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1. 发明申请

WO2012145700A1 BONE PLATES, SCREWS, AND INSTRUMENTS 审中-公开
标题翻译：骨板，螺丝和仪器
公开(公告)号：WO2012145700A1
公开(公告)日：2012-10-26
申请号：PCT/US2012/034553
申请日：2012-04-20
申请人： OSTEOMED LLC. , SCHMIERER, Doug, E. , FORTON, Charles Raymond , ZAPOROJAN, Victor , YAP, Marc, C.
发明人： SCHMIERER, Doug, E. , FORTON, Charles Raymond , ZAPOROJAN, Victor , YAP, Marc, C.
IPC分类号： A61B17/70
CPC分类号： A61B17/8033 , A61B17/1659 , A61B17/1671 , A61B17/7007 , A61B17/7059 , A61B17/7062 , A61B17/7064 , A61B17/7068 , A61B17/8028 , A61B17/8047 , A61B17/809 , A61B50/30
摘要： Systems for trauma and/or joint fusion implants and instruments include transarticular screw and intra-articular washer, polyaxial screw and plate, single- and multi-level polyaxial bone clamps, and minimally invasive adaptations.
摘要翻译：创伤和/或关节融合植入物和器械的系统包括经关节螺钉和关节内垫圈，多轴螺钉和板，单层和多层多轴骨夹，以及微创适应。

2. 发明申请

WO2009114524A1 INSTRUMENTS AND METHODS USED WHEN REPAIRING A DEFECT ON A TISSUE SURFACE 审中-公开
标题翻译：修复组织表面缺陷时使用的仪器和方法
公开(公告)号：WO2009114524A1
公开(公告)日：2009-09-17
申请号：PCT/US2009/036661
申请日：2009-03-10
申请人： ZIMMER ORTHOBIOLOGICS, INC. , RITTER, Robin , ZAPOROJAN, Victor , GAO, Jizong
发明人： RITTER, Robin , ZAPOROJAN, Victor , GAO, Jizong
IPC分类号： A61B17/17
CPC分类号： A61B17/1635 , A61B17/17
摘要： An instrument (10) for determining the proper orientation for repairing a defect site (12) on a tissue surface (14) generally comprises a shaft (20), a plurality of probes (40) operatively coupled to the shaft (20), and at least one indicator (50) operatively coupled to the plurality of probes (40). The probes (40) are configured to extend beyond a first end of the shaft (22) and are movable relative the shaft (20). The at least one indicator (50) is configured to display the displacements of the probes (40) relative to the first end (22) so that the displacements of the probes (40) may be compared. A method of using the instrument (10) when repairing a defect on a tissue surface (14) is also disclosed.
摘要翻译：用于确定用于修复组织表面（14）上的缺陷位点（12）的正确定向的仪器（10）通常包括轴（20），可操作地联接到所述轴（20）的多个探针（40），以及至少一个可操作地耦合到所述多个探针（40）的指示器（50）。探针（40）构造成延伸超过轴（22）的第一端并且可相对于轴（20）移动。所述至少一个指示器（50）构造成相对于所述第一端（22）显示所述探针（40）的位移，使得可以比较所述探针（40）的位移。还公开了在修复组织表面（14）上的缺陷时使用仪器（10）的方法。

