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1. 发明申请

WO2005044987A3 TOCOPHEROL ASSOCIATED PROTEIN AND USES THEREOF 审中-公开
标题翻译： TOCOPHEROL相关蛋白及其用途
公开(公告)号：WO2005044987A3
公开(公告)日：2007-02-08
申请号：PCT/US2004035646
申请日：2004-10-27
申请人： RES DEV FOUNDATION , SANDERS BOB G , KLINE KIMBERLY , YU WEIPING , LIU HUI , HANTASH FERAS
发明人： SANDERS BOB G , KLINE KIMBERLY , YU WEIPING , LIU HUI , HANTASH FERAS
IPC分类号： C12N9/00 , A61K48/00 , C07H21/04 , C07K14/47 , C12N20060101 , C12N1/21 , C12N15/70 , C12P21/06 , C12Q1/68
CPC分类号： C07K14/4747 , A61K48/00 , C07K14/47 , C07K2319/00
摘要： The present invention discloses cloning of tocopherol associated protein TAP-38 and deletion mutants of TAP-46. TAP-38, which shares homology with the previously identified TAP-46, enhances the apoptotic inducing properties of tocopherol based compounds, and blockage of TAP-38 or TAP-46 reduces the effectiveness of tocopherol based compounds. Thus, delivery of TAP-38 and TAP46 cDNA by aerosol liposome/transfection/infection methods, separately or in combination with tocopherol-based apoptosis-inducing agents as well as with other chemotherapeutic agents, would be useful for treatment and prevention of cellular proliferative diseases and disorders.
摘要翻译：本发明公开了生育酚相关蛋白TAP-38和TAP-46的缺失突变体的克隆。与先前鉴定的TAP-46共享的TAP-38增强了基于生育酚的化合物的凋亡诱导性质，并且阻断TAP-38或TAP-46降低了生育酚类化合物的有效性。因此，通过气溶胶脂质体/转染/感染方法分别或与基于生育酚的细胞凋亡诱导剂以及与其他化学治疗剂组合递送TAP-38和TAP46 cDNA可用于治疗和预防细胞增殖性疾病和疾病。

2. 发明申请

WO03089613A2 TOCOPHEROL ASSOCIATED PROTEIN AND USES THEREOF 审中-公开
标题翻译： TOCOPHEROL相关蛋白及其用途
公开(公告)号：WO03089613A2
公开(公告)日：2003-10-30
申请号：PCT/US0312238
申请日：2003-04-21
申请人： RES DEV FOUNDATION
发明人： SANDERS BOB G , KLINE KIMBERLY , YU WEIPING , HANTASH FERAS , LIU HUI
IPC分类号： A61K48/00 , C07K14/47 , C12N
CPC分类号： C07K14/47 , A61K48/00 , C07K2319/00
摘要： The present invention provides a novel tocopherol associated protein (TAP-38) DNA/protein with a (76) nucleotide base deletion resulting in a (25) amino acid deletion, followed by (90) novel nucleotides that code for (30) novel amino acids that are not expressed by TAP-46. The present invention provides data showing that TAP-38 enhances the apoptotic inducing properties of tocopherol based compounds, and blockage of TAP reduces the effectiveness of tocopherol based compounds. Thus, the present invention claim that expression of TAP-38 by tumor cells enhances the apoptotic inducing properties of tocopherol based compounds. The present invention provides aerosol liposome/transfection/infection methods for delivery of TAP-38 and TAP-46 cDNA plasmids separately and in combination with tocopherol based apoptotic inducing agents as well as with other chemotherapeutic agents as a method for treatment and prevention of cellular proliferative diseases and disorders.
摘要翻译：本发明提供了具有（76）核苷酸碱基缺失导致（25）氨基酸缺失的新生育酚相关蛋白（TAP-38）DNA /蛋白，其后是（90）编码（30）新氨基的新核苷酸 TAP-46不表达的酸。本发明提供了显示TAP-38增强基于生育酚的化合物的凋亡诱导性质的数据，并且TAP的阻断降低了基于生育酚的化合物的有效性。因此，本发明要求肿瘤细胞中TAP-38的表达增强了基于生育酚的化合物的凋亡诱导性质。本发明提供用于分别递送TAP-38和TAP-46 cDNA质粒的气溶胶脂质体/转染/感染方法，并与基于生育酚的凋亡诱导剂以及其它化学治疗剂一起作为治疗和预防细胞增殖的方法疾病和病症。

