HÜMMERICH, Daniel , FEHR, Markus
IPC分类号： C07K14/47 , C12N15/62
CPC分类号： C07K14/463 , C07K14/43563 , C07K2319/00 , C07K2319/20 , C07K2319/40
摘要： Die vorliegende Erfindung betrifft neuartige repetitive selbstassemblierende Vorläuferproteine, dafür kodierende Nukleinsäuresequenzen und Expressionskonstrukte, sowie Verfahren zur rekombinanten Herstellung von Peptiden unter Verwendung von solchen Vorläuferproteinen.
摘要翻译：本发明涉及新的重复自组装前体蛋白，核酸编码序列和表达构建体，以及用于重组产生使用这样的前体蛋白的肽的方法。

6. 发明申请

WO2017024318A1 TARGETED PROTEIN DEGRADATION TO ATTENUATE ADOPTIVE T-CELL THERAPY ASSOCIATED ADVERSE INFLAMMATORY RESPONSES 审中-公开
标题翻译：有针对性的蛋白质降解以减少通透性T细胞治疗相关的不良反应
公开(公告)号：WO2017024318A1
公开(公告)日：2017-02-09
申请号：PCT/US2016/046088
申请日：2016-08-08
申请人： DANA-FARBER CANCER INSTITUTE, INC.
发明人： BRADNER, James , ROBERTS, Justin , NABET, Behnam , WINTER, Georg , PHILLIPS, Andrew J. , HEFFERNAN, Timothy P. , BUCKLEY, Dennis
IPC分类号： C07K16/00 , A61K35/17 , A61P35/00
CPC分类号： C12N15/11 , A61K31/4525 , A61K31/4545 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/551 , A61K31/5513 , A61K31/575 , A61K31/58 , A61K35/17 , A61K48/00 , A61K2035/122 , C07K14/47 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K16/00 , C07K16/2863 , C07K2317/622 , C07K2319/03 , C07K2319/20 , C07K2319/95 , C12N15/907 , C12N2310/20 , C12N2800/80
摘要： This invention is in the area of compositions and methods for regulating chimeric antigen receptor immune effector cell, for example T-cell (CAR-T), therapy to modulate associated adverse inflammatory responses, for example, cytokine release syndrome and tumor lysis syndrome, using targeted protein degradation.
摘要翻译：本发明涉及用于调节嵌合抗原受体免疫效应细胞（例如T细胞（CAR-T）），调节相关不良炎症反应（例如细胞因子释放综合征和肿瘤溶解综合征）的治疗的组合物和方法领域，其使用靶向蛋白降解。

7. 发明申请

WO2017013567A1 A NEW APPROACH TO PRODUCE HIV-1 GP140 ENVELOPE PROTEIN TRIMERS 审中-公开
标题翻译：生产HIV-1 GP140包膜蛋白TRIMERS的新方法
公开(公告)号：WO2017013567A1
公开(公告)日：2017-01-26
申请号：PCT/IB2016/054260
申请日：2016-07-18
申请人： THE CATHOLIC UNIVERSITY OF AMERICA
发明人： RAO, Venigalla B. , ALSALMI, Wadad
IPC分类号： C12N15/63 , C12P21/00 , C07K14/005
CPC分类号： C07K14/005 , A61K9/7023 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/54 , A61K2039/627 , C07K1/22 , C07K1/36 , C07K14/162 , C07K2319/00 , C07K2319/20 , C07K2319/21 , C07K2319/22 , C07K2319/40 , C07K2319/50 , C12N7/00 , C12N2740/16022 , C12N2740/16043 , C12N2740/16051 , C12N2740/16111 , C12N2740/16122 , C12N2740/16134 , C12N2740/16234
摘要： An approach of producing recombinant trimers that mimic native HIV-1 envelope trimers is developed. A recombinant protein forming the recombinant trimers encompasses a recombinant HIV-1 gp140 fused to a tag through a linker at C-terminus of the recombinant HIV-1 gp140. The linker is sufficiently long so that the tag is accessible for binding by a binding molecule bound on a solid matrix. After expressed in a cell, the recombinant protein is secreted into the culture medium and assembles into recombinant trimers therein. The recombinant trimers may be directly purified from the culture medium. Cleaved and uncleaved trimers from different clade viruses are produced.
摘要翻译：开发了生产模仿天然HIV-1包膜三聚体的重组三聚体的方法。形成重组三聚体的重组蛋白包含通过重组HIV-1 gp140的C-末端的接头与标签融合的重组HIV-1 gp140。接头足够长，使得标签可通过结合在固体基质上的结合分子进行结合。在细胞中表达后，将重组蛋白分泌到培养基中并在其中组装成重组三聚体。重组三聚体可以从培养基中直接纯化。产生来自不同进化枝病毒的切割和未切割的三聚体。