3. 发明申请

WO2008147692A1 DIFFERENTIALLY PROCESSED TISSUE AND PROCESSING METHODS THEREOF 审中-公开
标题翻译：不同加工组织及其加工方法
公开(公告)号：WO2008147692A1
公开(公告)日：2008-12-04
申请号：PCT/US2008/063582
申请日：2008-05-14
申请人： ZIMMER ORTHOBIOLOGICS, INC. , YAO, Jian, Q. , XIAN, Hai-Qing , GAO, Jizong , BRISTOL, Rodney , ZAPOROJAN, Victor , WANG, Hali , LIU, Hul
发明人： YAO, Jian, Q. , XIAN, Hai-Qing , GAO, Jizong , BRISTOL, Rodney , ZAPOROJAN, Victor , WANG, Hali , LIU, Hul
IPC分类号： A61L27/14 , A61L31/10 , A61L27/36 , A61L27/38 , A61F2/00
CPC分类号： A61L27/3608 , A61L27/3604 , A61L27/3683
摘要： A method of preparing an implantable biological device having a first tissue part and a second tissue part includes exposing the first tissue part to a first preparation method and preventing exposure of the second biological tissue part to the first preparation method. Preventing exposure of the second biological tissue part to the first preparation method may be achieved using an embedding technique, a coating technique, a covering technique, or physical isolation. The method may further include exposing the second tissue part to a second preparation method and preventing exposure of the first biological tissue part to the second preparation method. An apparatus for preparing an implantable biologic device includes an enclosure having first and second chambers separated by a partition member wherein a substantial portion of the first tissue part is within the first chamber and a substantial portion of the second tissue part is within the second chamber.
摘要翻译：制备具有第一组织部分和第二组织部分的可植入生物装置的方法包括将第一组织部分暴露于第一制备方法并防止第二生物组织部分暴露于第一制备方法。可以使用嵌入技术，涂覆技术，覆盖技术或物理隔离来防止第二生物组织部分暴露于第一制备方法。该方法可以进一步包括将第二组织部分暴露于第二制备方法并防止第一生物组织部分暴露于第二制备方法。一种用于制备可植入生物装置的装置，包括具有由分隔构件分开的第一和第二腔室的外壳，其中所述第一组织部分的大部分位于所述第一腔室内，并且所述第二组织部分的大部分位于所述第二腔室内。

4. 发明申请

WO2008128075A1 COMPOSITIONS AND METHODS FOR TISSUE REPAIR 审中-公开
标题翻译：组织修复的组合物和方法
公开(公告)号：WO2008128075A1
公开(公告)日：2008-10-23
申请号：PCT/US2008/060078
申请日：2008-04-11
申请人： ISTO TECHNOLOGIES, INC. , ZIMMER, INC. , YAO, Jian , WALTHALL, Ben , GAO, Jizong , ZAPOROJAN, Victor
发明人： YAO, Jian , WALTHALL, Ben , GAO, Jizong , ZAPOROJAN, Victor
IPC分类号： A61F2/18 , A61F2/02
CPC分类号： A61F2/30756 , A61F2/3094 , A61F2/3859 , A61F2002/2817 , A61F2002/30764 , A61F2002/30957 , A61F2002/30971 , A61F2002/4635 , A61F2310/00365 , A61L27/3604 , A61L27/38 , A61L27/3817 , A61L27/54 , A61L2300/25 , A61L2300/414 , A61L2300/64
摘要： Implants for repairing tissue defects, such as cartilage tissue defects, and methods of their preparation and use are disclosed. A mold of a tissue defect is prepared by pressing upon the defect a substrate having shape memory, such as aluminum foil. The mold, which has contours substantially conforming to those of the defect, is removed from the defect, and tissue particles are added to the mold ex vivo. A biological carrier such as biocompatible glue is also added to the mold. The combination of tissue particles and the biological carrier thereby form an implant, which retains its shape after separation from the mold. The implant can be transferred to the tissue defect, with contours of the mold matching corresponding contours of the defect.
摘要翻译：公开了用于修复诸如软骨组织缺陷的组织缺陷的植入物及其制备和使用方法。通过将缺陷压在诸如铝箔的形状记忆衬底上来制备组织缺陷的模具。将具有基本上符合缺陷的轮廓的模具从缺陷中去除，并将组织颗粒离体加入到模具中。生物相容性胶水等生物载体也加入到模具中。因此，组织颗粒和生物载体的组合形成植入物，其在与模具分离后保持其形状。植入物可以转移到组织缺损，模具的轮廓匹配缺陷的对应轮廓。