3. 发明申请

WO2012044727A3 MANUFACTURING PROCESS FOR PYRIMIDINE DERIVATIVES 审中-公开
标题翻译：吡啶衍生物的制备方法
公开(公告)号：WO2012044727A3
公开(公告)日：2012-06-07
申请号：PCT/US2011053808
申请日：2011-09-29
申请人： NOVARTIS AG , CALIENNI JOHN VINCENT , DE LA CRUZ MARILYN , FLUBACHER DIETMAR , GONG BAOQING , KAPA PRASAD KOTESWARA , KARPINSKI PIOTR H , LIU HUI , MICHEL PASCAL , MOSE RASMUS , TESTA MARIA CATERINA , WAYKOLE LILADHAR MURLIDHAR
发明人： CALIENNI JOHN VINCENT , DE LA CRUZ MARILYN , FLUBACHER DIETMAR , GONG BAOQING , KAPA PRASAD KOTESWARA , KARPINSKI PIOTR H , LIU HUI , MICHEL PASCAL , MOSE RASMUS , TESTA MARIA CATERINA , WAYKOLE LILADHAR MURLIDHAR
IPC分类号： C07D239/28 , C07D239/30 , C07D401/04
CPC分类号： C07D401/04 , A61K31/535 , C07D213/72 , C07D413/14 , C07F5/025 , C07F5/04
摘要： The invention relates to processes for manufacturing a compound of formula (5) or a stereoisomer, tautomer or a salt thereof, wherein the substituents are as defined in the specification. The invention further relates to new manufacturing processes for specific solid forms of Compound A and its salts, to such solid forms and to use of said solid forms for the therapeutic treatment of warm-blooded animals.
摘要翻译：本发明涉及制备式（5）化合物或其立体异构体，互变异构体或其盐的方法，其中取代基如说明书中所定义。本发明还涉及用于化合物A及其盐的特定固体形式的这种固体形式的新制备方法，以及所述固体形式用于治疗温血动物的新方法。

4. 发明申请

WO0233848A2 CHANNEL ALLOCATION IN BROADBAND ORTHOGONAL FREQUENCY-DIVISION MULTIPLE-ACCESS/SPACE-DIVISION MULTIPLE-ACCESS NETWORKS 审中-公开
标题翻译：宽带正交频分多路访问/空间多路访问网络中的信道分配
公开(公告)号：WO0233848A2
公开(公告)日：2002-04-25
申请号：PCT/US0142716
申请日：2001-10-11
申请人： BROADSTORM TELECOMMUNICATIONS , LIU HUI , YIN HUJUN , LI XIAODONG , MU FUQI
发明人： LIU HUI , YIN HUJUN , LI XIAODONG , MU FUQI
IPC分类号： H04B7/005 , H04L5/02 , H04W52/50 , H04B7/00
CPC分类号： H04W52/50 , H04L5/023 , H04W72/0453
摘要： A network is described. In one embodiment, the network comprises multiple subscriber units to communicate with the base station using an orthogonal frequency-division multiple-access (OFDMA) protocol, and a base station. The base-station includes a memory unit to store broadband spatial signature vectors associated with each subscriber and raffic channel allocation logic. The vectors are a function of frequency. The traffic channel allocation logic allocates OFDMA channels using the broadband spatial signatures vectors of the subscribers.
摘要翻译：描述网络。在一个实施例中，网络包括使用正交频分多址（OFDMA）协议和基站与基站进行通信的多个用户单元。基站包括存储单元，用于存储与每个用户相关联的宽带空间签名向量和流量信道分配逻辑。向量是频率的函数。业务信道分配逻辑使用订户的宽带空间签名向量来分配OFDMA信道。

5. 发明申请

WO2010062523A3 PROSTAGLANDIN AND PROSTAMIDE DRUG DELIVERY SYSTEMS AND INTRAOCULAR THERAPEUTIC USES THEREOF 审中-公开
标题翻译： PROSTAGLANDIN和PROSTAMIDE药物输送系统及其内科治疗用途
公开(公告)号：WO2010062523A3
公开(公告)日：2010-07-22
申请号：PCT/US2009061798
申请日：2009-10-23
申请人： ALLERGAN INC , ROBINSON MICHAEL R , LIU HUI , HUGHES PATRICK M , SPADA LON T , GHEBREMESKEL ALAZAR N
发明人： ROBINSON MICHAEL R , LIU HUI , HUGHES PATRICK M , SPADA LON T , GHEBREMESKEL ALAZAR N
IPC分类号： A61K9/00 , A61K9/16 , A61K9/20 , A61K31/557 , A61K31/5575 , A61P27/06
CPC分类号： A61L31/06 , A61K9/0048 , A61K9/0051 , A61K9/1647 , A61K9/204 , A61K31/216 , A61K31/557 , A61K31/5575 , A61L31/16
摘要： Biocompatible, bioerodible implants and microspheres include latanoprost and a biodegradable polymer effective, when placed intraocular (such as into the subtenon space) to treat glaucoma.
摘要翻译：生物相容性，生物可侵蚀的植入物和微球体包括拉坦前列素和可生物降解的聚合物，当放置眼内（如进入subtenon空间）治疗青光眼时有效。

