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1. 发明申请

WO2008154149A3 TISSUE PROCESSING FOR NONIMMUNOGENIC IMPLANTS 审中-公开
标题翻译：非发育性植入物的组织加工
公开(公告)号：WO2008154149A3
公开(公告)日：2009-11-12
申请号：PCT/US2008064653
申请日：2008-05-23
申请人： ZIMMER ORTHOBIOLOGICS INC , WANG HALI , LIU HUI , XIAN HAI-QING , YAO JIAN Q , ZAPOROJAN VICTOR
发明人： WANG HALI , LIU HUI , XIAN HAI-QING , YAO JIAN Q , ZAPOROJAN VICTOR
IPC分类号： A61L27/36 , A61K35/32 , A61K35/34 , A61K35/36 , A61K35/44
CPC分类号： A61L27/3654 , A61K35/32 , A61K35/34 , A61K35/44 , A61L27/3633 , A61L27/3687 , A61L2430/40
摘要： Methods for processing tissues to render them suitable for implantation, e.g., in an orthopedic site. Tissues are rendered substantially acellular and substantially nonimmunogenic by exposure to processes that result in cell lysis 12, increasing permeability of the extracellular matrix 14, degrading the debris from lysis 16, and removing the debris 18. Methods of forming tissue implants, kits for processing tissue implants, and methods of using tissue implants are also disclosed.
摘要翻译：用于处理组织以使其适合植入的方法，例如在矫形部位。组织通过暴露于导致细胞裂解12，增加细胞外基质14的渗透性，降解碎裂16和去除碎屑的过程而呈现基本上无细胞并且基本上是非免疫原性的。形成组织植入物的方法，用于处理组织的试剂盒植入物和使用组织植入物的方法也被公开。

2. 发明申请

WO2009014996A2 MEDICAL DEVICES AND METHODS FOR CUTTING AND SUTURING BIOLOGICAL TISSUE 审中-公开
标题翻译：用于切割和切割生物组织的医疗装置和方法
公开(公告)号：WO2009014996A2
公开(公告)日：2009-01-29
申请号：PCT/US2008070406
申请日：2008-07-18
申请人： ZIMMER ORTHOBIOLOGICS INC , ZAPOROJAN VICTOR , YAO JIAN Q , BRISTOL RODNEY , LIU HUI , WANG HALI , XIAN HAI-QING
发明人： ZAPOROJAN VICTOR , YAO JIAN Q , BRISTOL RODNEY , LIU HUI , WANG HALI , XIAN HAI-QING
IPC分类号： A61B17/04 , A61B17/32
CPC分类号： A61B17/0469 , A61B17/0467 , A61B17/0482 , A61B17/06066 , A61B17/320016 , A61B2017/00353 , A61B2017/06042 , A61B2017/320052
摘要： Medical devices (100, 200, 400) for cutting and suturing biological tissue generally include a shaft (102) and first and second guide members (108, 110) each including a first portion (112, 114) coupled to the shaft (102) at a first location and a second portion (116, 118) coupled to the shaft (102) at a second location. The first portions (112, 114) are movable along the shaft (102) relative to the second portions (116, 118), and the first and second guide members (108, 110) define an arcuate profile and are configured to flex in response to such movement. When used to cut tissue, the medical device (100) may further include a blade (106) positioned between the first and second guide members (108, 110). When used to suture tissue, one or more suture guides (240) may be provided on the first guide member (108) for directing a suture needle through tissue proximate the first guide member (108). Methods of repairing and replacing a meniscus using the medical devices (100, 200, 400) are also provided.
摘要翻译：用于切割和缝合生物组织的医疗装置（100,200,400）通常包括轴（102）以及第一和第二引导构件（108,110），每个引导构件包括联接到轴（102）的第一部分（112,114）在第一位置和在第二位置与轴（102）连接的第二部分（116,118）。第一部分（112,114）可相对于第二部分（116,118）沿着轴（102）移动，并且第一和第二引导部件（108,110）限定弓形轮廓并且构造成响应地弯曲到这样的运动。当用于切割组织时，医疗装置（100）可以进一步包括定位在第一和第二引导构件（108,110）之间的刀片（106）。当用于缝合组织时，可以在第一引导构件（108）上提供一个或多个缝合线引导件（240），用于引导缝合针穿过靠近第一引导构件（108）的组织。还提供了使用医疗装置（100,200,400）修复和更换弯月面的方法。