8. 发明申请

WO2016205759A1 ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS, ENZYMES AND GUIDE SCAFFOLDS OF CAS9 ORTHOLOGS AND VARIANTS FOR SEQUENCE MANIPULATION 审中-公开
标题翻译： CAS9 ORTHOLOGS的系统，方法，酶和指导原则的工程与优化及其对序列操作的变体
公开(公告)号：WO2016205759A1
公开(公告)日：2016-12-22
申请号：PCT/US2016/038252
申请日：2016-06-17
申请人： THE BROAD INSTITUTE INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , UNIVERSITY OF TOKYO , ZHANG, Feng , YAN, Winston , NUREKI, Osamu , ZHENG, Kaijie , CONG, Le , NISHIMASU, Hiroshi , RAN, Fei , LI, Yinqing
发明人： ZHANG, Feng , YAN, Winston , NUREKI, Osamu , ZHENG, Kaijie , CONG, Le , NISHIMASU, Hiroshi , RAN, Fei , LI, Yinqing
IPC分类号： C12N9/22 , G06F19/16 , A61K48/00 , C12N15/63 , C12N15/79
CPC分类号： C12N9/22 , C07K2299/00 , C07K2319/09 , C07K2319/095 , C07K2319/20 , C07K2319/70 , C12N15/102
摘要： The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems. In particular the present invention comprehends engineered new guide architectures and enzymes to be used in optimized Staphylococcus aureus CRISPR-Cas enzyme systems.
摘要翻译：本发明提供用于改变靶基因序列和相关基因产物的表达的系统，方法和组合物。提供了关于CRISPR-Cas系统的Cas蛋白的结构信息，使用该信息来生成CRISPR复合物的修饰组分，编码CRISPR复合物的一种或多种组分或修饰组分的载体和载体系统，以及方法用于设计和使用这些矢量和组件。还提供了在真核细胞中引导CRISPR复合物形成的方法以及利用CRISPR-Cas系统的方法。特别地，本发明包括优化的功能性CRISPR-Cas酶系统。特别地，本发明包括用于优化的金黄色葡萄球菌CRISPR-Cas酶系统中的工程新指南体系结构和酶。

9. 发明申请

WO2016149222A2 INSULIN ANALOGUES CONTAINING A GLUCOSE-REGULATED CONFORMATIONAL SWITCH 审中-公开
标题翻译：含有葡萄糖调节构象开关的胰岛素类似物
公开(公告)号：WO2016149222A2
公开(公告)日：2016-09-22
申请号：PCT/US2016/022390
申请日：2016-03-14
申请人： CASE WESTERN RESERVE UNIVERSITY
发明人： WEISS, Michael
IPC分类号： A61K38/28 , C07K14/62
CPC分类号： C07K14/62 , A61K38/00 , C07K14/622 , C07K2319/20 , C07K2319/70 , Y02A50/473
摘要： A two-chain insulin analogue contains an A chain modified by (i) a monomeric glucose-binding element at or near its N terminus and (ii) a B chain modified by at or near its C terminus by an element that reversibly binds to the monomeric glucose-binding element such that this linkage is displaceable by glucose. The monomeric glucose-binding element may be phenylboronic acid derivative (optionally halogenated). The B chain may be modified by a diol-containing element derived from a monosaccharide, disaccharide or oligosaccharide, a non-saccharide diol-containing moiety or a α-hydroxycarboxylate-containing moiety. The analogue can be manufactured by trypsin-mediated semi-synthesis. Formulations can be at strengths U-10 to U-1000 in soluble solutions at pH 7.0-8.0 with or without zinc ions at a molar ratio of 0.0-3.0 ions per insulin analogue monomer. A patient with diabetes mellitus may be treated with subcutaneous, intraperitoneal, or oral administration of a physiologically effective amount of the insulin analogue.
摘要翻译：双链胰岛素类似物含有通过（i）在N端或其附近的单体葡萄糖结合元件和（ii）在C端或其附近修饰的B链修饰的A链通过可逆地结合单体葡萄糖结合元件的元件使得该连接可被葡萄糖置换。单体葡萄糖结合元件可以是苯基硼酸衍生物（任选卤化）。 B链可以由衍生自单糖，二糖或寡糖的含二醇的元件，含非糖类二醇的部分或含有α-羟基羧酸酯的部分修饰。类似物可以通过胰蛋白酶介导的半合成来制造。制剂可以在pH7.0-8.0的可溶性溶液中具有U-10至U-1000的强度，每种胰岛素类似物单体具有或不具有锌离子的摩尔比为0.0-3.0个离子。糖尿病患者可用皮下，腹膜内或口服生理有效量的胰岛素类似物进行治疗。

10. 发明申请

WO2016095856A1 COMPOSITIONS COMPRISING POLYPEPTIDES HAVING XYLANASE ACTIVITY AND POLYPEPTIDES HAVING ARABINOFURANOSIDASE ACTIVITY 审中-公开
标题翻译：包含具有XYLANASE活性的多肽的组合物和具有阿拉伯呋喃糖苷酶活性的多肽
公开(公告)号：WO2016095856A1
公开(公告)日：2016-06-23
申请号：PCT/CN2015/097895
申请日：2015-12-18
申请人： NOVOZYMES A/S , PENG, Wei
发明人： PENG, Wei , PEDERSEN, Ninfa Rangel , PETTERSSON, Dan , EKLOEF, Jens Magnus , NYMAND-GRARUP, Soren , PALMEN, Lorena G. , MONRAD, Rune Nygaard , SPODSBERG, Nikolaj , STRINGER, Mary Ann , BLOM, Charlotte , KIEMER, Lars , KROGH, Kristian Bertel Romer M. , SALOMON, Jesper
IPC分类号： C12N15/56 , C12N9/24 , A23L1/305
CPC分类号： C12N9/248 , C07K2319/02 , C07K2319/20 , C07K2319/21 , C12N9/2402 , C12Y302/01008 , C12Y302/01055
摘要： Compositions comprising polypeptides having xylanase activity and polypeptides having arabinofuranosidase activity for use in e.g. animal feed. Polypeptides having arabinofuranosidase activity, polypeptides having xylanase activity and polynucleotides encoding the polypeptides. Nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptide.
摘要翻译：包含具有木聚糖酶活性的多肽的组合物和具有阿拉伯呋喃糖苷酶活性的多肽，动物饲料。具有阿拉伯呋喃糖苷酶活性的多肽，具有木聚糖酶活性的多肽和编码多肽的多核苷酸。包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

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