6. 发明申请

WO2008014126A3 SPECTRUM SHARING BETWEEN BROADCASTING AND MULTIPLE-ACCESS NETWORKS 审中-公开
标题翻译：广播和多路访问网络之间的频谱共享
公开(公告)号：WO2008014126A3
公开(公告)日：2008-05-02
申请号：PCT/US2007073322
申请日：2007-07-12
申请人： ADAPTIX INC , LIU HUI
发明人： LIU HUI
IPC分类号： H04Q7/00
CPC分类号： H04H20/71 , H04H20/42 , H04H60/91
摘要： Advantage is taken of the fact that broadcast coverage is unevenly distributed across a geographical region and multiple-access transmissions can be interposed in regions where interference is minimum. In one embodiment, advantage is taken of the known broadcasting signal and techniques, such as, for example, dirty paper coding techniques, can be used to pre-cancel broadcasting differences, allowing a system to operate as if the interference did not exist.
摘要翻译：优点在于广播覆盖不均匀地分布在地理区域上，并且多址传输可以插入在干扰最小的区域中。在一个实施例中，采用已知的广播信号的优点，并且可以使用技术，例如脏纸编码技术来预取消广播差异，从而允许系统像干涉不存在一样操作。

7. 发明申请

WO2005077130A3 A METHOD FOR THE REMOVAL OF AGGREGATE PROTEINS FROM RECOMBINANT SAMPLES USING ION EXCHANGE CHROMATOGRAPHY 审中-公开
标题翻译：离子交换色谱法从重组样品中去除凝集蛋白的方法
公开(公告)号：WO2005077130A3
公开(公告)日：2005-12-29
申请号：PCT/US2005004729
申请日：2005-02-10
申请人： TANOX INC , LIU HUI , TANG KE
发明人： LIU HUI , TANG KE
IPC分类号： A61K39/395 , C07K1/18 , C07K16/00 , C07K16/06 , C07K16/42
CPC分类号： C07K16/065 , C07K1/18 , C07K16/4291
摘要： The present invention relates to processes for the removal of unwanted protein aggregates from antibody preparations. One process involves removal when the aggregate and antibody are very close in pl value ("Bind-Elute" process). Another process involves the removal when the aggregate and antibody are very close in net electric charge and retention time on ion exchange resin ("Bind-Washout" process). Using either process, at least 90% of the antibody is recovered and 70-90% of the aggregate is removed.
摘要翻译：本发明涉及从抗体制备物中去除不需要的蛋白质聚集物的方法。一个过程涉及聚集体和抗体非常接近pl值时的去除（“Bind-Elute”过程）。另一种方法涉及当聚集体和抗体在离子交换树脂上的净电荷和保留时间非常接近时的去除（“结合 - 冲洗”过程）。使用任一方法，至少90％的抗体被回收并且70-90％的聚集体被去除。

8. 发明申请

WO0231991A3 CHANNEL ASSIGNMENT IN AN OFDMA SYSTEM 审中-公开
标题翻译： OFDMA系统中的信道分配
公开(公告)号：WO0231991A3
公开(公告)日：2003-05-01
申请号：PCT/US0131766
申请日：2001-10-10
申请人： BROADSTORM TELECOMMUNICATIONS , LIU HUI , LI XIAODONG , MU FUQI
发明人： LIU HUI , LI XIAODONG , MU FUQI
IPC分类号： H04J11/00 , H04B7/26 , H04L1/00 , H04L5/02 , H04W28/04 , H04W48/16 , H04W72/02 , H04W72/04 , H04W72/08 , H04Q7/38 , H04L27/26
CPC分类号： H04L5/0007 , H04L1/0003 , H04L1/0009 , H04L1/0026 , H04L5/0023 , H04L5/0037 , H04L5/0046 , H04L5/006 , H04L5/0064 , H04W48/16 , H04W72/02 , H04W72/0453 , H04W72/082
摘要： A method and apparatus for controlling OFDMA cellular networks is described. In one embodiment, the method comprises receiving channel characteristics and noise-plus-interference information measured at spatially distributed subscribers and assigning traffic channels for an orthogonal frequency-division multiple-access (OFDMA) network.
摘要翻译：描述了一种用于控制OFDMA蜂窝网络的方法和装置。在一个实施例中，该方法包括接收在空间分布的用户处测量的信道特性和噪声加干扰信息，并为正交频分多址（OFDMA）网络分配业务信道。