3. 发明申请

WO2009158634A3 SCAFFOLD COATED AND/OR IMPREGNATED WITH AT LEAST ONE BIOACTIVE AGENT FOR TISSUE REPAIR AND OTHER MEDICAL APPLICATIONS 审中-公开
标题翻译：用于组织修复和其他医疗应用的至少一种生物活性剂的SCAFFOLD涂层和/或
公开(公告)号：WO2009158634A3
公开(公告)日：2010-08-12
申请号：PCT/US2009048885
申请日：2009-06-26
申请人： ZIMMER ORTHOBIOLOGICS INC , XIAN HAI-QING , YAO JIAN Q , WANG HALI , DAHESHIA MASSOUD , LIU HUI
发明人： XIAN HAI-QING , YAO JIAN Q , WANG HALI , DAHESHIA MASSOUD , LIU HUI
IPC分类号： A61L27/22 , A61L27/54
CPC分类号： A61L27/22 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2300/426 , A61L2300/43 , A61L2300/64
摘要： A system and method for producing a scaffold coated and/or impregnated with at least one bioactive agent. This is accomplished by culturing at least one cell in the same medium as a scaffold, but without physical contact between the at least one cell and the scaffold. The system includes a container having a surface defining an interior compartment. A medium is disposed within the interior compartment. At least one cell is disposed within the medium, the at least one cell being capable of producing at least one bioactive agent. Further, a scaffold is disposed within the medium. The scaffold is physically separated from the at least one cell such that there is no contact between the scaffold and the at least one cell. Thus, as the at least one cell produces at least one bioactive agent, such as a growth factor, the at least one bioactive agent enters the medium, and contacts and coats and/or impregnates the scaffold. However, due to the physical separation of the scaffold and at least one cell, the at least one cell is prevented from contacting and coating and/or impregnating the scaffold. Thus, only the desired bioactive agent or agents coat and/or impregnate the scaffold.
摘要翻译：用于生产用至少一种生物活性剂包被和/或浸渍的支架的系统和方法。这是通过在相同的培养基中培养作为支架的至少一个细胞，但是在至少一个细胞和支架之间没有物理接触来实现的。该系统包括具有限定内部隔间的表面的容器。介质设置在内部隔室内。至少一个细胞设置在培养基内，所述至少一个细胞能够产生至少一种生物活性剂。此外，在培养基内设置支架。骨架与至少一个细胞物理分离，使得支架与至少一个细胞之间不存在接触。因此，由于至少一个细胞产生至少一种生物活性剂，例如生长因子，所述至少一种生物活性剂进入培养基，并接触并涂覆和/或浸渍支架。然而，由于支架和至少一个电池的物理分离，所以防止了至少一个电池接触和涂覆和/或浸渍支架。因此，只有所需的生物活性剂或药剂包衣和/或浸渍支架。

4. 发明申请

WO2009100065A3 METHOD OF REMOVING UNDESIRED TISSUE FROM CONNECTIVE TISSUE 审中-公开
标题翻译：从连接组织中去除不良组织的方法
公开(公告)号：WO2009100065A3
公开(公告)日：2010-05-14
申请号：PCT/US2009032961
申请日：2009-02-03
申请人： ZIMMER ORTHOBIOLOGICS INC , XIAN HAI-QING , WANG HALI , LIU HUI , YAO JIAN Q , GAO JIZONG
发明人： XIAN HAI-QING , WANG HALI , LIU HUI , YAO JIAN Q , GAO JIZONG
IPC分类号： A61L27/36
CPC分类号： A61K38/4826 , A61K38/465 , C12Y301/01003 , C12Y304/21004
摘要： A method of removing undesired tissue from a connective tissue is provided that includes stretching the connective tissue and peeling away the undesired tissue. Some methods include soaking the connective tissue in a solution prior to and/or subsequent to stretching and peeling away the undesired tissue. The solution may include a detergent, an enzyme, a salt solution, an organic solvent, and combinations thereof.
摘要翻译：提供从结缔组织中去除不想要的组织的方法，其包括拉伸结缔组织并剥离不想要的组织。一些方法包括在拉伸和/或剥离不想要的组织之前和/或之后将结缔组织浸泡在溶液中。溶液可以包括洗涤剂，酶，盐溶液，有机溶剂及其组合。

