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1. 发明申请

WO2017127892A1 CANCER TREATMENT 审中-公开
标题翻译：癌症治疗
公开(公告)号：WO2017127892A1
公开(公告)日：2017-08-03
申请号：PCT/AU2017/050065
申请日：2017-01-27
申请人： PROPANC PTY LTD
发明人： PERAN, Macarena , KENYON, Julian , CORRALES, Juan Antonio Marchal , CHAVES, Maria Angel Garcia
IPC分类号： A61K38/43 , A61K38/48 , A61P35/00
CPC分类号： A61K38/4826 , C12Y304/21001 , C12Y304/21004 , A61K38/47 , A61K2300/00
摘要： The present invention relates to compositions, methods, uses and kits for treating cancer. The present invention relates to methods for minimising the progression of cancer in a subject, the method comprising administering to the subject therapeutically effective amounts of chymotrypsinogen and trypsinogen, thereby minimising the progression of cancer in the subject. In particular, the methods provide a means for treating cancer by reducing the number of cancer stem cells in the subject.
摘要翻译：本发明涉及用于治疗癌症的组合物，方法，用途和试剂盒。本发明涉及使受试者中癌症进展最小化的方法，所述方法包括向受试者施用治疗有效量的胰凝乳蛋白酶原和胰蛋白酶原，由此使受试者中癌症的进展最小化。具体而言，这些方法提供了通过减少受试者中癌症干细胞的数量来治疗癌症的手段。

2. 发明申请

WO2014176279A1 POLYMER-BASED PROTEIN ENGINEERING METHODS TO RATIONALLY TUNE ENZYME ACTIVITY, PH-DEPENDENCE AND STABILITY 审中-公开
标题翻译：基于聚合物的蛋白质工程方法来显着调节酶活性，PH依赖性和稳定性
公开(公告)号：WO2014176279A1
公开(公告)日：2014-10-30
申请号：PCT/US2014/035033
申请日：2014-04-22
申请人： CARNEGIE MELLON INIVERSITY , RUSSELL, Alan, J. , KOEPSEL, Richard, R. , CUMMINGS, Chad , MURATA, Hironobu
发明人： RUSSELL, Alan, J. , KOEPSEL, Richard, R. , CUMMINGS, Chad , MURATA, Hironobu
IPC分类号： A61K47/48
CPC分类号： A61K47/48176 , A61K38/4826 , A61K47/48769 , A61K47/58 , A61K47/69 , C08F289/00 , C08H1/00 , C12Y304/21001
摘要： Using a novel water-soluble, active ester amide-containing functionalized controlled radical polymerization initiator, stimuli responsive polymers have been grown from the surface of a protein, exemplified by chymotrypsin or any protein having surface amino acids that will covalently bind to the active ester amide-containing functionalized initiator. It is shown that changes in temperature or pH can change the conformation of the polymer surrounding the enzyme, which in turn enabled the rational tailoring of enzyme activity and stability. This method has afforded an increase in the activity and stability of the enzyme by an order of magnitude at pH's where the enzyme is usually inactive or unstable. Multimodal temperature responsive protein-block copolymer conjugates are described.
摘要翻译：使用新的具有水溶性的含活性酯酰胺的官能化受控自由基聚合引发剂，已经从蛋白质的表面生长了刺激响应性聚合物，例如糜蛋白酶或具有共价结合活性酯酰胺的表面氨基酸的任何蛋白质的官能化引发剂。显示温度或pH的变化可以改变酶周围的聚合物的构象，这反过来使得酶活性和稳定性的合理调整。这种方法使酶的活性和稳定性提高了一个数量级的pH值，其中酶通常是无活性的或不稳定的。描述了多峰温度反应性蛋白质 - 嵌段共聚物缀合物。