5. 发明申请

WO2008079194A1 METHOD OF OBTAINING VIABLE SMALL TISSUE PARTICLES AND USE FOR TISSUE REPAIR 审中-公开
标题翻译：获得可见的小组织颗粒的方法和用于组织修复的方法
公开(公告)号：WO2008079194A1
公开(公告)日：2008-07-03
申请号：PCT/US2007/025252
申请日：2007-12-11
申请人： ZIMMER ORTHOBIOLOGICS, INC. , YAO, Jian, Q. , ZAPOROJAN, Victor
发明人： YAO, Jian, Q. , ZAPOROJAN, Victor
IPC分类号： A61F2/02 , A61K35/12
CPC分类号： A61K35/32 , A61K9/14 , A61K38/4833 , A61K2300/00
摘要： The invention provides a composition including isolated small living tissue particles, a method of making the tissue particles, and a method of using the composition to ameliorate a tissue defect. The tissue particles are composed of cells and their associated extracellular molecules and are sized, in certain embodiments, to be smaller than about 1 mm. Another aspect of the inventive tissue particles is the large percentage of viable cells. In certain embodiments, the tissue particles are made from cartilage and the composition may also contain additives such as adhesives, solutions, and bioactive agents.
摘要翻译：本发明提供包含分离的小生物体组织颗粒的组合物，制备组织颗粒的方法，以及使用该组合物改善组织缺陷的方法。组织颗粒由细胞及其相关的细胞外分子组成，并且在某些实施方案中尺寸设定为小于约1mm。本发明组织颗粒的另一方面是大量的活细胞。在某些实施方案中，组织颗粒由软骨制成，并且组合物还可以含有添加剂，例如粘合剂，溶液和生物活性剂。

6. 发明申请

WO2008154149A3 TISSUE PROCESSING FOR NONIMMUNOGENIC IMPLANTS 审中-公开
标题翻译：非发育性植入物的组织加工
公开(公告)号：WO2008154149A3
公开(公告)日：2009-11-12
申请号：PCT/US2008064653
申请日：2008-05-23
申请人： ZIMMER ORTHOBIOLOGICS INC , WANG HALI , LIU HUI , XIAN HAI-QING , YAO JIAN Q , ZAPOROJAN VICTOR
发明人： WANG HALI , LIU HUI , XIAN HAI-QING , YAO JIAN Q , ZAPOROJAN VICTOR
IPC分类号： A61L27/36 , A61K35/32 , A61K35/34 , A61K35/36 , A61K35/44
CPC分类号： A61L27/3654 , A61K35/32 , A61K35/34 , A61K35/44 , A61L27/3633 , A61L27/3687 , A61L2430/40
摘要： Methods for processing tissues to render them suitable for implantation, e.g., in an orthopedic site. Tissues are rendered substantially acellular and substantially nonimmunogenic by exposure to processes that result in cell lysis 12, increasing permeability of the extracellular matrix 14, degrading the debris from lysis 16, and removing the debris 18. Methods of forming tissue implants, kits for processing tissue implants, and methods of using tissue implants are also disclosed.
摘要翻译：用于处理组织以使其适合植入的方法，例如在矫形部位。组织通过暴露于导致细胞裂解12，增加细胞外基质14的渗透性，降解碎裂16和去除碎屑的过程而呈现基本上无细胞并且基本上是非免疫原性的。形成组织植入物的方法，用于处理组织的试剂盒植入物和使用组织植入物的方法也被公开。

7. 发明申请

WO2009014996A3 MEDICAL DEVICES AND METHODS FOR CUTTING AND SUTURING BIOLOGICAL TISSUE 审中-公开
公开(公告)号：WO2009014996A3
公开(公告)日：2009-01-29
申请号：PCT/US2008/070406
申请日：2008-07-18
申请人： ZIMMER ORTHOBIOLOGICS, INC. , ZAPOROJAN, Victor , YAO, Jian Q. , BRISTOL, Rodney , LIU, Hui , WANG, Hali , XIAN, Hai-Qing
发明人： ZAPOROJAN, Victor , YAO, Jian Q. , BRISTOL, Rodney , LIU, Hui , WANG, Hali , XIAN, Hai-Qing
IPC分类号： A61B17/04 , A61B17/32
摘要： Medical devices (100, 200, 400) for cutting and suturing biological tissue generally include a shaft (102) and first and second guide members (108, 110) each including a first portion (112, 114) coupled to the shaft (102) at a first location and a second portion (116, 118) coupled to the shaft (102) at a second location. The first portions (112, 114) are movable along the shaft (102) relative to the second portions (116, 118), and the first and second guide members (108, 110) define an arcuate profile and are configured to flex in response to such movement. When used to cut tissue, the medical device (100) may further include a blade (106) positioned between the first and second guide members (108, 110). When used to suture tissue, one or more suture guides (240) may be provided on the first guide member (108) for directing a suture needle through tissue proximate the first guide member (108). Methods of repairing and replacing a meniscus using the medical devices (100, 200, 400) are also provided.