5. 发明申请

WO2012044727A3 MANUFACTURING PROCESS FOR PYRIMIDINE DERIVATIVES 审中-公开
标题翻译：吡啶衍生物的制备方法
公开(公告)号：WO2012044727A3
公开(公告)日：2012-06-07
申请号：PCT/US2011053808
申请日：2011-09-29
申请人： NOVARTIS AG , CALIENNI JOHN VINCENT , DE LA CRUZ MARILYN , FLUBACHER DIETMAR , GONG BAOQING , KAPA PRASAD KOTESWARA , KARPINSKI PIOTR H , LIU HUI , MICHEL PASCAL , MOSE RASMUS , TESTA MARIA CATERINA , WAYKOLE LILADHAR MURLIDHAR
发明人： CALIENNI JOHN VINCENT , DE LA CRUZ MARILYN , FLUBACHER DIETMAR , GONG BAOQING , KAPA PRASAD KOTESWARA , KARPINSKI PIOTR H , LIU HUI , MICHEL PASCAL , MOSE RASMUS , TESTA MARIA CATERINA , WAYKOLE LILADHAR MURLIDHAR
IPC分类号： C07D239/28 , C07D239/30 , C07D401/04
CPC分类号： C07D401/04 , A61K31/535 , C07D213/72 , C07D413/14 , C07F5/025 , C07F5/04
摘要： The invention relates to processes for manufacturing a compound of formula (5) or a stereoisomer, tautomer or a salt thereof, wherein the substituents are as defined in the specification. The invention further relates to new manufacturing processes for specific solid forms of Compound A and its salts, to such solid forms and to use of said solid forms for the therapeutic treatment of warm-blooded animals.
摘要翻译：本发明涉及制备式（5）化合物或其立体异构体，互变异构体或其盐的方法，其中取代基如说明书中所定义。本发明还涉及用于化合物A及其盐的特定固体形式的这种固体形式的新制备方法，以及所述固体形式用于治疗温血动物的新方法。

6. 发明申请

WO0233848A2 CHANNEL ALLOCATION IN BROADBAND ORTHOGONAL FREQUENCY-DIVISION MULTIPLE-ACCESS/SPACE-DIVISION MULTIPLE-ACCESS NETWORKS 审中-公开
标题翻译：宽带正交频分多路访问/空间多路访问网络中的信道分配
公开(公告)号：WO0233848A2
公开(公告)日：2002-04-25
申请号：PCT/US0142716
申请日：2001-10-11
申请人： BROADSTORM TELECOMMUNICATIONS , LIU HUI , YIN HUJUN , LI XIAODONG , MU FUQI
发明人： LIU HUI , YIN HUJUN , LI XIAODONG , MU FUQI
IPC分类号： H04B7/005 , H04L5/02 , H04W52/50 , H04B7/00
CPC分类号： H04W52/50 , H04L5/023 , H04W72/0453
摘要： A network is described. In one embodiment, the network comprises multiple subscriber units to communicate with the base station using an orthogonal frequency-division multiple-access (OFDMA) protocol, and a base station. The base-station includes a memory unit to store broadband spatial signature vectors associated with each subscriber and raffic channel allocation logic. The vectors are a function of frequency. The traffic channel allocation logic allocates OFDMA channels using the broadband spatial signatures vectors of the subscribers.
摘要翻译：描述网络。在一个实施例中，网络包括使用正交频分多址（OFDMA）协议和基站与基站进行通信的多个用户单元。基站包括存储单元，用于存储与每个用户相关联的宽带空间签名向量和流量信道分配逻辑。向量是频率的函数。业务信道分配逻辑使用订户的宽带空间签名向量来分配OFDMA信道。

7. 发明申请

WO2010062523A3 PROSTAGLANDIN AND PROSTAMIDE DRUG DELIVERY SYSTEMS AND INTRAOCULAR THERAPEUTIC USES THEREOF 审中-公开
标题翻译： PROSTAGLANDIN和PROSTAMIDE药物输送系统及其内科治疗用途
公开(公告)号：WO2010062523A3
公开(公告)日：2010-07-22
申请号：PCT/US2009061798
申请日：2009-10-23
申请人： ALLERGAN INC , ROBINSON MICHAEL R , LIU HUI , HUGHES PATRICK M , SPADA LON T , GHEBREMESKEL ALAZAR N
发明人： ROBINSON MICHAEL R , LIU HUI , HUGHES PATRICK M , SPADA LON T , GHEBREMESKEL ALAZAR N
IPC分类号： A61K9/00 , A61K9/16 , A61K9/20 , A61K31/557 , A61K31/5575 , A61P27/06
CPC分类号： A61L31/06 , A61K9/0048 , A61K9/0051 , A61K9/1647 , A61K9/204 , A61K31/216 , A61K31/557 , A61K31/5575 , A61L31/16
摘要： Biocompatible, bioerodible implants and microspheres include latanoprost and a biodegradable polymer effective, when placed intraocular (such as into the subtenon space) to treat glaucoma.
摘要翻译：生物相容性，生物可侵蚀的植入物和微球体包括拉坦前列素和可生物降解的聚合物，当放置眼内（如进入subtenon空间）治疗青光眼时有效。