3. 发明申请

WO2014141121A1 COMPOSITION CONTAINING DIGESTIVE ENZYMES AND NUTRIENTS SUITABLE FOR ENTERAL ADMINISTRATION 审中-公开
标题翻译：含有适用于肠内营养的消化酶和营养素的组合物
公开(公告)号：WO2014141121A1
公开(公告)日：2014-09-18
申请号：PCT/IB2014/059722
申请日：2014-03-13
申请人： APTALIS PHARMA LTD.
发明人： PIRONTI, Vincenza , RONDA, Emanuela , BOLTRI, Luigi
IPC分类号： A61K38/46 , A61K47/06 , A23L1/29 , A23L1/30 , A61K38/47 , A61K38/48 , C12N9/26
CPC分类号： A23L1/296 , A23L29/06 , A23L33/40 , A61K38/465 , A61K38/47 , A61K38/4826 , C12N9/20 , C12Y301/01003 , C12Y302/01001 , C12Y304/21002 , A61K2300/00
摘要： The present invention provides a process for the preparation of a stable and homogeneous liquid composition that is suitable for enteral administration comprising a digestive enzyme product and nutrients from a nutritional formula having specific amount of nutrients. The invention further provides a method for efficiently and effectively administering a therapeutically effective dose of the stable and homogeneous liquid composition by means of an enteral tube.
摘要翻译：本发明提供了一种制备稳定且均匀的液体组合物的方法，其适用于肠内施用，其包含消化酶产物和营养配方，其具有特定量的营养物质。本发明还提供了一种通过肠管有效和有效地施用治疗有效剂量的稳定和均匀液体组合物的方法。

4. 发明申请

WO2011071986A1 ENZYMATIC WOUND DEBRIDING COMPOSITIONS WITH ENHANCED ENZYMATIC ACTIVITY 审中-公开
标题翻译：具有增强酶活性的酶促破坏组合物
公开(公告)号：WO2011071986A1
公开(公告)日：2011-06-16
申请号：PCT/US2010/059409
申请日：2010-12-08
申请人： HEALTHPOINT, LTD. , SHI, Lei , JOVANOVIC, Aleksa , AUST, Duncan
发明人： SHI, Lei , JOVANOVIC, Aleksa , AUST, Duncan
IPC分类号： A61K38/48 , A61L15/38 , A61L26/00
CPC分类号： A61L15/26 , A61K9/06 , A61K9/10 , A61K38/4826 , A61K38/4873 , A61K38/488 , A61K38/4886 , A61K47/10 , A61K47/44 , A61L15/34 , A61L15/38 , A61L15/44 , A61L26/0019 , A61L26/0066 , A61L2300/254 , C12Y304/24027 , C08L71/02
摘要： The present invention is directed to topical enzymatic wound debriding compositions with enhanced enzymatic activity. These compositions comprise a dispersed phase comprising at least one proteolytic enzyme and at least one hydrophilic polyol; and a continuous phase comprising a hydrophobic base.
摘要翻译：本发明涉及具有增强的酶活性的局部酶促创伤清创组合物。这些组合物包含分散相，其包含至少一种蛋白水解酶和至少一种亲水多元醇; 和包含疏水性碱的连续相。

5. 发明申请

WO2010048628A1 METHODS FOR PREVENTING AGGREGATION OF ADIPOSE STROMAL CELLS 审中-公开
标题翻译：防止ADIPOSE STROMAL细胞聚集的方法
公开(公告)号：WO2010048628A1
公开(公告)日：2010-04-29
申请号：PCT/US2009/062120
申请日：2009-10-26
申请人： INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION , MARCH, Keith, L. , JOHNSTONE, Brian, H.
发明人： MARCH, Keith, L. , JOHNSTONE, Brian, H.
IPC分类号： A61K35/32
CPC分类号： A61K38/4826 , A61K31/198 , A61K31/727 , A61K35/35 , A61K45/06 , C12N5/0667 , C12N2500/10 , C12N2501/70 , C12N2501/91 , C12N2509/00 , A61K2300/00
摘要： The present invention relates to a methods, compositions, and admixtures which prevent the aggregation of a population of adipose stromal cells (ASCs), such as an isolated population of adipose stromal cells. In some embodiments, the present invention relates to admixtures and methods of use thereof comprising a population of ASC and a modulator of ASC aggregation. In some embodiments, a modulator of ASC aggregation includes, for example, ionic agents (e.g., heparin), chelating agents (e.g., EDTA), proteolytic agents. (e.g., trypsin or dispase), and agents which inhibit the expression of cell surface receptors and molecules on the surface of ASCs (e.g., inhibitors of integrins expression). In some embodiments, the methods to block ASC aggregration and the admixtures are useful in use of the ASCs to treat various diseases and/or conditions, and increases the safety and/or efficiency of ASCs. The methods, compositions and admixtures have utility in treating a number of conditions including, but not limited to, the treatment of any vascularized organs, such as heart, kidney, liver and the like.
摘要翻译：本发明涉及防止脂肪基质细胞（ASCs）群体聚集的方法，组合物和混合物，例如分离的脂肪基质细胞群体。在一些实施方案中，本发明涉及其包含ASC群体和ASC聚集调节剂的混合物及其使用方法。在一些实施方案中，ASC聚集的调节剂包括例如离子试剂（例如肝素），螯合剂（例如EDTA），蛋白水解剂。（例如胰蛋白酶或分泌酶）和抑制ASC表面上的细胞表面受体和分子表达的试剂（例如整合素表达的抑制剂）。在一些实施方案中，阻断ASC聚集和混合物的方法可用于使用ASC治疗各种疾病和/或病症，并且增加ASC的安全性和/或效率。方法，组合物和混合物可用于治疗许多病症，包括但不限于治疗任何血管化的器官，例如心脏，肾脏，肝脏等。