8. 发明申请

WO2009014996A2 MEDICAL DEVICES AND METHODS FOR CUTTING AND SUTURING BIOLOGICAL TISSUE 审中-公开
标题翻译：用于切割和切割生物组织的医疗装置和方法
公开(公告)号：WO2009014996A2
公开(公告)日：2009-01-29
申请号：PCT/US2008070406
申请日：2008-07-18
申请人： ZIMMER ORTHOBIOLOGICS INC , ZAPOROJAN VICTOR , YAO JIAN Q , BRISTOL RODNEY , LIU HUI , WANG HALI , XIAN HAI-QING
发明人： ZAPOROJAN VICTOR , YAO JIAN Q , BRISTOL RODNEY , LIU HUI , WANG HALI , XIAN HAI-QING
IPC分类号： A61B17/04 , A61B17/32
CPC分类号： A61B17/0469 , A61B17/0467 , A61B17/0482 , A61B17/06066 , A61B17/320016 , A61B2017/00353 , A61B2017/06042 , A61B2017/320052
摘要： Medical devices (100, 200, 400) for cutting and suturing biological tissue generally include a shaft (102) and first and second guide members (108, 110) each including a first portion (112, 114) coupled to the shaft (102) at a first location and a second portion (116, 118) coupled to the shaft (102) at a second location. The first portions (112, 114) are movable along the shaft (102) relative to the second portions (116, 118), and the first and second guide members (108, 110) define an arcuate profile and are configured to flex in response to such movement. When used to cut tissue, the medical device (100) may further include a blade (106) positioned between the first and second guide members (108, 110). When used to suture tissue, one or more suture guides (240) may be provided on the first guide member (108) for directing a suture needle through tissue proximate the first guide member (108). Methods of repairing and replacing a meniscus using the medical devices (100, 200, 400) are also provided.
摘要翻译：用于切割和缝合生物组织的医疗装置（100,200,400）通常包括轴（102）以及第一和第二引导构件（108,110），每个引导构件包括联接到轴（102）的第一部分（112,114）在第一位置和在第二位置与轴（102）连接的第二部分（116,118）。第一部分（112,114）可相对于第二部分（116,118）沿着轴（102）移动，并且第一和第二引导部件（108,110）限定弓形轮廓并且构造成响应地弯曲到这样的运动。当用于切割组织时，医疗装置（100）可以进一步包括定位在第一和第二引导构件（108,110）之间的刀片（106）。当用于缝合组织时，可以在第一引导构件（108）上提供一个或多个缝合线引导件（240），用于引导缝合针穿过靠近第一引导构件（108）的组织。还提供了使用医疗装置（100,200,400）修复和更换弯月面的方法。