8. 发明申请

WO2008014126A3 SPECTRUM SHARING BETWEEN BROADCASTING AND MULTIPLE-ACCESS NETWORKS 审中-公开
标题翻译：广播和多路访问网络之间的频谱共享
公开(公告)号：WO2008014126A3
公开(公告)日：2008-05-02
申请号：PCT/US2007073322
申请日：2007-07-12
申请人： ADAPTIX INC , LIU HUI
发明人： LIU HUI
IPC分类号： H04Q7/00
CPC分类号： H04H20/71 , H04H20/42 , H04H60/91
摘要： Advantage is taken of the fact that broadcast coverage is unevenly distributed across a geographical region and multiple-access transmissions can be interposed in regions where interference is minimum. In one embodiment, advantage is taken of the known broadcasting signal and techniques, such as, for example, dirty paper coding techniques, can be used to pre-cancel broadcasting differences, allowing a system to operate as if the interference did not exist.
摘要翻译：优点在于广播覆盖不均匀地分布在地理区域上，并且多址传输可以插入在干扰最小的区域中。在一个实施例中，采用已知的广播信号的优点，并且可以使用技术，例如脏纸编码技术来预取消广播差异，从而允许系统像干涉不存在一样操作。

9. 发明申请

WO2005044987A3 TOCOPHEROL ASSOCIATED PROTEIN AND USES THEREOF 审中-公开
标题翻译： TOCOPHEROL相关蛋白及其用途
公开(公告)号：WO2005044987A3
公开(公告)日：2007-02-08
申请号：PCT/US2004035646
申请日：2004-10-27
申请人： RES DEV FOUNDATION , SANDERS BOB G , KLINE KIMBERLY , YU WEIPING , LIU HUI , HANTASH FERAS
发明人： SANDERS BOB G , KLINE KIMBERLY , YU WEIPING , LIU HUI , HANTASH FERAS
IPC分类号： C12N9/00 , A61K48/00 , C07H21/04 , C07K14/47 , C12N20060101 , C12N1/21 , C12N15/70 , C12P21/06 , C12Q1/68
CPC分类号： C07K14/4747 , A61K48/00 , C07K14/47 , C07K2319/00
摘要： The present invention discloses cloning of tocopherol associated protein TAP-38 and deletion mutants of TAP-46. TAP-38, which shares homology with the previously identified TAP-46, enhances the apoptotic inducing properties of tocopherol based compounds, and blockage of TAP-38 or TAP-46 reduces the effectiveness of tocopherol based compounds. Thus, delivery of TAP-38 and TAP46 cDNA by aerosol liposome/transfection/infection methods, separately or in combination with tocopherol-based apoptosis-inducing agents as well as with other chemotherapeutic agents, would be useful for treatment and prevention of cellular proliferative diseases and disorders.
摘要翻译：本发明公开了生育酚相关蛋白TAP-38和TAP-46的缺失突变体的克隆。与先前鉴定的TAP-46共享的TAP-38增强了基于生育酚的化合物的凋亡诱导性质，并且阻断TAP-38或TAP-46降低了生育酚类化合物的有效性。因此，通过气溶胶脂质体/转染/感染方法分别或与基于生育酚的细胞凋亡诱导剂以及与其他化学治疗剂组合递送TAP-38和TAP46 cDNA可用于治疗和预防细胞增殖性疾病和疾病。

10. 发明申请

WO2005077130A3 A METHOD FOR THE REMOVAL OF AGGREGATE PROTEINS FROM RECOMBINANT SAMPLES USING ION EXCHANGE CHROMATOGRAPHY 审中-公开
标题翻译：离子交换色谱法从重组样品中去除凝集蛋白的方法
公开(公告)号：WO2005077130A3
公开(公告)日：2005-12-29
申请号：PCT/US2005004729
申请日：2005-02-10
申请人： TANOX INC , LIU HUI , TANG KE
发明人： LIU HUI , TANG KE
IPC分类号： A61K39/395 , C07K1/18 , C07K16/00 , C07K16/06 , C07K16/42
CPC分类号： C07K16/065 , C07K1/18 , C07K16/4291
摘要： The present invention relates to processes for the removal of unwanted protein aggregates from antibody preparations. One process involves removal when the aggregate and antibody are very close in pl value ("Bind-Elute" process). Another process involves the removal when the aggregate and antibody are very close in net electric charge and retention time on ion exchange resin ("Bind-Washout" process). Using either process, at least 90% of the antibody is recovered and 70-90% of the aggregate is removed.
摘要翻译：本发明涉及从抗体制备物中去除不需要的蛋白质聚集物的方法。一个过程涉及聚集体和抗体非常接近pl值时的去除（“Bind-Elute”过程）。另一种方法涉及当聚集体和抗体在离子交换树脂上的净电荷和保留时间非常接近时的去除（“结合 - 冲洗”过程）。使用任一方法，至少90％的抗体被回收并且70-90％的聚集体被去除。

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