6. 发明申请

WO2009010494A3 MICRO-PARTICLES, BLOOD-SUBSTITUTE AND METHOD FOR FORMING SAME 审中-公开
标题翻译：微粒，血液代用品及其形成方法
公开(公告)号：WO2009010494A3
公开(公告)日：2010-02-04
申请号：PCT/EP2008059192
申请日：2008-07-14
申请人： CHARITE UNIVERSITAETSMEDIZIN , GEORGIEVA RADOSTINA , BAEUMLER HANS
发明人： GEORGIEVA RADOSTINA , BAEUMLER HANS
IPC分类号： A61K9/16 , A61K47/42 , B01D9/00 , B01J13/14
CPC分类号： A61K9/0026 , A61K9/1611 , A61K9/1694 , A61K9/5052 , A61K9/5073 , A61K31/721 , A61K35/16 , A61K38/1703 , A61K38/28 , A61K38/38 , A61K38/42 , A61K38/4826 , A61K47/42 , A61K47/60 , A61K47/6927 , B01D9/005 , B01J13/14 , C12Y304/21004 , Y10T428/2982 , Y10T428/2989 , Y10T428/2991
摘要： A method for forming micro-particles is provided. The method includes the steps of: - providing a first solution which includes at least an anion; - providing a second solution which includes at least a cation; - mixing the first solution with the second solution in presence of at least a first compound for forming porous templates, wherein the porous templates are formed by precipitation of a salt which includes the anion and the cation and wherein the first compound is at least partially incorporated in the porous templates; and - at least partially cross-linking the first compound in the porous templates.
摘要翻译：提供了形成微粒的方法。该方法包括以下步骤： - 提供至少包含阴离子的第一溶液; - 提供至少包含阳离子的第二溶液; 在至少第一种形成多孔模板的化合物的存在下，将第一溶液与第二溶液混合，其中通过沉淀包括阴离子和阳离子的盐形成多孔模板，其中第一化合物至少部分地结合在多孔模板中; 和 - 至少部分交联多孔模板中的第一化合物。

7. 发明申请

WO2009114757A2 A NOVEL PHARMACEUTICAL PREPARATION FOR PREECLAMPSIA, ECLAMPSIA, AND TOXEMIA AND THEIR RELATED SYMPTOMS AND RELATED DISORDERS OF PREGNANCY 审中-公开
标题翻译：前列腺炎，ECLAMPSIA和TOXEMIA的新型药物制剂及其相关症状和相关疾病
公开(公告)号：WO2009114757A2
公开(公告)日：2009-09-17
申请号：PCT/US2009/037067
申请日：2009-03-13
申请人： FALLON, Joan, M.
发明人： FALLON, Joan, M.
IPC分类号： A61K38/48 , A61K38/46 , A61K38/43 , A61P15/06
CPC分类号： A61K38/54 , A61K36/185 , A61K38/465 , A61K38/47 , A61K38/48 , A61K38/4826 , A61K38/4873 , C12Y301/00 , C12Y302/01 , C12Y304/00 , C12Y304/21001 , C12Y304/21004 , C12Y304/22002 , A61K2300/00
摘要： A therapeutic agent for the treatment of toxemia, preeclampsia and eclampsia and the method for preparing the therapeutic agents is disclosed. The therapeutic agent is a stable pharmaceutical preparation containing, but not limited to, digestive/pancreatic enzymes. The therapeutic agent may be manufactured by a variety of encapsulation technologies. Delivery of the therapeutic agent may be made orally, through injection, by adherence of a medicated patch or other method. Further, a method of using of a biomarker, the presence of chymotrypsin in the maternal GI tract to determine the likelihood of developing preeclampsia, pregnancy induced hypertension, and eclampsia/toxemia is disclosed.
摘要翻译：公开了治疗毒血症，先兆子痫和子痫的治疗剂和治疗剂的制备方法。治疗剂是包含但不限于消化/胰酶的稳定的药物制剂。治疗剂可以通过各种封装技术制造。治疗剂的递送可以通过注射，通过粘附药膏或其它方法口服制备。此外，公开了使用生物标志物的方法，在母体胃肠道中存在糜蛋白酶以确定发生先兆子痫，妊娠诱发的高血压和子痫/毒血症的可能性。