9. 发明申请

WO2013016575A3 LOW VARIATION CURRENT MULTIPLIER 审中-公开
标题翻译：低变量电流乘法器
公开(公告)号：WO2013016575A3
公开(公告)日：2013-03-21
申请号：PCT/US2012048399
申请日：2012-07-26
申请人： SKYWORKS SOLUTIONS INC , LIU HUI , GREEN DUANE A , SAWATZKY DAVID ANTHONY
发明人： LIU HUI , GREEN DUANE A , SAWATZKY DAVID ANTHONY
IPC分类号： H03F1/30 , H03F3/24
CPC分类号： G05F1/46 , H03F1/0216 , H03F1/0227 , H03F1/30 , H03F1/56 , H03F3/195 , H03F3/211 , H03F3/245 , H03F3/72 , H03F2200/108 , H03F2200/111 , H03F2200/387 , H03F2200/429 , H03F2200/447 , H03F2203/7209 , H03F2203/7236 , H03G3/3042 , H04B1/0458 , H04B1/0475
摘要： Aspects of the present disclosure relate to a current multiplier that can generate an output current with high linearity and/or high temperature compensation. Such current multipliers can be implemented by complementary metal oxide semiconductor (CMOS) circuit elements. In one embodiment, the current multiplier can include a current divider and a core current multiplier. The current divider can generate a divided current by dividing an input current by an adjustable division ratio. The division ratio can be adjusted, for example, based on a comparison of the input current with a reference current. The core current multiplier can generate the output current based on multiplying the divided current and a different current. According to certain embodiments, the output current can be maintained within a predetermined range as the input current to the current divider varies within a relatively wide range.
摘要翻译：本公开的方面涉及可以产生具有高线性度和/或高温度补偿的输出电流的电流乘法器。这种电流乘法器可以由互补金属氧化物半导体（CMOS）电路元件实现。在一个实施例中，电流乘法器可以包括分流器和核心电流倍增器。电流分压器可以通过将输入电流除以可调分频比来产生分压电流。例如，可以基于输入电流与参考电流的比较来调整分频比。核心电流乘数可以基于乘以分流电流和不同电流来产生输出电流。根据某些实施例，当到分流器的输入电流在相对宽的范围内变化时，输出电流可以保持在预定范围内。

10. 发明申请

WO2009158634A3 SCAFFOLD COATED AND/OR IMPREGNATED WITH AT LEAST ONE BIOACTIVE AGENT FOR TISSUE REPAIR AND OTHER MEDICAL APPLICATIONS 审中-公开
标题翻译：用于组织修复和其他医疗应用的至少一种生物活性剂的SCAFFOLD涂层和/或
公开(公告)号：WO2009158634A3
公开(公告)日：2010-08-12
申请号：PCT/US2009048885
申请日：2009-06-26
申请人： ZIMMER ORTHOBIOLOGICS INC , XIAN HAI-QING , YAO JIAN Q , WANG HALI , DAHESHIA MASSOUD , LIU HUI
发明人： XIAN HAI-QING , YAO JIAN Q , WANG HALI , DAHESHIA MASSOUD , LIU HUI
IPC分类号： A61L27/22 , A61L27/54
CPC分类号： A61L27/22 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2300/426 , A61L2300/43 , A61L2300/64
摘要： A system and method for producing a scaffold coated and/or impregnated with at least one bioactive agent. This is accomplished by culturing at least one cell in the same medium as a scaffold, but without physical contact between the at least one cell and the scaffold. The system includes a container having a surface defining an interior compartment. A medium is disposed within the interior compartment. At least one cell is disposed within the medium, the at least one cell being capable of producing at least one bioactive agent. Further, a scaffold is disposed within the medium. The scaffold is physically separated from the at least one cell such that there is no contact between the scaffold and the at least one cell. Thus, as the at least one cell produces at least one bioactive agent, such as a growth factor, the at least one bioactive agent enters the medium, and contacts and coats and/or impregnates the scaffold. However, due to the physical separation of the scaffold and at least one cell, the at least one cell is prevented from contacting and coating and/or impregnating the scaffold. Thus, only the desired bioactive agent or agents coat and/or impregnate the scaffold.
摘要翻译：用于生产用至少一种生物活性剂包被和/或浸渍的支架的系统和方法。这是通过在相同的培养基中培养作为支架的至少一个细胞，但是在至少一个细胞和支架之间没有物理接触来实现的。该系统包括具有限定内部隔间的表面的容器。介质设置在内部隔室内。至少一个细胞设置在培养基内，所述至少一个细胞能够产生至少一种生物活性剂。此外，在培养基内设置支架。骨架与至少一个细胞物理分离，使得支架与至少一个细胞之间不存在接触。因此，由于至少一个细胞产生至少一种生物活性剂，例如生长因子，所述至少一种生物活性剂进入培养基，并接触并涂覆和/或浸渍支架。然而，由于支架和至少一个电池的物理分离，所以防止了至少一个电池接触和涂覆和/或浸渍支架。因此，只有所需的生物活性剂或药剂包衣和/或浸渍支架。

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