9. 发明申请

WO2008154149A2 TISSUE PROCESSING FOR NONIMMUNOGENIC IMPLANTS 审中-公开
标题翻译：非发育性植入物的组织加工
公开(公告)号：WO2008154149A2
公开(公告)日：2008-12-18
申请号：PCT/US2008/064653
申请日：2008-05-23
申请人： ZIMMER ORTHOBIOLOGICS, INC. , WANG, Hali , LIU, Hui , XIAN, Hai-Qing , YAO, Jian, Q. , ZAPOROJAN, Victor
发明人： WANG, Hali , LIU, Hui , XIAN, Hai-Qing , YAO, Jian, Q. , ZAPOROJAN, Victor
IPC分类号： A61L27/36
CPC分类号： A61L27/3654 , A61K35/32 , A61K35/34 , A61K35/44 , A61L27/3633 , A61L27/3687 , A61L2430/40
摘要： Methods for processing tissues to render them suitable for implantation, e.g., in an orthopedic site. Tissues are rendered substantially acellular and substantially nonimmunogenic by exposure to processes that result in cell lysis 12, increasing permeability of the extracellular matrix 14, degrading the debris from lysis 16, and removing the debris 18. Methods of forming tissue implants, kits for processing tissue implants, and methods of using tissue implants are also disclosed.
摘要翻译：用于处理组织以使其适合植入的方法，例如在矫形部位。组织通过暴露于导致细胞裂解12，增加细胞外基质14的渗透性，降解碎裂16和去除碎屑的过程而呈现基本上无细胞并且基本上是非免疫原性的。形成组织植入物的方法，用于处理组织的试剂盒植入物和使用组织植入物的方法也被公开。

10. 发明申请

WO2008079613A1 APPARATUS FOR DELIVERING A BIOCOMPATIBLE MATERIAL TO A SURGICAL SITE AND METHOD OF USING SAME 审中-公开
标题翻译：将生物成分材料递送至手术部位的装置及其使用方法
公开(公告)号：WO2008079613A1
公开(公告)日：2008-07-03
申请号：PCT/US2007/086468
申请日：2007-12-05
申请人： ZIMMER ORTHOBIOLOGICS, INC. , YAO, Jian, Q. , ZAPOROJAN, Victor , GAO, Jizong , HUANG, Xiao , GUO, Joe, Zhe
发明人： YAO, Jian, Q. , ZAPOROJAN, Victor , GAO, Jizong , HUANG, Xiao , GUO, Joe, Zhe
IPC分类号： A61F2/30 , A61F2/46 , A61B17/88
CPC分类号： A61F2/30756 , A61B17/8808 , A61B17/8811 , A61B17/8822 , A61B17/8836 , A61F2/4618 , A61F2002/30075 , A61F2002/30581 , A61F2002/30583 , A61F2002/465 , A61F2002/4692 , A61F2210/0061 , A61F2210/0085
摘要： A device (10, 60} for delivering a biocompatible material (12) to a surgical site (14) includes an elongate cannula (16) having a proximal portion (18), a distal portion (20), and at least one interior lumen (22) disposed between the proximal and distal portions (18, 20) through which the biocompatible material (12) is delivered. The device (10, 60) further includes a confinement member (26) adjacent the distal portion (18) of the cannula (16) having expanded and unexpanded positions. In the expanded position, the confinement member (26) defines an open cavity (28) about the distal portion (18) of the cannula (16) and in fluid communication with the interior lumen (22) to retain the biocompatible material (12). A method of delivering a curable biocompatible material (12) to a surgical site (14) includes positioning a distal portion (18) of a cannula (16) adjacent the surgical site (14) and actuating a confinement member (26) to define an open cavity (28) about the distal portion (18). The biocompatible material (12) is introduced into the cavity (28) through the cannula (16) and cross-linking of the curable biocompatible material (12) is initiated.
摘要翻译：用于将生物相容性材料（12）输送到外科手术部位（14）的装置（10,60）包括具有近端部分（18），远端部分（20）和至少一个内腔（22），其设置在所述生物相容性材料（12）被输送的所述近端部分（18,20）之间，所述装置（10,60）还包括与所述生物相容性材料（12）的远端部分（18）相邻的限制部件在膨胀位置，限制构件（26）限定围绕套管（16）的远端部分（18）的开放空腔（28）并且与内腔（...）流体连通将可固化生物相容性材料（12）递送到手术部位（14）的方法包括将邻近手术部位（14）的套管（16）的远端部分（18）定位，以及致动限制构件（26）以围绕所述远端部分（18）限定开放空腔（28）。生物相容性材料（12）通过插管（16）引入空腔（28）中，开始可固化生物相容性材料（12）的交联。

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