8. 发明申请

WO2009042962A3 ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME 审中-公开
标题翻译：因子XA抑制剂的抗体及其使用方法
公开(公告)号：WO2009042962A3
公开(公告)日：2009-06-04
申请号：PCT/US2008078014
申请日：2008-09-26
申请人： PORTOLA PHARM INC , LU GENMIN , PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA
发明人： LU GENMIN , PHILLIPS DAVID R , ANDRE PATRICK , SINHA UMA
IPC分类号： C12N9/64 , A61P7/04
CPC分类号： A61K38/4846 , A61K38/00 , A61K38/4826 , A61K38/4833 , A61K38/4853 , A61K39/00 , A61K47/60 , C07K14/435 , C12N9/6432 , C12Y304/21006
摘要： The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
摘要翻译：本发明涉及解毒剂靶向因子Xa的抗凝血剂。解毒剂是因子Xa蛋白衍生物，其与因子Xa抑制剂结合，从而基本上中和它们但不组装成凝血酶原酶复合物。本文描述的衍生物缺乏或降低了内在凝固剂活性。本文公开了停止或预防正在用Xa因子抑制剂进行抗凝血剂治疗的患者出血的方法。

9. 发明申请

WO2008141263A1 HEAT RESISTANT BIOACTIVE COMPOSITION 审中-公开
标题翻译：耐热生物组合物
公开(公告)号：WO2008141263A1
公开(公告)日：2008-11-20
申请号：PCT/US2008/063378
申请日：2008-05-12
申请人： TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC. , TOYOTA MOTOR CORPORATION , REGENTS OF THE UNIVERSITY OF MINNESOTA , WANG, Ping , WU, Songtao , JIA, Hongfei , ISHII, Masahiko , TONG, Xiaodong , ZHANG, Minjuan
发明人： WANG, Ping , WU, Songtao , JIA, Hongfei , ISHII, Masahiko , TONG, Xiaodong , ZHANG, Minjuan
IPC分类号： A61F2/00 , A61L24/00
CPC分类号： A61K9/06 , A61K38/443 , A61K38/4826 , A61K45/06 , A61K47/32 , A61K2300/00
摘要： A bioactive composition includes a hydrogel matrix. At least one protein is immobilized in the hydrogel matrix. The digestive protein has a half-life at least 1000 times longer than the half-life of a free digestive protein counterpart.
摘要翻译：生物活性组合物包括水凝胶基质。至少一种蛋白质固定在水凝胶基质中。消化蛋白的半衰期比游离消化蛋白对应物的半衰期长至少1000倍。

10. 发明申请

WO2008040516A3 MICROBIOLOGICAL COMPOSITION AND USE THEREOF 审中-公开
标题翻译：微生物学组成及其用途
公开(公告)号：WO2008040516A3
公开(公告)日：2008-05-22
申请号：PCT/EP2007008521
申请日：2007-10-01
申请人： FRITZMEIER GEORG GMBH & CO KG , UPHOFF MARIA , UPHOFF HEINRICH JOSEF
发明人： UPHOFF MARIA , UPHOFF HEINRICH JOSEF
IPC分类号： A61K35/66 , A61K8/99 , A61P17/02 , A61P31/00
CPC分类号： A61K35/74 , A61K8/99 , A61K31/722 , A61K36/00 , A61K38/4826 , A61K45/06 , A61K2800/438 , A61Q19/00 , A61K2300/00
摘要： A composition is described which comprises a mixture of magnetotactic and phototrophic microorganisms. The composition is suitable as an agent against pathogenic microorganisms and for the prevention and treatment of skin changes.
摘要翻译：据描述，包括助理磁战术和光养微生物UMF的混合物的组合物。所述组合物可用作对抗病原微生物的试剂和用于皮肤损害的预防和治疗。

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